ライフサイエンスコーパス: thymidine kinase

1 so a poor substrate for herpes simplex virus thymidine kinase.

2 inhibitory activity against the VZV-encoded thymidine kinase.

3 an optimal interaction with herpes simplex 1 thymidine kinase.

4 in, and a mutant herpes simplex virus type 1 thymidine kinase.

5 ruct coexpressing the herpes simplex virus 1 thymidine kinase.

6 me proliferator-activated receptor-alpha and thymidine kinase.

7 th an exogenous promoter from herpes simplex thymidine kinase.

8 status, serum beta2-microglobulin, and serum thymidine kinase.

9 ses and phosphorylation to ddTMP by the host thymidine kinase.

10 arrest in wild-type fission yeast expressing thymidine kinase.

11 used PRG based on the herpes simplex virus 1 thymidine kinase.

12 namely thymidylate synthase and cytoplasmic thymidine kinase.

13 Human thymidine kinase 1 (hTK1) and structurally related TKs f

14 d their specificities as substrate for human thymidine kinase 1 (hTK1) were evaluated.

15 ed in both models, which was correlated with thymidine kinase 1 (TK1) expression.

16 Quantitative relationships between PET, thymidine kinase 1 (TK1) protein levels and immunostaini

17 y were good substrates for recombinant human thymidine kinase 1 (TK1) with phosphorylation rates up t

18 s generated by the phosphorylation of FLT by thymidine kinase 1 (TK1), the initial step in the exogen

19 ilibrative nucleoside transporter 1 (hENT1), thymidine kinase 1 (TK1), thymidylate synthase, and thym

20 arried out by deoxycytidine kinase (dCK) and thymidine kinase 1 (TK1).

21 he fact that (18)F-FLT uptake is mediated by thymidine kinase 1 expression, which is higher in active

22 activity of the cell-growth-dependent enzyme thymidine kinase 1 is the rate-limiting factor driving t

23 cose uptake were due to changes in levels of thymidine kinase 1 protein, hexokinase, and ATP.

24 r 15, glutathione S-transferase omega-1, and thymidine kinase 1 were overexpressed in blood during th

25 enters cells and is phosphorylated by human thymidine kinase 1, but the 3' substitution prevents fur

26 ll as other E2F1-responsive genes, including thymidine kinase 1, proliferating cell nuclear antigen,

27 FLT is phosphorylated by thymidine kinase 1, thus being retained in proliferating

28 re associated with severe malaria, including thymidine kinase 1, which was recently found to be a bio

29 18)F-FLT is trapped after phosphorylation by thymidine kinase 1, whose expression is increased in rep

30 It is trapped in cells in proportion to thymidine-kinase 1 enzyme expression, which is upregulat

31 protein expression and enzymatic activity of thymidine kinase-1 (TK1) in surgically resected lung les

32 ompounds as substrates for recombinant human thymidine kinase-1 and the mitochondrial isoenzyme thymi

33 found that thymidine uptake correlated with thymidine kinase-1 protein levels and that thymidine lev

34 To compare compounds with high and low thymidine kinase-1 substrate activity, N5 and N7 and the

35 ng that there was selective retention by the thymidine kinase-1(+) tumors.

36 and murine L929 cell lines, all of which are thymidine kinase-1(+), and a mutant L929 cell line that

37 intracerebral implants of L929 (wt) or L929 thymidine kinase-1(-) tumors were 39.8 +/- 10.8 and 12.4

38 se-1(+), and a mutant L929 cell line that is thymidine kinase-1(-).

39 employs, as the PRG, a mutated form of human thymidine kinase 2 (TK2) and 2'-deoxy-2'-18F-5-methyl-1-

40 abolism or utilization, such as mutations in thymidine kinase 2 (TK2) as well as the mtDNA replicativ

41 Mitochondrial DNA depletion caused by thymidine kinase 2 (TK2) deficiency can be compensated b

42 A strategy to reverse the symptoms of thymidine kinase 2 (TK2) deficiency in a mouse model was

43 Deficiency of thymidine kinase 2 (TK2) is a frequent cause of isolated

44 Mitochondrial thymidine kinase 2 (TK2) is a key enzyme in mitochondria

45 Thymidine kinase 2 (TK2), a critical enzyme in the mitoc

46 Mutations of thymidine kinase 2 (TK2), an essential component of the

47 requires thymidine salvage by mitochondrial thymidine kinase 2 (TK2).

48 the mitochondrial nucleotide salvage enzyme thymidine kinase 2 (TK2).

49 seen in the heart because of a high level of thymidine kinase 2 and in the gallbladder because of exc

50 combination of the pyrimidine-specific human thymidine kinase 2 and the broad-specificity dNK from Dr

51 wn-regulated p53R2 ribonucleotide reductase, thymidine kinase 2, and deoxyguanosine kinase by siRNA t

52 , a phylogenetic tree is constructed for the thymidine kinase 2-like dNK gene family in metazoa.

53 in part because of the role of mitochondrial thymidine kinase 2.

54 ctivation were significantly down-regulated (thymidine kinase, 2.9-fold; orotate phosphoribosyltransf

55 Down-regulation of both DNC and thymidine kinase-2 also did not cause mtDNA depletion.

56 ine kinase-1 and the mitochondrial isoenzyme thymidine kinase-2, the highest phosphorylation levels r

57 1,3-dioxolan-4-yl)thymine (DOT) is the first thymidine kinase-activated nucleoside that is significan

58 stic factors such as beta2-microglobulin and thymidine kinase activity that have been partially valid

59 ography represents a new approach to imaging thymidine kinase activity, and hence, cellular prolifera

60 cell proliferation, glucose metabolism, and thymidine kinase activity, in multiple cancer cell lines

61 types of reactivating viruses: uniformly low thymidine kinase activity, mixed high and low activity,

62 obic residues at position 104 endow dCK with thymidine kinase activity.

63 ter gene (herpes simplex virus type 1 mutant thymidine kinase; Ad-CMV-VEGF121-CMV-HSV1-sr39tk) was us

64 modified version of the herpes simplex virus thymidine kinase along with eGFP that allows for the vis

65 genes for dihydrofolate reductase (DHFR) and thymidine kinase and are totally dependent on an alterna

66 Virally encoded kinases (thymidine kinase and BGLF4) which are expressed only dur

67 ) and genotypically (sequencing of the viral thymidine kinase and DNA polymerase genes).

68 VZV infection by sequence analysis of viral thymidine kinase and DNA polymerase genes.

69 le dual reporter herpes simplex virus type 1 thymidine kinase and enhanced green fluorescence protein

70 as a screening tool on two protein targets (thymidine kinase and estrogen receptor) using data sets

71 Comparisons to results for the thymidine kinase and estrogen receptors published by Rog

72 tection of incorporation in cells expressing thymidine kinase and human equilibrative nucleoside tran

73 y in infected cells by the promiscuous viral thymidine kinase and otherwise, mitochondrial toxicity w

74 ters, the mutant herpes simplex virus type I thymidine kinase and the human sodium-iodide symporter.

75 E2F and the EGFR pathway by deletion of the thymidine kinase and vaccinia growth factor genes.

76 l)thymine (FMAU), which is phosphorylated by thymidine kinases and incorporated into DNA.

77 lucuronidase) into the F14.5L, J2R (encoding thymidine kinase) and A56R (encoding hemagglutinin) loci

78 o cell toxicity, induced mutation at the TK (thymidine kinase) and HPRT loci, and gene expression pro

79 Conversely, the promoters of ORF 36 (thymidine kinase) and ORF 14 (glycoprotein C), genes exp

80 Applications of this unique split thymidine kinase are potentially far reaching, including

81 In addition, herpes virus thymidine kinases are being explored in gene/chemotherap

82 kinase-uracil phosphoribosyltransferase and thymidine kinase, are unique to C. parvum within the phy

83 d truncated herpes simplex virus type 1 sr39 thymidine kinase) by use of a lentiviral vector.

84 Thymidine kinase catalyzes the first step in the nucleot

85 Serum thymidine kinase changes predicted T-cell engraftment, w

86 split reporter (herpes simplex virus type 1 thymidine kinase), cleaved between Thr265 and Ala266, an

87 t with the 10-fold lower Mg2+ requirement of thymidine kinase compared with uridine kinase.

88 ced point mutation (V119C) markedly enhanced thymidine kinase complementation in PCAs, on the basis o

89 Our results suggest that thymidine kinase contributes to several DNA repair pathw

90 incorporation was increased in patients with thymidine kinase deficiency or PEO as the result of TWIN

91 formation of atypical plaques regardless of thymidine kinase deficiency, neoplasticity, and species

92 infected wild-type CEM/0 and HIV-2 infected thymidine kinase deficient CEM cells.

93 c1A11 (vNef1A11) produced typical plaques on thymidine kinase-deficient 143B cells, whereas rVVs expr

94 ounds were highly active against HIV even in thymidine kinase-deficient CEM cells.

95 rpes simplex virus (HSV) types -1 and -2 and thymidine kinase-deficient HSV-1 revealed different stru

96 n was specific for the vhs mutation, because thymidine kinase-deficient HSV-2 did not regain virulenc

97 months after intravaginal inoculation with a thymidine kinase-deficient HSV-2 strain and in lumbosacr

98 Early clearance of a thymidine kinase-deficient strain of herpes simplex viru

99 T cells from OT-I transgenic mice cleared a thymidine kinase-deficient, ovalbumin-expressing HSV-2 v

100 repeats of 59 base pairs (bp) that increased thymidine kinase-driven luciferase reporter activity in

101 l lines resulted in up-regulation of the EBV thymidine kinase (EBV-TK) transcript and sensitization o

102 ded protein kinase (EBV-PK), the EBV-encoded thymidine kinase (EBV-TK), or both is controversial.

103 engineered to express the Epstein-Barr virus thymidine kinase (EBV-TK).

104 say systems in the absence of an independent thymidine kinase-enzyme assay is discussed.

105 Thymidine kinase-expressing hCPCs were characterized in

106 vivo assays of Renilla luciferase and mutant thymidine kinase expression.

107 eric red fluorescence protein, and truncated thymidine kinase (fluc-mrfp-ttk).

108 nalysis suggests horizontal gene transfer of thymidine kinase from a proteobacterium.

109 of the reporter gene, comprised of a mutant thymidine kinase from herpes simplex virus 1 fused to gr

110 on and synthetically lethal with the loss of thymidine kinase function.

111 ause MIP-TF mouse beta-cells express a viral thymidine kinase, ganciclovir treatment induced hypergly

112 cade, various enzyme/prodrug systems such as thymidine kinase/ganciclovir (TK/GCV), yeast cytosine de

113 al scars, respectively; therefore, we used a thymidine kinase/ganciclovir paradigm to ablate both div

114 overexpression in situ and tumor killing by thymidine kinase/ganciclovir treatment, but neither stra

115 ates, including securin, cyclin A, cyclin B, thymidine kinase, geminin, and many others.

116 Tg) mice expressing the herpes simplex virus thymidine kinase gene (HSV-Tk) driven by the mouse GFAP

117 Mutations in the thymidine kinase gene (tk) of herpes simplex virus type

118 n of wild-type herpes simplex virus 1 (HSV1) thymidine kinase gene (wttk) retained a higher expressio

119 he assessment of herpes simplex virus type-1 thymidine kinase gene expression.

120 As a proof of concept, we delivered the HSV thymidine kinase gene for molecular-genetic imaging and

121 hyperactive variant of herpes simplex virus thymidine kinase gene into the 3'-untranslated region of

122 ement within the herpes simplex virus type 1 thymidine kinase gene that enables intron-independent ge

123 (n=9) were treated with herpes simplex virus thymidine kinase gene therapy and were compared with unt

124 e examined at 0, 4 and 8 days of ganciclovir/thymidine kinase gene therapy.

125 el that expresses the herpes simplex virus 1 thymidine kinase gene under the direction of the TAL-spe

126 ing protein, insertional inactivation of the thymidine kinase gene, and expression of RVFV glycoprote

127 ations, nor vaccinia virus deficient for the thymidine kinase gene, nor anaerobic growth conditions w

128 l vector containing the herpes simplex virus thymidine kinase gene, plus prodrug synergizes with surg

129 hifting at a sequence element within the HSV thymidine kinase gene.

130 pression whereas the other is deleted in the thymidine kinase gene.

131 the model plant Arabidopsis thaliana has two thymidine kinase genes (AtTK1a and AtTK1b) and microarra

132 fluorescent protein (GFP) expression in ARE/thymidine kinase GFP HepG2 cells, and both initiated nuc

133 on with viruses with deletions of functional thymidine kinase, glycoprotein E, ICP0, and US9 protein

134 only in the presence of herpes simplex virus thymidine kinase (HSV TK).

135 S-313) expressing the herpes simplex virus 1 thymidine kinase (HSV-1 TK).

136 binding domains and the herpes simplex virus thymidine kinase (HSV-TK) "suicide gene," we demonstrate

137 e gene therapy with the herpes simplex virus thymidine kinase (HSV-TK) cDNA and ganciclovir can elici

138 ibits the expression of herpes simplex virus thymidine kinase (HSV-TK) driven by an MDR1 minipromoter

139 nsgenic mice expressing herpes simplex virus thymidine kinase (HSV-TK) from the mouse glial fibrillar

140 porter probe to monitor herpes simplex virus thymidine kinase (HSV-tk) gene expression and bacterial

141 f dual specific vector, herpes simplex virus thymidine kinase (HSV-TK) gene was introduced for cancer

142 sing enhancer (PPE) of herpes simplex virus' thymidine kinase (HSV-TK) gene.

143 The herpes virus thymidine kinase (HSV-tk) is a critical enzyme for the a

144 uicide gene such as the herpes simplex virus thymidine kinase (HSV-TK) might allow exploitation of th

145 rthermore, an unrelated herpes simplex virus-thymidine kinase (HSV-TK) promoter was strongly represse

146 sine deaminase (CD) and herpes simplex virus thymidine kinase (HSV-TK) suicide gene protocols has res

147 a suicide gene encoding herpes simplex virus thymidine kinase (HSV-TK) using a Keratin 1-15 (Krt1-15)

148 ene in which the entire coding region of HSV thymidine kinase (HSV-tk) was fused in-frame to the extr

149 We also co-express Herpes Simplex Virus thymidine kinase (HSV-tk) with the transposase.

150 anine ([(18)F]FHBG) as the substrate for HSV thymidine kinase (HSV-TK).

151 s a truncated form of herpes simplex virus 1 thymidine kinase (HSV-TK).

152 Assessments of herpes simplex virus 1 thymidine kinase (HSV-tk)/ganciclovir (GCV) treatment re

153 (LV) vector expressing herpes simplex virus thymidine kinase (HSV-TK/GCV) under the regulation of an

154 obes for imaging herpes simplex virus type 1 thymidine kinase (HSV1- tk) gene expression.

155 esses the herpes simplex virus type 1 mutant thymidine kinase (HSV1-sr39tk) gene under the control of

156 the mutant viral herpes simplex virus type 1-thymidine kinase (HSV1-sr39tk) gene.

157 rter gene mutant herpes simplex virus type 1 thymidine kinase (HSV1-sr39tk) have been used for imagin

158 sion of a mutant herpes simplex type-1 virus thymidine kinase (HSV1-sr39tk) PET reporter gene in rat

159 (6)) expressing mutant herpes simplex type 1 thymidine kinase (HSV1-sr39tk) reporter gene.

160 0a) and a mutant herpes simplex virus type 1 thymidine kinase (HSV1-sr39tk), with the aid of an inter

161 porter gene herpes simplex virus type-1 sr39 thymidine kinase (HSV1-sr39tk).

162 ve expression of herpes simplex virus type 1 thymidine kinase (HSV1-TK) and inducible Tet-mediated ex

163 ing the PET reporter genes, herpes simplex 1 thymidine kinase (HSV1-tk) and its mutant HSV1-sr39tk.

164 Herpes virus type 1 thymidine kinase (HSV1-tk) and the mutant HSV1-sr39tk ar

165 epatic CRC tumors, using herpes virus type 1 thymidine kinase (HSV1-tk) as a therapeutic gene in conj

166 al PET agent for herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene expression.

167 The herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene is widely used as a suic

168 onverting enzyme herpes simplex virus type 1 thymidine kinase (HSV1-tk) into the genomes of cancer ce

169 Using herpes simplex virus-1 thymidine kinase (HSV1-tk) mutants with narrower substra

170 a PRP used to detect herpes simplex virus 1 thymidine kinase (HSV1-tk) or mutant HSV1-sr39tk PRG exp

171 an engineered cyclic herpes simplex virus 1-thymidine kinase (HSV1-TK) PET reporter whose kinase act

172 The herpes simplex 1 virus thymidine kinase (HSV1-tk) positron emission tomography

173 The herpes simplex virus type 1 thymidine kinase (HSV1-tk) positron emission tomography

174 In contrast, herpes virus thymidine kinase (HSV1-TK) readily activates ACV.

175 r imaging of the herpes simplex virus type 1 thymidine kinase (HSV1-tk) reporter gene expression in r

176 for use with the herpes simplex virus type 1 thymidine kinase (HSV1-tk) reporter gene system for gene

177 (18)F-FHBG), the herpes simplex virus type 1 thymidine kinase (HSV1-tk) variant sr39tk is actively be

178 rable to that of herpes simplex virus type-1 thymidine kinase (HSV1-tk)-transduced cells.

179 he expression of herpes simplex virus type-1 thymidine kinase (HSV1-TK).

180 nd a mutant herpes simplex virus type 1 sr39 thymidine kinase [HSV1-truncated sr39tk (ttk); a PET rep

181 utant version of herpes simplex virus type 1 thymidine kinase, HSV1-sr39tk, and also were labeled wit

182 eporter gene for herpes simplex virus type 1 thymidine kinase (HSV1tk) and green fluorescent protein,

183 n cassette that encodes herpes simplex virus thymidine kinase (HSVtk) for molecular chemotherapy and

184 nt (hdCKDM), and herpes simplex virus type 1 thymidine kinase (hsvTK) reporter genes.

185 firefly luciferase and herpes simplex virus thymidine kinase (HSVtk)) reporter genes using lentivira

186 interleukin (IL)-12 or Herpes Simplex Virus thymidine kinase (HSVtk), cured established metastatic d

187 ssing the suicide gene, herpes simplex virus thymidine kinase (HSVtk), driven by the promoter of stim

188 a proof-of-concept, we imaged Herpes simplex thymidine kinase in a clinic-ready setting with PET to s

189 tered gene were unable to produce functional thymidine kinase in an in vitro translation system.

190 enhanced green fluorescent protein/HSV1-sr39 thymidine kinase) in their beta-cells.

191 Derivatives of the herpes simplex thymidine kinase inhibitor HBPG [2-phenylamino-9-(4-hydr

192 drug converting enzyme, herpes simplex virus thymidine kinase, into therapeutic S-TRAIL secreting ste

193 As thymidine kinase is widely used in human gene therapy tr

194 ic mice (TGs) with cardiac overexpression of thymidine kinase isoforms (mitochondrial TK2 and cytopla

195 l, containing an integrated supF gene in the thymidine kinase locus (tk), exhibited supF mutation fre

196 ons that restored function at the selectable thymidine kinase locus.

197 sduction of acceptor loci, containing an HSV thymidine kinase marker, and subsequent integration of B

198 struct provides a potential combination with thymidine kinase-mediated gene therapy to optimize the t

199 porter gene (a mutant Herpes simplex virus-1 thymidine kinase (mHSV1-tk); 9-(4-(18)F-fluoro-3-hydroxy

200 V also inhibited the replication of an HSV-1 thymidine kinase mutant resistant to nucleoside analogue

201 Our results using thymidine kinase-null and rescued mutants as well as wil

202 -mediated microglial ablation on tga20/CD11b-thymidine kinase of Herpes simplex virus (HSVTK) cerebel

203 hout dying from GVHD, mice transplanted with thymidine kinase-positive T cells and subsequently admin

204 engineered to carry the herpes simplex virus thymidine kinase prodrug-converting enzyme effectively t

205 overexpression and ALF immunodepletion on a thymidine kinase promoter construct demonstrate that thi

206 ther the alpha-spectrin core promoter or the thymidine kinase promoter in reporter gene assays.

207 transcriptional activity to the heterologous thymidine kinase promoter irrespective of cytokine induc

208 nferred FXR responsiveness to a heterologous thymidine kinase promoter-reporter gene.

209 the consensus sequence AAAGTTT linked to the thymidine kinase promoter.

210 -dependent decreased expression on a minimal thymidine kinase promoter.

211 enhancer element in the context of a minimal thymidine kinase promoter.

212 R0 element conferred VDR responsiveness on a thymidine kinase promoter.

213 adult neurogenesis in naive transgenic GFAP-thymidine kinase rats resulted in social behavior simila

214 uction of new neurons in socially naive GFAP-thymidine kinase rats showed that loss of 6-week-old neu

215 Q151N vector expressing herpes simplex virus-thymidine kinase renders tumor cells sensitive to gancyc

216 iving the mutant herpes simplex virus type 1 thymidine kinase reporter gene (Ad-CMV-HSV1-sr39tk) was

217 firefly luciferase, and herpes simplex virus thymidine kinase reporter genes driven by a constitutive

218 five fluorescent proteins and the puromycin-thymidine kinase resistance gene in vitro, with up to 70

219 Varicella zoster virus encodes a thymidine kinase responsible for the activation of antih

220 p21-driven truncated herpes simplex virus-1 thymidine kinase sr39 mutant (ttksr39) in vitro and in v

221 es Cre/lox-assisted cell fate mapping with a thymidine kinase (sr39tk) reporter gene for cell detecti

222 a luciferase (hRluc), EGFP, and Herpes virus thymidine kinase (sr39TK).

223 A polymerase alpha, dihydrofolate reductase, thymidine kinase, stathmin, and MAP4 were down-regulated

224 of purified donor T cells expressing the HSV thymidine kinase suicide gene (TK+ cells).

225 coexpresses HSP70 and a herpes simplex virus thymidine kinase suicide gene.

226 In mammals thymidine kinase supplies deoxyribonucleotides for DNA r

227 Therefore, to establish whether thymidine kinase synthesized via a ribosomal frameshift

228 rferon response independent of its canonical thymidine kinase target.

229 cation of the pht genes between the putative thymidine kinase (tdk) and phosphopentomutase (deoB) gen

230 n the DNA precursor metabolism, inactivating thymidine kinase (tdk), that confirmed the redundancy ex

231 n of the immediate-early IE(-169/+73), early thymidine kinase TK(-215/+97), and late glycoprotein K g

232 pendent prognostic impact was found for FCR, thymidine kinase (TK) >/=10 U/L, unmutated IGHV, 11q del

233 Target validation was established using the thymidine kinase (TK) 1(+) wild-type, murine L929 cell l

234 pulmonary uptake of (18)F-FHBG increased as thymidine kinase (TK) activity increased only at low lev

235 scribes an innovative method for quantifying thymidine kinase (TK) activity that is compatible with b

236 raries of mutant enzymes and tested them for thymidine kinase (tk) activity.

237 herapeutic proteins in gene therapy, such as thymidine kinase (tk) and p53; however, the mechanism is

238 dant pathways to produce dTMP, one involving thymidine kinase (TK) and the second via thymidylate syn

239 5, and U87MG) was analyzed and quantified by thymidine kinase (TK) assay using 8-(3)H-penciclovir (8-

240 The thymidine kinase (TK) encoded by Epstein-Barr virus (EBV

241 Paradoxically, the thymidine kinase (TK) encoded by Kaposi sarcoma-associat

242 deletions in homopolymeric sequences in the thymidine kinase (TK) gene (tk).

243 bstrates were constructed, each containing a thymidine kinase (tk) gene disrupted by insertion of an

244 Each substrate contains a thymidine kinase (tk) gene fused to a neomycin resistanc

245 A DNA substrate containing a thymidine kinase (tk) gene fused to a neomycin-resistanc

246 ypervariable herpes simplex virus (HSV) gene thymidine kinase (TK) gene lead to acyclovir (ACV) resis

247 ncrease in mutation frequency as detected by thymidine kinase (TK) gene mutation assay.

248 of Ltk- cells with the herpes simplex virus thymidine kinase (tk) gene resulted in numerous TK+ colo

249 rate that herpes simplex virus type 1 (HSV1) thymidine kinase (TK) gene sequences (1,131 bp) fused to

250 ransgenic mouse model expressing herpesvirus thymidine kinase (TK) gene under the control of a 2.3-ki

251 run of six cytosines (C-chord) in the viral thymidine kinase (tk) gene.

252 otein or suicide genes [herpes simplex virus-thymidine kinase (TK) gene] when the adoptively transfer

253 odimerization of herpes simplex virus type 1 thymidine kinase (TK) in mammalian cells and in living m

254 l cytotoxic gene herpes simplex virus type 1-thymidine kinase (TK) induce tumor regression and long-t

255 Thymidine kinase (TK) is a key enzyme in the pyrimidine

256 Mutagenicity was assessed at the thymidine kinase (TK) locus, CYP1A activity was determin

257 We investigated thymidine kinase (tk) mutants isolated during multiple e

258 pound 2 exhibited reduced activity against a thymidine kinase (TK) negative strain of CV, implying a

259 ariants was used to target the mRNA encoding thymidine kinase (TK) of herpes simplex virus 1 (HSV-1).

260 stably transduced with herpes simplex virus thymidine kinase (TK) PET reporter gene.

261 al factor and repressed herpes simplex virus thymidine kinase (TK) promoter activity in a mammalian o

262 tively weak compared to the positive control thymidine kinase (TK) promoter and is stimulated by trea

263 n combined together or alone, with a minimal thymidine kinase (Tk) promoter, SSRE showed a weak incre

264 rs cytokine inducibility to the heterologous thymidine kinase (TK) promoter.

265 g T. brucei, contain genes where two or four thymidine kinase (TK) sequences are fused into a single

266 s on the phosphorylation and trapping of the thymidine kinase (TK) substrate 1-(2'-deoxy-2'-fluoro-be

267 genic mice that express herpes simplex virus thymidine kinase (TK) under control of the promoter for

268 stin-tk mouse expresses herpes simplex virus thymidine kinase (tk) under the control of the nestin 2n

269 on in the herpes simplex virus gene encoding thymidine kinase (TK) was previously found in an acyclov

270 ex virus mutant that expresses low levels of thymidine kinase (TK), a phenotype associated with drug

271 AT(+) virus had higher levels of ICP0, ICP4, thymidine kinase (TK), and PD-1 ligand 1 (PD-L1) transcr

272 ncode ribonucleotide kinase B subunit (RRB), thymidine kinase (TK), and UL9-like origin binding prote

273 yclovir (ACV) is phosphorylated by the viral thymidine kinase (TK), but not the cellular TK.

274 ynthesis and salvage, such as those encoding thymidine kinase (TK), cytidylate kinase, and purine nuc

275 iral enzyme target of these antiviral drugs, thymidine kinase (TK), is not expressed.

276 to 10-fold of its antiviral activity against thymidine kinase (TK)-deficient HSV-1 and VZV strains.

277 ven guanines (G string) in the gene encoding thymidine kinase (TK).

278 In contrast, the thymidine kinase (TK-1) promoter is also regulated by E2

279 tive immediate-early (IE) (ICP0), early (E) (thymidine kinase [tk]), and late (L) (glycoprotein C [gC

280 erase II to a representative early promoter (thymidine kinase [TK]).

281 reporter genes (herpes simplex virus type I thymidine kinase [tk], firefly luciferase [fl], and Reni

282 (NSP) enzymes deoxycytidine kinase (dCK) and thymidine kinase (TK1).

283 probe the mechanisms by which the two human thymidine kinases (TK1 and TK2) recognize and phosphoryl

284 mutations in nine autosomal genes, including thymidine kinase (TK2), which encodes a ubiquitous mitoc

285 for thymidine alone, unlike alphaherpesvirus thymidine kinases (TKs).

286 tures of hTK1 and of the Thermotoga maritima thymidine kinase (TmTK) in complex with the bisubstrate

287 ls with a suicide trap (herpes simplex virus thymidine kinase), to enable purging of the cells when d

288 fibrillary acid protein-herpes simplex virus-thymidine kinase transgene were given mild or moderate S

289 brillary acidic protein-herpes simplex virus-thymidine kinase transgene.

290 1, for fluorescent imaging), and a truncated thymidine kinase (ttk, for imaging of radiolabeled acycl

291 applied GDEPT, based on herpes simplex virus thymidine kinase type 1 (HSVtk) and ganciclovir (GCV).

292 The human mitochondrial thymidine kinase type 2 (hTK2) reporter gene truncated a

293 ed to deliver the human Herpes simplex virus thymidine kinase type-1 (HSVtk) gene, which has a dual f

294 er into the VC2 vector in place of the HSV-1 thymidine kinase (UL23) gene.

295 5 (helicase-primase helicase subunit), UL23 (thymidine kinase), UL25 (DNA packaging tegument protein)

296 genic mice that express herpes simplex virus thymidine kinase under control of the DCX promoter (DCX-

297 , we used transgenic mice that express viral thymidine kinase under control of the S100A4 promoter to

298 utagenesis studies of varicella zoster virus thymidine kinase (VZVTK).

299 , ORF36 (phosphotransferase) and KSHV ORF21 (thymidine kinase), which can phosphorylate ganciclovir a

300 Other mutants, such as the E59S and R84V thymidine kinases, which in wild-type VZVTK stabilize th