ライフサイエンスコーパス: thymectomize

1 EAE when fed MBP but are not protected when thymectomized.

2 grafts eventually fail unless recipients are thymectomized.

3 grafts eventually fail unless recipients are thymectomized.

4 Recipients were thymectomized 3 wk before receiving an organ and/or tiss

5 Chimeras were thymectomized 7 weeks later, and were either untreated o

6 e CD4, but not CD8, T cell population in the thymectomized adult mouse is dependent on the presence o

7 graft survival (>100 days) was achieved when thymectomized adult recipient mice were transplanted alo

8 Tx combined with donor BMC infusion in adult thymectomized, ALS-treated mice induced clonal deletion

9 Control chimeras that were not thymectomized also received anti-donor monoclonal antibo

10 ved in similar experiments in mice that were thymectomized and CD4 T cell depleted following complete

11 not in mice that were reconstituted and then thymectomized and CD8 T cell depleted.

12 Thymectomized and CD8 T cell-depleted mice that had been

13 from normal donors at preventing diabetes in thymectomized and irradiated PVG.RT1(u) rats.

14 ease development upon adoptive transfer into thymectomized and irradiated recipients.

15 The donor hearts in both the thymectomized and non-thymectomized animals developed fl

16 s demonstrated a striking difference between thymectomized and nonthymectomized animals.

17 However, both thymectomized and nonthymectomized MG patients had lower

18 Although thymectomized and sham-treated RMs manifested comparable

19 BALB/c mice were thymectomized and T cell-depleted by injection of monocl

20 Adult BALB/c mice were thymectomized and T-cell depleted using rat monoclonal a

21 dult irradiated C57BL/6 hosts that have been thymectomized and treated with anti-CD4 and CD8.

22 BALB/c mice were thymectomized and treated with anti-CD8 antibody resulti

23 DA recipients were thymectomized and treated with Ox8 and Ox38 murine monoc

24 Euthymic, sham-thymectomized, and day-greater than or equal to +42 thym

25 Studies in thymectomized animals demonstrated that the profound CD8

26 nor hearts in both the thymectomized and non-thymectomized animals developed florid CAV.

27 at can be prevented by reconstitution of the thymectomized animals early in life with normal adult ly

28 Nonthymectomized and sham thymectomized animals had a mild T cell infiltrate with

29 Two of the day -21 thymectomized animals received a day 0 host-MHC matched

30 Two of the partially thymectomized animals received irradiated (1000 cGy) as

31 Thymectomized animals receiving a kidney allograft alone

32 CD3+ cells obtained from thymectomized animals treated with whole but not F(ab')2

33 as compared between partially and completely thymectomized animals.

34 ce was seen between partially and completely thymectomized animals.

35 f whole mAb, persisted for several months in thymectomized animals.

36 In contrast to untreated control and thymectomized, anti-Dd-treated chimeras, these euthymic

37 Adult mice thymectomized at birth and adult SCID mice did not devel

38 nt xenogeneic barrier in T/NK cell-depleted, thymectomized (ATX) B10 mice by grafting of fetal pig th

39 lation of mouse CD4+ T cells are achieved in thymectomized (ATX) B6 mice that receive T cell and natu

40 Thymectomized (ATX) IIKO mice showed the presence of a g

41 d by grafting fetal porcine thymus tissue to thymectomized (ATX) mice treated with natural killer (NK

42 /LIV) tissue to T cell and NK cell-depleted, thymectomized (ATX) mice.

43 (FP THY/LIV) to T cell and NK cell-depleted, thymectomized (ATX) mice.

44 In adult thymectomized (ATx) transgenic mice, only a small propor

45 Lethally irradiated, adult-thymectomized (ATX), nontransgenic recipients reconstitu

46 pig thymus and liver tissue (FP THY/LIV) to thymectomized (ATX), T/NK cell-depleted mice.

47 cent of grafted nude mice and 10% of grafted thymectomized B6 mice develop a clinical illness resembl

48 In two thymectomized baboons that received porcine thymokidney

49 hymic emigrants as they were present in mice thymectomized before infection.

50 Two miniature swine were thymectomized before thymic tissue transplantation, and

51 Three of these recipients were thymectomized before transplantation and accepted their

52 Therefore, adult Tg mice were thymectomized before treatment.

53 ame treatments on anergy of CD4 T cells from thymectomized, BM5-infected mice to determine whether th

54 ory-like T cells to oral Ag were examined in thymectomized BMC 60 days after i.p. immunization with O

55 ell progenitors in the marrow of euthymic or thymectomized but not nu/nu hosts.

56 ctivated spleen cells recreated rejection in thymectomized, but not euthymic, hosts, suggesting that

57 ic tolerance is achieved in T cell-depleted, thymectomized C57BL/6 (B6) mice and nude mice by graftin

58 Thymectomized C57BL/6 mice, treated with different combi

59 PVG.RT1 rat hearts were transplanted into thymectomized CD8 T-cell-depleted allogeneic (PVG.R8) or

60 addition, CD4+ CD25- cells transferred into thymectomized congenic mice converted to CD4+ CD25+ cell

61 d3Tx and non-thymectomized controls were infected with either GML str

62 were compared to the same parameters in non-thymectomized, cyclosporine-treated recipients bearing e

63 Thymectomized cynomolgus macaques underwent depletion wi

64 on autoimmune ovarian disease (AOD) in day 3 thymectomized (d3tx) mice and polyclonal T regs expressi

65 D) and oocyte autoantibody response of day 3-thymectomized (d3tx) mice were inhibited by continuous C

66 In autoimmune prostatitis (EAP) of the day-3 thymectomized (d3tx) mice, male Tregs suppressed EAP 3 t

67 Injection of anti-RT6.1 mAb into thymectomized DR and diabetes-prone-BB rats increased so

68 cell compartments from elderly, young adults thymectomized during early childhood, and HIV-1-infected

69 naive T cells from elderly and young adults thymectomized during early childhood, who are characteri

70 ctions in abrogating autoimmunities in 3-day thymectomized experimental mice.

71 course of HIV-1 infection in three patients thymectomized for myasthenia gravis and determined the e

72 Euthymic (group A) and thymectomized (group B) Lewis recipients (LEW, RT1(1)) r

73 d into a recipient which had previously been thymectomized, had few circulating CD4-single positive c

74 In contrast, none of the thymectomized heart/kidney recipients survived >100 days

75 4+ or CD8+ T cells expressing the Tg+/TCR in thymectomized hosts after bone marrow transplantation.

76 (3) CLPs protected thymus-bearing as well as thymectomized hosts from MCMV infection and attenuated d

77 d also induce tolerance if transplanted into thymectomized hosts, which, if true, would imply that th

78 e threshold for clinical GVHD, especially in thymectomized hosts.

79 adoptively transferred into syngeneic adult thymectomized irradiated and bone marrow-reconstituted r

80 L development occurred efficiently in adult, thymectomized, irradiated C57BL/6J mice reconstituted wi

81 donors were capable of inducing tolerance in thymectomized juvenile hosts.

82 the euthymic rats and transient chimerism in thymectomized limb recipients.

83 In 17 nonthymectomized and 26 thymectomized MG patients studied at varying times after

84 splantation of DBA/2 donor spleen cells into thymectomized MHC-matched allogeneic BALB/c recipients i

85 eneic bone marrow transplantations (BMTs) on thymectomized mice and then vaccinated the mice with pep

86 Studies in thymectomized mice demonstrated that blockade of the cal

87 eration and cytokine production decreased in thymectomized mice even at wk 4 of infection, indicating

88 Accordingly, adult thymectomized mice exhibit no reduction in the severity

89 pulation can be achieved in T cell-depleted, thymectomized mice grafted with xenogeneic porcine thymu

90 lation blockade resulted in tolerance, adult-thymectomized mice immunized for uveitis and treated wit

91 elopment of autoimmune disease in neonatally thymectomized mice is caused by the escape of self-react

92 With the use of nude mice, thymectomized mice reconstituted with fetal liver cells,

93 Significantly, IL-7 administration into thymectomized mice resulted in patterns of decreased TRE

94 and skin xenograft survival in euthymic and thymectomized mice treated with combinations of DST, ant

95 In contrast, development in reconstituted thymectomized mice was heavily skewed toward TCR gammade

96 We found that unprimed thymectomized mice were able to generate a primary respo

97 lying long-term graft survival, as recipient thymectomized mice were immunocompetent and harbor allor

98 , naive CD4 T cells derived from middle-aged thymectomized mice were longer-lived in vivo, and their

99 n of the IL-6(-/-) knockout, irradiated, and thymectomized mice with murine recombinant IL-6 restores

100 dditional studies carried on thymic T cells, thymectomized mice, and young T transferred cells into R

101 These effects were also seen in young thymectomized mice, consistent with the role of the thym

102 In thymectomized mice, development of CD4+ 8- and CD4+ 8+ T

103 In thymus-intact but not thymectomized mice, IGF-1 administration increased perip

104 ctious tolerance, as originally described in thymectomized mice, may be applied to euthymic rat recip

105 matched skin grafts, originally described in thymectomized mice, may be applied to the euthymic prime

106 In thymectomized mice, the numbers of naive, central memory

107 for DC differentiation, and are abrogated in thymectomized mice.

108 in the OVA-fed euthymic mice but not in the thymectomized mice.

109 ollowing IL-7 treatment in thymus-intact and thymectomized mice.

110 skin allografts to survive for >100 days in thymectomized mice.

111 ould only be achieved in euthymic and not in thymectomized miniature swine using this treatment regim

112 histocompatibility complex (MHC) mismatch in thymectomized miniature swine.

113 Finally, thymectomized mixed chimeras showed increased GVHD follo

114 Monkeys that were thymectomized (n=3) and depleted recovered via homeostat

115 Recipients were thymectomized on day -21 (n=5) or day 0 (n=3), or were l

116 In contrast, all animals thymectomized on day -21 that did not receive thymocyte

117 came tolerant, animals that were euthymic or thymectomized on day 0, as well as recipients of day 0 h

118 Female B6AF1 mice thymectomized on day 3 (d3tx) develop autoimmune ovarian

119 f organ-specific autoimmune diseases in mice thymectomized on day 3 of life (d3tx mice) can be preven

120 Animals thymectomized on days +8 and +21 did not undergo severe

121 compared between mice that were either sham thymectomized or thymectomized (Thx) at approximately 6

122 Of three thymectomized patients, one rapidly progressed to AIDS,

123 ve in lymphopenic hosts, such as elderly and thymectomized patients.

124 For thymectomized rats, the median survival time (MST) of li

125 to the "noninfectious" form of tolerance in thymectomized rats.

126 ografts earlier (POD 8, 22, 27) than the non-thymectomized recipients (POD 33,35,45,47,55).

127 afts survived 100 days, but developed CAV in thymectomized recipients and in those permanently deplet

128 In contrast, day -21 and day 0 thymectomized recipients demonstrated allograft dysfunct

129 omized, and day-greater than or equal to +42 thymectomized recipients demonstrated stable renal funct

130 Results of experiments with thymectomized recipients demonstrated that an intact thy

131 Grafting of donor thymic tissue to thymectomized recipients is an alternative approach for

132 he same protocol did not induce tolerance in thymectomized recipients nor in recipients beyond the ag

133 ated class I disparate heart allografts, the thymectomized recipients rejected their allografts earli

134 survival and the development of CAV in these thymectomized recipients were compared to the same param

135 hout immunosuppression into two of the three thymectomized recipients, and one of the three euthymic

136 These renal allografts were accepted by thymectomized recipients, but rejected by the euthymic r

137 eceptor (TCR)+ T cells have been reported in thymectomized recipients, whether this represents clonal

138 one autoimmune disease over another in day 3 thymectomized recipients.

139 ical controls consisted of euthymic and sham-thymectomized recipients.

140 ce to class I-disparate kidney allografts in thymectomized recipients.

141 mic grafts simultaneously with the kidney in thymectomized recipients.

142 nor-reactive host CD4 cells also occurred in thymectomized, similarly treated marrow recipients, demo

143 Thymectomized swine developed acute cellular rejection c

144 Although thymectomized, T cell-depleted normal mice usually remai

145 Grafting of thymectomized, T cell-depleted normal mice with xenogene

146 tal pig thymic and hematopoietic tissue into thymectomized, T cell-depleted, and natural killer-cell-

147 TCR expression returns in thymectomized Tg mice 3 days after MBP feeding and then

148 ted here is the first definitive study using thymectomized (ThX) animals to directly evaluate the con

149 mice that were either sham thymectomized or thymectomized (Thx) at approximately 6 weeks of age.

150 ibility of restoring transplant tolerance to thymectomized (TMX) ACI recipients with concomitant adop

151 d IL-10 genes was diminished in euthymic and thymectomized tolerant hosts.

152 In addition, thymectomized Vbeta5 transgenic RAG reporter mice are us

153 proximately 3% of CD4(+)Vbeta5(+) T cells in thymectomized Vbeta5 transgenic reporter mice have under

154 peripheral T-cell expansion is increased in thymectomized versus thymus-bearing hosts after bone mar