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1 ound (RAG-2(-/-)TAP-1(-/-)OT-1, nonselecting thymi).
2 d that CD8(+) T cells populated MRV-infected thymi.
3 idization between selecting and nonselecting thymi.
4 of spleens (peak at day 7) but were rare in thymi.
5 arathymic lymph nodes were excluded from the thymi.
6 atin in short term organ culture of neonatal thymi.
7 ant NKT cells were detected in Ly9-deficient thymi.
8 mic progenitors (ETPs) relative to wild type thymi.
9 tionated cells isolated from pediatric human thymi.
10 etect class II aggregates in Ii chain mutant thymi.
11 les than those isolated from lymph nodes and thymi.
12 BB rats may be absent or deficient in BB rat thymi.
13 deficient in Ealpha(6) TCR Tg H-2Malpha(-/-) thymi.
14 le-Tg mice: (1) increased apoptosis in their thymi, (2) remarkable reduction in the proportion of the
15 indle to <5% in FTOC established from day 14 thymi; 3) NK1.1+ cells dominate in FTOC supplemented wit
16 was increased compared to non-islet-bearing thymi (93.7+/-48.6 ng/g tissue vs. 0.7+/-0.4 ng/g tissue
21 promoted its pro-apoptotic activity in mouse thymi and small intestines, the chromosomal instability
22 killed 18-24 hrs after study entry, and the thymi and spleen were removed for analysis of apoptosis.
27 y barriers show that allogeneic transplanted thymi are not rejected, and allogeneic cells do not indu
28 direct examination of freshly obtained fetal thymi as well as fetal thymi established in organ cultur
29 entical subtype (CD8-CD4+) were protected in thymi but not in spleens indicates that cell susceptibil
30 ge in H-2(b) mice (RAG-2(-/-)OT-1, selecting thymi), but are not selected on a transporter associated
32 re examined for increased apoptosis in their thymi by the TUNEL assay, as well as for loss of HEL-spe
33 tion of SLC/ELC- expression alone in Ltbr-/- thymi can be sufficient to impair thymic negative select
34 Moreover, these findings suggest that fetal thymi contain several novel lymphocyte subsets that can
36 ilizing FTOC, we found that: 1) day 12 fetal thymi contained a progenitor that can differentiate into
38 from adult diabetes-resistant BB (BBDR) rat thymi cultured for up to 14 days can adoptively transfer
39 Immunohistochemical staining of pediatric thymi demonstrated the presence of CD20+ B cells and CD1
41 -specific responses, and WT recipients of KO thymi developed enhanced responses and a highly exacerba
42 ous stages, we show that fetal and postnatal thymi differ in the frequency and localization of IL-7-e
46 Inhibition of glucocorticoid production in thymi from alpha/beta-TCR transgenic mice resulted in th
54 ll, tissues of recipient mice implanted with thymi from NOD mice lacking expression of the autoimmune
59 We report that cultured DR- and DP-BB rat thymi generate mature CD4 and CD8 single-positive cells
65 compartment in wild-type and Aire-deficient thymi in an effort to integrate the proapoptotic activit
70 ressing these Vbeta families was observed in thymi in which rat class II+ cells were not detectable.
71 ing gene 1 (RAG-1(-/-)) and TCRbetaxdelta-/- thymi in which T-cell development is blocked at the CD4(
72 g with cleft palates and ectopically located thymi, in Wnt1-Cre alpha5/alphav mutants, suggesting tha
74 , the cellularity of the spleens but not the thymi is significantly increased compared with that of t
76 In contrast, recipients of 10 d or older thymi lacked diabetogenic T cells but developed severe c
78 e thymic cortex was observed in CCX-CKR(-/-) thymi, likely accounting for their defects in thymocyte
80 pontaneous apoptosis is also observed in the thymi of Akt1(-/-) mice, and Akt1(-/-) thymocytes are mo
81 deficient (Gb3S(-/-)) mouse and show that in thymi of alphaGalA(-/-)/Gb3S(-/-) double-knockout mice,
82 s, which are differentially expressed in the thymi of C57BL/6 and 129S6 mice that express the lupus-r
83 om donor mice have the capability to home to thymi of fully allogeneic recipients after intravenous i
85 contrast, K8(+)K5(+) TECs predominate in the thymi of human CD3epsilon transgenic mice in which thymo
86 recipients., Identification of islets within thymi of hyperglycemic IT recipients was problematic as
93 beta sequences from the CNSs, periphery, and thymi of mice at different stages of autoimmune encephal
94 sed these probes to monitor apoptosis in the thymi of mice treated with dexamethasone as well as in t
101 n addition, the actual deletional process in thymi of the double-Tg mice was visualized in situ by th
108 thoracic thymus, parathyroid-origin cervical thymi (pCT) express low levels of the thymic epithelial
110 ion of PDGFRalpha+ mesenchyme from embryonic thymi prior to their transplantation to ectopic sites re
111 mocyte populations in a number of individual thymi provides evidence for a new pathway of lineage com
112 e conclude that cultured DR-BB and DP-BB rat thymi, respectively, recapitulate the normal and abnorma
115 Furthermore, RasGRP1/3 double-deficient thymi show significant reductions in ETP numbers compare
116 e report that RasGRP1- and RasGRP3-deficient thymi show significantly reduced numbers of early thymic
119 e expression profiling of Ly9-deficient mice thymi showed a significant upregulation of IL-4 and prom
122 h either RasGRP1 or RasGRP3 single-deficient thymi, suggesting that both RasGRP1 and RasGRP3 regulate
124 ested that the failure of cultured DP-BB rat thymi to generate T cells with a mature phenotype is due
125 II+ antigen-presenting cells remain in their thymi, tolerance will persist as a result of deletion of
126 In contrast, here we show that neonatal thymi transplanted into interleukin 7 receptor-deficient
128 ation of newborn human CD3epsilon transgenic thymi under the kidney capsule of RAG-1(-/-) mice result
130 e marrow chimeras indicated that the smaller thymi were due to a lack of ERalpha in radiation-resista
134 ing popliteal lymph nodes [LN], spleens, and thymi) were removed 1, 2, 7, and 14 days later and stain
135 cipients was similar to that in normal mouse thymi, whereas CD4 SP thymocytes in grafts of IIKO mice
136 related orphan receptor gamma (ROR gamma)0/0 thymi, which accumulate immature single-positive (ISP) t
137 rable in day 15 to 16 freshly obtained fetal thymi, which was markedly decreased by day 17 of gestati
140 unction contain fewer stromal cells, whereas thymi with robust function contain proliferating stromal
141 mma in Nes-expressing cells also had smaller thymi, with reductions in double-negative 4 T cell precu
142 ferentiation origin for a subset of cervical thymi, with specific functional consequences for T-cell
143 SP cells were less abundant in CCX-CKR(-/-) thymi, yet expansion of both DP and immature SP cells wa
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