ライフサイエンスコーパス: thymus

1 mmunogen are the product of the foster pup's thymus.

2 -expressing regulatory T (Treg) cells in the thymus.

3 one marrow, are resident in the normal human thymus.

4 ling to suppress iNKT cell generation in the thymus.

5 ids cause immature T-lymphocyte apoptosis in thymus.

6 lay a role in T cell progenitor entry to the thymus.

7 and specifically iNKT cell generation in the thymus.

8 uring self-tolerant T-cell production in the thymus.

9 lular selection of developing T cells in the thymus.

10 ithout affecting NKT cell development in the thymus.

11 e 1 diabetes, express proinsulin (PI) in the thymus.

12 iated with inadequate Treg generation in the thymus.

13 on at 6 dpf, but this was not evident in the thymus.

14 nt of stem cells and immature T cells in the thymus.

15 ced iNKT cell percentages and numbers in the thymus.

16 progenitor cells from the bone marrow to the thymus.

17 evelopment of single positive T cells in the thymus.

18 cells caused by arrested development in the thymus.

19 the thyroid and (shown in this article) the thymus.

20 te to the periphery and were retained in the thymus.

21 E-responsive tissue-specific antigens in the thymus.

22 t on migration of malignant cells out of the thymus.

23 the level of early T cell development in the thymus.

24 e kidney, gastrointestinal tract, brain, and thymus.

25 an NKT17 cytokine secretion phenotype in the thymus.

26 ry cues and restricts malignant cells to the thymus.

27 mmac in regulating T cell development in the thymus.

28 ol lymphoid differentiation in the zebrafish thymus.

29 tivation; and that develop after leaving the thymus.

30 controls entry of T cell progenitors to the thymus.

31 +) and CD8(+) single-positive T cells in the thymus.

32 s a hallmark of necroptosis, in the skin and thymus.

33 ) led to increased fractions of Tregs in the thymus.

34 induces thymic atrophy and apoptosis in the thymus.

35 rs (GCs) development and inflammation in the thymus.

36 exogenous strategies to help regenerate the thymus.

37 ents with advanced carcinoids of the lung or thymus.

38 their escape from negative selection in the thymus.

39 ent transplantation with allogeneic cultured thymus.

40 r all CD8(+)-lineage-fate 'decisions' in the thymus.

41 /genome higher than 1 in the BM and 2 in the thymus.

42 aused an increase in mature cells within the thymus.

43 in hematopoietic progenitors led to a small thymus, a double negative (DN)1/DN2 thymocyte transition

44 e exposed to during their development in the thymus, a phenomenon known as positive selection.

45 ents, and antioxidant activities of fourteen Thymus accessions belonging to ten species were evaluate

46 tosis and its pathologic consequences in the thymus after dexamethasone treatment and in advanced ath

47 IR and an impaired ability to repopulate the thymus after IR.

48 striction to the T cell lineage occur in the thymus after the entry of thymus-seeding progenitors (TS

49 The molecular basis by which the thymus allows high-efficiency Treg induction remains lar

50 The thymus, an organ responsible for T cell development, is

51 mmune MP Ag-specific T cells in the skin and thymus and a distinct pattern of activation upon TCR eng

52 genitors (T-IPs) before their entry into the thymus and activation of Notch signaling.

53 acrophage-derived chemokine/CCL22) and TARC (thymus and activation-regulated chemokine/CCL17), and th

54 in response to IL-4, first appearing in the thymus and bearing high expression levels of Eomesodermi

55 effects we find are nearly identical between thymus and blood, suggesting that our analysis mainly de

56 the bone marrow that persists in the spleen, thymus and blood.

57 Here we show that MRV infects the thymus and causes T-cell depletion, suggesting that othe

58 y occurring murine pathogen that infects the thymus and establish a novel infection model for MRV in

59 high levels in cerebellum, skeletal muscle, thymus and kidney.

60 s attributable to increased PARP activity in thymus and liver, as cotreatment with dioxin and the PAR

61 on complex surgery to transplant human fetal thymus and liver.

62 mus drastically increased ILC2 counts in the thymus and other organs where ILC2 normally reside.

63 The thymus and parathyroids develop from third pharyngeal po

64 roles in patterning and organogenesis of the thymus and parathyroids.

65 e what regulates NKT17 cell frequency in the thymus and peripheral lymphoid organs.

66 shown to cause absence of iNKT cells in the thymus and periphery due to defective self glycolipid pr

67 reduced in the absence of Bcl11b both in the thymus and periphery, associated with the decrease in iN

68 gene, iNKT cell numbers were reduced in the thymus and periphery.

69 ment and function of NKT cell subsets in the thymus and periphery.

70 in both lymphoid and epithelial cells in the thymus and resulted in increased expression of important

71 cant role in lymphocyte trafficking from the thymus and secondary lymphoid organs, resulting in immun

72 9)Zr-labeled PEGylated anti-CD8 VHH detected thymus and secondary lymphoid structures as well as intr

73 D4(+)MHC class II(+), accumulated in the pup thymus and spleen during the nursing period.

74 l for Treg cell lineage specification in the thymus and that its perturbation is causative of autoimm

75 Thymocytes are highly motile within the thymus and travel between specialized microenvironments

76 b2(fl/fl) CD4cre(tg) mice were normal in the thymus and were only slightly affected in the periphery.

77 ingual epithelia, salivary gland, esophagus, thymus, and bladder.

78 hypoplasia, pale livers, hypoplastic spleen, thymus, and bone marrow, cardiac hypertrophy, placental

79 gens of single-sorted B cells from pediatric thymus, and compared these with mature B cells from feta

80 t-derived structures, including aortic arch, thymus, and cranial nerves.

81 Here we show that humanized bone marrow, thymus, and liver (hu-BLT) mice are susceptible to all s

82 discuss the mechanisms that establish in the thymus, and maintain in postthymic cells, the separation

83 entions did not reverse the arrest in tooth, thymus, and parathyroid gland development, suggesting th

84 od and hematopoietic organs, such as the BM, thymus, and spleen.

85 te survival and development, egress from the thymus, and survival of recent thymic emigrants.

86 stances of alternative splicing in the human thymus, and uncover novel mechanisms for CELF2 regulatio

87 e signatures for AD (Immunoglobulin E (IgE), thymus- and activation-regulated chemokine (TARC) and ma

88 irst dose of BV, and reduced serum levels of thymus- and activation-regulated chemokine concurrent wi

89 Mechanisms of tolerance initiated in the thymus are indispensable for establishing immune homeost

90 Thus, most B cells in the thymus are resident rather than developing, and are enri

91 that drive NKT17 cell differentiation in the thymus are still largely unknown.

92 Notch receptors further validates the human thymus as a DC-poietic organ, which provides selective m

93 (+) regulatory T (Treg) cells develop in the thymus as a functionally mature T cell subpopulation spe

94 They arise in the thymus as a separate lineage from conventional CD4(+)Fox

95 ating cellular organization, using the mouse thymus as a test organ.

96 he naive T cell compartment, implicating the thymus as having functional regenerative capacity.

97 This led to studies of the thymus as the site of maturation of T cells, which led t

98 grammed for cytotoxic differentiation in the thymus as they acquire expression of the transcription f

99 uman HSCs to study T-cell development in the thymus at a clonal level.

100 icotinamide, a form of vitamin B3, prevented thymus atrophy and hepatosteatosis by dioxin and increas

101 4 increased NAD(+) levels and prevented both thymus atrophy and hepatosteatosis.

102 CLP caused bone marrow (BM) and thymus atrophy, decreased innate immune cells in BM.

103 ive roles by significantly decreasing BM and thymus atrophy, restoring innate immune cells in BM, inc

104 that includes wasting, hepatosteatosis, and thymus atrophy.

105 results provide evidence that the atrophied thymus attempts to balance the defective negative select

106 ar bone in long bones, as well as uterus and thymus being partly dependent (40-70% reduction in estro

107 , including the use of precursor T cells and thymus bioengineering.

108 lemented an in vivo model of ART in BM/liver/thymus (BLT) humanized mice in order to better understan

109 Inoculation of bone marrow/liver/thymus (BLT) mice with CCR5-tropic HIV-1JRCSF(JRCSF) exp

110 econstitution by the bone marrow, liver, and thymus (BLT) reconstitution method, in addition to lung

111 Two of these models (bone marrow/liver/thymus [BLT] mice and T cell-only mice [ToM]) have been

112 ietic stem cells (termed Bone marrow, Liver, Thymus [BLT]).

113 ort that these CD3(+)CD20(+) T cells pervade thymus, bone marrow, and secondary lymphatic organs.

114 r number of maternal cells in the spleen and thymus but a much larger percentage was Foxp3(+), result

115 otection relied on ferrying of PPI-Fc to the thymus by migratory dendritic cells and resulted in a ri

116 udied tTreg cell generation in the atrophied thymus by utilizing both postnatal TEC-defective (result

117 and stage-specific requirements for CXCR4 in thymus colonisation and pre-TCR mediated selection, its

118 is significance, the mechanisms that control thymus colonization are poorly understood.

119 We applied this method to study thymus colonization in CCR7(-/-)CCR9(-/-) (DKO) mice, wh

120 between LTbetaR and thymic stromal cells in thymus colonization, and highlight its potential as an i

121 High expression of FAT10 in the mouse thymus could be assigned to strongly autoimmune regulato

122 In this work, an essential oil (Thymus daenensis) was formulated as a water-dispersible

123 We found that FGF21 expression in thymus declines with age and is induced by CR.

124 As the regular function of the thymus declines with age, it is of fundamental and clini

125 In contrast, overt thymus deletion and functionally impaired TEIPP T cells

126 During the immune response to so-called "thymus-dependent Ags," activated B cells seek T cell hel

127 ripheral niches that are usually occupied by thymus-derived gammadeltaT17 cells.

128 Tregs can be divided into thymus-derived natural Tregs (tTregs) and peripherally-d

129 overy of thymopoiesis and development of new thymus-derived peripheral T cells.

130 (CD4CD45ROCD25-CD127) cells, Th1 cells, and thymus-derived regulatory (Treg) (CD4CD45ROCD25CD127) ce

131 Thymus-derived regulatory T (tTreg) cells are key to pre

132 esting that Th1/Th17 cells are not converted thymus-derived regulatory T cells.

133 phaalpha IELs) are an abundant population of thymus-derived T cells that protect the gut barrier surf

134 s how self-antigens define the repertoire of thymus-derived Treg cells to subsequently endow this cel

135 Thymus-derived Treg cells were selected by self-antigens

136 ecreted Wnt ligands are essential for normal thymus development and normal peripheral T cell frequenc

137 occasional myocardial fibrosis and minimized thymus development.

138 styryl derivativatives intercalate into calf thymus DNA (ct DNA), whereas photocyclization products o

139 mall fluorescent organic molecules with calf thymus DNA was developed using two-photon absorption (TP

140 PH radical) and biocompatibility (using calf-thymus DNA) of curcumin-loaded mixed surfactant formulat

141 g Id1 or deleting two E protein genes in the thymus drastically increased ILC2 counts in the thymus a

142 ression of tissue-restricted antigens in the thymus, driven in part by autoimmune regulator (Aire), i

143 uced to express IL-23R and IL-17 outside the thymus during skin inflammation.

144 IPP T cells were efficiently selected in the thymus, egressed with a naive phenotype, and could be ex

145 ereas T-like cells develop in the thymoid, a thymus-equivalent region at the gill fold tips.

146 ave smaller, aparathyroid primordia in which thymus fate specification extends into the pharynx.

147 In human and mouse thymus, females expressed less AIRE (mRNA and protein) t

148 ECs plays critical roles in thymopoiesis and thymus function.

149 AIRE levels in human thymus grafted in immunodeficient mice depended upon the

150 Although the thymus has a remarkable capacity to regenerate after inj

151 The human thymus has been shown to host B cells, which have been i

152 As the importance of the role of the thymus has grown, so too has the understanding that it i

153 process because prior TCR engagement in the thymus has initiated their commitment to the gammadeltaT

154 D-L1 in tumors as well as the spleen, liver, thymus, heart, and lungs peaked 72 hours after injection

155 In the thymus, hematopoietic progenitors commit to the T cell l

156 entified by the coexpression of CD4 and TOX (thymus high-mobility group box), in the skin and blood o

157 t it acts independently of its regulation of thymus-homing chemokines.

158 s hematopoietic cells in the bone marrow and thymus; however, the long-term effects of irradiation wi

159 The discovery of thymus immune function, T cells, and immune surveillance

160 Therefore, the thymus 'imprints' distinct gene programs on subsets of i

161 T cell compartment and the importance of the thymus in human naive T cell homeostasis and premature a

162 al FoxP3(+)CD4(+)Treg cells developed in the thymus in the absence of other T cells.

163 wn stages of T-cell development in the mouse thymus, including the bifurcation point.

164 ough the majority of Tregs are formed in the thymus, increasing evidence suggests that induced Tregs

165 g of the associated mechanisms is limited to thymus-independent (TI) antibody production by the margi

166 In contrast, thymus-independent Ags generally do not induce germinal

167 er oral immunization with cholera toxin or a thymus-independent antigen, a substantial number of anti

168 ery asymmetrically distributed and uncover a thymus-independent pathway for mature T cell production

169 cell antigen receptor (TCR) signaling in the thymus initiates positive selection, but the CD8(+)-line

170 react with MHC or, instead, processes in the thymus involving coreceptors and other molecules select

171 The thymus is a primary lymphoid organ required for the indu

172 The thymus is a primary lymphoid tissue that supports the ge

173 any patients, the next regeneration of their thymus is a step closer.

174 Thymus is crucial for generation of a diverse repertoire

175 T cell egress from the thymus is essential for adaptive immunity and involves c

176 continuous egress of new T lymphocytes from thymus is essential for maintenance of peripheral immune

177 Regulatory T-cell (Treg) selection in the thymus is essential to prevent autoimmune diseases.

178 e recruitment of lymphoid progenitors to the thymus is essential to sustain T cell production through

179 development of T-cell self-tolerance in the thymus is important for establishing immune homeostasis

180 T-cell development in the thymus is largely controlled by an epigenetic program, i

181 n and TCRVgamma/delta recombination in fetal thymus is lost in mTORC1KO thymus, leading to elevated g

182 us stages of T cell development in the human thymus is missing.

183 ntrol of CD4(+)-CD8(+) lineage choice in the thymus is now better understood, less was known about wh

184 Here we show that T-cell development in the thymus is severely impaired in Cxxc1-deficient mice.

185 The thymus is the primary lymphoid organ responsible for gen

186 The main function of the thymus is to generate an immunocompetent set of T cells

187 , respectively) resident in the steady-state thymus is whether early thymic progenitors (ETPs) could

188 The thymus is, however, capable of regenerating, restoring i

189 s of CD4(+)-CD8(+) lineage commitment in the thymus, is critical for CD4(+) T cell helper functions.

190 bination in fetal thymus is lost in mTORC1KO thymus, leading to elevated gammadeltaT17 differentiatio

191 l cells (TECs) to a middle-aged or defective thymus leads to thymic growth and increased T cell produ

192 gh selection of self-specific T cells in the thymus limits responses to mammalian tissue antigens, th

193 SG-SGM3) strain of mice engrafted with human thymus, liver, and hematopoietic stem cells (termed Bone

194 gamma-/- mice reconstituted with human fetal thymus, liver, and liver-derived hematopoietic stem cell

195 750 fluorescent signal was attributed to the thymus, liver, and spleen as determined by ex vivo imagi

196 In the thymus, low-affinity T cell antigen receptor (TCR) engag

197 necrosis factor receptor superfamily have on thymus medulla development and formation, and highlight

198 ht the impact that T-cell development has on thymus medulla formation.

199 , by performing TEC-specific deletion of the thymus medulla regulator lymphotoxin beta receptor (LTbe

200 During alphabetaT cell development, the thymus medulla represents an essential microenvironment

201 In all, our study demonstrates that thymus medulla specialization for thymic tolerance segre

202 describe the processes that give rise to the thymus medulla, a site that nurtures self-tolerant T-cel

203 lator Aire are involved in the regulation of thymus medullary microenvironments.

204 d NOD scid IL-2Rgamma(-/-) bone marrow-liver-thymus mice up to 11 weeks after treatment cessation.

205 -infected huBLT (humanized Bone marrow-Liver-Thymus) mice.

206 ified in effector subsets that emerge in the thymus, namely, iNKT1, iNKT2, and iNKT17.

207 results prompt the questions of whether the thymus naturally has the capacity to produce ILC2s and w

208 In the thymus, Nes expression was restricted to thymic stromal

209 , Hawaii, was the home for the latest Global Thymus Network meeting 5-9 June 2016.

210 om plants belonging to the Lamiaceae family (Thymus, Ocimum, Origanum, and Monarda genera), and other

211 ls, and increased expression of IL-7R in the thymus of mice expressing Cre under the proximal lck pro

212 equence repertoires taken from the blood and thymus of mice of different ages, we quantify the change

213 ntional and regulatory T cell subsets in the thymus of neonates and young mice expressed higher level

214 the spleen and liver of mice but not in the thymus or adipose tissues.

215 rise in absence of antigenic exposure in the thymus or in the periphery.

216 ious effects of LPS on Treg frequency in the thymus or spleen.

217 ed to immunodeficient mice, and murine fetal thymus organ cultures.

218 of thymic NKT17 cell differentiation in the thymus, our data indicate that excessive NKT17 cell freq

219 olecules involved in T-cell selection in the thymus, our understanding of the spatial and temporal as

220 cluding the intestines, lung, liver, kidney, thymus, pancreas, and skin.

221 genous repair is unable to fully restore the thymus, particularly in the aged population, and this pa

222 the primary site of T-cell development, the thymus plays a key role in the generation of a strong ye

223 The thymus plays a key role post allogeneic hematopoietic st

224 In the thymus, precursor cells recognize self-glycolipids by vi

225 effector potential is acquired in the human thymus, prior to TCR signaling, but rather than describi

226 The mouse thymus produces discrete gammadelta T cell subsets that

227 Upon reaching the thymus, progenitors undergo a complex developmental prog

228 wing bone marrow transplant enhances initial thymus recovery and boosts donor-derived T cell numbers,

229 ly showed impaired T cell reconstitution and thymus regeneration after allogeneic bone marrow nucleat

230 positive selection of CD8(+) T cells in the thymus requires that T cell antigen receptor (TCR) signa

231 tudy, we investigated if such effects on the thymus result from alterations in the expression of micr

232 of ARID5B in immature thymocytes results in thymus retention, differentiation arrest, radioresistanc

233 c emigrants (CD4+recently emigrated from the thymus (RTE), CD4+CD31+) quantified by flow cytometry.

234 ein genes in single cultured cells and mouse thymus sections, revealing cell-type-specific gene expre

235 uantitative parameters and the mechanisms of thymus seeding remain poorly understood.

236 betaR in relationship to known regulators of thymus seeding suggests that it acts independently of it

237 neage occur in the thymus after the entry of thymus-seeding progenitors (TSPs).

238 iNKT) cells develop and differentiate in the thymus, segregating into iNKT1/2/17 subsets akin to Th1/

239 In the present study, we analyzed thymus selection and peripheral behavior of T cells with

240 issue of the JCI, Doorduljn et al. evaluated thymus selection and peripheral behavior of TEIPP-specif

241 urther analysis of maternal cells in the pup thymus showed that a proportion was positive for materna

242 Finally, the Thymus species with high bioactive compounds may be reco

243 Although small-molecule thymus-specific isoform of retinoic acid receptor-relate

244 Thymus-specific serine protease (TSSP) is expressed by t

245 Tbx1 expression and partially suppressed the thymus-specific transcription factor Foxn1, identifying

246 -cre Runx1 cKO mice lack iNKT17 cells in the thymus, spleen and liver.

247 severe decrease in iNKT cell numbers in the thymus, spleen and liver.

248 ous Pten(FV/+) mice develop carcinoma in the thymus, stomach, adrenal medulla, and mammary gland but

249 s that depends upon continuous guidance from thymus stromal cell microenvironments.

250 In the thymus, stromal microenvironments support a developmenta

251 In the thymus, T cell-specific ablation of the Roquin paralogs

252 ow that during T reg cell development in the thymus, TET proteins mediate the loss of 5mC in T reg ce

253 are less affected by antigen exposure in the thymus than in the periphery.

254 e-like phenotype have been identified in the thymus that are distinct from conventional Th17 and Th1

255 small population of T cells developed in the thymus that produce large amounts of cytokines and chemo

256 erentiated NKT and gammadelta T cells in the thymus, the colon submucosa, and during early tumorigene

257 ermine the outcome of Ag presentation in the thymus, the maternal or foster pup origin of immunogen-r

258 In the thymus, the recirculating cells exerted their regulatory

259 In the thymus, there is a severe block in all aspects of intrat

260 Without the proper education in the thymus, these cells will turn on their host and cause au

261 In the thymus, they differentiate into iNKT1, iNKT2 and iNKT17

262 sGRP3 may regulate progenitor entry into the thymus through a CCR9-dependent mechanism.

263 t self-tolerant repertoire of T cells by the thymus through mechanisms that remain incompletely resol

264 During negative selection in the thymus, thymocytes with autoreactive potential are eithe

265 ated positive and negative selections in the thymus.Thymocytes are screened by two processes, termed

266 oteins and implanting human bone, liver, and thymus tissue to facilitate immune cell maturation and t

267 ity depends on mature thymocytes leaving the thymus to enter the bloodstream and the trafficking of T

268 proteins E2A and HEB acted in synergy in the thymus to establish T cell identity and to suppress the

269 on of the cells that ultimately populate the thymus to generate alpha/beta T cells has been controver

270 d can be 'developmentally programmed' in the thymus to generate discrete gammadelta T cell effector s

271 erative strategies may ultimately enable the thymus to play as prominent a role after transplant as i

272 tent hematopoietic progenitor cells into the thymus to sustain T cell development.

273 arly in life, whereas the receptivity of the thymus to TEC engraftment remains relatively constant wi

274 e egress of mature thymocytes from the human thymus to the periphery remain understudied yet are of u

275 Surprisingly, in the steady-state postnatal thymus TPA(lo)MHCII(lo) pre-Aire rather than terminally

276 his study confirms the previous reports that thymus transplantation can reconstitute T cells in patie

277 Thymus transplantation is a promising strategy for the t

278 Thymus transplantation shows this requirement maps to IL

279 eneration of skin-reactive Treg cells in the thymus (tTreg).

280 Using an in vitro mouse thymus tumor cell line, we determined that H2(18)O provi

281 h (2)H2(18)O and (2)H2O down modulated mouse thymus tumor cell proliferation, whereas H2(18)O water h

282 higher UBE2W expression levels in testis and thymus, Ube2w KO mice showed a disproportionate decrease

283 hat recognize these self-antigens within the thymus undergo clonal deletion.

284 The thymus undergoes rapid degeneration following a range of

285 ytes through maturation processes within the thymus via interaction with self-ligands displayed on th

286 tifungal and antiaflatoxigenic properties of Thymus vulgaris essential oil (TEO) were evaluated upon

287 -22.2 ppm) were similar to concentrations in Thymus vulgaris nectar (mean 5.2 ppm).

288 At 72 h, uptake in the thymus was significantly increased at protein concentrat

289 ve selection of self-specific T cells in the thymus was the major mechanism of central tolerance.

290 role of mesenchymal cells (MCs) in the adult thymus, we performed whole transcriptome analyses of pri

291 deletion, whereas peptides excluded from the thymus were ignored.

292 Nearly all B cells in thymus were mature and displayed an Ig gene repertoire t

293 (ENS) and hematopoietic organs (bone marrow, thymus) where they participate in lymphocyte trafficking

294 the modulation of insulin gene expression in thymus, which is essential to induce either insulin tole

295 Cs are the main source of Wnt ligands in the thymus, which serves a nonredundant role, and lack of TE

296 age 1 and stage 2 MAIT cells predominated in thymus, while stage 3 cells progressively increased in a

297 t leads to inadequate Treg generation in the thymus with a switch of splenic Tregs toward an inflamma

298 echanisms.CD4 and CD8 T cells develop in the thymus with their transcription programs controlled by T

299 d postfertilization (dpf) in the developing thymus, with il-2rgammac.a expression also confirmed in

300 ferentiated carcinoid tumours of the lung or thymus, with radiological progression within 12 months b