ライフサイエンスコーパス: tiagabine

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1 concise synthesis of the epilepsy medication tiagabine.

2 measured before and after administration of tiagabine (0.2 mg/kg of body weight), a GABA membrane tr

3 suppressed by the GABA transport inhibitors tiagabine (10 microM) and SKF89976-A (100 microM), but w

4 thyl-2-thienyl)but-3-enl-yl] nipecotic acid (tiagabine) (10 microM, n = 12) significantly prolonged t

5 thyl-2-thienyl)but-3-enl-yl] nipecotic acid (tiagabine) (10 microM, n = 12) significantly prolonged t

6 Perfusion of tiagabine (50 microM) for 15 min, evoked large, slow dep

7 ar memories, as supported by the efficacy of tiagabine, a GABA reuptake inhibitor, to rescue fear res

8 hancement of extracellular GABA levels, thus tiagabine, a GABA transporter inhibitor, was evaluated a

9 GABA transport inhibitors (tiagabine and NO-711) prolonged evoked IPSC decay kineti

10 Two others, tiagabine and vigabatrin, are likely to be approved in t

11 l efficacy findings for baclofen, modafinil, tiagabine, and topiramate.

12 clinical trials, namely baclofen, modafinil, tiagabine, and topiramate.

13 lian cells and studied with [3H]GABA and [3H]tiagabine binding.

14 gabapentin, lamotrigine, oxcarbazepine, and tiagabine, compared with the use of topiramate, may be a

15 Tiagabine had antinociceptive activity in both phase 1 (

16 oxcarbazepine (HR, 2.07; 95% CI, 1.52-2.80), tiagabine (HR, 2.41; 95% CI, 1.65-3.52), and valproate (

17 the gamma-aminobutyric acid uptake inhibitor tiagabine hydrochloride was studied on electrical respon

18 It is concluded that the tiagabine-induced depolarizations in this in vitro prepa

19 grating stimulus, before, 1, 3 and 5 h post tiagabine ingestion.

20 docking of derivatives of the GAT1 inhibitor tiagabine into a protein homology model of GAT1 allowed

21 articipants, we administered either 15 mg of tiagabine or a placebo.

22 Enhancement of GABAergic transmission with tiagabine plus clonazepam partially rescues the effects

23 nhibitor vigabatrin and blocking uptake with tiagabine reduced the power of gamma oscillations more i

24 ially phenocopy the clinical side effects of tiagabine, suggesting that these side effects are inhere

25 AEDs gabapentin, lamotrigine, levetiracetam, tiagabine, topiramate, vigabatrin, and zonisamide do not

26 hich are substrates of the same enzymes (eg, tiagabine, valproic acid, lamotrigine, and topiramate).

27 Tiagabine, which blocks GABA reuptake, does not prolong

28 ologically manipulated the GABA system using tiagabine, which blocks the synaptic GABA transporter 1,

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