ライフサイエンスコーパス: thyroiditis

1 h SLE and AITD (Graves' disease or Hashimoto thyroiditis).

2 in human autoimmune thyroiditis (Hashimoto's thyroiditis).

3 tiation between Graves' disease and painless thyroiditis.

4 ation of susceptibility genes for autoimmune thyroiditis.

5 ded our understanding of the pathogenesis of thyroiditis.

6 igation that have been applied to autoimmune thyroiditis.

7 es that resemble those observed in Hashimoto thyroiditis.

8 before developing hypothyroidism, suggesting thyroiditis.

9 y present in the pathogenesis of Hashimoto's thyroiditis.

10 these families: T1D, RA, SLE, and Hashimoto thyroiditis.

11 ng and presentation to T-cells in autoimmune thyroiditis.

12 sites and in the development of spontaneous thyroiditis.

13 s allowed for the development of spontaneous thyroiditis.

14 sue from patients diagnosed with Hashimoto's thyroiditis.

15 such as the autoimmune disease, Hashimoto's thyroiditis.

16 y correlated with the progress of autoimmune thyroiditis.

17 ase-limiting role of IFN-gamma in autoimmune thyroiditis.

18 T cell response to mTg and failed to develop thyroiditis.

19 thyrocytes, but did not develop spontaneous thyroiditis.

20 nt autoimmune diseases including Hashimoto's thyroiditis.

21 autoimmune disorders, particularly Hashimoto thyroiditis.

22 hyroid dysfunction that occurs in autoimmune thyroiditis.

23 ized by the sera of patients with autoimmune thyroiditis.

24 ti-RT6.1 mAb induced autoimmune diabetes and thyroiditis.

25 -versus-host disease, multiple sclerosis and thyroiditis.

26 ce with mouse or human Tg resulted in severe thyroiditis.

27 t none of the patients actually had subacute thyroiditis.

28 B rats develop spontaneous hyperglycemia and thyroiditis.

29 ht prevent missing a diagnosis of autoimmune thyroiditis.

30 lphian lymph node during different stages of thyroiditis.

31 Eight patients had a history of Hashimoto thyroiditis.

32 f hyperthyroidism consistent with autoimmune thyroiditis.

33 uitary gland), features found in Hashimoto's thyroiditis.

34 pithelial cells of patients with Hashimoto's thyroiditis.

35 h other abnormalities of hyperthyroidism and thyroiditis.

36 like structures is a hallmark of Hashimoto's thyroiditis.

37 ion of granulomatous experimental autoimmune thyroiditis.

38 -3) mm(2)/sec, and in patients with painless thyroiditis 1.46+/-0.22x10(-3) mm(2)/sec, respectively.

39 enile rheumatoid arthritis, 1 with Hashimoto thyroiditis, 1 with psoriasis and iritis, 1 with diabete

40 The most common were Hashimoto thyroiditis (10%), psoriasis (6%), inflammatory bowel di

41 showed autoimmune disorders, i.e. autoimmune thyroiditis (26.3%), dermatitis herpetiformis (4%) and d

42 d CD (29%) developed ADs (mainly Hashimoto's thyroiditis, 29 cases), compared with a smaller proporti

43 enced ongoing autoimmune problems, including thyroiditis (3), hemolysis (1), thrombocytopenia (4), an

44 ic thyroiditis that mimics human Hashimoto's thyroiditis, a disease where iodine, IFN-gamma, and adhe

45 a (PTC) and thyroid epithelia in Hashimoto's thyroiditis activates nuclear factor-kappa B (NF-kappaB)

46 iabetes, rheumatoid arthritis, lupus, Graves thyroiditis, Addison disease and other autoimmune disord

47 nce of rheumatoid arthritis (RA), autoimmune thyroiditis (AIT), multiple sclerosis (MS), and insulin-

48 hypothyroidism, hyperthyroidism, autoimmune thyroiditis (AIT), serum concentrations of thyroid-stimu

49 ence of type 1 diabetes (T1D) and autoimmune thyroiditis (AITD).

50 ic stimulation in the setting of Hashimoto's thyroiditis and aberrant somatic hypermutation may play

51 between the ultrasonography (US) results of thyroiditis and characteristics of the Delphian lymph no

52 iated with chronic lymphocytic (Hashimoto's) thyroiditis and does not seem to be affected by thyroid

53 me to target tissues involved in Hashimoto's thyroiditis and Graves' disease, we performed ex vivo an

54 diseases, chronic lymphocytic (Hashimoto's) thyroiditis and Graves' disease.

55 hism determines susceptibility to autoimmune thyroiditis and implicate Tg as an important autoantigen

56 is an excellent animal model for Hashimoto's thyroiditis and provides a unique opportunity to investi

57 hyroid-infiltrating T cell of a patient with thyroiditis and specific for a cryptic thyroid-peroxidas

58 evaluate the association between autoimmune thyroiditis and the Delphian lymph node during different

59 The association of Hashimoto's thyroiditis and thyroid cancer remains an active focus o

60 ort no linkage between serologic Hashimoto's thyroiditis and thyroid cancer, yet they are limited by

61 Eleven other patients with thyroiditis and two with Graves' disease recognized only

62 children had autoimmune comorbidity, such as thyroiditis and type 1 diabetes.

63 both autoimmune hypothyroidism (Hashimoto's thyroiditis) and autoimmune thyrotoxicosis (Graves' dise

64 gkin's lymphoma [NHL]); endocrine (diabetes, thyroiditis); and rheumatologic (Sjogren's syndrome).

65 , 2 had multiple sclerosis, 2 had autoimmune thyroiditis, and 7 had other conditions.

66 rats, including insulin-dependent diabetes, thyroiditis, and experimental autoimmune uveitis.

67 lin-dependent diabetes mellitus, Hashimoto's thyroiditis, and primary ovarian failure).

68 seases such as systemic lupus erythematosus, thyroiditis, and rheumatic autoimmune diseases.

69 dal lymphocytes isolated from a patient with thyroiditis, and unexpectedly, thyroid follicular cells

70 hip between thyroid lymphoma and Hashimoto's thyroiditis appears to be well established.

71 e regulatory T cells that prevent autoimmune thyroiditis are generated in vivo only when the relevant

72 Hypothyroidism and Hashimoto's thyroiditis are more common than hyperthyroidism and Gra

73 We used thyroiditis as a model to dissect these possibilities.

74 thyroxine at position 2553 (T4p2553) induces thyroiditis as well as strong specific T and B cell resp

75 Tg-cleaving activity in IgG from autoimmune thyroiditis (ATh) and systemic lupus erythematosus (SLE)

76 , thymus hyperplasia, autoimmune lymphocytic thyroiditis, autoimmune hemolytic anemia, and colitis.

77 matoid arthritis, Graves' disease, Hashimoto thyroiditis, autoimmune thyroid disease, and systemic lu

78 on self-Ag presentation, not only suppressed thyroiditis but also prevented reemergence of the diseas

79 rther diagnostic work-up revealed autoimmune thyroiditis, but no signs of inflammatory bowel disease.

80 cells offset the suppression of H2E-mediated thyroiditis by H2A.

81 Previous studies have shown that autoimmune thyroiditis can be induced in normal laboratory rats aft

82 Subacute thyroiditis can be unilateral or focal (1,2).

83 roiditis cases; Group 4: advanced-late stage thyroiditis cases.

84 2: indeterminate cases; Group 3: established thyroiditis cases; Group 4: advanced-late stage thyroidi

85 utonomously functioning thyroid nodules, and thyroiditis caused by inflammation, which results in rel

86 ase (TPO), a region frequently recognized in thyroiditis, cDNA sequences coding for peptide fragments

87 mice treated with Flt3-L showed more severe thyroiditis characterized by enhanced lymphocytic infilt

88 TD), Graves' disease and chronic lymphocytic thyroiditis (CLT) are amongst the most common endocrine

89 blication of a paper showing that autoimmune thyroiditis could be induced in animals.

90 umatoid arthritis, Graves disease, Hashimoto thyroiditis, Crohn disease, ulcerative colitis, systemic

91 Thyroiditis developed in aged CD7/CD28-double-deficient

92 eptide when inducing experimental autoimmune thyroiditis (EAT) in NOD mice expressing human DRbeta1-A

93 i-B7.2 had decreased experimental autoimmune thyroiditis (EAT) severity compared with recipients of c

94 model (A(-)E(+)) of experimental autoimmune thyroiditis (EAT) that permits disease induction with he

95 to rat neu and mTg with resultant autoimmune thyroiditis (EAT) were both enhanced.

96 Experimental autoimmune thyroiditis (EAT) with granulomatous histopathological f

97 LA-DR) predispose to experimental autoimmune thyroiditis (EAT), a classical mouse model of HT.

98 e other hand, murine experimental autoimmune thyroiditis (EAT), a model for HT, presents a clear link

99 ent of granulomatous experimental autoimmune thyroiditis (EAT), DBA1 mice with a disrupted IFN-gamma

100 t the development of experimental autoimmune thyroiditis (EAT), experimental autoimmune myasthenia gr

101 ent of granulomatous experimental autoimmune thyroiditis (EAT), IL-4 gene-disrupted mice expressing t

102 ut also to suppress, experimental autoimmune thyroiditis (EAT).

103 diseases, as well as experimental autoimmune thyroiditis (EAT).

104 he cases with a sonographic finding matching thyroiditis formed Group 2.

105 ion of granulomatous experimental autoimmune thyroiditis (G-EAT) at least in part through regulation

106 Granulomatous experimental autoimmune thyroiditis (G-EAT) is induced by mouse thyroglobulin-se

107 Granulomatous experimental autoimmune thyroiditis (G-EAT) is induced by mouse thyroglobulin-se

108 Granulomatous experimental autoimmune thyroiditis (G-EAT) is induced by mouse thyroglobulin-se

109 When granulomatous experimental autoimmune thyroiditis (G-EAT) was induced in CBA/J or DBA/1 mice,

110 ion of granulomatous experimental autoimmune thyroiditis (G-EAT) was promoted when thyroid epithelial

111 del of granulomatous experimental autoimmune thyroiditis (G-EAT) was used to determine the role of TG

112 erse events (myositis in addition to grade 3 thyroiditis, grade 3 hepatitis, grade 3 pneumonia, and g

113 Fifty percent of the strains susceptible to thyroiditis had a unique SNP haplotype at exons 10 and 1

114 of the mouse strains that were resistant to thyroiditis had this SNP haplotype (P = 0.01).

115 oral autoimmune response in human autoimmune thyroiditis (Hashimoto's thyroiditis).

116 expression of ICAM-1 in this mouse model of thyroiditis, highlighting the complex interplay present

117 Hashimoto's thyroiditis (HT) is associated with HLA, but the associa

118 One such gene implicated in Hashimoto's thyroiditis (HT) is HLA-DR3, but the association is weak

119 comprising Graves disease (GD) and Hashimoto thyroiditis (HT), develop as a result of a complex inter

120 cluding Graves' disease (GD) and Hashimoto's thyroiditis (HT), is one of the most common of the immun

121 imately 30% of CIU patients have Hashimoto's thyroiditis (HT).

122 include Graves disease (GD) and Hashimoto's thyroiditis (HT); although these diseases contrast clini

123 Thus, interferon induced thyroiditis (IIT) is a major clinical problem for patien

124 1, may mediate the occurrence of Hashimoto's thyroiditis in AIS1-susceptible family members.

125 We report a case of Coccidioides thyroiditis in an HIV-infected patient with a history of

126 ted their effects on experimental autoimmune thyroiditis in CBA/J mice.

127 xistence of CD4(+)CD25(+) T cells regulating thyroiditis in E(+)B10.Ab(0) (A(-)E(+)) and B10 (A(+)E(-

128 A two-locus analysis of Hashimoto thyroiditis in family members segregating an AIS1 suscep

129 r similar to what is observed in Hashimoto's thyroiditis in humans.

130 differentiate Graves' disease from painless thyroiditis in patients with untreated thyrotoxicosis.

131 ajor role in the expression of insulitis and thyroiditis in the BB rat, that Th1 lymphocytes may pred

132 ore the challenge to determine their role in thyroiditis in the presence of both H2A and H2E genes.

133 Moreover, mTg1677 induced mild thyroiditis in Treg-depleted B10 mice, and in E(+)B10 mi

134 r, whether treatment can prevent post-partum thyroiditis in women who are or have been antibody posit

135 follicular cells in experimental autoimmune thyroiditis, in a manner similar to what is observed in

136 disorders, Graves disease (GD) and Hashimoto thyroiditis, in which perturbations of immune regulation

137 Experimental autoimmune thyroiditis, induced in mice after challenge with thyrog

138 depletion of CD4(+)CD25(+) T cells enhanced thyroiditis induction in the context of either H2E or H2

139 ditionally resistant B10 (H2(b)) mice permit thyroiditis induction with mouse thyroglobulin (mTg) aft

140 molecules (E(+)B10 mice), are susceptible to thyroiditis induction without Treg depletion.

141 sed risk for autoimmune disorders, including thyroiditis, inflammatory bowel disease, rheumatoid arth

142 H2A genes is protective against H2E-mediated thyroiditis, inhibiting EAT development.

143 dermatomyositis, Graves' disease, Hashimoto thyroiditis, insulin-dependent diabetes mellitus, inflam

144 dence and severity of spontaneous autoimmune thyroiditis [iodide-accelerated spontaneous autoimmune t

145 r important causes of thyrotoxicosis include thyroiditis, iodine-induced and drug-induced thyroid dys

146 prevalent in older women, in whom autoimmune thyroiditis is common.

147 en than men, and post partum exacerbation of thyroiditis is common.

148 ty and resistance to experimental autoimmune thyroiditis is encoded by MHC H2A genes.

149 The lymphocytic infiltration of Hashimoto's thyroiditis is frequently associated with papillary thyr

150 The lymphocytic infiltration of Hashimoto's thyroiditis is frequently encountered in thyroid glands

151 Subacute thyroiditis is generally felt to have a viral etiology,

152 results suggest that spontaneous autoimmune thyroiditis is inhibited in mice expressing transgenic T

153 Post-partum thyroiditis is substantially more frequent in women who

154 s, which suffers from spontaneous autoimmune thyroiditis, is an excellent animal model for Hashimoto'

155 op iodine-accelerated spontaneous autoimmune thyroiditis (ISAT) with chronic inflammation of the thyr

156 s [iodide-accelerated spontaneous autoimmune thyroiditis (ISAT)] in NOD.H2(h4) mice.

157 opment of lymphocytic spontaneous autoimmune thyroiditis (L-SAT) in NOD.H-2h4 mice and inhibits the d

158 h develop lymphocytic spontaneous autoimmune thyroiditis (L-SAT), all TGF-beta transgenic (Tg) mice g

159 ch tolerance is typically lost in autoimmune thyroiditis leading to hypothyroidism.

160 -requiring diabetes mellitus and lymphocytic thyroiditis (LT).

161 pressive effect of H2A genes on H2E-mediated thyroiditis mirrors previous reports of H2E suppression

162 mmune neutropenia, n = 1) and other tissues (thyroiditis, n = 3; psoriasis, n = 2; Graves disease, n

163 ld block the continuous T-cell activation in thyroiditis needed to maintain the autoimmune response t

164 mily cluster in which vitiligo and Hashimoto thyroiditis occur in numerous individuals.

165 Post-partum thyroiditis occurs in 5-10% of women, and many of those

166 One serious adverse event-autoimmune thyroiditis of grade 2 severity-was reported in the vite

167 or diagnosis of hypothyroidism or autoimmune thyroiditis, of whom 56 were receiving thyroxine therapy

168 effective in relieving symptoms of subacute thyroiditis, often within 24 hr (3).

169 n-autoimmune IIT can manifest as destructive thyroiditis or as hypothyroidism with negative thyroid a

170 (MS), autoimmune thyroid disease (Hashimoto thyroiditis or Graves disease), juvenile RA, inflammator

171 Nineteen were found with autoimmune thyroiditis or hypothyroidism, and replacement therapy w

172 causes and comorbidities, such as autoimmune thyroiditis or infections.

173 ce, which developed an extensive lymphocytic thyroiditis or insulitis that nevertheless did not elimi

174 cytes could transfer experimental autoimmune thyroiditis or L-SAT to Tg mice, indicating that the tra

175 ied associations with additional phenotypes: thyroiditis (OR = 0.58, p = 1.4 x 10(-5)), nodular (OR =

176 values between Graves' disease and painless thyroiditis (P=0.001).

177 al Ig-gene libraries derived from autoimmune thyroiditis patients and specific for the main autoantig

178 otes are absent from a cohort of Hashimoto's thyroiditis patients.

179 C3H/gld mice, lupus patients, and autoimmune thyroiditis patients.

180 odine increases the incidence of Hashimoto's thyroiditis, perhaps by augmenting the antigenicity of t

181 autoimmune diseases, including scleroderma, thyroiditis, primary biliary cirrhosis, Sjogren syndrome

182 Similar to index cases, Hashimoto thyroiditis, psoriasis, and inflammatory bowel disease w

183 ng thyroidectomy with coexisting Hashimoto's thyroiditis report an increased prevalence of papillary

184 ve been published in the field of autoimmune thyroiditis (represented by Graves' disease and Hashimot

185 We previously reported that in wild-type, thyroiditis-resistant BALB/c mice that underwent regress

186 Although thyroiditis risk was slightly increased, risk for thyroi

187 OD.H-2h4 mice develop spontaneous autoimmune thyroiditis (SAT) and anti-mouse thyroglobulin (MTg) aut

188 OD.H-2h4 mice develop spontaneous autoimmune thyroiditis (SAT) and produce anti-mouse thyroglobulin a

189 ed for development of spontaneous autoimmune thyroiditis (SAT) in NOD.H-2h4 mice where they function

190 Spontaneous autoimmune thyroiditis (SAT) is an organ-specific autoimmune diseas

191 OD.H-2h4 mice develop spontaneous autoimmune thyroiditis (SAT) when given 0.05% NaI in their drinking

192 in a murine model of spontaneous autoimmune thyroiditis (SAT), B cells were depleted from adult NOD.

193 presented by Graves' disease and Hashimoto's thyroiditis) since January 2005.

194 significant difference in the prevalence of thyroiditis, Sjogren's syndrome, or Hodgkin's or NHL.

195 yroid lymphomas in patients with Hashimoto's thyroiditis strongly suggests a pathogenetic link betwee

196 row transplantation, patient 1 had Hashimoto thyroiditis, suggesting that organ-specific autoimmunity

197 icularly either Graves' disease or Hashimoto thyroiditis, suggesting the possibility of different pat

198 gland during the early stages of autoimmune thyroiditis suggests a possible effector function of CD1

199 spontaneously develop autoimmune lymphocytic thyroiditis that mimics human Hashimoto's thyroiditis, a

200 ifferentiating Graves' disease from painless thyroiditis, the best result was obtained with area unde

201 ogenetic process of autoimmune (Hashimoto's) thyroiditis, the most common cause of hypothyroidism in

202 cluded atopy, granulomatous rash, autoimmune thyroiditis, the presence of antinuclear antibodies, sin

203 ed where the initial impression was subacute thyroiditis, there was a clinical response to prednisone

204 gest that sunitinib may induce a destructive thyroiditis through follicular cell apoptosis.

205 Autoimmune postpartum and subacute thyroiditis, tumours that secrete thyrotropin, and drug-

206 reated PVG donors were still able to prevent thyroiditis upon adoptive transfer.

207 oth peptides induced experimental autoimmune thyroiditis upon direct challenge of CBA/J mice with pep

208 portantly, treatment of mice with autoimmune thyroiditis using mouse thyroglobulin (mTg)-pulsed anti-

209 minority of CS patients, include Hashimoto's thyroiditis, vascular malformations and mental retardati

210 Diagnosis of Coccidioides thyroiditis was made based on histopathologic examinatio

211 The prevalence of Hashimoto thyroiditis was significantly higher in the relatives of

212 rom macroglobulinemia, cryoglobulinemia, and thyroiditis were all <.0038, the Bonferroni threshold fo

213 , and might be the only treatment needed for thyroiditis, which is transient.

214 and mice spontaneously developed destructive thyroiditis with histological, clinical and hormonal sig

215 12 induced severe, destructive granulomatous thyroiditis with neutrophil inflammation, fibrin deposit