ライフサイエンスコーパス: thymidine phosphorylase

1 y carboxylesterases, cytidine deaminase, and thymidine phosphorylase.

2 tions, and mutations in the nuclear gene for thymidine phosphorylase.

3 soDDU is completely resistant to cleavage by thymidine phosphorylase.

4 ble clinical syndrome caused by mutations in thymidine phosphorylase.

5 phosphorolytic activity was independent from thymidine phosphorylase.

6 factor, basic fibroblast growth factor, and thymidine phosphorylase.

7 Thymidine phosphorylase, a cellular enzyme markedly indu

8 Thymidine phosphorylase, a pyrimidine salvage enzyme, tr

9 several features of these patients including thymidine phosphorylase activity deficiency, elevated th

10 Thymidine phosphorylase activity rose from undetectable

11 ytes contained low levels of dTTP due to low thymidine phosphorylase activity.

12 s of 5-FU response: thymidylate synthase and thymidine phosphorylase activity; and p53 and mismatch r

13 ve TYMP mutations cause severe reductions of thymidine phosphorylase activity; marked elevations of t

14 ng the migration and signaling components of thymidine phosphorylase and 2-deoxyribose action.

15 the first to demonstrate a direct effect of thymidine phosphorylase and 2-deoxyribose on signaling p

16 Here we show that both thymidine phosphorylase and 2-deoxyribose stimulated the

17 Further, thymidine phosphorylase and 2-deoxyribose, but not VEGF,

18 Thymidine phosphorylase and 2-deoxyribose-induced focal

19 sion of alpha 5 beta 1 was also increased by thymidine phosphorylase and 2-deoxyribose.

20 tes several proangiogenic factors, including thymidine phosphorylase and angiopoietin-1 both in vitro

21 the intracellular metabolism of thymidine by thymidine phosphorylase and subsequent extracellular rel

22 Thymidine phosphorylase and uridine phosphorylase double

23 Recombinant human thymidine phosphorylase catalyzes the reaction of arsena

24 ointestinal encephalomyopathy and had severe thymidine phosphorylase deficiency in the buffy coat (<1

25 l recessive multisystemic disorder caused by thymidine phosphorylase deficiency.

26 disease due to TYMP mutations that result in thymidine phosphorylase deficiency.

27 r vascular endothelial growth factor (VEGF), thymidine phosphorylase differed from VEGF in that its e

28 ccur from docetaxel-mediated upregulation of thymidine phosphorylase (dThdPase), an enzyme responsibl

29 Two new crystal forms of Escherichia coli thymidine phosphorylase (EC 2.4.2.4) have been found; a

30 oietic stem cell transplantation can restore thymidine phosphorylase enzyme function in patients with

31 Based on high thymidine phosphorylase expression in the liver, a 25-ye

32 Cdk5 (cyclin-dependent kinase 5) from Cdk2, thymidine phosphorylase from a bacterial homologue, and

33 and control brains, indicating that loss of thymidine phosphorylase function impairs the integrity o

34 mine and deoxyribose-1-phosphate by the host thymidine phosphorylase greatly increases the sensitivit

35 Thymidine phosphorylase has been implicated in angiogene

36 Human thymidine phosphorylase (hTP) is responsible for thymidi

37 Human thymidine phosphorylase (hTP) is responsible for thymidi

38 hanisms by which 2-deoxyribose might mediate thymidine phosphorylase-induced cell migration in vitro,

39 Thymidine phosphorylase is an angiogenic factor that is

40 ase caused by mutations in the gene encoding thymidine phosphorylase, leading to reduced enzymatic ac

41 e synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, microsatellite instability, 18q

42 e in thymidylate synthase and an increase in thymidine phosphorylase mRNA expression as determined by

43 The enzyme/cytokine thymidine phosphorylase/platelet-derived endothelial cel

44 of the transition state confirms that human thymidine phosphorylase proceeds through an S(N)2-like t

45 Thymidine phosphorylase replacement has been achieved by

46 revious studies showed that cells expressing thymidine phosphorylase stimulated endothelial cell migr

47 s-of-function mutations in the gene encoding thymidine phosphorylase (TP) a cytosolic enzyme.

48 Accordingly, we have generated thymidine phosphorylase (TP) and uridine phosphorylase (

49 essive human disease due to mutations in the thymidine phosphorylase (TP) gene.

50 The disease is caused by mutations in the thymidine phosphorylase (TP) gene.

51 Thymidine phosphorylase (TP) is an angiogenic growth fac

52 Thymidine phosphorylase (TP) is an important target enzy

53 ic pyrimidine nucleoside inhibitors of human thymidine phosphorylase (TP) is described.

54 The angiogenic factor thymidine phosphorylase (TP) is highly expressed in huma

55 The angiogenic factor thymidine phosphorylase (TP) is highly expressed in many

56 ne kinase 1 (TK1), thymidylate synthase, and thymidine phosphorylase (TP) were analyzed by Western bl

57 eterozygous mutations in the gene specifying thymidine phosphorylase (TP), located on chromosome 22q1

58 with nuclease P1, alkaline phosphatase, and thymidine phosphorylase (TP), or from chlorinated nucleo

59 is caused by mutations in the gene encoding thymidine phosphorylase (TP).

60 s-of-function mutations in the gene encoding thymidine phosphorylase (TP).

61 Thymidine phosphorylase (TP; also known as platelet-deri

62 s-of-function mutations in the gene encoding thymidine phosphorylase (TP; endothelial cell growth fac

63 Platelets contain abundant thymidine phosphorylase (TYMP), which is highly expresse

64 Here, we now identify thymidine phosphorylase (TYMP; previously known as endot