ライフサイエンスコーパス: thyrotrope

1 d biopotency of TSH, the hormone secreted by thyrotropes.

2 egion and identified the major start site in thyrotropes.

3 was suppressed 50% by 9-cis-RA in the TtT-97 thyrotropes.

4 gamma expression is limited primarily to the thyrotropes.

5 as somatotropes, lactotropes and caudomedial thyrotropes.

6 sources such as GH3 somatotropes and TtT-97 thyrotropes.

7 ively decreased TRbeta2 promoter activity in thyrotropes.

8 (P1) is required for promoter expression in thyrotropes.

9 o be necessary for full promoter activity in thyrotropes.

10 We show here that IGSF1 is expressed both in thyrotropes and gonadotropes of the pituitary and in Ley

11 region that directs high level expression to thyrotropes and gonadotropes of transgenic mice.

12 ted to alpha glycoprotein subunit-expressing thyrotropes and gonadotropes.

13 ior pars distalis (APD), increased number of thyrotropes and loss of somatotrope cell types in the po

14 verning expression of the TRbeta2 isoform in thyrotropes and showed that transcription arose from mul

15 ormone (TSH), which is released by pituitary thyrotropes and which is normally suppressed by increase

16 uously, highly expressed in the somatotrope, thyrotrope, and lactotrope cells of the adult.

17 cell-specific expression in gonadotropes and thyrotropes, and we show here that it encodes two bidire

18 otropin (TSH) beta-subunit gene in pituitary thyrotropes are not well understood.

19 rtant for basal TRbeta2 promoter activity in thyrotropes as constructs lacking them by deletion or mu

20 iodinase (dio2) are coexpressed in zebrafish thyrotropes by 48 hours after fertilization and that TH-

21 l approaching that seen in expressing TtT-97 thyrotropes by cotransfecting a Pit-1 expression vector.

22 tion of ventral cell types (gonadotropes and thyrotropes) by inducing Bmp2 expression in Rathke's pou

23 that early exposure to elevated TH leads to thyrotrope cell death.

24 ical for embryonic pituitary gonadotrope and thyrotrope cell differentiation have been identified mai

25 the opposite result, loss of lactotrope and thyrotrope cell specification, and an increased number o

26 in the expression of markers of the ventral thyrotrope cells and SF-1-expressing cells of gonadotrop

27 imited tissue distribution that includes the thyrotrope cells of the anterior pituitary gland.

28 H, the expression of which is limited to the thyrotrope cells of the anterior pituitary gland.

29 ate areas that bind other factors present in thyrotrope cells.

30 This promoter has much less activity in thyrotrope-derived alphaTSH cells, pituitary-derived GH3

31 ed the major transcription start site in the thyrotrope-derived TtT-97 cells.

32 We have utilized the thyrotrope-derived TtT-97 thyrotropic tumors to investig

33 ather than alpha-GSU was the lead protein in thyrotrope development.

34 tion and examined the effect of excess TH on thyrotrope development.

35 Thyrotrope differentiation occurs normally, but thyrotro

36 nd found that it can inhibit gonadotrope and thyrotrope differentiation.

37 to -19, whose pattern differed from Pit-1 in thyrotrope extracts, showed protection patterns with GH3

38 r the control of the tshb promoter to follow thyrotrope fates in vivo.

39 ontogeny of negative feedback regulation of thyrotrope function and examined the effect of excess TH

40 rotrope differentiation occurs normally, but thyrotrope function is impaired resulting in mild hypoth

41 lpha-GSU gene expression in gonadotropes and thyrotropes in the developing human fetal pituitary now

42 TSH beta promoter activity in thyrotropes is conferred by sequences between -270 and -

43 his transgene also immortalized cells of the thyrotrope lineage that express both alpha- and beta-sub

44 Thyrotrope numbers slowly recovered following the remova

45 e is expressed in pituitary gonadotropes and thyrotropes of all mammals and in placental trophoblasts

46 expressed in somatotropes, lactotropes, and thyrotropes of the anterior pituitary.

47 in gonadotrope, lactotrope, somatotrope, and thyrotrope pituitary cells.

48 transient TH exposure profoundly impacts the thyrotrope population during a critical period of pituit

49 re both cell-autonomous factors required for thyrotrope, somatotrope and lactotrope ontogeny, but the

50 It gives rise to gonadotrope, thyrotrope, somatotrope, corticotrope and lactotrope cel

51 ary hypocellularity due to a general lack of thyrotropes, somatotropes and lactotropes.

52 producing pituitary cell types-gonadotropes, thyrotropes, somatotropes, lactotropes, corticotropes, a

53 a tool for further investigation focusing on thyrotrope-specific gene expression as well as negative

54 ights into the transcriptional mechanisms of thyrotrope-specific gene expression.

55 biting GATA2 binding to gonadotrope- but not thyrotrope-specific genes, indicating that both DNA bind

56 uitary-derived GH3 cells and may represent a thyrotrope-specific transcription factor.

57 necessary for TSH beta promoter activity in thyrotropes, this transcription factor is not alone suff

58 Furthermore, the TSHbeta-only thyrotropes were dividing, and TSHbeta rather than alpha

59 th TSHbeta, we observed that most if not all thyrotropes were TSHbeta-positive but alpha-GSU-negative

60 s to be the lead protein in gonadotropes, in thyrotropes which ultimately express alpha-GSU with TSHb

61 combinant Pit-1; however, extracts of TtT-97 thyrotropes, which express Pit-1, footprinted this proxi