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1 ound (RAG-2(-/-)TAP-1(-/-)OT-1, nonselecting thymi).
2 d that CD8(+) T cells populated MRV-infected thymi.
3 idization between selecting and nonselecting thymi.
4  of spleens (peak at day 7) but were rare in thymi.
5 arathymic lymph nodes were excluded from the thymi.
6 atin in short term organ culture of neonatal thymi.
7 ant NKT cells were detected in Ly9-deficient thymi.
8 mic progenitors (ETPs) relative to wild type thymi.
9 tionated cells isolated from pediatric human thymi.
10 etect class II aggregates in Ii chain mutant thymi.
11 les than those isolated from lymph nodes and thymi.
12 BB rats may be absent or deficient in BB rat thymi.
13 deficient in Ealpha(6) TCR Tg H-2Malpha(-/-) thymi.
14 le-Tg mice: (1) increased apoptosis in their thymi, (2) remarkable reduction in the proportion of the
15 indle to <5% in FTOC established from day 14 thymi; 3) NK1.1+ cells dominate in FTOC supplemented wit
16  was increased compared to non-islet-bearing thymi (93.7+/-48.6 ng/g tissue vs. 0.7+/-0.4 ng/g tissue
17 c Hoxa3 deletions resulted in small, ectopic thymi, although each had a unique phenotype.
18                                In all of the thymi analyzed, alphabeta thymocytes have rearrangements
19 nd tissue-restricted antigens in both intact thymi and cultured thymic epithelial cell line.
20 y self-reactive T cells are present in their thymi and peripheral lymphoid organs.
21 promoted its pro-apoptotic activity in mouse thymi and small intestines, the chromosomal instability
22  killed 18-24 hrs after study entry, and the thymi and spleen were removed for analysis of apoptosis.
23 s of donor (IAb+) cells were detected in the thymi and spleens of FL-BM recipients.
24    However, these mice also exhibit enlarged thymi and spleens.
25                    Tissue, including brains, thymi, and adrenal glands was collected on Day 11.
26 st, infused splenic DCs immigrated poorly to thymi, and did not affect graft survival.
27 y barriers show that allogeneic transplanted thymi are not rejected, and allogeneic cells do not indu
28 direct examination of freshly obtained fetal thymi as well as fetal thymi established in organ cultur
29 entical subtype (CD8-CD4+) were protected in thymi but not in spleens indicates that cell susceptibil
30 ge in H-2(b) mice (RAG-2(-/-)OT-1, selecting thymi), but are not selected on a transporter associated
31  with tTregs being detected only in neonatal thymi by day 3 after birth.
32 re examined for increased apoptosis in their thymi by the TUNEL assay, as well as for loss of HEL-spe
33 tion of SLC/ELC- expression alone in Ltbr-/- thymi can be sufficient to impair thymic negative select
34  Moreover, these findings suggest that fetal thymi contain several novel lymphocyte subsets that can
35                                    Wild-type thymi contain ~200 small medullae that are connected to
36 ilizing FTOC, we found that: 1) day 12 fetal thymi contained a progenitor that can differentiate into
37                       In addition, the NHD13 thymi contained fewer thymocytes, with an increased perc
38  from adult diabetes-resistant BB (BBDR) rat thymi cultured for up to 14 days can adoptively transfer
39    Immunohistochemical staining of pediatric thymi demonstrated the presence of CD20+ B cells and CD1
40           NOD.scid recipients of newborn NOD thymi developed diabetes.
41 -specific responses, and WT recipients of KO thymi developed enhanced responses and a highly exacerba
42 ous stages, we show that fetal and postnatal thymi differ in the frequency and localization of IL-7-e
43 reshly obtained fetal thymi as well as fetal thymi established in organ cultures (FTOC).
44                       However, recipients of thymi from 7- and 10-d-old NOD donor mice remained diabe
45                                              Thymi from aged Tbata-deficient mice are larger and cont
46   Inhibition of glucocorticoid production in thymi from alpha/beta-TCR transgenic mice resulted in th
47               Between 6 and 10 weeks of age, thymi from Bax-expressing mice (either p53+/+ or p53-/-)
48               At 8 weeks posttransplantation thymi from both partially and totally pancreatectomized
49                                 We show that thymi from Carm1(-/-) embryos (E18.5) have a 5-10-fold r
50          We examined thymocyte emigration in thymi from CXCR4-deficient C57BL/6 embryos in a modified
51                                              Thymi from different aged NOD mice, representing distinc
52                                              Thymi from mI-kappaBalpha mice contained increased numbe
53                                              Thymi from NHD13 mice were smaller and overexpressed Hox
54 ll, tissues of recipient mice implanted with thymi from NOD mice lacking expression of the autoimmune
55                                 By contrast, thymi from Rag1(-/-) mice contain as much IL-17A as thos
56                                              Thymi from Vhlh-deficient mice were small due to a sever
57                                     In other thymi, gammadelta cells showed no obvious beta gene rear
58                       Interestingly, in some thymi, gammadelta thymocytes have out-of-frame beta rear
59    We report that cultured DR- and DP-BB rat thymi generate mature CD4 and CD8 single-positive cells
60                  Namely, KO recipients of WT thymi generated reduced IRBP-specific responses, and WT
61                             The hyperplastic thymi had normal histology revealing a well-differentiat
62                           Accessory cervical thymi have also been identified in humans and mice, and
63                                 Rare PU.1-/- thymi, however, contained small numbers of thymocytes ex
64 titutively tyrosine phosphorylated in murine thymi in a SAP- and Fyn kinase-dependent manner.
65  compartment in wild-type and Aire-deficient thymi in an effort to integrate the proapoptotic activit
66                                              Thymi in Id3-deficient mice had aberrant development of
67                   Here we show that cervical thymi in mice have following two origins: delayed differ
68                               In contrast to thymi in mice with the null allele, the Foxn1(Delta/Delt
69                     Co-culture of adult BBDR thymi in the presence of BBDR thyrocytes had no effect o
70 ressing these Vbeta families was observed in thymi in which rat class II+ cells were not detectable.
71 ing gene 1 (RAG-1(-/-)) and TCRbetaxdelta-/- thymi in which T-cell development is blocked at the CD4(
72 g with cleft palates and ectopically located thymi, in Wnt1-Cre alpha5/alphav mutants, suggesting tha
73      Soon after transplantation of wild-type thymi into immunodeficient mice lacking functional T cel
74 , the cellularity of the spleens but not the thymi is significantly increased compared with that of t
75               This expansion, as in TAP-1o/o thymi, is evident in each of the limited T cell receptor
76     In contrast, recipients of 10 d or older thymi lacked diabetogenic T cells but developed severe c
77                                              Thymi lacking functional Rho isolated from C3 transgenic
78 e thymic cortex was observed in CCX-CKR(-/-) thymi, likely accounting for their defects in thymocyte
79             T cell apoptosis was abundant in thymi of ADA(-/-) mice, but no increase in apoptosis was
80 pontaneous apoptosis is also observed in the thymi of Akt1(-/-) mice, and Akt1(-/-) thymocytes are mo
81 deficient (Gb3S(-/-)) mouse and show that in thymi of alphaGalA(-/-)/Gb3S(-/-) double-knockout mice,
82 s, which are differentially expressed in the thymi of C57BL/6 and 129S6 mice that express the lupus-r
83 om donor mice have the capability to home to thymi of fully allogeneic recipients after intravenous i
84 ro as well as from APCs from the spleens and thymi of hen egg-white lysozyme transgenic mice.
85 contrast, K8(+)K5(+) TECs predominate in the thymi of human CD3epsilon transgenic mice in which thymo
86 recipients., Identification of islets within thymi of hyperglycemic IT recipients was problematic as
87 asmic deletion mutants of IL-7R alpha in the thymi of IL-7R alpha(-/-) mice.
88          Surprisingly, however, although the thymi of IL-7Ralpha Tg mice were comparable at birth, th
89                                 In contrast, thymi of immunodeficient Rag2(-/-) mice exhibit only ~20
90                             Furthermore, the thymi of LIGHT transgenic mice show severe atrophy with
91         The failure of Aire induction in the thymi of lymphotoxin-deficient and lymphotoxin-beta rece
92 increased rate of thymocyte apoptosis in the thymi of M-MuLV-inoculated mice.
93 beta sequences from the CNSs, periphery, and thymi of mice at different stages of autoimmune encephal
94 sed these probes to monitor apoptosis in the thymi of mice treated with dexamethasone as well as in t
95                                              Thymi of primary donor mice showed reduced cellularity,
96 a-specific T cells were centrally deleted in thymi of progeny that inherited the kappaTg.
97 jected IL-7-secreting stromal cells into the thymi of recipient mice.
98                                          The thymi of Sh2d3c(-/-) mice showed no maturational abnorma
99            Furthermore, when analyzing whole thymi of T reg TCR Tg RAG-deficient mice, we found signi
100 ) skin gammadelta T cell precursors in fetal thymi of the B6 background mice.
101 n addition, the actual deletional process in thymi of the double-Tg mice was visualized in situ by th
102                       Moreover, we find that thymi of TL+ mice congenic or transgenic for H-2T18 also
103                             By 14 weeks, the thymi of transgenic mice increased in weight up to 40-fo
104 ling demonstrated increased apoptosis in the thymi of v-cyclin-transgenic mice.
105 lls, undetectable by conventional assays, in thymi of WT (but not of KO) mice.
106 creased in the thymocytes from the atrophied thymi of young Atm-/- mice.
107                 CD4(+) T cells purified from thymi or lymph nodes of normal mice prevented the occurr
108 thoracic thymus, parathyroid-origin cervical thymi (pCT) express low levels of the thymic epithelial
109           Furthermore, almost 40% of PU.1-/- thymi placed in fetal thymic organ culture are capable o
110 ion of PDGFRalpha+ mesenchyme from embryonic thymi prior to their transplantation to ectopic sites re
111 mocyte populations in a number of individual thymi provides evidence for a new pathway of lineage com
112 e conclude that cultured DR-BB and DP-BB rat thymi, respectively, recapitulate the normal and abnorma
113        Microscopic analysis of islet-bearing thymi revealed positive staining for islet-specific horm
114             Finally, an analysis of neonatal thymi revealed that the CD44(lo/int) precursors of gamma
115      Furthermore, RasGRP1/3 double-deficient thymi show significant reductions in ETP numbers compare
116 e report that RasGRP1- and RasGRP3-deficient thymi show significantly reduced numbers of early thymic
117                                  Repopulated thymi showed a clear increase of CD4-/CD8- and CD8+ frac
118                                     CD6(-/-) thymi showed a reduction in both CD4(+) and CD8(+) singl
119 e expression profiling of Ly9-deficient mice thymi showed a significant upregulation of IL-4 and prom
120                            Five of six NHD13 thymi showed an unusual Tcrb gene rearrangement pattern
121 oes not affect virus titers in infected mice thymi, spleens or infected C1 astrocytes.
122 h either RasGRP1 or RasGRP3 single-deficient thymi, suggesting that both RasGRP1 and RasGRP3 regulate
123         ERKO mice have significantly smaller thymi than their wild-type (WT) littermates.
124 ested that the failure of cultured DP-BB rat thymi to generate T cells with a mature phenotype is due
125 II+ antigen-presenting cells remain in their thymi, tolerance will persist as a result of deletion of
126      In contrast, here we show that neonatal thymi transplanted into interleukin 7 receptor-deficient
127                We conclude that neonatal pig thymi transplanted to BALB/c nu/nu mice can support the
128 ation of newborn human CD3epsilon transgenic thymi under the kidney capsule of RAG-1(-/-) mice result
129            The presence of HEL mRNA in mouse thymi was determined by RT-PCR.
130 e marrow chimeras indicated that the smaller thymi were due to a lack of ERalpha in radiation-resista
131 , newborn TCR beta-deficient (TCR beta(-/-)) thymi were grafted to IL-7(-/-) mice.
132                      However, when IL-7(-/-) thymi were grafted to TCR beta(-/-) mice, no development
133                                        Their thymi were smaller, contained significantly fewer cells,
134 ing popliteal lymph nodes [LN], spleens, and thymi) were removed 1, 2, 7, and 14 days later and stain
135 cipients was similar to that in normal mouse thymi, whereas CD4 SP thymocytes in grafts of IIKO mice
136 related orphan receptor gamma (ROR gamma)0/0 thymi, which accumulate immature single-positive (ISP) t
137 rable in day 15 to 16 freshly obtained fetal thymi, which was markedly decreased by day 17 of gestati
138               Transgenic mice showed smaller thymi with a dramatic reduction of CD4+CD8+, CD4+ and CD
139                                              Thymi with diminished function contain fewer stromal cel
140 unction contain fewer stromal cells, whereas thymi with robust function contain proliferating stromal
141 mma in Nes-expressing cells also had smaller thymi, with reductions in double-negative 4 T cell precu
142 ferentiation origin for a subset of cervical thymi, with specific functional consequences for T-cell
143  SP cells were less abundant in CCX-CKR(-/-) thymi, yet expansion of both DP and immature SP cells wa

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