ライフサイエンスコーパス: thymectomy

1 functional diversity is lost after neonatal thymectomy.

2 ow chimeras prepared after complete surgical thymectomy.

3 s by combined cyclophosphamide treatment and thymectomy.

4 imilar to the previously described effect of thymectomy.

5 n, and these cells disappear following early thymectomy.

6 hymus prevents the induction of disease post-thymectomy.

7 utes of Health-funded international trial of thymectomy.

8 ult male C57BL/6 mice with and without prior thymectomy.

9 cells, and rapidly decreased after complete thymectomy.

10 reduction surgery, lung transplantation and thymectomy.

11 n target peripheral T cells up to 2 mo after thymectomy.

12 eated with FK506, anti-CD4 mAbs (GK1.5), and thymectomy.

13 atients before and from 27 to 517 days after thymectomy.

14 for MG decreased thymopoiesis independent of thymectomy.

15 nt ways: total body irradiation and neonatal thymectomy.

16 fficacy is questionable or unproved, such as thymectomy.

17 loantigenic stimulation 2 wk after the adult thymectomy.

18 ejected and survival was not affected by the thymectomy.

19 frequency that is enhanced significantly by thymectomy.

20 d MG patients studied at varying times after thymectomy (1 day to 41 years), we found no significant

21 Group 5 animals underwent thymectomy 100 days after co-transplantation (n=4).

22 uction of tolerance by performing a complete thymectomy 21 d before renal transplantation.

23 2 days of CyA underwent either (1) a partial thymectomy 21 days before kidney transplantation (day -2

24 urse of cyclosporine (CyA), and that a total thymectomy 21 days before transplantation abrogates the

25 Thymectomy 3 wk after neonatal MTLV infection enhances t

26 treated with modified regimens that omitted thymectomy, 3 Gy TBI, anti-Thy1.2, and anti-NK1.1 mAbs,

27 prognosis was good, with a reduced need for thymectomy (6.3% vs 19.2%) and a high proportion of pati

28 ptide induces operational tolerance, whereas thymectomy abrogates this effect.

29 Moreover, halting thymic output by thymectomy accelerates the age-dependent decline in peri

30 IL-7R, or devoid of T cell renewal via adult thymectomy, all exhibited significant increases in TCE i

31 ally transplanted into recipients undergoing thymectomy alone or recipients undergoing thymectomy plu

32 st, using the complementary methods of early thymectomy and adoptive transfers, we found that PTEN-de

33 Here we have used thymectomy and antibody depletion to examine the effect

34 c age of residual PTK7 (+) T cells following thymectomy and may also explain in part the prematurely

35 When adult thymectomy and postgraft donor ThyTx were combined with

36 n be induced in normal laboratory rats after thymectomy and split dose gamma-irradiation.

37 etes, induced in rats by a protocol of adult thymectomy and split-dose gamma irradiation, can be prev

38 with naive CD4+CD25- effector T cells after thymectomy and T-cell depletion in CBA mice that receive

39 rgan-specific autoimmune disease after day 3 thymectomy and the effector function of cloned autoantig

40 responses could first be detected 5 wk post-thymectomy and were accompanied by high background respo

41 ed through a partial (n=6) or complete (n=2) thymectomy, and growth of the autologous thymic graft wa

42 the response to extended cervicomediastinal thymectomy as a component of the integrated management o

43 A cohort of BALB/c mice underwent thymectomy at day 3 after birth (d3Tx).

44 D mice did not result in suppression of post-thymectomy autoimmunity.

45 Thymectomy before HIV-1 infection did not preclude eithe

46 Thymectomy before i.v. injection of P5-activated syngene

47 primary response to H-Y for some time after thymectomy but lost this ability at approximately 6 mo.

48 press not only the induction of disease post-thymectomy, but can also efficiently suppress disease in

49 ast, mice that were primed to H-Y just after thymectomy continued to display immunological memory to

50 Day 3 thymectomy (D3Tx) leads to a paucity of CD4(+)CD25(+) su

51 Day 3 thymectomy (D3Tx) results in a loss of peripheral tolera

52 Day 3 thymectomy (D3Tx) results in a loss of peripheral tolera

53 We found that thymectomy decreased CD4 or CD8 T cell TREC concentratio

54 ting to the relevance of the thymic effects, thymectomy decreases by approximately 50% the bone loss

55 Thymectomy did not influence xenograft survival in any t

56 Pretransplant thymectomy diminished the efficacy of CD4-targeted thera

57 the T cell pool in fetal life, but postnatal thymectomy does not lead to immunodeficiency in humans.

58 However, thymectomy does not result in homeostatic proliferation

59 In contrast, thymectomy eliminated LN recent thymic emigrants.

60 Timed thymectomy experiments confirmed that the CD8-SP autoeff

61 s' most recent 100 consecutive transcervical thymectomies for nonthymoma-associated MG was performed

62 ecutive patients who underwent trans-sternal thymectomy for symptomatic myasthenia gravis from 1969 t

63 The transcervical approach for thymectomy for the treatment of MG produces results simi

64 ne (6.15 vs. 8.99, P<0.001); patients in the thymectomy group also had a lower average requirement fo

65 between groups (P=0.73), but patients in the thymectomy group had fewer treatment-associated symptoms

66 Fewer patients in the thymectomy group than in the prednisone-only group requi

67 by multiple doses of AH.F5 with and without thymectomy (groups 7 and 8).

68 Patients who underwent thymectomy had a lower time-weighted average Quantitativ

69 Thymectomy has been a mainstay in the treatment of myast

70 Thymectomy improved clinical outcomes over a 3-year peri

71 pread acceptance of the notion that complete thymectomy improves the course of the disease.

72 Neonatal thymectomy in BALB/c mice has been described as a model

73 Because thymectomy in humans is performed for treatment of myast

74 ld be reserved for difficult cases or before thymectomy in lieu of plasma exchange.

75 The role of thymectomy in the management of the disease remains unpr

76 The role of thymectomy in the management of these patients remains u

77 ll with acute hepatitis B after undergoing a thymectomy in which a thoracic-surgery resident who had

78 lls in PG and SMG following short-term adult thymectomy indicated that immature salivary gland T cell

79 ls that inhibit SAT were eliminated by day 3 thymectomy, indicating they belong to the subset of natu

80 A/J and (C57BL/6J x A/J)F1 hybrids, neonatal thymectomy-induced autoimmune ovarian dysgenesis (AOD) i

81 uggests that, as in adult myasthenia gravis, thymectomy is a viable therapeutic option for selected c

82 Extended cervicomediastinal thymectomy is the procedure of choice as a component of

83 and naive CD4 T cells, is enhanced by 3-day thymectomy, is independent of IL-7, and requires a class

84 Autoimmune thymectomy models have revealed suppressor cell populati

85 ment, compared to conventional trans-sternal thymectomy, neither the pathologic diagnosis (presence o

86 e gastritis spontaneously develops following thymectomy of 3-day-old BALB/c mice (d3Tx).

87 Thymectomy of BALB/c mice on day 3 of life results in th

88 Thymectomy of neonatal mice can result in the developmen

89 Thymectomy of recipient animals before transplantation d

90 of donor-specific thymus combined with adult thymectomy of recipients enhances the tolerogenic effect

91 Thymectomy of susceptible strains of mice on day 3 of li

92 plant tolerance, which was then abrogated by thymectomy of the recipient before intravenous injection

93 contrast, there was no significant effect of thymectomy on absolute numbers of naive PB T cells.

94 Animals undergoing a partial thymectomy on day -21 or serial thymic biopsies showed s

95 ay 0 host-type thymocyte infusions following thymectomy on day -21, developed donor-specific hyporesp

96 ithout changes in thymic volume), (3) a sham thymectomy on day -21, or serial sham thymic surgery on

97 Female (C57BL/6xA/J)F(1) mice undergoing thymectomy on day 3 after birth (d3tx) developed autoimm

98 We have also determined the effect of thymectomy on levels of PB cells containing signal joint

99 have studied patients with MG for effects of thymectomy on peripheral blood (PB) naive (CD45RA(+), CD

100 le tolerance induction, because either prior thymectomy or a series of thymic biopsies induce a spont

101 Suppression of resistance of recipients by thymectomy or injections of granulocyte colony-stimulati

102 ssential for tolerance because pretransplant thymectomy or peritransplant depletion of CD25(+) cells

103 A partial thymectomy or serial thymic biopsies markedly interfere

104 nosuppressive-conditioning regimen including thymectomy or thymic irradiation, extracorporeal immunoa

105 equently performed surgical procedure (e.g., thymectomy) or in cases where there was no predominant p

106 myasthenic patients, for whom treatment with thymectomy, plasmapheresis, and conventional immunothera

107 We compared extended transsternal thymectomy plus alternate-day prednisone with alternate-

108 ng thymectomy alone or recipients undergoing thymectomy plus either CD4+ or CD8+ T cell depletion.

109 ed a multicenter, randomized trial comparing thymectomy plus prednisone with prednisone alone.

110 ic rats before the onset of disease by adult thymectomy plus short-term anti-CD8alpha mAb treatment.

111 r-old man with myasthenia gravis and a prior thymectomy presenting with 2 months of diffuse, involunt

112 Thymectomy prevented disease, confirming the causal asso

113 Thymectomy prevented the induction of tolerance.

114 The results show that adult thymectomy prevents the inhibition of trinitrophenol (TN

115 sponse of patients with myasthenia gravis to thymectomy primarily with respect to the bivariate endpo

116 Although thymectomy prolongs enhanced CTLA-4 expression, long-ter

117 ntinuous isotype-matched control mAb, 3) the thymectomy/pulse anti-CD8alpha regimen, or 4) no treatme

118 and contrast-enhanced CT groups had similar thymectomy rates (P = .97) and disease-related symptom t

119 ted with RIB 5/2 plus an i.v. alloantigen +/-thymectomy received kidney transplants after 40 days.

120 ever, the best technique to achieve complete thymectomy remains controversial.

121 Thymectomy resulted in the gradual loss of these DNA del

122 Thymectomy showed that thymic output of IGRP-specific tr

123 Thymectomy significantly reduces survival after MCMV cha

124 ons most when thymopoiesis was active before thymectomy (six of six patients), but had little effect

125 aboons underwent a conditioning regimen with thymectomy, splenectomy, and anti-monkey CD3 antibody co

126 ppressive conditioning regimen that included thymectomy, splenectomy, extracorporeal immunoadsorption

127 patient with myasthenia gravis treated with thymectomy subsequently developed extensive granulomatou

128 days, whereas anti-CD4, in combination with thymectomy, synergistically prolonged survival of pancre

129 in patients without bilateral transcervical thymectomy (TCT).

130 onships between performance on the UPSIT and thymectomy, time since diagnosis, type of treatment regi

131 Failure of thymectomy to affect the course of tolerance after day +

132 We now report: (a) addition of thymectomy to the protocol permitted skin allografts to

133 In agreement, adding thymectomy to the regimen results in permanent engraftme

134 c graft-vs-host reaction (synGVHR) and timed thymectomy (Tx) assays revealed that autoeffector T cell

135 s were created by subjecting juvenile RMs to thymectomy versus sham surgery, respectively, followed b

136 ereas the use of extended cervicomediastinal thymectomy was associated with a greater than twofold ch

137 The effect of thymectomy was particularly notable in those individuals

138 Adult thymectomy was performed 4 weeks before grafting.

139 Thymectomy was performed in 17 children, of whom 11 expe

140 ldren and adolescents who underwent neonatal thymectomy, we demonstrate that the naive CD4+ T cell co

141 s without adoptive transfer, irradiation, or thymectomy, we developed genetically modified mice that

142 Total thymectomies were performed in six animals (postoperativ

143 Thymectomies were performed on days -21, 0, +8, +21, and

144 at their numbers progressively decline after thymectomy with a half-life of approximately 2 weeks.

145 th a history of thymoma or thymic neoplasms, thymectomy within 12 months before screening, or use of

146 y the escape of self-reactive T cells before thymectomy without accompanying T reg cells.

147 e neonatal thymus/T cells (e.g., by neonatal thymectomy) without virus infection.