ライフサイエンスコーパス: throughput

1 -speed, large-area, high-resolution and high-throughput.

2 ionation is experimentally difficult and low throughput.

3 roxyl-5-methyl-4-isoxazole-propionate (AMPA) throughput.

4 yeast genome at unprecedented resolution and throughput.

5 often carried out sequentially and with low throughput.

6 cumulation are limited in their relevance or throughput.

7 volumes (>10 ml) within minutes, increasing throughput 100 times over cuvettes.

8 imate of net community production, with high-throughput 18 S ribosomal DNA sequencing to elucidate th

9 asitemia quantification in under 1min with a throughput 500 cells/s.

10 Thanks to the high throughput acquisition of biomarker levels in G. fossaru

11 table, active enzymes without laborious high-throughput activity screens.

12 roposed mutants were tested in a second high-throughput AFM SMFS experiment revealing that in one cas

13 fic Biosciences and Oxford Nanopore increase throughput also but require high input amounts or amplif

14 This high-throughput analysis detected Ag-specific human T cells o

15 e of ethoscopes, which are machines for high-throughput analysis of behavior in Drosophila and other

16 To permit high-throughput analysis of gene networks, we have implemente

17 fication due to a lack of tools for the high-throughput analysis of RNA-RNA interactions in bacteria.

18 DL-based approach enabled sensitive and high-throughput analysis of the enzymatic hydrolysis of eight

19 mpatible with laboratory automation for high-throughput analysis.

20 t currently no annotation technique combines throughput and accuracy.

21 literature data and were obtained in a high-throughput and automated manner.

22 This enables high-throughput and automated single-cell microscopy for a wi

23 ers markedly in resolution, reproducibility, throughput and biases.

24 e, there is an urgent need to develop a high-throughput and efficient strategy to identify the E3-sub

25 MS setup was employed, providing accelerated throughput and high sensitivity and permitting a lateral

26 This work reports a high throughput and label-free microfluidic cell deformabilit

27 To meet high throughput and rapid turnaround time requirements, newbo

28 their dynamics have been hindered by the low throughput and resolution of currently available researc

29 With the goal to develop high-throughput and robust quantitative methods for the profi

30 Here, we present a new version with improved throughput and sensitivity by coupling the DNA walking s

31 logical advances in FT-IR microscopy, sample throughput and speed of acquisition are key barriers to

32 ng the field of metabolomics include scaling throughput and technical capacity for metabolomics appro

33 sample and reagent consumption and increase throughput, and additionally uncover static and dynamic

34 Here, we adopt a label-free, high-throughput, and continuous technique utilizing inertial

35 ompatible with high-content imaging and high-throughput applications.

36 ering these experiments ineffective for high-throughput applications.

37 Using this high-throughput approach, we defined three sets of chromosoma

38 These high-throughput approaches offer investigators a toolkit for

39 Our device allows high-throughput approaches, patterning different cell types a

40 ve precision and much higher sample analysis throughput as compared with prior methods.

41 High-throughput assays for measuring the three-dimensional (3

42 High-throughput assays that produce hundreds of measurements

43 opmental toxicity compared to BDE 47 in high-throughput assays.

44 d sequences increasingly available from high-throughput assays.

45 rential splicing, but has potentially higher throughput at a lower cost, along with the ability to im

46 mmunication networks to optimize information throughput at the group level.

47 single specimen and can be applied to a high-throughput automated platform.

48 gy opens the possibility to combine the high-throughput biochemical or living cell screenings using t

49 High-throughput biology presents unique opportunities and cha

50 LOC platform would be widely used as a high-throughput biosensor to analyze food, clinical and envir

51 d cytoplasmic and nuclear morphology in high throughput, but only the final cell counts are commonly

52 ctor, can increase analytical and volumetric throughputs by orders of magnitude in a compact, simple,

53 We used high-throughput calcium-flux assays and patch clamp recording

54 Based on the high-throughput calculation, a sandwich microstructure for PV

55 nefit from low reagents consumption and high throughput capacity of droplet-based microfluidic system

56 Thus, we designed a high-throughput chemical screen platform to quantify PGC-1alp

57 Here, we use high-throughput coarse-grained molecular dynamics simulations

58 Here, we demonstrate a high-throughput communication approach using the orbital angu

59 hortcoming, we have developed a robust, high-throughput compatible, click chemistry-based approach to

60 get properties, such as auxetics, using high-throughput computations, open databases, and efficient s

61 omated Web service running on community high-throughput computing and distributed data storage infras

62 uantum cascade lasers has increased the PTIR throughput considerably, making nanoscale hyperspectral

63 V-1 splicing is regulated and, with moderate throughput, could be used to screen for structural eleme

64 ions regarding the potential synergy of high-throughput data acquisition, data-driven modeling, and m

65 ly facilitated neuroscience research in high-throughput data acquisition.

66 y concentrations (AWBCs) generated from high throughput data as a health-based screen for endocrine b

67 l samples (iii) filter large amounts of high-throughput data based on user custom filter requirements

68 t and user-friendly network analysis of high-throughput data by mapping the data onto a biological ne

69 nological developments a vast amount of high-throughput data has been profiled to understand the mech

70 interactive exploration and analysis of high throughput data.

71 study, we employed the next generation high-throughput deep sequencing technology to sequence all sm

72 n be identified by analyzing reads from high-throughput deep sequencing.

73 The high-throughput detection of organelle composition and proteo

74 Here we report a method for the high-throughput determination of extracellular segments of tr

75 present an approach to multidimensional high-throughput discovery of catalytic coupling reactions tha

76 paving the way for a broadly applicable high-throughput-discovery and materials-by-design feedback lo

77 rol studies of MDD: the GlaxoSmithKline-High-Throughput Disease-specific target Identification Progra

78 The advent of high-throughput DNA methylation profiling techniques has enab

79 High throughput DNA sequencing (HTS) technologies generate an

80 High-throughput DNA sequencing modalities, including single m

81 High-throughput DNA sequencing of microbiota from a diverse c

82 With the development of new high-throughput DNA sequencing technologies and decreasing co

83 With the advent of next generation high-throughput DNA sequencing technologies, omics experiment

84 using 2D arrays of electrodes and ultrahigh throughput droplet microfluidics focused on the generati

85 viability has been developed towards a high throughput drug screening.

86 of DEP separation by orders of magnitude in throughput, efficiency, purity, recovery (cells arriving

87 The dimensional transition enabled by a high throughput electrohydrodynamic process provides highly a

88 This strategy enables higher molecular throughput, enhanced signal-to-noise, and even heightene

89 s to be widely applicable to supplement high-throughput experimental antibody sequencing workflows.

90 Recently developed high-throughput experimental methods, including protein bindi

91 ave applications for certain classes of high-throughput experiments and the analysis of noisy dataset

92 work may set the stage for non-invasive high-throughput experiments evaluating sleep and breathing pa

93 introducing cost-effective, rapid, and high-throughput fabrication techniques and low-cost recording

94 f this work is the demonstration of how high-throughput fluorescence lifetime measurements correlate

95 e development of an array platform with high-throughput for CEA together with other tumor biomarkers

96 ted a continuous enzymatic assay to a medium-throughput format and carried out a primary screening of

97 been assumed that miniaturisation to a high-throughput format would not be possible without concomit

98 system also functions at varying analytical throughputs from 24 to 1200 samples per day to enable di

99 ndrial homeostasis and lipid metabolism.High-throughput genetic screens in animals could benefit from

100 Using high-throughput genetics, 5560 minigene molecules were assaye

101 Although recent high-throughput genome-wide mapping approaches have allowed u

102 Our high-throughput genome-wide siRNA screen identified host fact

103 High-throughput genomic and molecular profiling of tumors is

104 The increasing volume and complexity of high-throughput genomic data make analysis and prioritization

105 Multiple types of high throughput genomics data create a potential opportunity

106 The development and application of high-throughput genomics technologies has resulted in massive

107 To facilitate high-throughput genotyping of Arachis species, 20 genotypes w

108 PR/Cas9 gene editing with an innovative high-throughput genotyping pipeline utilizing KASP (Kompetiti

109 Due to a lack of high throughput glycan sequencing software, glycan spectra ar

110 a and operates in a continuous and ultrahigh-throughput (>1 mL/min) manner.

111 A high-throughput H2 production assay device (H2 PAD) is presen

112 y that is highly sensitive, robust, and high-throughput has the potential to improve patient care by

113 logies, detection sensitivity and analytical throughput have delivered a significant expansion in our

114 cell types possesses the capacity to be high-throughput, highly reproducible and integrate the comple

115 Thus, the high-throughput (HT)-CBS technology was used for the concomit

116 ter, a new open source software for the high-throughput identification of phospholipids in data acqui

117 High-throughput imaging and analysis of large DNA single mole

118 High-throughput immunological testing of such lymphocytes in

119 Here we have combined high-throughput immunophenotypic screens with large-scale sin

120 ty, speed, wider compound coverage, and high-throughput in comparison to the LC-MS based approach.

121 t (clinical science) the vast amount of high-throughput information that existing technology provides

122 chniques have been developed to conduct high-throughput large-scale phenotyping on animals, plants an

123 the impact of matrix effects, even for high-throughput LC-MS methods.

124 KEY MESSAGE: Exploration with high throughput leaf metabolomics along with functional genom

125 Optical analog computing offers high-throughput low-power-consumption operation for specializ

126 I-HDX approach can also be applied in a high-throughput manner for batch-to-batch higher-order struct

127 ry networks in a modular, parallel, and high-throughput manner.

128 sible therapeutics in a mechanistic and high-throughput manner.

129 rdinal for analysis of high-resolution, high-throughput mass spectrometry imaging experiments.

130 chastic nature of the process precludes high-throughput measurement (and sorting) of single cells.

131 as a foundation for massive scaling in high-throughput measurements and new insights into the interp

132 llenging when using culture-independent high-throughput metagenomics.

133 i.e. BP) and further validates a rapid, high-throughput method for immunoproteomic antigen identifica

134 Here, we describe a high-throughput method for rapid identification of synergisti

135 Using a high-throughput method, we developed a T7 phage display cDNA

136 6-S rRNA gene amplicon sequencing), yet high-throughput methods for assessing community structure in

137 nment is hampered by a lack of adequate high-throughput methods for distinguishing and quantifying sm

138 has been hindered by a lack of simple, high-throughput methods for mapping the transcriptomes of sub

139 High-throughput methods for screening protein-protein interac

140 Here we report improved high-throughput methods for single-nucleus droplet-based sequ

141 High-throughput methods now allow us to interrogate the human

142 western Arctic and sub-Arctic, we used high throughput methods to sequence 18S rRNA, cloned and sequ

143 s and computational identification from high-throughput methylome data.

144 Recently, the high-throughput microarray and sequencing technologies have p

145 ddressing of many microrobots enables higher-throughput microassembly of micro-objects, and cooperati

146 d fluorescence microscopy combined with high-throughput microfluidic chips is a powerful method to ob

147 s differentiation switch, we employed a high-throughput microfluidic imaging system that allows real-

148 In this paper, we use a high-throughput microfluidic platform as a quantitative scree

149 for tracking GPCR signaling suffer from low throughput, modification or overexpression of effector p

150 High throughput mRNA expression profiling can be used to char

151 The high-throughput multiplex assay allowed us to simultaneously

152 paring its predictions with outcomes of high-throughput mutagenesis experiments and measurements of h

153 m in yield and accuracy, coupled with higher throughput nanopore sequencers, mean that human genome s

154 used to identify protein complexes from high-throughput network data has been to extract near-cliques

155 The advent of high-throughput next generation sequencing technology has gre

156 Using high-throughput next-generation sequencing techniques optimiz

157 ing metabolic traits were quantified by high-throughput nuclear magnetic resonance metabolomics.

158 A sample-to-sample throughput of approximately 45 s with a approximately 4.

159 lgorithm severely underestimates the network throughput of congested networks, and a rich phenomenolo

160 The method advances usability and throughput of DEP separation by orders of magnitude in t

161 oach is capable of increasing the sequencing throughput of the PacBio RSII platform by more than five

162 ividual dual-labeled protein samples at high throughputs or protein libraries compatible with multipl

163 Filopodyan supports high-throughput phenotype characterization as well as detaile

164 Here, we used high-throughput phenotype data from 14,250 wildtype and 40,19

165 Even though high-throughput phenotyping platforms have been developed for

166 as proven robust to obtain ground-based high-throughput plant architecture parameters of sorghum, a t

167 been active research efforts to develop high-throughput platforms to mechanically characterize single

168 oducibility, short turnaround time, and high-throughput potential of this platform demonstrate EMMA's

169 thod, DRNApred, which accurately and in high-throughput predicts and discriminates between DNA- and R

170 stems are increasingly being studied by high throughput profiling of molecular data over time.

171 h and introduce emerging strategies for high-throughput progression from profiles to function.

172 tory of skin disease was analysed using high-throughput proteomic analysis that detects expression of

173 ascular risk proteins, we used an OLINK high-throughput proteomic assay to analyze moderate-to-severe

174 Using high throughput proteomics, we identified 84 candidate mitoch

175 measurement system that allows for the high-throughput quantification of gas evolution under realist

176 s to be a promising alternative for the high-throughput quantification of lignin in milled biomass sa

177 r HIV antibody responses as measured by high-throughput quantitative and qualitative assays could be

178 We developed a high-throughput quantitative microarray antibody capture assa

179 g with automated analysis, provides for high-throughput quantitative volumetric interrogation of spat

180 SynAg enables the high-throughput, quantitative characterization of protein-pro

181 we demonstrate that Mt/AFM-SECM enables high throughput reading of dense nanoarrays, with a sensitivi

182 tium, made possible by a new, low-cost, high-throughput reduced representation expression profiling m

183 Nevertheless, designing high-throughput reporter assay experiments such as massively

184 chromatography (LC) approaches hamper sample throughput, reproducibility, and robustness.

185 e use of reversible technologies enable high-throughput, reproducible, functional annotation of the g

186 ins we engineered, they can be used for high-throughput reverse genetic screens to help functionally

187 High-throughput RNA sequencing (RNA-seq) analysis of HIF-2alp

188 In the presented study we used high-throughput RNA sequencing in combination with systems-ba

189 High-throughput RNA sequencing methods coupled with specializ

190 Using a high-throughput RNA structure probing method, we provide nucl

191 Illumina high throughput RNA-Seq technology was employed and generated

192 Although ultrahigh-throughput RNA-Sequencing has become the dominant techno

193 indicated AutoTip has applications for high-throughput sample preparation for studying the N-linked

194 Cas9-mediated, high-throughput, saturating in situ mutagenesis permits fine-

195 fy reversible inhibitors of LSD1 from a high throughput screen and subsequent in silico modeling appr

196 A duplexed, functional multiaddition high throughput screen and subsequent optimization effort ide

197 We performed a high-throughput screen of 484 small-molecule compounds to ide

198 ere, we report a nanotechnology-enabled high-throughput screen to identify small-molecule agonists of

199 wo different formats of an enzyme-based high-throughput screen yielded two attractive chemotypes capa

200 rapolation (IVIVE) analyses translating high-throughput screening (HTS) data to human relevance have

201 In this study, we utilized high-throughput screening (HTS) in vitro data of PAHs to pred

202 ly required, however current cell-based high-throughput screening (HTS) models to identify molecules

203 In parallel, high-throughput screening (HTS) was conducted using the fluor

204 ding site using an ADP-TAMRA probe in a high-throughput screening assay.

205 and has immense potential for fast and high-throughput screening bacterial chemotaxis.

206 we prioritized candidate compounds via high-throughput screening based on reversal of green fluoresc

207 lse positives and false negatives under high-throughput screening conditions is particularly difficul

208 High-throughput screening identified anthracyclines including

209 ce spectroscopy could offer a rapid and high-throughput screening method for identification of Leptos

210 ng considered for large-scale use, this high-throughput screening method will facilitate rapid screen

211 In this study, using a cell-based high-throughput screening model representing Runt-related tra

212 zolidine-2,4-dione, was obtained from a high throughput screening of 40000 compounds against KGA.

213 tative sensing technology allowed for a high-throughput screening of a panel of polymer carriers towa

214 xes opens up the possibility to perform high-throughput screening of G-quadruplex ligands for the dev

215 ISPR/Ca9s system is also being used for high-throughput screening of genes, gene regulatory regions,

216 of both bacterial and host factors and high throughput screening of novel therapeutics becoming the

217 High-throughput screening of the host transcriptional respons

218 zation for fundamental studies, and for high-throughput screening of various biomolecules for stem ce

219 We used a genetically encoded high throughput screening platform to screen a SICLOPPS libra

220 ctrochemical methods for the purpose of high-throughput screening remains very limited.

221 We previously identified, by high-throughput screening, aminophenyl-1,3,5-triazine CFTRact

222 stem, from efficient genome editing, to high-throughput screening, to recruitment of a range of DNA a

223 s that are currently encountered during high-throughput screening.

224 ant RSV virus and applied the strain to high-throughput screening.

225 We performed fragment-based and high-throughput screens against an amino-sugar acetyltransfer

226 f action (MoA) of hits from these noisy high-throughput screens remain difficult.

227 Utilizing high-throughput screens, we identify prion-curing mutants and

228 We developed an assay for the high-throughput search for compounds that prime microbial pat

229 g protein binding microarrays (PBM) and high-throughput SELEX (HT-SELEX), have enabled rapid measurem

230 This has created a need for high throughput sequence analysis directly on surfaces.

231 One of the most crucial steps in high-throughput sequence-based microbiome studies is the taxo

232 sposase-accessible chromatin coupled to high-throughput sequencing (ATAC-seq) data, we found that the

233 inked ImmunoPrecipitation associated to high-throughput sequencing (CLIP-seq).

234 s many advantages over laboratory-based high-throughput sequencing (HTS) methods for species level id

235 athogenic RASGRP2 variants, we compared high-throughput sequencing and phenotype data from 2042 cases

236 oaches (transcriptomics, proteomics and high throughput sequencing crosslinking immunoprecipitation)

237 High-throughput sequencing data are widely collected and anal

238 By integrating high-throughput sequencing data for binding and splicing quan

239 The use of high-throughput sequencing data has improved the results of g

240 We also applied the algorithm to high throughput sequencing data obtained for viruses present

241 which allows online browsing of mapped high throughput sequencing data, and its implementation for s

242 High-throughput sequencing has made it theoretically possible

243 High-throughput sequencing in the four remaining families ide

244 High-throughput sequencing of 16SrRNA genes demonstrated that

245 Most discordances were clarified upon high-throughput sequencing of antigen-receptor rearrangements

246 As high-throughput sequencing of B cells becomes more common, th

247 es by combining systemic dsx knockdown, high-throughput sequencing of diverse tissues and a genome-wi

248 Short- and long-read high-throughput sequencing of DNA and RNA demonstrated that t

249 ts and 7 healthy controls, we performed high-throughput sequencing of immunoglobulin heavy chain VDJ

250 We used high-throughput sequencing of short, cyclobutane pyrimidine d

251 High-throughput sequencing revealed that a 22 nt miRNA with 3

252 However, despite high-throughput sequencing studies, the cause of the disease

253 and compositions were determined using high-throughput sequencing targeting the V3-V4 regions of the

254 High throughput sequencing techniques are poorly adapted for

255 with advances in mass spectrometry and high-throughput sequencing techniques, have caused research i

256 Due to the recent advances in high throughput sequencing technologies, an increased number

257 High-throughput sequencing technology contributed to consolid

258 Here, we develop a high-throughput sequencing technology to define TOP2 cleavage

259 Massively parallel high-throughput sequencing technology, where DNA is sheared i

260 combination of targeted enrichment and high-throughput sequencing to assemble and interpret a data s

261 nd RNA sequencing (RNA-Seq), which uses high-throughput sequencing to capture all sequences.

262 nced in-solution mitogenome capture and high-throughput sequencing to fourteen dental samples obtaine

263 High-throughput sequencing was performed on 12 different norm

264 oblem, particularly given the growth of high-throughput sequencing, cell sorting and single cell biol

265 By high-throughput sequencing, we identified the main bacterial

266 Tn5 tagmentation, PCR amplification and high-throughput sequencing.

267 anscriptase PCR, microarray analysis or high-throughput sequencing.

268 rated transposon mutagenesis coupled to high-throughput sequencing.

269 yielding to much larger data sets from high-throughput sequencing.

270 ing and immunoprecipitation followed by high-throughput sequencing.

271 or developing STR markers directly from high-throughput shotgun sequencing data without a reference g

272 d dynamics on alphavbeta3 binding using high-throughput single-molecule three-color Forster resonance

273 High throughput size based separation and sorting of bioparti

274 his technique performs continuous-flow, high throughput size based sorting of millions of particles a

275 erformed miRNA and mRNA profiling using high throughput stem-loop reverse-transcriptase quantitative

276 ngs demonstrate a previously unexplored high-throughput strategy for GSC-selective antibody discovery

277 tic networks will require new tools for high-throughput structural and molecular profiling of the div

278 can be used for biomarker discovery in high throughput studies is yet to be determined.

279 ual studies with those identified in 13 high-throughput studies reveals limited consistency.

280 extracting single-cell data, mean that high-throughput systematic analyses of signalling dynamics ar

281 ort analysis time, make it suitable for high-throughput targeted UPLC-ESI-MS/MS metabonomic analysis

282 In summary, this high-throughput technique catalogs the potential phosphorylat

283 Tn-Seq is a high throughput technique for analysis of transposon mutant l

284 are significant improvements using this high-throughput technique for the generation of mAbs includin

285 Our precise, high-throughput technique revealed stable between-host variat

286 tion assays are a relatively new set of high throughput techniques that measure the location of activ

287 Advances in high-throughput technologies allow for measurements of many t

288 High-throughput technologies have revolutionized medical rese

289 eneration capacity outpaces the rate of high-throughput testing and screening.

290 not previously been reported and with sample throughput that greatly exceeds other existing proteomic

291 the algorithms and network structure affect throughput, the fairness of flow allocation, and the loc

292 Despite that many techniques are high-throughput, they usually use singular features of the da

293 basis of calculations, once coupled to high throughput, this method can potentially yield preparatio

294 ) was developed to provide comparable sample throughput to flow injection analysis-tandem MS (FIA-MS/

295 , which assay one PPI at a time, are too low throughput to make it practical to study protein interac

296 ER and 212 AR bioactive chemicals using high throughput ToxCast data from in vitro screening assays a

297 g assays and predictive pathway models, high-throughput toxicokinetic data, and data-driven assumptio

298 ay distinct transcriptional profiles in high-throughput transcription analyses.

299 High-throughput UV-vis titrations in combination with chemica

300 ure integrin-binding of RGD-peptides in high-throughput without using cells, ECM-proteins, or antibod