ライフサイエンスコーパス: thymine dimer

1 her undamaged or contained a single cis, syn thymine dimer.

2 corporates two adenines opposite the thymine-thymine dimer.

3 on of the complex leads to the repair of the thymine dimer.

4 5'-GT<>TG-3' tetrad only in the presence of thymine dimer.

5 isruption in the base stack generated by the thymine dimer.

6 GC), where TT denotes a cis, syn cyclobutane thymine dimer.

7 cription bubble terminating at a cyclobutane thymine dimer.

8 observed during bypass of a cis-syn thymine-thymine dimer.

9 tiated by H atom abstraction from C-6 of the thymine dimer.

10 cates that the photoproduct is a cyclobutane thymine dimer.

11 lectronic coupling to acceptor states of the thymine dimer.

12 y to analyze simulations of DNA containing a thymine dimer.

13 lesions such as a UV-induced cis-syn thymine-thymine dimer.

14 olymerase II and RNA polymerase I stalled at thymine dimers.

15 e 1,25(OH)(2)D(3)-induced protection against thymine dimers.

16 rations shown to block decreases in post-UVR thymine dimers.

17 esions, such as abasic sites and cyclobutane thymine dimers.

18 ng DNA synthesis through cis-syn cyclobutane thymine dimers.

19 olymerase when the template contains thymine-thymine dimers.

20 were stained with a monoclonal antibody for thymine dimers.

21 n vitro and assessed their ability to bypass thymine dimers.

22 uggesting a possible mechanism for bypassing thymine dimers.

23 ry in which the major UV photoproduct is the thymine dimer 5-thyminyl-5,6-dihydrothymine (spore photo

24 V-irradiated Bacillus subtilis spores is the thymine dimer 5-thyminyl-5,6-dihydrothymine [spore photo

25 V-irradiated dormant bacterial spores is the thymine dimer 5-thyminyl-5,6-dihydrothymine, commonly re

26 uct in UV-irradiated spore DNA is the unique thymine dimer 5-thyminyl-5,6-dihydrothymine, commonly re

27 d in UV-irradiated bacterial endospores is a thymine dimer, 5-thyminyl-5,6-dihydrothymine, i.e., the

28 (6)-MeG, 8-oxoG, an abasic site or a thymine-thymine dimer); a greater proofreading activity; an incr

29 mapping of the repair processes of a flavin-thymine dimer adduct with femtosecond resolution.

30 correlates with higher levels of UV-induced thymine dimer adducts being formed in cells lacking Nhp6

31 m for the low repair quantum yield of flavin-thymine dimer adducts is the short-lived excited flavin

32 ite specificity and integrity of the cis-syn thymine dimer after both primer extension and ligation w

33 surface areas are incorporated opposite the thymine dimer almost as effectively as an abasic site, a

34 nctional classes, which photo-reactivate the thymine dimer along different pathways.

35 Single- or double-thymine dimers also allow cleavage.

36 and pyrene nucleotide insertion opposite the thymine dimer and its N3-methyl derivatives was determin

37 he ternary complex of RNA polymerase II at a thymine dimer and surprisingly exerts the same effect on

38 lineC/C-C stretch vibrations) of cyclobutane thymine dimer and thymine dinucleotide radical anion, th

39 rease with aging in the repair rates of both thymine dimers and (6-4) photoproducts (P<0.001).

40 Direct measurement of thymine dimers and (6-4) photoproducts by immunoassay de

41 We studied the rate of removal of thymine dimers and (6-4) photoproducts in UV-irradiated

42 We used monoclonal antibodies against thymine dimers and 6-4 photoproducts and image analysis

43 sunscreen, resulted in comparable levels of thymine dimers and 6-4 photoproducts to one minimal eryt

44 fluorescent-tagged monoclonal antibodies for thymine dimers and melanocytes.

45 suppressed the formation of cyclobutane-type thymine dimers and promoted the formation of the spore p

46 We show that Pol eta copies thymine dimers and the flanking bases with higher proces

47 to A opposite an abasic site, the 3'-T of a thymine dimer, and a normal T with almost equal efficien

48 erted opposite an abasic site, the 3'-T of a thymine dimer, and most undamaged bases by yeast DNA pol

49 d site for oxidative reaction, repair of the thymine dimer appears to be kinetically more favorable.

50 rate constants for incorporation opposite a thymine dimer are considerably slower than those measure

51 Interloop-specific anti thymine dimers are incompatible with hybrid-type structu

52 Cis-syn thymine dimers are the major photoproducts of DNA and ar

53 lex and was approximately equal to a thymine-thymine dimer as a substrate for the former.

54 ng progressively greater numbers of KCs with thymine dimers as the dose of UV-light was increased; in

55 ication of an abasic site, a cis-syn thymine-thymine dimer, as well as acetyl aminofluorene adducted-

56 ontaining a single cyclo-dA or a cyclobutane thymine dimer at a specific site on the transcribed stra

57 at the damage site that initiates removal of thymine dimers at a physiologically relevant rate and sp

58 Oligonucleotide-treated adult cells removed thymine dimers at least as rapidly as diluent treated ne

59 n the presence of Na(+) results in a cis,syn thymine dimer between two adjacent Ts in a TTA loop and

60 a TTA loop and a mixture of nonadjacent anti thymine dimers between various loops.

61 IDS, at concentrations that had no effect on thymine dimers, blocked UVR-induced upregulation of p53.

62 f the bacteriophage enzyme is activated by a thymine dimer but not by an abasic site.

63 ly opposite an abasic site and the 3'-T of a thymine dimer but not opposite undamaged DNA.

64 istance between intercalated rhodium and the thymine dimer, but it diminished with disruption of the

65 oride currents help protect from UVR-induced thymine dimers, but further increases in p53 or reductio

66 ls against UVR-induced DNA damage, including thymine dimers, but the mechanism is unknown.

67 ions responsible for recognition of cis, syn thymine dimers by repair enzymes is not sensitive to the

68 UV-irradiated Bacillus spore DNA is a unique thymine dimer called spore photoproduct (SP, 5-thyminyl-

69 and imino proton signals of an (15)N-labeled thymine dimer-containing decamer duplex were assigned by

70 alent UV photoproduct, a cis-syn cyclobutane thymine dimer (cs CTD), was chemically synthesized and i

71 which contained a single cis-syn cyclobutane thymine dimer (CTD) at one of six different sites in the

72 Cyclobutane-thymine dimers (CTDs), the most common DNA lesion induce

73 We found that, like the cyclobutane thymine dimer, cyclo-dA is a strong block to gene expres

74 A dodecamer containing a cis-syn cyclobutane thymine dimer d(GCACGAAT[cs]TAAG).d(CTTAATTCG TGC) and i

75 of epidermal cells with DNA strand breaks or thymine dimers decreased markedly between 12 and 36 h.

76 the presence of both a 5'-GG-3' site and the thymine dimer diminished the dimer repair efficiency by

77 ms error-free bypass of the 8-oxoguanine and thymine dimer DNA lesions, though with a 10(3) and 10(2)

78 s simulations of the solvated protein with a thymine dimer docked in its active site.

79 cently built a computer molecular model of a thymine dimer docked to photolyase catalytic site and st

80 ase eta (Pol eta) bypasses a cis-syn thymine-thymine dimer efficiently and accurately, and inactivati

81 de Pol eta, which bypasses a cis-syn thymine-thymine dimer efficiently and accurately.

82 rase eta (Poleta) bypasses a cis-syn thymine-thymine dimer efficiently and accurately.

83 y of DNA polymerases which is able to bypass thymine dimers efficiently and in a relatively error-fre

84 nary 8-oxo-2'-deoxyguanosine and cyclobutane thymine dimers following ultraviolet exposure of healthy

85 dark (1)npi* excited states does not lead to thymine dimer formation.

86 antioxidant formulation efficiently reduced thymine dimer formation.

87 me products, a large amount of specific anti thymine dimers formed between either T in loop 1 and the

88 or without XPC, compared with the removal of thymine dimer from a base paired duplex by the entire se

89 o 5'-GG-3' doublets in DNA and the repair of thymine dimers from a remote site on the DNA duplex.

90 C-HHR23B complex is required for excision of thymine dimers from DNA in a human excision nuclease sys

91 ion of dAMP opposite the 3'-T of the cis-syn thymine dimer happens by way of a loosely held dimer in

92 transfer (ET) from the excited flavin to the thymine dimer in 79 ps.

93 d correctly replicate past a cis-syn-thymine-thymine dimer in template DNA.

94 Furthermore, the thymine dimer in the bubble-containing substrate was rem

95 ing the adenovirus major late promoter and a thymine dimer in the template strand downstream of the t

96 ur data show that UVB and UVA readily induce thymine dimers in melanocytes at levels that are compara

97 assay is convenient for monitoring repair of thymine dimers in oligonucleotides.

98 On day 12, there were more thymine dimers in skin type IV than skin type II, again

99 d 19, however, showed a much greater loss of thymine dimers in skin type IV, suggesting better thymin

100 It was recently shown that thymine dimers in the all-thymine oligonucleotide (dT)(1

101 e is an enzyme that catalyses photorepair of thymine dimers in UV damaged DNA by electron transfer re

102 y bypasses UV-associated cis-syn cyclobutane thymine dimers in vitro and contributes to normal resist

103 adenines during efficient bypass of thymine-thymine dimers in vitro, has led to the description of p

104 leave SP but not cyclobutane cis,syn thymine-thymine dimers in vitro.

105 eater opposite the 5'-T than the 3'-T of the thymine dimer, in accord with previous work suggesting t

106 l-2,2'-bipyridine) catalyzed the repair of a thymine dimer incorporated site-specifically in a 16-bas

107 TP nick end labeling-positive cells) or with thymine dimers increased to maximal levels within 30 min

108 contrast, binding of a nucleotide opposite a thymine dimer is directly correlated with the overall pi

109 lecule carrying a single cis,syn-cyclobutane thymine dimer is replicated in vitro by human cell extra

110 The cyclobutane thymine dimer is the major DNA lesion induced in human s

111 This suggests that formation of thymine dimers is not the sole mechanism of ARB inactiva

112 The formation of cyclobutane thymine dimers is one of the most important DNA carcinog

113 godeoxynucleotide (ODN) containing a cis-syn thymine dimer labeled at the N3 of both T's with 15N by

114 DNA-mediated repair of a thymine dimer lesion by charge transfer from the tethere

115 ciently but cannot trigger the repair of the thymine dimer lesion.

116 Similarly, cyclobutane thymine dimer levels peaked 3 d postexposure, before ret

117 ltheta is unable to bypass a cis-syn thymine-thymine dimer, nor does it bypass a (6-4) photoproduct o

118 The footprint of RNAP II stalled at the thymine dimer, obtained using DNase I, lambda exonucleas

119 n vitro replication of duplex DNA containing thymine dimers occurs by translesion synthesis.

120 de currents in osteoblasts, had no effect on thymine dimers on its own but prevented the 1,25(OH)(2)D

121 Cyclobutane thymine dimer, one of the major lesions in DNA formed by

122 The presence of a thymine dimer or a cisplatin diadduct in the context of

123 ynthesized from a mixture of [3-15N]-labeled thymine dimer phosphoramidites after which the cis-syn d

124 If these unique nonadjacent anti thymine dimer photoproducts also form in vivo, they woul

125 ne dimers in skin type IV, suggesting better thymine dimer repair.

126 However, rates of thymine-dimer repair and UV-induced apoptosis were signi

127 uences lacking either the guanine doublet or thymine dimer, respectively.

128 Dpo3 bypassed uracil and cis-syn cyclobutane thymine dimer, respectively.

129 s out TLS to bypass abasic sites and thymine-thymine dimers resulting from UV radiation.

130 oproducts as determined by reacting DNA with thymine dimer-specific antibodies: 40+/-5% vs. 20+/-9% a

131 ct lyase (SPL) repairs a covalent UV-induced thymine dimer, spore photoproduct (SP), in germinating e

132 lease were required for dual incision of the thymine dimer substrate.

133 ne, and either uracil or cis-syn cyclobutane thymine dimer, suggesting their catalytically limited ro

134 prevalent UV-derived DNA lesion, the cis,syn-thymine dimer (T x T), we have recently found that a T x

135 d with DNA duplexes containing a cyclobutane thymine dimer (T<>T), here we probe the electrochemistry

136 mid containing a single cis, syn-cyclobutane thymine dimer (T[c,s]T) 385 base pairs from the center o

137 s (TLS) of site-specific cis-syn cyclobutane thymine dimers (T (wedge)T).

138 ctly, leading to lesions such as cyclobutane thymine dimers (T<>T), or indirectly, via photosensitize

139 Cyclobutane thymine dimers (T-T) comprise the majority of DNA damage

140 synthetic primers past template cyclobutane thymine dimers (T[CPD]T) or undamaged T-T under physiolo

141 DNA damage (thymine dimers: T-T dimers) and vitamin D (25(OH)D) synt

142 s a base excision repair enzyme that removes thymine dimers (TD) from damaged DNA.

143 PL) repairs 5-thyminyl-5,6-dihydrothymine, a thymine dimer that is also called the spore photoproduct

144 UV light causes the formation of thymine dimers that can be misreplicated to induce mutag

145 staining with a monoclonal antibody against thymine dimers that were quantitated by image analysis.

146 s value is comparable to that of cyclobutane thymine dimers (the major UV-induced lesions) in genomic

147 structed an SV40 vector containing a cis-syn thymine dimer, the major DNA photoproduct induced by UVB

148 ucture-activity relationships of the cis-syn thymine dimer, the major photoproduct of DNA, has been g

149 nd non-natural nucleotides paired opposite a thymine dimer through exonuclease degradation or pyropho

150 Pol eta replicate through a cis-syn thymine-thymine dimer (TT dimer) by inserting two As opposite th

151 st skin cancer caused by cyclobutane thymine-thymine dimers (TTDs), a frequent form of DNA damage ari

152 nduces cyclobutane pyrimidine dimers, mainly thymine dimers (TTs), and pyrimidine (6-4) pyrimidone ph

153 m was highly efficient, removing >30% of the thymine dimers under optimal conditions.

154 In this system the thymine dimer was excised independent of XPC.

155 nary 8-oxo-2'-deoxyguanosine and cyclobutane thymine dimers was by competitive enzyme-linked immunoso

156 oach involving monoclonal antibodies against thymine dimers we provide direct evidence for the presen

157 tand the nature of base pairing with cis-syn thymine dimers, we have synthesized a decamer oligodeoxy

158 lculated distortions of DNA structure by the thymine dimer were qualitatively and quantitatively simi

159 Protection factors for erythema and thymine dimers were calculated and shown to be about 2 i

160 Thymine dimers were quantified by image analysis.

161 A by converting two adjacent thymines into a thymine dimer which is potentially mutagenic, carcinogen

162 induces the formation of a novel cyclobutane thymine dimer which lacks an intradimer phosphodiester b

163 An enlarged active site accommodates the thymine dimer with excellent stereochemistry for two-met

164 Exonuclease-deficient pol gamma bypassed thymine dimers with low relative efficiency; bypass was

165 f <310 nm wavelength to photo-reactivate CPD thymine dimers within a substrate DNA.