ライフサイエンスコーパス: thymidine

1 cy by re-examining the SP formation using d3-thymidine.

2 is hypersensitivity is reversed by exogenous thymidine.

3 fic TP/PyNP inhibitor (TPI), or by exogenous thymidine.

4 cleosides: cytidine, uridine, adenosine, and thymidine.

5 ine triphosphatelation of [(3)H]TMP to [(3)H]thymidine.

6 re we report Peroxy-Caged-[(18)F]Fluorodeoxy thymidine-1 (PC-FLT-1), an oxidatively immolative positr

7 +2] cycloaddition reaction with the opposing thymidine, 2'-deoxycytidine, or 2'-deoxyadenosine.

8 radioactive DNA replication marker tritiated thymidine ([(3)H]dT, or TdR) at early embryonic ages wer

9 Analogues 1-3 at 100 muM inhibited thymidine 5'-monophosphate p-nitrophenyl ester hydrolysi

10 he phosphodiesterase substrate p-nitrophenyl thymidine 5'-monophosphate.

11 eration and isolation of various thymine and thymidine 5,6-epoxides from the corresponding trans-5,6-

12 phenylalanine, as well as nucleosides (e.g. thymidine, 5'-methylthioadenosine, xanthosine), the orga

13 ososynthase that initiates the conversion of thymidine-5'-diphosphate-l-epi-vancosamine to a ring-ope

14 rivatives of UV-induced DNA lesions, namely, thymidine (6-4) photoproducts.

15 Using this assay, the three ethylated thymidine adducts were detected and quantified for the f

16 kylation of DNA, and the resulting alkylated thymidine (alkyldT) lesions were found to be poorly repa

17 Using a thymidine analog (EdU), we were able to label mitoticall

18 ncorporation and fluorescent labeling of the thymidine analog 5-ethynyl-2'-deoxyuridine (EdU) into na

19 Using the thymidine analog 5-ethynyl-2'-deoxyuridine to monitor DN

20 oreactive tectal progenitors incorporate the thymidine analog chlorodeoxyuridine after injury.

21 nd an AZT-resistant (AZT(R)) RT containing a thymidine analog mutation set-D67N, K70R, D215F, and K21

22 ith preferential tenofovir activity, >/= two thymidine analog mutations (TAMs) or Q151M, occurred in

23 oexisted unlinked with variants carrying 2-5 thymidine analog mutations at frequencies of 1.6%-23.0%.

24 dividuals and are highly associated with the thymidine analog mutations D67N and K70R, which confer d

25 with nucleoside resistance including type 2 thymidine analog mutations, K65R, a T69del, and M184V.

26 owing for reporter-specific detection with a thymidine analog probe.

27 EdU (ethynyl deoxyuridine, a thymidine analog) and annexin-propidium iodide flow cyto

28 ntrols, received 10 weekly injections of the thymidine analog, bromodeoxyuridine (BrdU) to mark new c

29 5-ethynyl-2'deoxyuridine (EdU)-a thymidine analog-containing minipumps were inserted at t

30 Complex mutation patterns, including thymidine-analog mutations, K65R, and multinucleoside mu

31 ntate gyrus (DG) were labeled with different thymidine analogs (EdU, IdU, and CldU) at 4, 8, and 21 d

32 of cells in the entire retina employing the thymidine analogs and also determined their phenotype by

33 full agreement with previous findings using thymidine analogs and retroviral labeling, thus providin

34 Prolonged wide-scale use of thymidine analogs in the setting of viral failure has li

35 Pre-steady-state kinetic studies of thymidine analogs revealed that the major determinant fo

36 ation and maturation labels with each of the thymidine analogs was quantified.

37 g studies using sequential administration of thymidine analogs, rat insulin 2 promoter-driven cre-lox

38 and three cell cycle analysis methods using thymidine analogs, we determined the proliferation dynam

39 ration imaging mainly based on (18)F-labeled thymidine analogs.

40 The thymidine analogue (DMA)T was used for the first fluores

41 eening and characterization, we identified a thymidine analogue as a probe for imaging the expression

42 The synthesis of a novel bicyclic thymidine analogue carrying a beta-fluoro substituent at

43 , i.e., mitotic quiescence with retention of thymidine analogue label and activation by injury.

44 94% vs 44%), M184V/I (94% vs 26%), and >/= 1 thymidine analogue mutations (47% vs 18%), all P = .01;

45 % acquired DRMs were found, including M184V, thymidine analogue mutations (T215F, D67N, K70R, K219Q),

46 investigate the prevalence and correlates of thymidine analogue mutations (TAM) in patients with viro

47 Most thymidine analogue mutations (TAMs) and T215 revertants

48 HIV-1 drug resistance to older thymidine analogue nucleoside reverse transcriptase inhi

49 BMS-986001 is a thymidine analogue nucleoside reverse transcriptase inhi

50 i-HIV activity of 29 (uridine analogue), 31 (thymidine analogue), and 34 (cytidine analogue) was expl

51 e incorporations of our previously published thymidine analogue, 5-(1-phenyl-1H-1,2,3-triazol-4-yl)-2

52 A thymidine analogue, bromodeoxyuridine (BrdU), was added

53 At least 1 thymidine-analogue mutations was present in 2.7% of pati

54 ver, the presence of common TDRMs, including thymidine-analogue mutations/T215rev, showed no impact o

55 such as M41L, D67N, K70R, or S215Y (known as thymidine-analogue resistance mutations (TAMs)) are rare

56 oviral therapy (ART) coformulations based on thymidine analogues to second-generation ART coformulati

57 e in the range of +1-2 degrees C compared to thymidine and +1-3 degrees C compared to a standard bc-T

58 provide insights into the pathogenic role of thymidine and deoxyuridine imbalance in mitochondrial ne

59 ked elevations of the pyrimidine nucleosides thymidine and deoxyuridine in plasma and tissues, and so

60 phosphorylase activity deficiency, elevated thymidine and deoxyuridine in tissues, mitochondrial DNA

61 Mutant mice treated with exogenous thymidine and deoxyuridine showed reduced survival, body

62 stressed double knockout mice with exogenous thymidine and deoxyuridine, and assessed clinical, neuro

63 nd matrix cells (M cells) in cats with (3) H-thymidine and followed their distributions during fetal

64 tion forks, which reduces the consumption of thymidine and increases resistance to trimethoprim under

65 the mitochondrial isoform required exogenous thymidine and purine but not glycine for optimal growth

66 re the first CpG motif is preceded by the 5'-thymidine and the elongated poly-thymidine tail at the 3

67 in pH, calcium, magnesium, zinc, potassium, thymidine, and polysorbate 80 levels were tested by BMD

68 n its structure and reactivity have utilized thymidine as a precursor, which limits quantitative prod

69 (3)H]TTP than the amount observed with [(3)H]thymidine as the precursor.

70 Tritiated thymidine based lymphocyte proliferation assays and inte

71 -thymidine with varying amounts of unlabeled thymidine before the SP photochemistry is performed.

72 A protein peaked 12 hours after release from thymidine block, corresponding to M-phase.

73 Lp02, which is attenuated in the absence of thymidine but has a functional T4SS, resisted clearance

74 nucleotide radical anion, thymidylyl(3'-->5')thymidine, can be directly probed with femtosecond stimu

75 nografts, which was accompanied by low tumor thymidine concentrations, suggesting that tumor thymidin

76 High frequency of cytidine to thymidine conversions was identified in the genome of se

77 ffects of uracil incorporation into DNA from thymidine-deficient nucleotide pools.

78 liferation arrest is characterized by severe thymidine depletion, and supplying exogenous thymine res

79 A thymidine-derived bicyclic monomer, 3',5'-cyclic 3-(3-bu

80 affinity of RecA binding to DNAs carrying a thymidine dimer than to those with an abasic site.

81 The length polymorphism of guanosine thymidine dinucleotide repeats in the heme oxygenase-1 g

82 nalyzed the allelic frequencies of guanosine thymidine dinucleotide repeats in the heme oxygenase-1 g

83 In conclusion, a greater number of guanosine thymidine dinucleotide repeats in the heme oxygenase-1 g

84 The DNA nucleoside, thymidine, does not self-assemble into stable adlayers b

85 cells avoid lethal replication stress after thymidine (dT)-induced inhibition of DNP dCTP synthesis

86 , addition of OH(-) to one-electron oxidized thymidine (dThd) and thymine nucleotides in basic aqueou

87 marked reduction in intracellular levels of thymidine, due to suppression of both uptake and de novo

88 thymidine enantiomers can be used to resolve thymidine enantiomers at an achiral surface with an OPV3

89 tereoselective recognition between OPV3T and thymidine enantiomers can be used to resolve thymidine e

90 as the platform for the chiral resolution of thymidine enantiomers.

91 s were protected by excess adenosine but not thymidine, establishing de novo purine nucleotide biosyn

92 he resulting poly(3',5'-cyclic 3-(3-butenyl) thymidine ethylphosphate)s with low dispersities (D < 1.

93 bicyclic monomer, 3',5'-cyclic 3-(3-butenyl) thymidine ethylphosphate, was synthesized in two steps d

94 Thymidine exudation could be attributed to ABCG36 functi

95 levels were imageable with [(18)F]-fluoro-L-thymidine (FLT)-positron emission tomography (PET).

96 some agar types and also with potassium and thymidine for S. pneumoniae For all other variations, ge

97 Diastereomeric mixtures of thymidine glycol and the corresponding 5-hydroxperoxides

98 osure times to LPS, lipoteichoic acid (LTA), thymidine homopolymer phosphorothioate oligonucleotide [

99 ed distribution must be co-determined by the thymidine hydroxylases (JBP1 and JBP2) that catalyze the

100 ces the sole intracellular de novo source of thymidine (i.e., the DNA base T) and thus is a common ta

101 ron spectroscopy is performed on thymine and thymidine in aqueous solution to study the excited-state

102 addition between an alkyne-functionalized C5-thymidine in DNA and an azide-containing 10-mer peptide.

103 oxuridine, suggesting an unexpected role for thymidine in flavivirus replication.

104 se there is no interaction between OPV3T and thymidine in solution, the liquid/solid interface acts a

105 rsor, in the presence of methotrexate and by thymidine in the presence of floxuridine, suggesting an

106 n is highly sensitive to the trace protiated thymidine in the starting material.

107 heral blood were measured by using tritiated thymidine incorporation and carboxyfluorescein succinimi

108 ntigens using proliferation assays (based on thymidine incorporation and carboxyfluorescein succinimi

109 10 ng/ml GH stimulated chondrocyte thymidine incorporation and collagen X mRNA expression,

110 knock-out (P4KO) mice showed impaired [(3)H]thymidine incorporation and G1 phase arrest as compared

111 Proliferation was measured by (3)H-thymidine incorporation and TGF-beta by RT-PCR and ELISA

112 or determining T cell responses (i.e., [(3)H]thymidine incorporation and the use of cell proliferatio

113 ocyte proliferation was demonstrated by (3)H thymidine incorporation assay and carboxyfluorescein suc

114 Tritiated thymidine incorporation assay revealed that Cu(GTSC) and

115 f gemcitabine was retained as tested using a thymidine incorporation assay.

116 ed Ki-67 mRNA expression levels and enhanced thymidine incorporation in Wnt6-treated macrophage cultu

117 Liver regeneration peaked at 24 h ([(3)H]-thymidine incorporation into hepatic DNA and mitotic ind

118 rtial hepatectomy and peaked at 32 h ([(3)H]-thymidine incorporation into hepatic DNA and mitotic ind

119 Liver regeneration was evaluated by [(3)H]-thymidine incorporation into hepatic DNA, the mitotic in

120 transgenic OT-II) was measured via a [(3)H]-thymidine incorporation proliferation assay.

121 cytometry), T-cell proliferative responses (thymidine incorporation), and cytokine expression (Fluor

122 acid-induced increase in mPGES1 expression, thymidine incorporation, and PGE(2) production.

123 acid-induced increase in mPGES1 expression, thymidine incorporation, and PGE2 production.

124 id not prevent the GH stimulatory effects on thymidine incorporation, collagen X, and IGF-1 expressio

125 ected with control siRNA, GH increased [(3)H]thymidine incorporation, collagen X, and IGF-1 mRNA expr

126 mM peptides for 7 days) was assessed by (3)H-thymidine incorporation.

127 acid-induced increase in PGE2 production and thymidine incorporation.

128 eus-specific T-cells were quantified by (3)H-thymidine incorporation; cytokine release was measured b

129 Parallel [3H]-leucine and [3H]-thymidine incubations indicated active protein and DNA s

130 Consistent with this, we show that excess thymidine induces G1 arrest in wild-type fission yeast e

131 ine nucleosides uridine, 2'-deoxyuridine and thymidine inhibited mycoplasma-associated dFdC deaminati

132 yme assay and by the inhibition of precursor thymidine into DNA during cell growth.

133 Since thymidine is not incorporated into RNA genomes, it is li

134 Out of the five randomized bases, a 5' thymidine is present in most of the top ranking elements

135 limits quantitative product analysis because thymidine is readily reformed from 1.

136 Thymidine is the major product (33%) from 1 at pH 7.2.

137 N3-Methyl-thymidine is, however, the major product and is produced

138 S-313) expressing the herpes simplex virus 1 thymidine kinase (HSV-1 TK).

139 f dual specific vector, herpes simplex virus thymidine kinase (HSV-TK) gene was introduced for cancer

140 rthermore, an unrelated herpes simplex virus-thymidine kinase (HSV-TK) promoter was strongly represse

141 We also co-express Herpes Simplex Virus thymidine kinase (HSV-tk) with the transposase.

142 s a truncated form of herpes simplex virus 1 thymidine kinase (HSV-TK).

143 (LV) vector expressing herpes simplex virus thymidine kinase (HSV-TK/GCV) under the regulation of an

144 onverting enzyme herpes simplex virus type 1 thymidine kinase (HSV1-tk) into the genomes of cancer ce

145 an engineered cyclic herpes simplex virus 1-thymidine kinase (HSV1-TK) PET reporter whose kinase act

146 r imaging of the herpes simplex virus type 1 thymidine kinase (HSV1-tk) reporter gene expression in r

147 he expression of herpes simplex virus type-1 thymidine kinase (HSV1-TK).

148 nt (hdCKDM), and herpes simplex virus type 1 thymidine kinase (hsvTK) reporter genes.

149 ssing the suicide gene, herpes simplex virus thymidine kinase (HSVtk), driven by the promoter of stim

150 es Cre/lox-assisted cell fate mapping with a thymidine kinase (sr39tk) reporter gene for cell detecti

151 cation of the pht genes between the putative thymidine kinase (tdk) and phosphopentomutase (deoB) gen

152 pendent prognostic impact was found for FCR, thymidine kinase (TK) >/=10 U/L, unmutated IGHV, 11q del

153 Paradoxically, the thymidine kinase (TK) encoded by Kaposi sarcoma-associat

154 ncrease in mutation frequency as detected by thymidine kinase (TK) gene mutation assay.

155 Thymidine kinase (TK) is a key enzyme in the pyrimidine

156 Mutagenicity was assessed at the thymidine kinase (TK) locus, CYP1A activity was determin

157 We investigated thymidine kinase (tk) mutants isolated during multiple e

158 AT(+) virus had higher levels of ICP0, ICP4, thymidine kinase (TK), and PD-1 ligand 1 (PD-L1) transcr

159 ncode ribonucleotide kinase B subunit (RRB), thymidine kinase (TK), and UL9-like origin binding prote

160 yclovir (ACV) is phosphorylated by the viral thymidine kinase (TK), but not the cellular TK.

161 ynthesis and salvage, such as those encoding thymidine kinase (TK), cytidylate kinase, and purine nuc

162 er into the VC2 vector in place of the HSV-1 thymidine kinase (UL23) gene.

163 ed in both models, which was correlated with thymidine kinase 1 (TK1) expression.

164 Quantitative relationships between PET, thymidine kinase 1 (TK1) protein levels and immunostaini

165 ilibrative nucleoside transporter 1 (hENT1), thymidine kinase 1 (TK1), thymidylate synthase, and thym

166 he fact that (18)F-FLT uptake is mediated by thymidine kinase 1 expression, which is higher in active

167 18)F-FLT is trapped after phosphorylation by thymidine kinase 1, whose expression is increased in rep

168 Mitochondrial DNA depletion caused by thymidine kinase 2 (TK2) deficiency can be compensated b

169 A strategy to reverse the symptoms of thymidine kinase 2 (TK2) deficiency in a mouse model was

170 Thymidine kinase 2 (TK2), a critical enzyme in the mitoc

171 requires thymidine salvage by mitochondrial thymidine kinase 2 (TK2).

172 the mitochondrial nucleotide salvage enzyme thymidine kinase 2 (TK2).

173 wn-regulated p53R2 ribonucleotide reductase, thymidine kinase 2, and deoxyguanosine kinase by siRNA t

174 , a phylogenetic tree is constructed for the thymidine kinase 2-like dNK gene family in metazoa.

175 erase II to a representative early promoter (thymidine kinase [TK]).

176 ) and genotypically (sequencing of the viral thymidine kinase and DNA polymerase genes).

177 VZV infection by sequence analysis of viral thymidine kinase and DNA polymerase genes.

178 ters, the mutant herpes simplex virus type I thymidine kinase and the human sodium-iodide symporter.

179 Thymidine kinase catalyzes the first step in the nucleot

180 Our results suggest that thymidine kinase contributes to several DNA repair pathw

181 infected wild-type CEM/0 and HIV-2 infected thymidine kinase deficient CEM cells.

182 Tg) mice expressing the herpes simplex virus thymidine kinase gene (HSV-Tk) driven by the mouse GFAP

183 the model plant Arabidopsis thaliana has two thymidine kinase genes (AtTK1a and AtTK1b) and microarra

184 V also inhibited the replication of an HSV-1 thymidine kinase mutant resistant to nucleoside analogue

185 -mediated microglial ablation on tga20/CD11b-thymidine kinase of Herpes simplex virus (HSVTK) cerebel

186 engineered to carry the herpes simplex virus thymidine kinase prodrug-converting enzyme effectively t

187 adult neurogenesis in naive transgenic GFAP-thymidine kinase rats resulted in social behavior simila

188 uction of new neurons in socially naive GFAP-thymidine kinase rats showed that loss of 6-week-old neu

189 five fluorescent proteins and the puromycin-thymidine kinase resistance gene in vitro, with up to 70

190 p21-driven truncated herpes simplex virus-1 thymidine kinase sr39 mutant (ttksr39) in vitro and in v

191 In mammals thymidine kinase supplies deoxyribonucleotides for DNA r

192 rferon response independent of its canonical thymidine kinase target.

193 ed to deliver the human Herpes simplex virus thymidine kinase type-1 (HSVtk) gene, which has a dual f

194 ates, including securin, cyclin A, cyclin B, thymidine kinase, geminin, and many others.

195 drug converting enzyme, herpes simplex virus thymidine kinase, into therapeutic S-TRAIL secreting ste

196 found that thymidine uptake correlated with thymidine kinase-1 protein levels and that thymidine lev

197 ounds were highly active against HIV even in thymidine kinase-deficient CEM cells.

198 struct provides a potential combination with thymidine kinase-mediated gene therapy to optimize the t

199 status, serum beta2-microglobulin, and serum thymidine kinase.

200 ses and phosphorylation to ddTMP by the host thymidine kinase.

201 arrest in wild-type fission yeast expressing thymidine kinase.

202 cade, various enzyme/prodrug systems such as thymidine kinase/ganciclovir (TK/GCV), yeast cytosine de

203 al scars, respectively; therefore, we used a thymidine kinase/ganciclovir paradigm to ablate both div

204 It is trapped in cells in proportion to thymidine-kinase 1 enzyme expression, which is upregulat

205 Because thymidine labeled with (11)C undergoes rapid biologic de

206 also suggested that these carboxymethylated thymidine lesions may constitute efficient substrates fo

207 the presence of floxuridine, consistent with thymidine-less stress triggering p53-mediated antiflaviv

208 midine concentrations, suggesting that tumor thymidine levels influence (18)F-FLT uptake in the tumor

209 Thymidine levels were determined by liquid chromatograph

210 h thymidine kinase-1 protein levels and that thymidine levels were imageable with [(18)F]-fluoro-L-th

211 these compounds are the first reports of non-thymidine-like inhibitors of Mtb TMK.

212 First, in broth cultures that mimicked thymidine limitation or starvation, L. pneumophila exhib

213 Galactose-modified thymidine, LNA-T, and 2'-amino-LNA-T nucleosides were sy

214 However, this thymidine maps to a region outside of the Pax half site

215 thway by transferring a phosphate group to a thymidine molecule.

216 melting probe embedded with a single locked thymidine monomer (tL) can reliably differentiate the fo

217 e of ATP to 2'-deoxythymidine (dThd) forming thymidine monophosphate (dTMP).

218 g a colorimetric assay with p-nitrophenyl 5'-thymidine monophosphate (p-Nph-5'-TMP) as an artificial

219 Second, in medium that lacked thymidine, multicopy phtC(+) or phtD(+) alleles enhanced

220 One-electron oxidation of N3-methyl-thymidine (N3-Me-dThd) by Cl(2)(*-) at ca. 155 K produce

221 anti-folate that inhibits de novo purine and thymidine nucleotide synthesis.

222 ization of this pathway and the transport of thymidine nucleotides are not well understood.

223 developed through the incorporation of caged thymidine nucleotides into a DNA-based logic gate.

224 Model studies using thymidine nucleotides to lock in i-motif loop lengths su

225 cumulation of radiolabeled deoxycytidine and thymidine nucleotides within the mitochondria.

226 showed that the minor-groove O(2)-alkylated thymidine (O(2)-alkyldT) lesions are poorly repaired and

227 O(2)- and O(4)-[4-(3-pyridyl)-4-oxobut-1-yl]-thymidine (O(2)-POBdT and O(4)-POBdT).

228 reasing the immobilization efficiency of the thymidine oligonucleotide, oligo(dT)25, and providing a

229 DarT is an enzyme that specifically modifies thymidines on single-stranded DNA in a sequence-specific

230 ective by up to 18-fold for incorporation of thymidine opposite unmodified A over m(6)A.

231 We investigated the metabolism of [(3)H]thymidine or [(3)H]TMP as precursors of [(3)H]TTP in iso

232 Proliferation was estimated using (3) H-thymidine or CFSE labeling and ICAM-1 blocking.

233 olic FPGS required exogenous glycine but not thymidine or purine, whereas cells expressing the mitoch

234 ified by the analysis of the binding mode of thymidine or TP(5)A in a PaTMK homology model.

235 ficient diets and supplemented with uridine, thymidine, or deoxyuridine were bred, and litters (n = 1

236 ion with the pyrimidine nucleosides uridine, thymidine, or deoxyuridine with and without folate defic

237 ne kinase 1 (TK1), thymidylate synthase, and thymidine phosphorylase (TP) were analyzed by Western bl

238 Platelets contain abundant thymidine phosphorylase (TYMP), which is highly expresse

239 Here, we now identify thymidine phosphorylase (TYMP; previously known as endot

240 several features of these patients including thymidine phosphorylase activity deficiency, elevated th

241 Thymidine phosphorylase activity rose from undetectable

242 ve TYMP mutations cause severe reductions of thymidine phosphorylase activity; marked elevations of t

243 tes several proangiogenic factors, including thymidine phosphorylase and angiopoietin-1 both in vitro

244 Thymidine phosphorylase and uridine phosphorylase double

245 disease due to TYMP mutations that result in thymidine phosphorylase deficiency.

246 oietic stem cell transplantation can restore thymidine phosphorylase enzyme function in patients with

247 Based on high thymidine phosphorylase expression in the liver, a 25-ye

248 mine and deoxyribose-1-phosphate by the host thymidine phosphorylase greatly increases the sensitivit

249 Thymidine phosphorylase replacement has been achieved by

250 ase caused by mutations in the gene encoding thymidine phosphorylase, leading to reduced enzymatic ac

251 essing mice showed a substantial increase in thymidine-phosphorylating activity in investigated tissu

252 istant from substrate binding sites, reduced thymidine phosphorylation 10-20-fold, and acyclovir phos

253 replication was restored by folinic acid, a thymidine precursor, in the presence of methotrexate and

254 nto RNA genomes, it is likely that increased thymidine production is indirectly involved in flaviviru

255 was evaluated using flow-cytometry and (3)H-thymidine proliferation assays, respectively.

256 Thymidine radical cation (1) is produced by ionizing rad

257 n contrast, in undamaged 2'-deoxyuridine and thymidine, reactions at elevated temperatures lead to th

258 de-modified 523 bp PCR amplicon with all 335 thymidines replaced by AHP dU was shown to be a perfect

259 ing radiation damage to 2'-deoxycytidine and thymidine, respectively, under anoxic conditions.

260 thway of TTP synthesis in the heart requires thymidine salvage by mitochondrial thymidine kinase 2 (T

261 ssion and the extent to which tumors utilize thymidine salvage for DNA synthesis decouple [(18)F]-FLT

262 ed that the phtC and phtD loci contribute to thymidine salvage in L. pneumophila.

263 these data, taken together, suggest that the thymidine salvage pathway is compartmentalized so that T

264 eflects tumor proliferation as a function of thymidine salvage pathway utilization.

265 annot discriminate moderately proliferative, thymidine salvage-driven tumors from those of high proli

266 s death, the phenomenon of cell death due to thymidine starvation.

267 MTX inhibits thymidine synthesis by targeting dihydrofolate reductase

268 Our data reveal thymidine synthesis pathways as new and unexpected thera

269 Folate one-carbon units support purine and thymidine synthesis, and thus cell growth.

270 ative index that rely primarily upon de novo thymidine synthesis.

271 2'-alpha-fluoro analogue of thymidylyl(3',5')thymidine, synthesized to probe the effect of a minimum

272 activity on both (5m)C (major activity) and thymidine (T) (minor activity) in all DNA forms tested,

273 eoside, we previously replaced around 75% of thymidine (T) with 5'-hydroxymethyl-2'-deoxyuridine (5hm

274 d by the 5'-thymidine and the elongated poly-thymidine tail at the 3' end of the ODN.

275 sis was initially studied with the tritiated thymidine technique, later replaced by the injection and

276 analogs (lamivudine and emtricitabine) and L-thymidine (telbivudine) have been widely used as antivir

277 am and at a site-specifically placed cis-syn thymidine-thymidine dimer generated individually by thre

278 trum from an absorption maximum at 267 nm in thymidine to 363 nm in 2,4-dithiothymine (DeltaE = 9905

279 ss-links via the nucleophilic addition of N3-thymidine to C8-guanine (5'-G*CT* and 5'-T*CG*).

280 We also show that cleavage of thymidine to thymine and deoxyribose-1-phosphate by the

281 ytic hydrogenation of the 5,6-double bond of thymidine to yield 5,6-dihydrothymidine, which is methyl

282 we could introduce site-specific cytidine to thymidine transitions in the absence of targeted genomic

283 fatty acids, NADPH, NADP+, some amino acids, thymidine, trigonelline, nicotinic acid, 5,6-dihydrourac

284 chia coli); when fed food with a low uridine/thymidine (U/T) level, germline proliferation is arreste

285 n occurs between the coumarin moiety and the thymidine upon 350 nm irradiation forming both syn- and

286 tion/survival in these cells using MTT, (3)H-thymidine uptake and Annexin-V apoptosis assays.

287 We found that thymidine uptake correlated with thymidine kinase-1 prot

288 -cell and cytokine responses were studied by thymidine uptake, carboxyfluorescein diacetate succinimi

289 , was synthesized in two steps directly from thymidine, via butenylation and diastereoselective cycli

290 In broken mitochondria, [(3)H]thymidine was readily converted to [(3)H]TMP, but furthe

291 The results demonstrated that [(3)H]thymidine was readily metabolized by the mitochondrial s

292 Trifluoromethyl-1H-1,2,3-triazol-1-yl)methyl]thymidine was synthesized and incorporated as a phosphor

293 In addition, thymidine was taken up inefficiently through a P1-type n

294 ryonic day [E]27-E35 following E24-E28 (3) H-thymidine) was characterized by a transient medial accum

295 contained all amino acids and low amounts of thymidine were treated with trimethoprim under aerobic a

296 iothymine, respectively, relative to that of thymidine, whereas the triplet yield increases 60-fold t

297 Thymidine, which is incorporated into DNA but not RNA, h

298 Replacement of thymidine with AHP dU increases duplex stability, accoun

299 We spiked the d3-thymidine with varying amounts of unlabeled thymidine be

300 es effectively convert specific cytidines to thymidines with 13% efficiency in Escherichia coli and 2