ライフサイエンスコーパス: thymic epithelial cell

1 s can be selected on either hematopoietic or thymic epithelial cells.

2 a interaction with self-ligands displayed on thymic epithelial cells.

3 expansion of early thymocyte progenitors and thymic epithelial cells.

4 thymocytes, early thymocyte progenitors, and thymic epithelial cells.

5 tion of this, BTN1A1 protein was detected in thymic epithelial cells.

6 quantitative expression of insulin in human thymic epithelial cells.

7 gher insulin expression than class I VNTR in thymic epithelial cells.

8 better define the heterogeneity of medullary thymic epithelial cells.

9 tissue-specific antigens is impaired only in thymic epithelial cells.

10 progenitor pool affects the number of mature thymic epithelial cells.

11 mily members in the development of medullary thymic epithelial cells.

12 y for the differentiation and maintenance of thymic epithelial cells.

13 ll Ag receptors (TCR) to bind MHC ligands on thymic epithelial cells.

14 ping T cells encounter antigens expressed by thymic epithelial cells.

15 ited P-TEFb to target promoters in medullary thymic epithelial cells.

16 earliest thymocyte progenitors and cortical thymic epithelial cells.

17 neage, whereas there is no role for Foxp3 in thymic epithelial cells.

18 progenitor cells but without deletion among thymic epithelial cells.

19 ical for the activation of INS-VNTR in human thymic epithelial cells.

20 a developmental basis for TSA expression by thymic epithelial cells.

21 ions and MHC class II expression on cortical thymic epithelial cells.

22 , in particular dendritic cells and cortical thymic epithelial cells.

23 on the interaction of T cell precursors with thymic epithelial cells.

24 ve selection as a result of interaction with thymic epithelial cells.

25 blasts, myocardial endothelium, and cortical thymic epithelial cells.

26 idence of a single endodermal origin for all thymic epithelial cells.

27 roliferation and differentiation of immature thymic epithelial cells.

28 essed on placental endothelium and medullary thymic epithelial cells.

29 lex class II molecules expressed on cortical thymic epithelial cells.

30 bound peptide ligands presented by cortical thymic epithelial cells.

31 creased death and decreased proliferation of thymic epithelial cells.

32 d to B cells, dendritic cells, and medullary thymic epithelial cells.

33 ides bound to the MHC molecules expressed by thymic epithelial cells.

34 a stage that just precedes its detection in thymic epithelial cells.

35 stimulatory ligands (Dll4, Il7, and Vegf) by thymic epithelial cells.

36 presented by hematopoietic cells rather than thymic epithelial cells.

37 type cyclin produces a distinct phenotype in thymic epithelial cells.

38 pends on interactions between thymocytes and thymic epithelial cells.

39 cell receptor and MHC molecules expressed on thymic epithelial cells.

40 y was observed in various tissues, including thymic epithelial cells.

41 e (ALCAM) mediates adhesion of thymocytes to thymic epithelial cells.

42 tical thymic epithelial cells, and medullary thymic epithelial cells.

43 ption factor which is expressed in medullary thymic epithelial cells.

44 particularly in keratinocytes and medullary thymic epithelial cells.

45 hematopoietic cells, such as AIRE-expressing thymic epithelial cells.

46 atients with APECED, especially in medullary thymic epithelial cells.

47 xpression of tissue-restricted Ags (TRAs) in thymic epithelial cells.

48 d for the interaction between thymocytes and thymic epithelial cells.

49 PO mRNA predominantly localized to medullary thymic epithelial cells.

50 class II was expressed by thymocytes than by thymic epithelial cells.

51 and autoimmune regulator-positive medullary thymic epithelial cells, a key process for central toler

52 cule) interaction, which mediates thymocyte--thymic epithelial cell adhesion, is a previously unobser

53 of autoimmune receptor-expressing medullary thymic epithelial cells (Aire1 mTEC) and a decrease in t

54 Deletion of TRAF3 in thymic epithelial cells allowed RelB-dependent developme

55 -galactoside binding protein, is produced by thymic epithelial cells and binds to human thymocytes.

56 sed expression of tissue-specific Ags in the thymic epithelial cells and defective Ag presentation; h

57 study that increased MHC I up-regulation on thymic epithelial cells and double-positive CD3(-/int)CD

58 Expressed only by thymic epithelial cells and epidermal keratinocytes, Ski

59 sue culture system of thymic nodules wherein thymic epithelial cells and fibroblasts were grown in no

60 examined the role of E-cadherin expressed by thymic epithelial cells and immature thymocytes in thymu

61 s preferentially damaged recipient medullary thymic epithelial cells and impaired negative selection,

62 tant role in interactions of thymocytes with thymic epithelial cells and in mature T cell interaction

63 nsplantation (allo-BMT) recipients, supports thymic epithelial cells and increases thymic output of n

64 vealed prominent cytosolic immunostaining in thymic epithelial cells and lymph node dendritic cells b

65 or thymic epithelial cell lineages--cortical thymic epithelial cells and medullary thymic epithelial

66 le in mediating the binding of thymocytes to thymic epithelial cells and of T cells to activated leuk

67 IL-22, which signaled through thymic epithelial cells and promoted their proliferation

68 n-like (Btnl) gene expressed specifically by thymic epithelial cells and suprabasal keratinocytes.

69 x class II (MHCII) is regulated similarly to thymic epithelial cells and that MHCII(+) ILC3s directly

70 IL-21 is produced by thymic epithelial cells and the IL-21 receptor-alpha is

71 th the highest levels of HLA-DQ8 on cortical thymic epithelial cells and the largest numbers of CD4 T

72 of respiratory TSA by an organized subset of thymic epithelial cells and the phenotypic resemblance o

73 cific serine protease (TSSP) is expressed by thymic epithelial cells and thymic dendritic cells (DCs)

74 tative serine protease expressed by cortical thymic epithelial cells and thymic dendritic cells, may

75 f NF-kappaB2 in the development of medullary thymic epithelial cells and, thus, the control of self-t

76 iates invariant chain processing in cortical thymic epithelial cells, and animals of the I-A(b) haplo

77 equires Skint-1 expression on the surface of thymic epithelial cells, and depends upon specific resid

78 in organ-specific self-antigens in medullary thymic epithelial cells, and has a role in the negative

79 urface of B cells, dendritic cells, cortical thymic epithelial cells, and medullary thymic epithelial

80 Skint-1 is expressed by medullary thymic epithelial cells, and unlike lipid-CD1 complexes,

81 his observation indicates that MHC class II+ thymic epithelial cells are both necessary and sufficien

82 Previous studies suggest that thymic epithelial cells are crucial for the positive sel

83 s that regulate the development of medullary thymic epithelial cells are not fully understood.

84 thelial cells, the implication is that mouse thymic epithelial cells are tolerogenic only for mouse a

85 Thymic epithelial cells are uniquely efficient in mediat

86 echanisms regulating development of immature thymic epithelial cells are unknown.

87 ides, purified from the H-2D(b) molecules of thymic epithelial cells, are specifically recognized dur

88 howed that the TTC7A protein is expressed in thymic epithelial cells, as well as in thymocytes.

89 t been fully evaluated, H2-O is expressed by thymic epithelial cells, B cells, and dendritic cells (D

90 lecule expressed in association with H2-M in thymic epithelial cells, B lymphocytes, and primary dend

91 (+) readily acquired MHC class I and II from thymic epithelial cells but plasmacytoid DC were less ef

92 First, we increase medullary thymic epithelial cells by using mice lacking osteoprote

93 o the suggestion that local GC production by thymic epithelial cells, by opposing TCR signaling for a

94 These data suggest that TSLP expressed by thymic epithelial cells can activate mDCs and pDCs to po

95 MHC class II-expressing thymocytes and thymic epithelial cells can mediate CD4 T-cell selection

96 c mice, we provide qualitative evidence that thymic epithelial cells can transition to mesenchymal ce

97 ter system, CD4 T cells that are selected by thymic epithelial cells cannot transcribe the IL-4 repor

98 ese surprising findings suggest that, unlike thymic epithelial cells, cortical thymocytes can provide

99 ic regions, where interactions with cortical thymic epithelial cell (cTEC) and medullary thymic epith

100 ucidated, the signals that regulate cortical thymic epithelial cell (cTEC) homeostasis remain elusive

101 e protease expressed exclusively in cortical thymic epithelial cells (cTEC) of the thymus, suggesting

102 Cortical thymic epithelial cells (CTEC) present self-peptide self

103 Cortical thymic epithelial cells (cTECs) express a unique thymopr

104 sis is through direct inhibition in cortical thymic epithelial cells (cTECs) of Delta-like 4 (Dll4),

105 be necessary for Ii degradation in cortical thymic epithelial cells (cTECs), but not in bone marrow

106 ominance of immature thymocytes and cortical thymic epithelial cells (cTECs).

107 ional programs were determined by Skint-1, a thymic epithelial cell determinant.

108 nscriptional regulatory pathway required for thymic epithelial cell development and define multiple r

109 Pax1, act synergistically to cause defective thymic epithelial cell development, resulting in thymic

110 demonstrated that loss of H2-O expression in thymic epithelial cells did not induce ANAs, and that la

111 t, deletion of a conditional Foxp3 allele in thymic epithelial cells did not result in detectable cha

112 allele of the nude gene that causes arrested thymic epithelial cell differentiation and abnormal thym

113 Foxn1Delta/Delta mutants have a block in thymic epithelial cell differentiation at an intermediat

114 Thymic epithelial cell differentiation, growth and funct

115 cell development as efficiently as cortical thymic epithelial cells do.

116 Human and murine B cells and thymic epithelial cells express DO, while monocytes/macr

117 A subset of thymic epithelial cells express MHC class II molecules.

118 Both cystic and conventional medullary thymic epithelial cells express these TRAs, as do extrat

119 Thymic epithelial cells expressed an LRRC8A ligand that

120 Medullary thymic epithelial cells expressing the Aire gene play a

121 ched, particularly in neonates, in medullary thymic epithelial cells expressing the autoimmune regula

122 Thymic epithelial cell expression of CD83 is also necess

123 In addition to the proliferative block, most thymic epithelial cells fail to progress from an immatur

124 Injection of thymic epithelial cells from normal BALB/c mice into fet

125 nctioning in clinical certain contexts where thymic epithelial cell function is perturbed.

126 Medullary thymic epithelial cells function as antigen-presenting c

127 differentiation of Aire-expressing medullary thymic epithelial cells have been defined.

128 no evidence that TSAs presented by medullary thymic epithelial cells in Aire+TCRmini mice are often r

129 e IA-IE expression on cortical and medullary thymic epithelial cells in an IFN-gamma-dependent manner

130 that in wild-type mice, suggesting cortical thymic epithelial cells in cathepsin L knockout mice exp

131 e selection, including the role of medullary thymic epithelial cells in displaying tissue specific an

132 rowth factor (KGF) has been shown to protect thymic epithelial cells in mice.

133 histocompatibility complex (MHC) proteins on thymic epithelial cells in order to mature into either C

134 when presented to DP thymocytes by cortical thymic epithelial cells in reaggregate cultures, rather

135 We have evaluated a subset of thymic epithelial cells in the murine thymus that displa

136 olocalize with dendritic cells and medullary thymic epithelial cells in the thymic medulla.

137 plasia is caused by reduced proliferation of thymic epithelial cells in the thymus primordium.

138 o be improved by coimplantation of recipient thymic epithelial cells in the thymus xenograft.

139 Thymic epithelial cells in these mutants have reduced ab

140 of transcription in the nucleus of medullary thymic epithelial cells in vivo.

141 In contrast, differentiation of immature thymic epithelial cells, including acquisition of marker

142 opiridol were reduced by Hnrnpl knockdown in thymic epithelial cells, independently of their dependen

143 2 expression is a common feature of cortical thymic epithelial cells, indicating widespread availabil

144 on (CR) can slow thymic aging by maintaining thymic epithelial cell integrity and reducing the genera

145 encoding tissue-specific antigens (TSAs) by thymic epithelial cells is critical for this process and

146 we could show in vivo that NIK signaling in thymic epithelial cells is essential for the thymic hard

147 The display of self-antigens by thymic epithelial cells is key to inducing tolerance in

148 receptor (TCR) transgenic thymocytes and the thymic epithelial cell line ANV indicated that low conce

149 A thymic epithelial cell line transfected with I-Ek was us

150 AIRE nuclear localization in the human thymic epithelial cell line was disrupted by mutations i

151 d antigens in both intact thymi and cultured thymic epithelial cell line.

152 the developmental pathways of the two major thymic epithelial cell lineages--cortical thymic epithel

153 In the present report we show that thymic epithelial cell lines express vascular cell adhes

154 In both medullary and cortical thymic epithelial cell lines transduced with TLP, the pr

155 Thymic epithelial cell lines were generated and shown to

156 s and in a nurse cell line, but not in other thymic epithelial cell lines, while the short form was m

157 at IFN-alpha-mediated MHC I up-regulation on thymic epithelial cells may lead to high avidity interac

158 pressing BM-derived dendritic cells, but not thymic epithelial cells, mediate the efficient negative

159 regulator classically expressed in medullary thymic epithelial cells, monocytes, macrophages, and den

160 Previous studies show that medullary thymic epithelial cell (mTEC) development involves hemop

161 in T cell tolerance by regulating medullary thymic epithelial cell (mTEC) development.

162 minal differentiation model of the medullary thymic epithelial cell (mTEC) lineage from immature MHC

163 molecular mediators that stimulate medullary thymic epithelial cell (mTEC) maturation are partially e

164 branching structure that contains medullary thymic epithelial cell (mTEC) networks to support negati

165 thymic epithelial cell (cTEC) and medullary thymic epithelial cell (mTEC) subsets take place.

166 ve previously reported that mature medullary thymic epithelial cells (mTEC(high)) expressing the auto

167 antigens (TRA), which is in mature medullary thymic epithelial cells (mTEC(high)) partly controlled b

168 velopmental pathways that generate medullary thymic epithelial cells (mTEC) from their immature proge

169 In the thymus, medullary thymic epithelial cells (mTEC) regulate T cell tolerance

170 ing T cells is highly dependent on medullary thymic epithelial cells (mTEC), and mTEC development in

171 s expressed on Aire(-) and Aire(+) medullary thymic epithelial cells (mTECs) and on dendritic cells (

172 6 transcripts were absent in mouse medullary thymic epithelial cells (mTECs) and peripheral lymphoid

173 scription of a battery of genes in medullary thymic epithelial cells (mTECs) and, consequently, negat

174 Medullary thymic epithelial cells (mTECs) are critical in establis

175 n this study, we reveal a role for medullary thymic epithelial cells (mTECs) during iNKT cell develop

176 immune regulator (Aire)-expressing medullary thymic epithelial cells (mTECs) during the embryonic-neo

177 Medullary thymic epithelial cells (mTECs) eliminate self-reactive

178 Medullary thymic epithelial cells (mTECs) express a broad spectrum

179 of peripherally restricted Ags by medullary thymic epithelial cells (mTECs) is associated with negat

180 restricted self antigens (TRAs) in medullary thymic epithelial cells (mTECs) is essential for the ind

181 restricted self-antigens (TRAs) in medullary thymic epithelial cells (mTECs) is essential to safeguar

182 tissue-specific antigens (TSAs) by medullary thymic epithelial cells (Mtecs) leads to deletion of aut

183 bone marrow (BM)-derived APCs and medullary thymic epithelial cells (mTECs) on the conventional and

184 Aire-expressing medullary thymic epithelial cells (mTECs) play a key role in preve

185 Medullary thymic epithelial cells (mTECs) play an essential role i

186 Medullary thymic epithelial cells (mTECs) play an important role i

187 how that bone marrow (BM) APCs and medullary thymic epithelial cells (mTECs) played nonoverlapping ro

188 of tissue-restricted Ags (TRAs) by medullary thymic epithelial cells (mTECs) plays an essential role

189 immune regulator (Aire)-expressing medullary thymic epithelial cells (mTECs) provide a spectrum of ti

190 tions in terminally differentiated medullary thymic epithelial cells (MTECs) to derepress the express

191 In medullary thymic epithelial cells (mTECs), the Autoimmune regulato

192 ntral tolerance mechanisms involve medullary thymic epithelial cells (mTECs), which use endogenously

193 e in developing T cells depends on medullary thymic epithelial cells (mTECs), whose development, in t

194 pecifically in the Aire-expressing medullary thymic epithelial cells (mTECs), without affecting its e

195 rtical thymic epithelial cells and medullary thymic epithelial cells (mTECs)--are yet to be developed

196 e in the absence of RelB-dependent medullary thymic epithelial cells (mTECs).

197 ng, autoimmune regulator (AIRE)(+) medullary thymic epithelial cells (mTECs).

198 In contrast, the rate of decline in thymic epithelial cell numbers with age was radiation-se

199 l MHC class II-positive cells, restricted to thymic epithelial cells, or restricted to B cells, dendr

200 hymus involutes, reduction in thymocytes and thymic epithelial cells precede the emergence of mature

201 Perhaps surprisingly, thymic epithelial cells produce glucocorticoids, and bas

202 ively induced in vitro to differentiate into thymic epithelial cell progenitors (TEPs).

203 ular, mesenchymal cells are shown to mediate thymic epithelial cell proliferation through their provi

204 Thymic epithelial cells provide unique cues for the life

205 Ps differentiate into cortical and medullary thymic epithelial cells, reconstitute the normal thymic

206 er model has suggested that this property of thymic epithelial cells reflects transcriptional activit

207 miRNA in the maintenance and function of the thymic epithelial cell scaffold and establish a novel me

208 rvical thymi (pCT) express low levels of the thymic epithelial cell-specific transcription factor FOX

209 eport that germinal center B lymphocytes and thymic epithelial cells strongly express one of the RGS

210 omoting self-antigen expression in medullary thymic epithelial cells, such that developing T cells th

211 strate that endogenous RA signaling promotes thymic epithelial cell (TEC) cell-cycle exit and restric

212 ous tissue-specific antigens (TSAs) in human thymic epithelial cell (TEC) cultures.

213 Thymocyte and thymic epithelial cell (TEC) development are interdepend

214 jor source of Wnt ligands and to what extent thymic epithelial cell (TEC) development is dependent on

215 x N1 (Foxn1) protein is the key regulator of thymic epithelial cell (TEC) development, yet how Foxn1

216 s, radiation exposure, and steroids, impairs thymic epithelial cell (TEC) functions and induces the p

217 Postnatal thymic epithelial cell (TEC) homeostatic defect- or natu

218 Myeloablative conditioning results in thymic epithelial cell (TEC) injury, slow T-cell reconst

219 bone marrow transplantation (BMT) results in thymic epithelial cell (TEC) injury, T-cell immune defic

220 or FoxN1 is essential for differentiation of thymic epithelial cell (TEC) progenitors during thymic o

221 red for differentiation and proliferation of thymic epithelial cell (TEC) progenitors.

222 ene (Tbata; also known as SPATIAL) regulates thymic epithelial cell (TEC) proliferation and thymus si

223 Progress in our understanding of thymic epithelial cell (TEC) renewal and homeostasis is

224 Using an allelic series of the thymic epithelial cell (TEC) specific transcription fact

225 eactivity, which was secondary to changes in thymic epithelial cell (TEC) stimuli that drive thymocyt

226 that precursors within the keratin (K) 8+5+ thymic epithelial cell (TEC) subset generate the major c

227 Recently, diminished expression of the thymic epithelial cell (TEC)-specific transcription fact

228 blation of ghrelin and GHSR leads to loss of thymic epithelial cells (TEC) and an increase in adipoge

229 drogen withdrawal by proliferation of UEA(+) thymic epithelial cells (TEC) and increased TEC producti

230 ations of immature CD4+8+ cells and purified thymic epithelial cells (TEC) are reaggregated in tissue

231 e thymic epithelium and is required to prime thymic epithelial cells (TEC) for effective Treg inducti

232 The regulation of cytokine production by thymic epithelial cells (TEC) in the thymus is under coo

233 In this study, we demonstrated that human thymic epithelial cells (TEC) inhibit NK cell developmen

234 Promiscuous gene expression (PGE) by thymic epithelial cells (TEC) is essential for generatin

235 ells, which discordant studies identified as thymic epithelial cells (TEC) or CD11c+ dendritic cells

236 expression of tissue-restricted Ags (TRA) by thymic epithelial cells (TEC).

237 is accompanied by a decline in the number of thymic epithelial cells (TECs) and a severely restricted

238 nal CD8(+) T cells are primarily selected on thymic epithelial cells (TECs) and certain innate T cell

239 reby inhibiting IL-22-mediated protection of thymic epithelial cells (TECs) and impairing recovery of

240 (ephrins) are expressed both on T cells and thymic epithelial cells (TECs) and play a role in defini

241 Although thymic epithelial cells (TECs) are crucial for thymopoie

242 Thymic epithelial cells (TECs) are required for T cell m

243 damage to the interleukin 7 (IL-7)-producing thymic epithelial cells (TECs) by irradiation and chemot

244 ing human pluripotent stem cells to generate thymic epithelial cells (TECs) capable of supporting T c

245 e characterize the role of macroautophagy in thymic epithelial cells (TECs) for negative selection.

246 om NCC-derived mesenchyme or differentiating thymic epithelial cells (TECs) had no effects on thymus-

247 Thymic epithelial cells (TECs) help orchestrate thymopoi

248 Thymic epithelial cells (TECs) in adult mice have been c

249 ffects on T-cell precursors, thymocytes, and thymic epithelial cells (TECs) in normal and genetically

250 role of hematopoietic-derived APCs (HCs) and thymic epithelial cells (TECs) in Treg selection, we con

251 The importance of thymic epithelial cells (TECs) is evidenced by clear lin

252 Thymic epithelial cells (TECs) provide crucial microenvi

253 toimmunity is largely prevented by medullary thymic epithelial cells (TECs) through their expression

254 We identified IL-7-expressing thymic epithelial cells (TECs) throughout ontogeny and i

255 we find that resupplying young, engraftable thymic epithelial cells (TECs) to a middle-aged or defec

256 Although SPL is robustly expressed in thymic epithelial cells (TECs), in this study, we show t

257 estrogens have strong regulatory effects on thymic epithelial cells (TECs), inducing a decreased pro

258 ty interaction with MHC class I molecules on thymic epithelial cells (TECs).

259 mocyte development require interactions with thymic epithelial cells (TECs).

260 aged mice by restoration of the function of thymic epithelial cells (TECs).

261 se results were confirmed in purified murine thymic epithelial cells (TECs).

262 originates from the expansion of functional thymic epithelial cells (TECs).

263 iated effects on homeostasis and function of thymic epithelial cells that affect thymic selection pro

264 reduction in the number of mature medullary thymic epithelial cells that express CD80 and bind the l

265 ably through recognition of host antigens on thymic epithelial cells, the implication is that mouse t

266 to regulate the differentiation of immature thymic epithelial cells, thereby affecting tissue-restri

267 ve been done with populations of dissociated thymic epithelial cells; therefore, there is little info

268 tors into preimmune sheep fetuses transduces thymic epithelial cells thought to present antigen and t

269 ally affect human insulin gene expression in thymic epithelial cells through INS-VNTR and subsequentl

270 -regulation of ICA69 expression in medullary thymic epithelial cells, thus providing a novel mechanis

271 Thus we conclude that the ability of thymic epithelial cells to support positive selection do

272 ce MHC-self peptide complexes from medullary thymic epithelial cells to thymic DC.

273 ional deletion of Traf6 expression in murine thymic epithelial cells (Traf6DeltaTEC mice) showed a su

274 xamined how peptide/MHC ligands expressed on thymic epithelial cells trigger the positive selection o

275 pment depends critically on several distinct thymic epithelial cell types that are organized into two

276 ifferent individual K(b) binding peptides in thymic epithelial cells under the control of the human k

277 In addition to their differentiation, thymic epithelial cells undergo cellular expansion to en

278 he predominant isozyme expressed in cortical thymic epithelial cells was COX-1, while COX-2 predomina

279 tal numbers of EpCAM+ MHC II+ and MHC II(hi) thymic epithelial cells were higher in young and old Fox

280 n to T reg cells, Foxp3 is also expressed in thymic epithelial cells where it is involved in regulati

281 une regulator), which is highly expressed in thymic epithelial cells, where it is known to play a key

282 unctions within stroma to generate medullary thymic epithelial cells, which are essential for negativ

283 Unlike medullary thymic epithelial cells, which express and present perip

284 ative selection of immature T cells, than on thymic epithelial cells, which mediate for positive sele

285 mmune regulator-expressing, mature medullary thymic epithelial cells, which play a pivotal role in ne

286 n of many tissue-specific genes in medullary thymic epithelial cells, which plays an important role i

287 ifferential insulin gene expression in human thymic epithelial cells, which should have profound effe

288 en in reaggregates of purified MHC class II+ thymic epithelial cells, while CD4+ and CD8+ cells gener