ライフサイエンスコーパス: thymic

1 ces, including hematopoietic progenitors and thymic activity, which could contribute to the long-term

2 gests that caloric restriction (CR) can slow thymic aging by maintaining thymic epithelial cell integ

3 F21 function in middle-aged mice accelerated thymic aging, increased lethality, and delayed T-cell re

4 and tissue-specific role for Bim in limiting thymic agonist selection of CD8alphaalpha precursors and

5 Thymic and bone MCs share other sets of differentially e

6 Despite the thymic and lymph node egress defects, sphingosine-1-phos

7 an increase in the proportion and number of thymic and peripheral Foxp3(+) regulatory T cells.

8 c cells (DCs) as critical modulators of both thymic and peripheral immune tolerance.

9 ction of OTII(+) thymocytes and in increased thymic and peripheral T regulatory cells.

10 ent for A20 in T lineage cells, we show that thymic and peripheral Treg cell compartments are quantit

11 Consistent with the fact that thymic and skin MCs have to support epithelial cells, th

12 ral infections, IL-22 deficiency resulted in thymic and splenic hypertrophy, while excessive IL-22 in

13 Peptides presented uniformly by thymic antigen-presenting cells were tolerated by clonal

14 sion of insulin epitope B:9-23 (InsB9-23) by thymic APCs is insufficient to induce deletion of high-

15 CD4+ thymic conventional T cells, suggesting thymic atrophy positively influences tTreg cell generati

16 homeostatic defect- or natural aging-induced thymic atrophy results in a decline in central T-cell to

17 /gel significantly attenuated tumor-mediated thymic atrophy, which is associated with immunosuppressi

18 sthenia gravis patient by immortalization of thymic B cells using Epstein-Barr virus and TLR9 activat

19 In contrast, thymic B cells were enriched for autoreactive clones tha

20 elusive because of the difficulty of taking thymic biopsy specimens from affected children.

21 rmed whole transcriptome analyses of primary thymic, bone, and skin MCs.

22 clusively on patients with advanced lung and thymic carcinoids.

23 ostatin analogue with everolimus in lung and thymic carcinoids.

24 ients with advanced/recurrent thymoma (T) or thymic carcinoma (TC) who have progressed after platinum

25 lovirus (MRV), causes loss of peripheral and thymic CD4(+) cells during neonatal infection of BALB/c

26 ng PI3K signaling reduced MHC acquisition by thymic CD8alpha(+) cDC and plasmacytoid DC but not SIRPa

27 capacities to acquire MHC-peptide complexes, thymic CD8alpha(+) cDC elicited increased T cell stimula

28 locations exhibit a substantial reduction in thymic cellularity and limited CD4(-)CD8(-) (double-nega

29 Although thymic cellularity was comparable between wild type (WT)

30 Although thymic cellularity was diminished in p45(-/-) mice, tran

31 owed a long-term dose-dependent reduction in thymic cKit(+) lymphoid progenitors that was maintained

32 Thymic conventional DC (cDC) subsets signal regulatory p

33 generation was not impaired compared to CD4+ thymic conventional T cells, suggesting thymic atrophy p

34 Positive selection occurs in the thymic cortex, but critical maturation events occur late

35 accumulated in the perivascular channels of thymic corticomedullary venules.

36 e TCRB sequences, which are not subjected to thymic culling, suggesting that the shorter CDR3s arise

37 -follicular helper paradigms with consequent thymic damage and impaired donor antigen presentation in

38 cGVHD pathogenesis includes thymic damage, impaired antigen presentation, and a fail

39 Despite the importance of thymic DC cross-dressing in negative selection, the fact

40 involves LTbetaR-mediated regulation of the thymic DC pool.

41 llular MHC transfer was donor-cell specific; thymic DC readily acquired MHC from TEC plus thymic or s

42 te the process and the capacity of different thymic DC subsets to acquire MHC and stimulate thymocyte

43 In this study intercellular MHC transfer by thymic DC subsets was investigated using an MHC-mismatch

44 chanisms drive intercellular MHC transfer by thymic DC subsets.

45 es from medullary thymic epithelial cells to thymic DC.

46 Importantly, although human thymic DCs express TSSP, individuals segregate into two

47 Therefore, the level of TSSP expression by thymic DCs may modify the risk factors for MS conferred

48 ulture with tumor-associated, but not normal thymic DCs, sustained IGF1R activation.

49 Age-related thymic degeneration is associated with loss of naive T c

50 of retinal protein-specific T cells escaped thymic deletion as a result of the hypomorphic Aire func

51 ruction by self-reactive T cells that escape thymic deletion.

52 The mechanistic basis of age-related thymic demise is unclear, but prior evidence suggests th

53 Thymic dendritic cells (DC) delete self-antigen-specific

54 is expressed by thymic epithelial cells and thymic dendritic cells (DCs) and, in these two stromal c

55 XP3 regulatory T (Treg) cells are progeny of thymic-derived CD4CD25FOXP3 Treg (tTreg) cells or are in

56 decrease in proliferation at Stage 1 during thymic development and increased apoptosis.

57 nt and functionally identifies the arrest in thymic development caused by several SCID mutations.

58 ring early/cortical, but not late/medullary, thymic development controls the agonist selection of CD8

59 We examined iNKT thymic development in limited-dilution bone marrow chime

60 Here, we show that the thymic development of Treg cells depends on the expressi

61 can be imposed on the TCR repertoire during thymic development, and it has been proposed that the in

62 During thymic development, iNKT cells also differentiate into N

63 e defects resulting from impaired CD8 T cell thymic development.

64 l receptor (TCR) repertoire is shaped during thymic development.

65 within a narrow time window during prenatal thymic development.

66 Thus, TCR signal strength within specific thymic developmental windows is a major determinant of t

67 e MLL4-binding site and compromised both the thymic differentiation and the inducible differentiation

68 cellular and molecular pathway that governs thymic EC differentiation for HPC homing.

69 tance of intact CORO1A C-terminal domains in thymic egress and T-cell survival, as well as in defense

70 failed to rescue the phenotype of decreased thymic egress.

71 monoclonal anti-CD4 and anti-CD31 and recent thymic emigrants (CD4+recently emigrated from the thymus

72 Recent thymic emigrants (RTEs) are the youngest peripheral T ce

73 The youngest peripheral T cells (recent thymic emigrants [RTEs]) are functionally distinct from

74 s without affecting thymocytes and/or recent thymic emigrants remains unknown.

75 thymic maturation, T cells egress as recent thymic emigrants to peripheral lymphoid organs where the

76 This enables some recent thymic emigrants to undergo LIP and convert into long-li

77 in newly arising T cells (so-called "recent thymic emigrants") in adults, as well as in babies.

78 ues the main subset consists of naive recent thymic emigrants, with effector memory T cells (T(EM)) f

79 s were CD45RA CD31, suggesting they were new thymic emigrants.

80 ress from the thymus, and survival of recent thymic emigrants.

81 ascular spaces and reduced numbers of recent thymic emigrants.

82 maturation (CCR7, CD45RA, CD57, PD1), recent thymic emigration (CD31), and the IL-7 receptor-alpha (I

83 sms which govern iNKT cell homeostasis after thymic emigration are incompletely understood.

84 Collectively, we define a new axis for thymic emigration involving stimulation of the thymic mi

85 the differentiation programme of specialized thymic endothelial cells (ECs) controlling this process

86 EC development/function and establishment of thymic environment for proper T cell development, and mo

87 How the thymic environment guides ETP commitment and maturation

88 minal differentiation model of the medullary thymic epithelial cell (mTEC) lineage from immature MHC

89 branching structure that contains medullary thymic epithelial cell (mTEC) networks to support negati

90 s, radiation exposure, and steroids, impairs thymic epithelial cell (TEC) functions and induces the p

91 Postnatal thymic epithelial cell (TEC) homeostatic defect- or natu

92 on (CR) can slow thymic aging by maintaining thymic epithelial cell integrity and reducing the genera

93 In contrast, the rate of decline in thymic epithelial cell numbers with age was radiation-se

94 e thymic epithelium and is required to prime thymic epithelial cells (TEC) for effective Treg inducti

95 reby inhibiting IL-22-mediated protection of thymic epithelial cells (TECs) and impairing recovery of

96 Although thymic epithelial cells (TECs) are crucial for thymopoie

97 The importance of thymic epithelial cells (TECs) is evidenced by clear lin

98 Thymic epithelial cells (TECs) provide crucial microenvi

99 toimmunity is largely prevented by medullary thymic epithelial cells (TECs) through their expression

100 Although SPL is robustly expressed in thymic epithelial cells (TECs), in this study, we show t

101 estrogens have strong regulatory effects on thymic epithelial cells (TECs), inducing a decreased pro

102 se results were confirmed in purified murine thymic epithelial cells (TECs).

103 cific serine protease (TSSP) is expressed by thymic epithelial cells and thymic dendritic cells (DCs)

104 (+) readily acquired MHC class I and II from thymic epithelial cells but plasmacytoid DC were less ef

105 First, we increase medullary thymic epithelial cells by using mice lacking osteoprote

106 ce MHC-self peptide complexes from medullary thymic epithelial cells to thymic DC.

107 urface of B cells, dendritic cells, cortical thymic epithelial cells, and medullary thymic epithelial

108 2 expression is a common feature of cortical thymic epithelial cells, indicating widespread availabil

109 Unlike medullary thymic epithelial cells, which express and present perip

110 a interaction with self-ligands displayed on thymic epithelial cells.

111 earliest thymocyte progenitors and cortical thymic epithelial cells.

112 ical for the activation of INS-VNTR in human thymic epithelial cells.

113 tical thymic epithelial cells, and medullary thymic epithelial cells.

114 stimulatory ligands (Dll4, Il7, and Vegf) by thymic epithelial cells.

115 ly unrecognized role for Prdm1 in regulating thymic epithelial function.

116 ematopoietic progenitor cells and defects of thymic epithelial progenitor cell differentiation.

117 actor 4 (Irf4) is highly expressed in murine thymic epithelium and is required to prime thymic epithe

118 tion p53 as a novel molecular determinant of thymic epithelium function throughout life.

119 To study the cell-autonomous role of p53 in thymic epithelium functioning, we developed and analyzed

120 The thymic epithelium within the thymic stroma comprises hig

121 tput and parasite-induced destruction of the thymic epithelium, as well as disruption of the overall

122 Alloreactive donor T cells can damage thymic epithelium, thus limiting new T-cell development.

123 s, and we provide evidence that it regulates thymic exit via a process distinct from S1P-mediated mig

124 gram that generates mature T cells ready for thymic exit.

125 sary for IL-4Ralpha signaling that regulates thymic exit.

126 poised to provide homeostatic regulation of thymic export.

127 Peptides with limited thymic expression induced partial clonal deletion and im

128 n, making it difficult to assess the role of thymic failure in human immunodeficiency virus (HIV) dis

129 Nur77 deficiency increased the frequency of thymic Foxp3(+) T regulatory cells and Foxp3(-)FR4(hi)CD

130 Associations between thymic function and CD4 T-cell dynamics and combination

131 data indicate the relevance of the remaining thymic function before the start of treatment to the CD4

132 Thymic function failure (sj/beta-TREC ratio <10) was ind

133 thymic function levels whereas patients with thymic function failure had lower CD4 T-cell levels, low

134 Thymic function has been mainly analyzed with surrogate

135 Thymic function is crucial for the maintenance of T cell

136 ng HIV controllers) had significantly higher thymic function levels whereas patients with thymic func

137 We explored the impact of thymic function on the CD4/CD8 ratio of HIV-infected sub

138 Thymic function was quantified in peripheral blood sampl

139 This work establishes the relevance of thymic function, measured by sj/beta-TREC ratio, in HIV

140 m of this study was to determine the role of thymic function, measured by the sj/beta-TREC ratio, on

141 hymic volume, as a representative marker for thymic function, was available at baseline and at 12, 24

142 trategies to help regenerate or even replace thymic function.

143 icting viewpoints on the signals involved in thymic gammadelta T cell development and differentiation

144 ogens in the molecular processes involved in thymic GCs formation.

145 ed LTbetaR signalling results in a defect in thymic HPC homing, suggesting the feedback regulation of

146 ition receptors in mice causes a more severe thymic hypoplasia and delayed T cell recovery when miR-2

147 We sought to better define the thymic IEL precursor (IELp) through analysis of its matu

148 Loss of thymic ILC3s resulted in deficiency of intrathymic inter

149 or T cells and inhibiting the elimination of thymic ILCs improved thymopoiesis in an IL-22-dependent

150 ates metabolic and immune systems to prevent thymic injury and may aid in the reestablishment of a di

151 r T-cell regeneration on irradiation-induced thymic injury.

152 unction in mice protects against age-related thymic involution with an increase in earliest thymocyte

153 h a moderate systemic GR-effect, assessed as thymic involution.

154 low TBI dose, accelerating aging-associated thymic involution.

155 letion of mTORC1 in adult mice caused severe thymic involution.

156 C1 activity can be a strategy for preventing thymic involution/atrophy.

157 cyte development, which could lead to lethal thymic lymphoma.

158 ession of Id1 causes intestinal adenomas and thymic lymphomas in mice, suggesting that Id1 could func

159 Thymic maturation and peripheral T cell survival depend

160 Following thymic maturation, T cells egress as recent thymic emigr

161 heterogeneity and that the transcriptome of thymic MCs is exquisitely suited for interactions with e

162 c expression of tissue-specific genes in the thymic medullary epithelium.

163 The identification of a discrete JAG1(+) thymic medullary niche enriched for DC-lineage cells exp

164 These mice lacked a thymic medullary region, exhibited thymocyte retention,

165 Here, we show the thymic microenvironment expresses the type 2 IL-4R compl

166 ymic emigration involving stimulation of the thymic microenvironment via type 2 cytokines from innate

167 red migration of immature thymocytes through thymic microenvironments generates both adaptive MHC res

168 ation of developing T cells through distinct thymic microenvironments is enforced by the ordered expr

169 his TNFR superfamily member in regulation of thymic microenvironments.

170 erein we describe a virus that causes severe thymic necrosis in neonatal mice, characterized by a los

171 egulator (AIRE) protein is the key factor in thymic negative selection of autoreactive T cells by pro

172 gen, DC must acquire self-antigen to mediate thymic negative selection.

173 Patients with a history of thymoma or thymic neoplasms, thymectomy within 12 months before scr

174 ptive transfer experiments revealed that the thymic niche is not a limiting factor in nTreg developme

175 utropenia and anemia, spared bone marrow and thymic niches, enabling rapid recovery of T and B cells,

176 ere we have analyzed purified populations of thymic NKT cell subsets at both the transcriptomic level

177 factor Th-POK is a key negative regulator of thymic NKT17 cell differentiation in the thymus, our dat

178 from TEC plus thymic or splenic DC, whereas thymic or splenic B cells were poor donors.

179 thymic DC readily acquired MHC from TEC plus thymic or splenic DC, whereas thymic or splenic B cells

180 We describe here a serum-free, artificial thymic organoid (ATO) system that supports efficient and

181 Further evidence suggests a thymic origin of these mutant ILC2s.

182 Human MHC II yielded greater thymic output and a more diverse TCR repertoire.

183 s immune defect is associated with decreased thymic output and parasite-induced destruction of the th

184 Because the blood accumulates thymic output over time, blood repertoires are mixtures

185 Immune phenotyping, thymic output, and telomere length were assessed in 94 H

186 generation of naive T cells is dependent on thymic output, but in adults, the naive T cell pool is p

187 for promoting thymocyte survival to maintain thymic output.

188 ction produce the S1P egress signal, whereas thymic parenchymal S1P levels are kept low through S1P l

189 the differentiation and homeostasis of these thymic portal ECs.

190 and pre-TCR mediated selection, its role in thymic positive selection is unclear.

191 tly reduced in DKO mice, implying defects in thymic-positive selection.

192 Purpose Early thymic precursor (ETP) acute lymphoblastic leukemia (ALL

193 Holding thymic production of natural Treg cells in check, A20 th

194 ck regulation of thymic progenitor homing by thymic products.

195 oming, suggesting the feedback regulation of thymic progenitor homing by thymic products.

196 Early thymic progenitors (ETPs) are endowed with diverse poten

197 in the steady-state thymus is whether early thymic progenitors (ETPs) could escape T cell fate const

198 show significantly reduced numbers of early thymic progenitors (ETPs) relative to wild type thymi.

199 lights the role of innate immune function in thymic regeneration and restoration of adaptive immunity

200 acity to regenerate after injury, endogenous thymic regeneration is impaired in GVHD.

201 innate lymphoid cells (ILC3s) necessary for thymic regeneration.

202 ction and cluster of differentiation (CD) 4+ thymic regulatory T (tTreg) cell generation.

203 Although endogenous thymic repair is possible it is often suboptimal, and th

204 ngest peripheral T cells that have completed thymic selection and egress to the lymphoid periphery.

205 control of self-reactive T cells that escape thymic selection and end up in the periphery.

206 For thymic selection and responses to pathogens, T cells int

207 se results highlight both the flexibility of thymic selection and the evolutionary bias of TCRs for M

208 lated following both MHC and CD1d-restricted thymic selection events.

209 Therefore, differences in thymic selection in young versus adult mice skew the TCR

210 tion, we sought to determine whether altered thymic selection influences the self-reactivity of the T

211 Rather, our data suggest that thymic selection is altered in young mice such that thym

212 role in endogenous viral Ag presentation and thymic selection of CD4(+) T cells, in HIV endogenous pr

213 amined the spatiotemporal role of Bim in the thymic selection of CD8alphaalpha precursors and the fat

214 e that RasGRP1-dependent signaling underpins thymic selection processes induced by both weak and stro

215 S content by intrathymic injection inhibited thymic selection, indicating that this molecule is an in

216 During thymic selection, T cells bearing T cell receptors (TCRs

217 ard by allowing self-reactive TCRs to escape thymic selection.

218 The thymic epithelium within the thymic stroma comprises highly specialized cells with a

219 We show that this requirement maps to thymic stroma, further underlining the key importance of

220 cellular and molecular specialization within thymic stromal cells that enables their regulation of sp

221 the thymus, Nes expression was restricted to thymic stromal cells that expressed cerebellar degenerat

222 a large repertoire of genes specifically in thymic stromal cells.

223 rowth and survival advantages as revealed in thymic stromal cultures, imprinting fundamental self-rea

224 We evaluated the role of the innate cytokine thymic stromal lymphopoietin (TSLP) acting on mast cells

225 ls that was dependent on the innate cytokine thymic stromal lymphopoietin (TSLP) and also induced ano

226 Thymic stromal lymphopoietin (TSLP) and calpain 14 (CAPN

227 nses are developed simultaneously, driven by thymic stromal lymphopoietin (TSLP) and IL-23, respectiv

228 irements for the epithelial cytokines IL-33, thymic stromal lymphopoietin (TSLP) and IL-25 in the act

229 eosinophilia, as well as increased levels of thymic stromal lymphopoietin (TSLP) and IL-5 in the skin

230 Thymic stromal lymphopoietin (TSLP) and IL-7 are related

231 in the blood myeloid compartment as well as thymic stromal lymphopoietin (TSLP) and transforming gro

232 The pro-TH2 cytokines IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) are associated with

233 that both genetic and chemical induction of thymic stromal lymphopoietin (TSLP) at a distant site le

234 Thymic stromal lymphopoietin (TSLP) has emerged as an im

235 Thymic stromal lymphopoietin (TSLP) is a cytokine produc

236 Thymic stromal lymphopoietin (TSLP) is an epithelium-der

237 Thymic stromal lymphopoietin (TSLP) is known to be eleva

238 RATIONALE: Thymic stromal lymphopoietin (TSLP) is known to be eleva

239 triggered by an increased expression of the thymic stromal lymphopoietin (TSLP) proinflammatory cyto

240 so when ILC2s were stimulated with IL-7 and thymic stromal lymphopoietin (TSLP), 2 ligands of IL-7 r

241 nd mast cells, a higher expression levels of thymic stromal lymphopoietin (TSLP), cathelicidin, prote

242 at epithelial cell-derived cytokines such as thymic stromal lymphopoietin (TSLP), IL-33, and IL-25 ma

243 was associated with an increase in levels of thymic stromal lymphopoietin (TSLP), IL-9, and IL-13, bu

244 fic for the epithelial-cell-derived cytokine thymic stromal lymphopoietin (TSLP), in patients whose a

245 ons of the other innate cytokines, IL-33 and thymic stromal lymphopoietin (TSLP), to the observed ast

246 ratinocytes is the pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP).

247 cytokines interleukin 33 (IL-33), IL-25 and thymic stromal lymphopoietin (TSLP).

248 cytokines interleukin 25 (IL-25), IL-33 and thymic stromal lymphopoietin (TSLP).

249 pithelial cell (EC)-derived cytokines (e.g., thymic stromal lymphopoietin [TSLP]) activating human ba

250 Epithelial cytokines (IL-33, IL-25, and thymic stromal lymphopoietin [TSLP]) and mast cell media

251 on house dust mite (HDM)-induced release of thymic stromal lymphopoietin and GM-CSF from tracheal ep

252 cytokine expression in response to IL-33 and thymic stromal lymphopoietin in vitro.

253 and stimulated secretion of IL-8, IL-10, and thymic stromal lymphopoietin independent of PAR2 activit

254 ar destruction, which results in lower serum thymic stromal lymphopoietin levels, milder B-cell lymph

255 atitis via the protease-activated receptor 2-thymic stromal lymphopoietin pathway.

256 Thymic stromal lymphopoietin production and dermatitis i

257 Wild-type (WT) BALB/c, thymic stromal lymphopoietin receptor (TSLPR) knockout (

258 f autocrine/paracrine IL-10, IL-4, IL-22 and thymic stromal lymphopoietin regulated these JAK-depende

259 serum markers (CCL2, CCL5, CCL11, IL-3, and thymic stromal lymphopoietin) at 3 time points (ie, duri

260 of cytokines (interleukin [IL] 25, IL33, and thymic stromal lymphopoietin) by colon tissues, which ac

261 f CCL20/macrophage-inducible protein 3alpha, thymic stromal lymphopoietin, and CCL3-like 1 because of

262 and a reduction in AD-related cytokine IL-8, thymic stromal lymphopoietin, and IL-10 secretion were o

263 mulation with a combination of IL-25, IL-33, thymic stromal lymphopoietin, and IL-2.

264 outcomes, with an emphasis on the actions of thymic stromal lymphopoietin, IL-25, and IL-33 at the ep

265 r biologics similarly inhibit TH2 cytokines (thymic stromal lymphopoietin, IL-4, IL-5, IL-13, and the

266 2-associated cytokines (interleukin (IL)-33, thymic stromal lymphopoietin, IL-5 and IL-13), serum imm

267 the interplay with dendritic cells primed by thymic stromal lymphopoietin.

268 inflammatory markers IL-1, IL-4, IL-13, and thymic stromal lymphopoietin.

269 ds chosen to reflect experimentally observed thymic survival rates result in near-optimal production

270 iation of the TH17 subset of helper T cells, thymic T cell development and lymph-node genesis.

271 Thus, early events in thymic T cell development and repertoire generation are

272 The striking reduction in early thymic T cell progenitors results in compensatory hyperp

273 However, mutant fish had reduced lck:GFP+ thymic T cells by 5 days post-fertilization that persist

274 IRE expression in cultured human TECs, human thymic tissue grafted to immunodeficient mice, and murin

275 reover, we demonstrate that LTbetaR controls thymic tolerance by regulating the frequency and makeup

276 otoxin beta receptor (LTbetaR), we show that thymic tolerance mechanisms operate independently of LTb

277 rates that thymus medulla specialization for thymic tolerance segregates from medulla organogenesis a

278 show that androgen upregulates Aire-mediated thymic tolerance to protect against autoimmunity.

279 t in normal tissues and hence bypass central thymic tolerance.

280 Here, we analyzed human thymic transcriptome and revealed sex-associated differe

281 GITR, whose stimulation is closely linked to thymic Treg cell development.

282 (+) single-positive CD25(+) GITR(+) Foxp3(-) thymic Treg cell progenitors.

283 A20-deficient thymic Treg cells exhibit reduced dependence on IL-2 but

284 tion of c-Rel was decreased in A20-deficient thymic Treg cells.

285 ficiency resulted in a significantly reduced thymic Treg compartment and increased susceptibility to

286 c-Rel was critical for thymic Treg development while p65 was essential for matu

287 sic developmental advantage of A20-deficient thymic Treg differentiation.

288 We propose that Irf4 is imperative for thymic Treg homeostasis because it regulates TEC-specifi

289 t Thpok is needed for the differentiation of thymic Treg precursors, an observation in line with the

290 The T cell repertoire is a function of thymic V(D)J rearrangement and of peripheral selection.

291 rrelates with defective Th-POK expression by thymic Valpha14iNKT cells.

292 hermore DC origin influenced cross-dressing; thymic versus splenic DC exhibited an increased capacity

293 ose caused by the previously described mouse thymic virus (MTV), a putative herpesvirus that has not

294 t, in contrast to published studies on mouse thymic virus, MRV appears to robustly infect neonatal C5

295 with prior studies on a related virus, mouse thymic virus.

296 after treatment (n = 33), a higher baseline thymic volume was associated with a higher increase in C

297 Baseline thymic volume was associated with the CD4/CD8 ratio ( Rh

298 Moreover, the baseline thymic volume was independently associated with the norm

299 -naive HIV-infected subjects, the measure of thymic volume, as a representative marker for thymic fun

300 Radiological evidence supports the loss in thymic volume, correlating with the decrease in repertoi