ライフサイエンスコーパス: thumb

1 stics-guided appraisal (i.e. mental rules of thumb).

2 coordinate actions of another effector (the thumb).

3 the presumptive anterior wrist and proximal thumb.

4 to be the most common cause of triphalangeal thumb.

5 arm movement and an isometric press with the thumb.

6 he helix-loop-helix domain of the polymerase thumb.

7 architecture, comprising Fingers, Palm, and Thumb.

8 in the active site between the Palm and the Thumb.

9 m the globular domain of M like a finger and thumb.

10 replicate the motion of the index finger and thumb.

11 ed instead to stimuli located near the right thumb.

12 onserved subdomains called palm, fingers and thumb(1,2).

13 w well the same subjects learned a ballistic thumb abduction task using the APB muscle.

14 ity in six subjects trained to perform rapid thumb abductions over 5 d.

15 EMG signals recorded from the short and long thumb abductor muscles during steady isometric contracti

16 cts in individuals with OS range from subtle thumb abnormalities to truncated limbs.

17 raction obtained while subjects abducted the thumb against a manipulandum.

18 The benzimidazoles bind to the thumb allosteric pocket and inhibit the conformational c

19 lso observed a cross interaction between the thumb allosteric pocket and the initiation pocket using

20 eveal the large-scale closing motions of the thumb and 8-kDa subdomains in the presence of the correc

21 to the structural dynamics propagate to the thumb and connection subdomains and RNase H domain of th

22 This hand reveals a long, robust thumb and derived wrist morphology that is shared with N

23 p59 insert into the interface created by the thumb and exonuclease domains of gp43.

24 jor domains in the extracellular region, the thumb and finger domains.

25 strength of the interaction between adjacent thumb and finger domains.

26 M cells that project to motoneurons of three thumb and finger muscles.

27 es LRET efficiency between the probes at the thumb and finger subdomains in the extracellular domain

28 ormation in which the separation between the thumb and fingers subdomains is much higher than in the

29 s suggest that termination requires that the thumb and fingers subdomains move apart, in a reversal o

30 s consistent with forceful opposition of the thumb and fingers typically adopted during tool use.

31 pocket of a basic cleft adjacent to flexible thumb and forefinger loops, which could provide further

32 nd hypoplasia or aplasia of the nails of the thumb and great toe.

33 dorsal rootlets that enervate the macaque's thumb and index finger (segments C6-C8), the cortical re

34 grasping a small (6 mm) cylinder between the thumb and index finger and during index finger abduction

35 hat the recovery of precision grip using the thumb and index finger depends on the survival of affere

36 Wnt engages FZD through protruding thumb and index finger domains, which are each assembled

37 idence for our theory that grasping with the thumb and index finger is based on a combination of two

38 retrieve a target object from a clamp using thumb and index finger opposition.

39 radish peroxidase was then injected into the thumb and index finger pads bilaterally to label the cen

40 gically identified axons projecting from the thumb and index finger were then cut in two monkeys (Gro

41 the control of a precision grip between the thumb and index finger.

42 reen users, the cortical potentials from the thumb and index fingertips were directly proportional to

43 tical representations of the stroke-affected thumb and little finger following TFD but not following

44 nied by a distance increase between adjacent thumb and palm domains as well as a movement of Glu-235

45 nhibitors bind to a site on NS5B between the thumb and palm regions adjacent to the active site as de

46 e H domain of the p66 subunit as well as the thumb and palm subdomains of the p51 subunit.

47 cular wedges", disrupting the region between thumb and palm subdomains of the p66 subunit and locking

48 form so as to be in closer contact with the thumb and palm subdomains of the polymerase domain.

49 report that one histidine at the base of the thumb and residues in the channel pore influence proton

50 lecule in which the fingers/palm/connection, thumb and RH substructures are connected by flexible (di

51 bunit and reduced the relative motion of the thumb and RNase H regions, suggesting that NNRTI enhance

52 combination with the biodegradation rules of thumb and some basic organic chemistry has allowed 281 p

53 cular communications between residues of the thumb and the C-terminal domains are important for HCV r

54 ike and cytokine-like domains, including the thumb and the index finger in Wnt folding/secretion and

55 index finger into a pocket at the top of the thumb and the presence of Trp403 on the thumb domain are

56 of interaction of the DNA with the extended thumb and thioredoxin.

57 own protein folds, resembling a "hand" with "thumb" and "index" fingers extended to grasp the Fz8-CRD

58 affinity through a palmitoylated N-terminal "thumb" and a disulfide-stabilized C-terminal "index fing

59 that pol lambda contains the palm, fingers, thumb, and 8 kDa lyase domains present in pol beta, as w

60 n/activity, those in the amino terminus, the thumb, and at the tip of the index finger are incompatib

61 sical abnormalities, including craniofacial, thumb, and heart anomalies, whereas isolated thumb malfo

62 ased prevalence of OA in the IP joint of the thumb, and in the second and third PIP and MCP joints.

63 e cavity formed by the reverse transcriptase thumb, and the endonuclease-like and RNaseH-like domains

64 Combined treatment with a thumb- and a palm-binding polymerase inhibitor had a dra

65 Rules of thumb appropriate for neuroscience and cardiology may no

66 ely corresponds to the reverse transcriptase thumb, are required for RNA splicing, while the C-termin

67 ulation to alter functional responses in the thumb area of the primary motor cortex.

68 signals to two fingertips (index finger and thumb) as they traveled along collinear paths.

69 various resistance mutations in the palm and thumb binding sites correlated well with resistance -fol

70 ingly, however, following the closing of the thumb but prior to the rotation of Arg258, the E295K mut

71 in the loop containing beta-strand 8 in the thumb, but closing occurred only in the Ile(492)Ala muta

72 Back-of-the-envelope or rule-of-thumb calculations involving rough estimates of quantiti

73 or of these drugs is contrary to the rule of thumb called Overton's rule, which holds that more lipop

74 Patients underwent serial assessments of thumb capillary lactate (the primary endpoint), thumb pl

75 Analyses reveal that the thumb closing of pol beta before chemistry is hampered w

76 reaction after partial closing or even full thumb closing, we suggest that pol beta is tightly contr

77 nds from southern England with triphalangeal thumb, demonstrated significant linkage of the phenotype

78 on of ASIC1a involving the upper part of the thumb domain (residues Asp-349 and Phe-350), the palm do

79 the polyadenylation of virion RNA include a thumb domain alpha helix that is positioned in the minor

80 date; it lacks two DNA-binding domains (the thumb domain and 8-KD domain) conserved in the homologou

81 fingers domain, a beta-hairpin from the NS5B thumb domain and the C-terminal arm.

82 inding site lying at the surface between the thumb domain and the fingertip about 30 A away from the

83 the thumb and the presence of Trp403 on the thumb domain are key interactions required to maintain t

84 C1a-ASIC2a chimeras showed that swapping the thumb domain between subunits results in faster channel

85 hrough the inability of hPolbeta to complete thumb domain closure.

86 A unique beta-strand motif in the PolC thumb domain contacts the minor groove, allowing replica

87 tion and of ENaC gating and suggest that the thumb domain contributes to the channel gating machinery

88 nt with the prediction of this region as the thumb domain from the structural alignment of RT-Ec86 wi

89 The interactions between the Delta1 loop and thumb domain in NS5B are required for de novo initiation

90 map to thealpha5 helix in the extracellular thumb domain in the chicken acid sensing ion channel 1 s

91 The thumb domain in the extracellular region of ASIC1 has a

92 also examined the importance of the fingers-thumb domain interaction for the function and structural

93 5-6 degrees C while mutations in the fingers-thumb domain interface destabilize the protein and reduc

94 by removing residues that bind at the finger-thumb domain interface.

95 We propose that the thumb domain moves upon continuous exposure to an acidic

96 One is formed by residues in the thumb domain of alphaENaC and the palm domain of betaENa

97 s formed by residues at the interface of the thumb domain of betaENaC and the palm domain of gammaENa

98 In contrast, mutations in the thumb domain of gammaENaC and palm of alphaENaC had litt

99 curs via an arginine patch in the C-terminal thumb domain of RdRp.

100 e inhibitors that bind to the surface of the thumb domain of the viral RNA-dependent RNA polymerase (

101 e highly conserved regions of the telomerase thumb domain referred to as motifs E-I (thumb loop and h

102 l changes in the fingertip region and in the thumb domain that may help to translocate the RNA templa

103 fingers domain interacts with the top of the thumb domain to create a tunnel through which nucleotide

104 at used a fluorescent probe located near the thumb domain to measure the kinetic properties of Dpo4 c

105 he human telomerase C-terminal extension (or thumb domain) determined by the method of single-wavelen

106 A polymerase at an analogous position in the thumb domain, converts the Taq DNA polymerase from a low

107 in the region surrounding the H-helix of the thumb domain.

108 Leu419, Met423, and Ile482 in the polymerase thumb domain.

109 er that links this novel domain to its small thumb domain.

110 One set of polymerase contacts, between the "thumb" domain of one polymerase and the back of the "pal

111 arrow cleft on the protein's surface in the "thumb" domain, about 30 A from the enzyme's catalytic ce

112 h the polymerase 3D(pol), at the tip of the "thumb" domain, and the protease 3C(pro), on the side opp

113 e transmembrane pore lies a disulphide-rich 'thumb' domain poised to couple the binding of protons to

114 ed grip on the DNA by the palm, fingers, and thumb domains and the PAD and provides additional thermo

115 omain, in addition to the fingers, palm, and thumb domains common to other polymerases.

116 e for the dynamic interaction of fingers and thumb domains in an environment that supports the format

117 gineered disulfide bond between the palm and thumb domains leads to partial channel closure.

118 s to specific residues within the finger and thumb domains of ENaC.

119 ive reagents revealed that the beta-ball and thumb domains reside apart in the resting state but that

120 e contribution of the finger, beta-ball, and thumb domains to activation and desensitization through

121 We examined whether loops at the base of the thumb domains within ENaC subunits have a similar role i

122 MutS mismatch recognition and DNA polymerase thumb domains.

123 (HCV) polymerase, including in the palm and thumb domains.

124 ded architecture with the palm, fingers, and thumb domains.

125 The lemurs adopted the thumb-down posture when that hand position afforded a th

126 canonical thumb-up posture or a noncanonical thumb-down posture.

127 e structures ("predigits"), such as pandas' "thumbs." Elephants similarly have expanded structures in

128 evolution in hylobatids (extreme digital and thumb elongation), convergent adaptation between chimpan

129 Three rules of thumb emerge from our studies to aid further design: (i)

130 We have characterized the gene emperor's thumb (et) and showed that it is required for the regula

131 g rest, thumb flexion (trained movement) and thumb extension (untrained movement) were analysed using

132 ade possible by significant movements of the thumb, finger, and beta-binding domains relative to thei

133 The introduced cysteines disrupt a thumb-fingers salt-bridge and, under reducing conditions

134 66 resulted in even greater increases in the thumb/fingers opening, RT sliding, dNTP binding disrupti

135 s of RT, which contributes to opening of the thumb/fingers subdomains.

136 fMRI data obtained during rest, thumb flexion (trained movement) and thumb extension (un

137 subjective due to its dependence on rules of thumb for deriving geometric constraints and suitable va

138 A rule of thumb for discriminating between the predicted integral

139 We further propose rules of thumb for guiding the choice of strategy: For example, s

140 The rule of thumb for such efforts is that a factor-of-four sample s

141 new insight but it provides a simple rule of thumb for the design of monitoring programmes in practic

142 the identification of conservation 'rules of thumb' for these taxa, and supports the notion of local

143 (S) decreases exponentially, with a "rule-of-thumb" formula S=0.75*0.85(depth).

144 These rules of thumb illustrate how cost-effective conservation outcome

145 the object by opposing the index finger and thumb in >80% of trials.

146 ubdomains of the p66 subunit and locking the thumb in a wide-open conformation.

147 er speckle imprinting and provides a rule of thumb in selecting the laser power required to optimally

148 to identify the reorganized region of D1-D3 (thumb, index finger, and middle finger) representation.

149 cutaneous and proprioceptive input from the thumb, index finger, and middle finger.

150 nkeys, the region deprived of input from the thumb, index, and middle finger was found to be unrespon

151 dorsal rhizotomy that removes input from the thumb, index, and middle fingers, the macaque is unable

152 tials in response to mechanical touch on the thumb, index, and middle fingertips of touchscreen phone

153 ch-dynamic parameters and the grip aperture (thumb-index finger distance) were calculated.

154 Rheb that TSC2 uses a catalytic "asparagine thumb" instead of the arginine finger found in Ras-GAP.

155 Although the thumb interacted predominantly with the screen, the pote

156 A relaxed thumb interaction with the DNA could account for the not

157 idues at selected positions in the beta-ball-thumb interface accelerates the desensitization of the m

158 operative unfolding in the fingers extension-thumb interface and primer grip, which may contribute th

159 Formation of the inter-subunit RH:thumb' interface occurs at an early stage, while maturat

160 ojecting from serine 187 at the tip of Wnt's thumb into a deep groove in the Fz8-CRD.

161 The prevalence ratio for OA of the thumb IP joint in the chopsticks hand was 1.2 (range 1.1

162 Thumb IP joint OA affected 26% of the entire population

163 A simple rule of thumb is also presented.

164 rase thumb domain referred to as motifs E-I (thumb loop and helix), E-II, and E-III (the FVYL pocket,

165 thumb, and heart anomalies, whereas isolated thumb malformations are predominantly present in patient

166 election is normally made based on a rule of thumb, meaning that the calculated threshold level may b

167 is formed by the previously uncharacterized thumb mini-loop (NSH motif) and the positively charged h

168 ion of additional muscles that integrate the thumb more closely with surrounding structures.

169 mplex vocal organs, bipedalism and opposable thumbs--most (if not all) are likely the product of stro

170 domain (DRD), a unique RED motif, a flexible thumb motif (ThM), and implied conformational changes wi

171 the apo enzyme, suggesting the constraint of thumb motion is not as complete as previously believed.

172 for subtle active-site rearrangements after thumb movement but before chemistry.

173 Furthermore, the acceleration of TMS-evoked thumb movements along the principal movement axis and th

174 Kinematics of thumb movements before, during and after training were c

175 Before training, thumb movements elicited more prominent activation of th

176 ther individual performing simple repetitive thumb movements gives rise to a kinematically specific m

177 An extended period of observation of thumb movements that were oriented oppositely to the pre

178 bias increased the probability of TMS-evoked thumb movements to fall within the observed direction.

179 petition of directionally specific voluntary thumb movements, before and after motor training in a gr

180 separate muscles (flexor pollicis longus, a thumb muscle, and flexor digitorum profundus, an index-f

181 e as that for pairs of units both within the thumb muscle.

182 one of the few taxa we studied in which the thumb musculoskeletal structures do not form an independ

183 a direct interaction between the back of the thumb of 3Dpol and 3C that is required for 3Dpol recruit

184 p66 ribonuclease H (RNase H) domain and p51 thumb of human immunodeficiency virus reverse transcript

185 They differ in whether the wrist or the thumb of the hand is controlled.

186 polymerase, and a unique loop located on the thumb of the polymerase also stabilizes this primer exte

187 es in response to tactile stimulation of the thumb of the stroke-affected hand during TFD but not fol

188 le they either imagined or executed a finger-thumb opposition sequence.

189 n consisting of self-paced, bilateral finger-thumb opposition task, 3) resting-state with ESB (Stim-1

190 actional dimer concentration and the fingers/thumb orientation are found to depend strongly on the ex

191 efined domains termed the finger, beta-ball, thumb, palm, and knuckle.

192 Thumb pinch force was measured by a pressure sensor, whe

193 mb capillary lactate (the primary endpoint), thumb plethysmography, and ulnar frame count to investig

194 evaluation led to the discovery of the first thumb pocket 1 NS5B inhibitor (BILB 1941) that demonstra

195 low-up compound (BI 207524, 27) to the first thumb pocket 1 NS5B inhibitor to demonstrate antiviral a

196 We have discovered allosteric (thumb pocket 1) non-nucleoside inhibitors of HCV NS5B po

197 H-quinazolin-4-one (QAZ) allosteric HCV NS5B thumb pocket 2 (TP-2) inhibitors was recently reported.

198 An anthranilic acid series of allosteric thumb pocket 2 HCV NS5B polymerase inhibitors exhibited

199 ckbone carbonyl groups, leading to the first thumb pocket 2 NS5B inhibitor with picomolar antiviral p

200 nhibitors of NS5B polymerase that act at the thumb pocket 2 site.

201 Patients with an altered thumb print due to other causes and palmar hyperhidrosis

202 gh the analyses of VOC profiles of the human thumb prints recovered from a nonbiological smooth surfa

203 rigger finger persisted in 10 cases, and one thumb pulley could not be released.

204 DRRS had radial ray abnormalities including thumb, radial artery, radial bone, and pectoral muscle h

205 malities, abnormal skin pigmentation, and/or thumb/radius malformations.

206 an HIV-1 genome with a G262A mutation in the thumb region of the reverse transcriptase, a significant

207 ining the minor groove-binding track, in the thumb region.

208 distinguished from apes by possessing longer thumbs relative to fingers.

209 ensory processing from the hand and that the thumb representation was updated daily depending on its

210 ng 3Dpol-R455A, a residue on the back of the thumb required for VPg uridylylation.

211 sented with isolated bilateral triphalangeal thumb resembling the heterozygous phenotype, suggesting

212 In addition, we identify other thumb residues (Arg538, Lys521, Arg517, and Arg514) that

213 As simple 'rules of thumb', sequence identity thresholds do not require a bi

214 nuckle), flexor pulley injuries, and skier's thumb, should also be detected.

215 After a single treatment with a thumb site inhibitor (thiophene-2-carboxylic acid NNI-1)

216 The binding affinity of four palm and thumb site representative non-nucleoside inhibitors (NNI

217 wed that nonnucleoside inhibitors binding to thumb site-2 (NNI2) do not block initiation or elongatio

218 how that nonnucleoside inhibitors binding to thumb site-2 (NNI2) lead to the accumulation of abortive

219 ges indicative of binding to both allosteric thumb sites I and II of NS5BDelta21 and induces long-ran

220 temporally overlap, the brain controlled the thumb solely based on an internal estimate of time.

221 s callosum hypoplasia, retardation, adducted thumbs, spastic paraplegia, and hydrocephalus).

222 utations at highly conserved residues in the thumb subdomain (G848S, c.2542g-->a; T851A, c.2551a-->g;

223 may be controlled by the interaction of its thumb subdomain (potentially via the minor groove bindin

224 e contact with the Ty3 reverse transcriptase thumb subdomain and RNase H catalytic center, respective

225 ng in recognition of this duplex include the thumb subdomain and the ribonuclease H (RNase H) primer

226 ct incoming nucleotide, alpha-helix N of the thumb subdomain believed to be required for pol beta's c

227 ese processes, we analysed the function of a thumb subdomain beta-hairpin using initiation, elongatio

228 ese processes, we analysed the function of a thumb subdomain beta-hairpin using initiation, elongatio

229 The small thumb subdomain contributes to the formation of a large

230 ers, allows the same bulge to slide past its thumb subdomain during synthesis.

231 the first structure-function analysis of the thumb subdomain in pol gamma and examines the consequenc

232 y 22 residues into the tip of the polymerase thumb subdomain is predicted to confer considerable flex

233 state with incoming nucleotide exhibit more thumb subdomain motion, particularly in the loop contain

234 Some, but not all, of the unstable RT thumb subdomain mutants we analyzed have a temperature-s

235 quire an interaction between the back of the thumb subdomain of 3Dpol and an undefined region of the

236 nding sites at the subunit interface between thumb subdomain of alphahENaC and palm subdomain of beta

237 redoxin binding domain (TBD), located in the thumb subdomain of bacteriophage T7 gene 5 DNA polymeras

238 ghtly (Kd = 5 nM) to a unique segment in the thumb subdomain of gp5 and increases processivity.

239 e single point mutations we generated in the thumb subdomain of HIV-1 (RT) affect the stability of RT

240 data suggest an interaction between the p66 thumb subdomain of HIV-1 reverse transcriptase, and the

241 scriptase (HIV-1 RT) by interacting with the thumb subdomain of its non-catalytic p51 subunit.

242 beta12-beta13-beta14 lies at the base of the thumb subdomain of p66 and contains highly conserved res

243 oming nucleotide, and two divalent ions, the thumb subdomain of pol X undergoes a large conformationa

244 alignment was used to identify the putative thumb subdomain of reverse transcriptase (RT) from the S

245 ved amino acids Asn(335) and Ser(338) of the thumb subdomain of T7 DNA polymerase are seen to interac

246 the ribonuclease H (RNase H) active site and thumb subdomain of the p66 RT subunit, suggest that desp

247 xin binds to a segment of 76 residues in the thumb subdomain of the polymerase and increases the proc

248 Mutations in the thumb subdomain of Ty3 also affected RNase H activity, s

249 ction and in an upstream 5' region where the thumb subdomain of Ty3 RT putatively grips the substrate

250 gamma revealed that Alpers mutations in the thumb subdomain reduced polymerase activity more than 99

251 3 sequences in the carboxy-terminal portion (thumb subdomain) of the polymerase resulted in transcrip

252 25 A from the active site in the polymerase thumb subdomain.

253 to evaluate the conformation of the fingers/thumb subdomain.

254 redoxin, via a unique loop at the tip of the thumb subdomain.

255 domain, connecting loops between fingers and thumb subdomains and in the putative RNA binding channel

256 a "fisted right hand" with Fingers, Palm and Thumb subdomains connected to an N-terminal domain.

257 ight hand (containing the fingers, palm, and thumb subdomains), a hydrophobic C-terminal region, and

258 nce for the open conformation of the fingers/thumb subdomains, and a reported variation of three orde

259 terminal region that tethers the fingers and thumb subdomains, forming a completely encircled active

260 ing to RT induces opening of the fingers and thumb subdomains, which increases the dynamic sliding mo

261 s subdomain as it closed toward the palm and thumb subdomains.

262 fide bond between the polymerase fingers and thumb subdomains.

263 es positioned near the tip of the fingers or thumb subdomains.

264 rigid-body motion between the "fingers" and "thumb" subdomains of the p66 subunit.

265 increase in self-comforting behaviors (e.g., thumb sucking) over development, whereas in contrast, mo

266 tardation, Aphasia, Shuffling gait, Adducted thumbs) syndrome.

267 in 3D during 15-s repetitive index finger-to-thumb tapping trials.

268 he same letters) the joints of the wrist and thumb tended to show assimilation.

269 The rule of thumb that logistic and Cox models should be used with a

270 study also supports a fairly simple rule of thumb that may be useful in the interpretation of dietar

271 hese results are an exception to the rule-of-thumb that membrane-spanning bolaamphiphiles are inheren

272 are exceptions to the long-standing rule-of-thumb that proteins with as little as 30% sequence ident

273 urements and also identify a general rule of thumb that the surface contacted by electrolyte is of th

274 Described numbers comprise useful 'rules of thumb' that are applicable to most technologies dependen

275 iour can be implemented by a simple 'rule of thumb' that requires no detailed knowledge of the state

276 Here, a third domain of L3 called the basic thumb, that protrudes roughly perpendicular from the W-f

277 As a rule of thumb, the achievable spatial resolution is on the order

278 imensional array inside a chip the size of a thumb, the lateral dimension of each oscillator must be

279 Remarkably, the thumb tip was sensitive to the day-to-day fluctuations i

280 We also give simple rules of thumb to achieve the best separation efficacy in nanocha

281 f basically charged amino acids of the basic thumb to alanines followed by detailed analyses suggests

282 on trait profiles that may serve as rules of thumb to distinguish reservoirs from nonreservoir specie

283 al (shoulder to finger) and anteroposterior (thumb to little finger) axes.

284 it pattern across the antero-posterior axis (thumb to little finger).

285 inct behaviors that result, develop rules of thumb to quickly determine how a given system will behav

286 Proximity of the p51 thumb to the p66 RNase H domain implied that inhibitor b

287 -20 min and 60-70 min and tapped their right thumb to their fingers at 35-45 min and 85-95 min.

288 We discover a "rule of thumb" to safeguard against the long-term catch depletio

289 The human (and australopith) high thumb-to-digits ratio required little change since the L

290 n posture when that hand position afforded a thumb-up posture following object transport, thereby exh

291 d measured the grasp used-either a canonical thumb-up posture or a noncanonical thumb-down posture.

292 porally overlapped, the brain controlled the thumb using an estimate of the state of the arm.

293 dent and cannot be approximated by a rule-of-thumb value because these residues can contribute to bot

294 A locus for triphalangeal thumb, variably associated with pre-axial polydactyly, w

295 imensional positions of the index finger and thumb were recorded while subjects with bilateral scotom

296 nded to visual stimuli located near the left thumb, which was targeted by PAS, LTP-like increases in

297 ng a 6 mm cylinder with the index finger and thumb while the hand was held in the neutral position or

298 t arises through relatively simple "rules of thumb" without requiring advanced cognitive mechanisms s

299 ourinary tract of women, was isolated from a thumb wound in a male patient subsequent to trauma.

300 ans share a suite of derived features in the thumb, wrist, and radial carpometacarpal joints that is