ライフサイエンスコーパス: tick

1 is microbiota to more efficiently infect the tick.

2 ave arisen during evolution of parasitism in ticks.

3 IMD networks, one in insects and another in ticks.

4 that can target pathogens in the host or in ticks.

5 a turicatae, which is transmitted by argasid ticks.

6 e xanthurenic acid (XA), for its survival in ticks.

7 us that is transferred to humans by infected ticks.

8 n that produces OspB in place of OspA within ticks.

9 s in malaria, platyhelminths, nematodes, and ticks.

10 lycerol (PODAG) stimulate the IMD pathway of ticks.

11 lators to ensure normal ovary development of ticks.

12 acaricide has been shown to kill 68%-100% of ticks.

13 tification of the species ofRickettsiain the ticks.

14 l viruses and other pathogens transmitted by ticks.

15 e transmitted primarily by Ixodes scapularis ticks.

16 hot, we describe the basics of how the clock ticks.

17 roup rickettsiae are exclusively vectored by ticks.

18 mometry with quantum mechanically calibrated ticks.

19 e detected a Francisella endosymbiont in 174 ticks (70%), and Rickettsia spp. in 19 ticks (8%); Ricke

20 n 174 ticks (70%), and Rickettsia spp. in 19 ticks (8%); Rickettsia-infected ticks contained R. rhipi

21 analysis during infection of HMECs vis-a-vis tick AAE2 cells revealed significantly higher expression

22 during mouse infection, but also during the tick acquisition, intermolt, and transmission phases.

23 nsus-level mutations in CCHFV recovered from ticks after only a single transstadial transmission, whe

24 rom the salivary glands of the tropical bont tick (Amblyomma variegatum) using primers based on the v

25 LE, termed FLE-Am, present in the Gulf Coast tick, Amblyomma maculatum.

26 ecursor in the salivary glands of the ixodid tick, Amblyomma variegatum.

27 a documented bite from an Ixodes scapularis tick and the erythema migrans rash associated with Lyme

28 This pathogen has evolved with its tick and vertebrate hosts through dynamic processes invo

29 of virus replication in live Ixodes ricinus ticks and abolished virus neurotropism in highly permiss

30 Using Ixodes scapularis ticks and age-matched mice purchased from two independen

31 other challenges faced by the spirochete in ticks and animal reservoirs.

32 n and animal viruses that are transmitted by ticks and associated with serious or fatal disease.

33 mphal ticks, B. burgdorferi-infected nymphal ticks and B. mayonii-infected nymphal ticks by measuring

34 deletion mutants are unable to transmit from ticks and establish infection in mammalian hosts.

35 cs of FLEs-Hd at each developmental stage of ticks and in tissues at different reproductive statuses

36 During its transit between ticks and mammalian hosts, B. burgdorferi must dramatica

37 aks in window seals allowed entry of swallow ticks and swallow bugs.

38 -year-old Cretaceous amber showing that hard ticks and ticks of the extinct new family Deinocrotonida

39 say was developed to detectRickettsiaspp. in ticks and tissue samples from humans and laboratory anim

40 lly, current knowledge of haem auxotrophy in ticks and underscores the importance of haem and iron me

41 r cell type 2 immune responses to helminths, ticks, and certain other parasites.

42 ed from three different methods of infecting ticks, and they confirm and extend previous studies indi

43 ressing combinations of target sequences for tick- and vertebrate CNS-specific miRNAs were developed.

44 Ticks are currently among the most prevalent blood-feedi

45 Although ticks are important vectors of infectious emerging disea

46 The identification of pigeon ticks as a trigger of anaphylaxis would greatly improve

47 ipicephalus sanguineus sensu lato (brown dog ticks) as drivers of epidemic levels of Rocky Mountain s

48 ofile among uninfected I. scapularis nymphal ticks, B. burgdorferi-infected nymphal ticks and B. mayo

49 rs larval molting, indicative of its role in tick biology.

50 tive to doxycycline for treatment of African tick bite fever in some selective situations.

51 African tick bite fever is the most commonly encountered travel-

52 index patient acquired the disease through a tick bite in the province of Avila - 300 km away from th

53 f severe nocturnal anaphylaxis due to pigeon tick bite showing the diagnostic value of the extract an

54 eliosis, disseminate hematogenously from the tick bite site to the joints, the heart, and the central

55 igrans (EM) skin lesion that develops at the tick bite site typically between 7 and 14 days after inf

56 uitment of leukocytes to the location of the tick bite.

57 h a transient expression in the host only at tick-bite sites.

58 Tick bites constitute the primary sensitization source,

59 effectiveness of these pesticides to prevent tick bites or human tick-borne diseases is unknown.

60 he Flaviviridae family and is transmitted by tick bites.

61 associated with total IgE levels and recent tick bites.

62 metabolic capacity, spirochetes rely on the tick blood meal for nutrients and metabolic intermediate

63 erized unique lipocalins that play a role in tick blood-feeding and transmission of the most importan

64 ichia chaffeensis, an obligate intracellular tick-borne bacterium responsible for human monocytic ehr

65 SFTS phlebovirus (SFTSV) is an emerging tick-borne bunyavirus that was first reported in China i

66 Tick-borne Crimean-Congo hemorrhagic fever virus (CCHFV)

67 ombocytopenia syndrome (SFTS) is an emerging tick-borne disease endemic in parts of Asia.

68 Lyme borreliosis is the most common tick-borne disease in the northern hemisphere.

69 ato spirochetes, the causative agents of the tick-borne disease Lyme borreliosis, disseminate hematog

70 sehold risk of tick exposure or incidence of tick-borne disease.

71 In the northeastern United States, tick-borne diseases are a major public health concern.

72 An increasing number of emerging tick-borne diseases has been reported in the United Stat

73 se pesticides to prevent tick bites or human tick-borne diseases is unknown.

74 Measures for preventing tick-borne diseases should be evaluated against human ou

75 Information on human-tick encounters and tick-borne diseases was collected through monthly survey

76 Tick-borne encephalitis (TBE) is caused by a virus that

77 ferent types of CpG oligodeoxynucleotides or tick-borne encephalitis vaccine, which occurred in an S1

78 Tick-borne encephalitis virus (TBEV) is a flavivirus tha

79 Tick-borne encephalitis virus (TBEV) is a vector-transmi

80 lisporivir-susceptible virus, the flavivirus tick-borne encephalitis virus.

81 The virus causes tick-borne encephalitis, a severe infection of the CNS w

82 eloped a new approach for miRNA-targeting of tick-borne flavivirus (Langat virus, LGTV) in the duplic

83 To restrict tick-borne flavivirus (Langat virus, LGTV) vector tropis

84 BEV infection using the naturally attenuated tick-borne flavivirus Langat virus (LGTV).

85 rved in insect-specific, mosquito-borne, and tick-borne flaviviruses and flaviviruses with no known v

86 esulting kissing-loop interaction, common in tick-borne flaviviruses, supports a single pair of cycli

87 Lyme disease (LD), the most prevalent tick-borne illness in North America, is caused by Borrel

88 se prevails as the most commonly transmitted tick-borne infection in the United States, and serologic

89 smosis, a debilitating and potentially fatal tick-borne infection of cattle.

90 nferring significant host protection against tick-borne infection.

91 s on diagnosis, treatment, and prevention of tick-borne infections published in English from January

92 plasmosis (HGA), and babesiosis are emerging tick-borne infections.

93 table to increased risk of rickettsioses and tick-borne infectious diseases.

94 Human babesiosis is a tick-borne multisystem disease caused by Babesia species

95 n-Congo hemorrhagic fever virus (CCHFV) is a tick-borne Nairovirus of the Bunyaviridae family, causin

96 eding and transmission of the most important tick-borne pathogen in North America and Eurasia.

97 e agent of Mediterranean spotted fever, is a tick-borne pathogen that primarily infects microvascular

98 In the last decade, novel tick-borne pathogenic phleboviruses in the family Bunyav

99 ys the basis for future research on not only tick-borne phleboviruses but also all viruses and other

100 Tick-borne phleboviruses represent a growing threat to h

101 identified as a human pathogen causing hard tick-borne relapsing fever (HTBRF) across the Northern H

102 Tick-borne relapsing fever (RF) borreliosis is a neglect

103 The tick-borne rickettsial pathogen Anaplasma phagocytophilu

104 ll-based model that allows production of the tick-borne Uukuniemi virus to high titers.

105 thrombocytopenia syndrome (SFTS) is a novel tick-borne viral disease with high mortality.

106 Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral hemorrhagic disease seen exclusively in

107 ore, ensure the environmental safety of live tick-borne virus vaccine candidates.

108 ORTANCE SFTS phlebovirus (SFTSV) and related tick-borne viruses have emerged globally since 2009.

109 Tick-borne viruses include medically important zoonotic

110 ia mosquito population control programs, for tick-borne viruses only vaccination remains the reliable

111 ff hypothesis is assumed to be applicable to tick-borne viruses too, although studies are lacking.

112 Babesiosis is a tick-borne zoonosis caused by protozoans of the genus Ba

113 Rocky Mountain spotted fever, a tick-borne zoonosis caused by Rickettsia rickettsii, is

114 use of acute febrile illness and an emerging tick-borne zoonosis in the United States.

115 sis caused by Babesia microti is an emerging tick-borne zoonosis of increasing importance due to its

116 d interaction region were able to persist in ticks but failed to transmit to mice or to establish inf

117 ymphal ticks and B. mayonii-infected nymphal ticks by measuring metabolism every 24 hours over the co

118 th this study, we have developed an in vitro tick cell-based model that allows production of the tick

119 protein GC was mainly highly mannosylated on tick cell-derived viral progeny.

120 1 cells, suggesting a higher infectivity for tick cell-derived viruses.

121 cate that UUKV particles derived from vector tick cells have glycosylation and structural specificiti

122 hanisms for infection in both vertebrate and tick cells, including remodeling of the cytoskeleton, in

123 ilum burden in both tick salivary glands and tick cells.

124 host but affected the bacterial survival in tick cells.

125 philum survival and isoatp4056 expression in tick cells.

126 ction, which already occurs in prediabetes ("ticking clock hypothesis").

127 This same genospecies was detected in ticks collected at a probable patient exposure site.

128 OspA is required for normal tick colonization and has been shown to bind a tick midg

129 Tick colonization by spirochetes lacking OspA is increas

130 further study the importance of OspA during tick colonization, we constructed a form of B. burgdorfe

131 ntibody and serves an additional role during tick colonization.

132 ral intra-host diversity was detected in the tick compared to the vertebrate host.

133 r in vitro growth conditions mimicking unfed ticks compared to the level in fed ticks, while the leve

134 a spp. in 19 ticks (8%); Rickettsia-infected ticks contained R. rhipicephali (16 of 250, 6.4%) or R.

135 The saliva of ixodid ticks contains a mixture of bioactive molecules that tar

136 of potential molecular targets for efficient tick control.

137 ntified and found to be present in 20-91% of ticks, depending on the year of collection.

138 By using eculizumab and the tick-derived C5 inhibitor coversin, we determined condit

139 elective attenuation of viral replication in tick-derived cells.

140 ver were severely restricted to replicate in tick-derived cells.

141 By shedding light on molecular aspects of tick-derived viral particles, our data illustrate the im

142 ilipii, in a population of the Pacific Coast tick, Dermacentor occidentalis in Mendocino County sampl

143 ks, mice fed upon by the DeltacheY2-infected ticks did not develop a persistent infection in the muri

144 Our results broaden the current knowledge of tick digestive system and may lead to the discovery of p

145 We demonstrated, by membrane feeding, that ticks do not acquire bioavailable iron from haemoglobin-

146 Tick drags were conducted 3-4 weeks after treatment on 1

147 pecially humans, and their potential role in tick ecology.

148 tively, these results not only indicate that ticks elicit variable fibrinogenolysis upon feeding on h

149 Information on human-tick encounters and tick-borne diseases was collected th

150 genic strain of Francisella, indicating that tick endosymbionts can evolve from mammalian pathogens.

151 These findings provide insight into early tick evolution and ecology, and shed light on poorly kno

152 spatial and temporal variation in levels of tick exposure and temporal variation in environmental co

153 aris ticks from regions of suspected patient tick exposure and tested them by oppA1 PCR.

154 t significantly reduce the household risk of tick exposure or incidence of tick-borne disease.

155 He had no known tick exposure.

156 ptember and were often associated with known tick exposures.

157 rooms, hallways, and stairwells; 17% of the ticks fed on humans.

158 on immunodeficient animals in comparison to ticks fed on immunocompetent animals.

159 on immunodeficient animals in comparison to ticks fed on immunocompetent animals.

160 d fibrinogenolytic activity in comparison to ticks fed on immunocompetent animals.

161 immune backgrounds as a model, we show that ticks fed on immunodeficient animals demonstrate decreas

162 Increased engorgement weights were noted for ticks fed on immunodeficient animals in comparison to ti

163 (fibrin degradation product) were evident in ticks fed on immunodeficient animals in comparison to ti

164 Tick saliva facilitates tick feeding and infection of the host.

165 utes to differential fibrinogenolysis during tick feeding.

166 athway of the host physiological response to tick feeding.

167 a activates an antimicrobial response within ticks feeding on blood.

168 iding in the tick vector, competing with the tick for nutrients in the blood meal.

169 g that OspA both protects spirochetes within ticks from mammalian antibody and serves an additional r

170 We collected Ixodes scapularis ticks from regions of suspected patient tick exposure an

171 yielded a strain that produces OspC within a tick (from the fusion gene) and during early mammalian i

172 nization increases the expression of several tick gut genes including pixr, encoding a secreted gut p

173 This study highlights the role of the tick gut in actively managing its microbiome, and how th

174 ations influence the spirochete entering the tick gut in multiple ways.

175 a tick secreted protein (PIXR) modulates the tick gut microbiota and facilitates B. burgdorferi colon

176 IAFGP thereby perturbs the tick gut microbiota, which influences the integrity of t

177 We noted that tick gut transcriptomes are subject to substantial tempo

178 he ability of B. burgdorferi to colonize the tick gut.

179 cisella-like endosymbiont (FLEs-Hd) from the tick Haemaphysalis doenitzi and evaluated the putative f

180 Ixodes scapularis ticks harbor numerous human pathogens, including Anaplas

181 hts into the molecular mechanisms underlying tick hematophagy, pathogen transmission, and tick-host-p

182 contributes to the invasion of mammalian and tick host cells.

183 Long-term association of CCHFV with its tick host for 1 year demonstrated mutations in the viral

184 expansions of gene families associated with tick-host interactions.

185 Herein, we challenge the evidence of tick-host-pathogen coevolution by hypothesizing that A.

186 tick hematophagy, pathogen transmission, and tick-host-pathogen interactions.

187 be developed targeted at both vertebrate and tick hosts for more complete control of A. phagocytophil

188 otility to invade and colonize mammalian and tick hosts.

189 ductive infection within vertebrate, but not tick, hosts.

190 The tick IMD network protects against colonization by three

191 service employees who are highly exposed to ticks in comparison with a residential population and a

192 analyses into parasitic processes unique to ticks, including host 'questing', prolonged feeding, cut

193 Tick-induced allergy to red meat is associated with anti

194 ubiquitously expressed throughout the rodent-tick infection cycle.

195 ipoproteins at different stages of its mouse-tick infectious cycle.

196 eminated Lyme disease (12 to 13 months after tick inoculation) in doxycycline-treated (28 days; 5 mg/

197 During this period, ticks internalise components of host blood by endocytic

198 iron metabolism as rational targets for anti-tick interventions.

199 Control of salivary secretion in ticks involves autocrine dopamine activating two dopamin

200 A daggerCornupalpatum burmanicum hard tick is entangled in a pennaceous feather.

201 s; however, the viability of cheD mutants in ticks is marginally reduced compared to that of the wild

202 The black-legged tick Ixodes scapularis transmits the human anaplasmosis

203 rrelia burgdorferi, colonizes the gut of the tick Ixodes scapularis, which transmits the pathogen to

204 agent of Lyme disease, is transmitted by the tick Ixodes scapularis.

205 Additionally, ticks lacking the transcription factor STAT, which signa

206 places the three I. ricinus lipocalins with tick lipocalins that sequester monoamines, leukotrienes

207 the environments encountered throughout its tick-mammal infectious cycle.

208 To reproduce the tick-mammal switch in vitro, we first established a reve

209 udies to determine the role of BTA121 in the tick-mammalian transmission cycle of B. turicatae.

210 on the 150 kb linear megaplasmid during the tick-mammalian transmission cycle, including bta121.

211 m infection at 10 mg/kg in a murine model of tick-mediated transmission of B. burgdorferi CONCLUSIONS

212 s are able to survive normally in the Ixodes ticks, mice fed upon by the DeltacheY2-infected ticks di

213 protein, indicating that OspA may serve as a tick midgut adhesin.

214 lood by endocytic digest cells that line the tick midgut epithelium.

215 ck colonization and has been shown to bind a tick midgut protein, indicating that OspA may serve as a

216 Mouse-tick-mouse infection assays indicated that CheD is dispe

217 log using genetics and biochemical and mouse-tick-mouse infection cycle studies.

218 Cretaceous amber showing that hard ticks and ticks of the extinct new family Deinocrotonidae fed on b

219 ed markedly whether viruses were produced in tick or BHK-21 cells, suggesting a higher infectivity fo

220 Ticks (order Ixodida) vector pathogenic bacteria that ca

221 of ticks with IFNgamma induced IGTPase, and ticks parasitizing IFNgamma knockout mice, failed to upr

222 ities recommend use of acaricides to control tick populations in yards, the effectiveness of these pe

223 Unlike most eukaryotes, ticks possess an incomplete haem biosynthetic pathway an

224 gests that previously-described members of a tick protein family bearing high sequence homology to Ja

225 How tick proteins regulate immune signaling, however, is inc

226 tions has revealed a wide range of bioactive tick proteins.

227 in DNA methylation at these sites defines a tick rate which correlates with the estimated rate of st

228 y of ageing and will allow modulation of its ticking rate and resetting the clock in vivo to study th

229 heir distribution and population dynamics in ticks remains meager.

230 However, ticks require dietary haemoglobin as an exogenous source

231 entic virus isolated from the Ixodes ricinus tick reservoir.

232 Studies in ticks, reservoir hosts, and humans indicate that coinfec

233 evelopment in Ankole, and heat tolerance and tick resistance across African cattle especially in zebu

234 In particular, the tick Rhipicephalus sanguineus has been shown to produce

235 mune-modulatory lipocalin from the Brown Ear Tick (Rhipicephalus appendiculatus), have been determine

236 Tick saliva contains a number of effector molecules that

237 Dog tick saliva contains polyvalent CC-chemokine binding pep

238 Tick saliva facilitates tick feeding and infection of th

239 Tick saliva is a rich source of antihemostatic compounds

240 before transmission to a vertebrate host via tick saliva.

241 Gene expression analysis of tick salivary glands and other tissues involved in host-

242 ession and A. phagocytophilum burden in both tick salivary glands and tick cells.

243 High-throughput sequencing of tick salivary glands has thus become a major focus, reve

244 that redundancy and pluripotency evolved in tick salivary immunomodulators to evade immune recogniti

245 We propose that tick salivary prostaglandin E2 triggers antibody class s

246 Tick salivary proteins cluster in multigenic protein fam

247 To prolong residence on their hosts, ticks secrete many salivary factors that target host def

248 Ticks secrete several anti-hemostatic factors in their s

249 Here, the authors show that a tick secreted protein (PIXR) modulates the tick gut micr

250 or visceral transcriptomes of numerous hard ticks, spanning the genera Rhipicephalus, Amblyomma, and

251 n model for CCHFV, utilizing the main vector tick species and mice plus next generation sequencing, w

252 ptides from salivary transcriptomes of eight tick species in Rhipicephalus and Amblyomma genera.

253 g evasin proteins are widely expressed among tick species of the Ixodidae family, are likely to play

254 otential to bind monoamines similar to other tick species previously reported.

255 bacteria) have been characterized in several tick species, whereas knowledge on their distribution an

256 as a novel thrombin inhibitor from the same tick species.

257 the ospB gene, encoding a mammal-specific or tick-specific lipoprotein, respectively.

258 or tropism, we inserted target sequences for tick-specific microRNAs (mir-1, mir-275 and mir-279) ind

259 Here we show that the related, tick-specific protein OspB can fully substitute for OspA

260 from host antibody, which will not recognize tick-specific proteins such as OspA.

261 blood meal among the three groups of nymphal ticks suggest that B. mayonii and B. burgdorferi may hav

262 tubules, salivary glands and midguts of the ticks, suggesting that FLEs-Hd presumably is a crucial s

263 of these bunyaviruses in sampled Dermacentor ticks suggests that they may be viral endosymbionts, alt

264 oi is a relapsing fever spirochete in Ixodes ticks that has been recently identified as a human patho

265 While most cases are transmitted by Ixodes ticks, the disease may also be transmitted through blood

266 min and its derivatives in Ixodes scapularis ticks, the enzootic vector of Bb, is extremely low.

267 predict that this honey bee population is a ticking time-bomb, protected by its isolated position an

268 dge on the transcriptomics and proteomics of tick tissues from a systems-biology perspective and disc

269 y an interspecies signaling cascade allowing ticks to detect invading bacteria and mount microbicidal

270 A. phagocytophilum induces ticks to express Ixodes scapularis antifreeze glycoprote

271 spectrum of host defense mechanisms to allow ticks to feed on the vertebrate host for several days.

272 acquisition by the vector, transmission from ticks to hosts, or induction of disease.

273 opod vector (e.g., mosquitos, sandflies, and ticks) to spread throughout human populations.

274 stitute the primary sensitization source, as ticks transfer alpha-gal in their saliva to a host durin

275 Tick transmission of Borrelia spirochetes to humans resu

276 Ticks transmit more pathogens to humans and animals than

277 use of thiamin, Borrelia, and perhaps other tick-transmitted bacterial pathogens, are uniquely adapt

278 Infections with tick-transmitted Borreliella (Borrelia) burgdorferi, the

279 In healthy individuals, tick-transmitted infection with Babesia causes no specif

280 he spirochete that causes Lyme disease, is a tick-transmitted pathogen that requires motility to inva

281 Babesia microti, a tick-transmitted, intraerythrocytic protozoan parasite c

282 ats the spirochetes from the time they enter ticks until they are transmitted to a mammal.

283 etabolic intermediates while residing in the tick vector, competing with the tick for nutrients in th

284 selves for extended periods of time in their tick vectors and vertebrate reservoirs is crucial for co

285 of spirochete survival and multiplication in tick vectors before transmission to a vertebrate host vi

286 athogens, are uniquely adapted to survive in tick vectors before transmitting to mammalian hosts.

287 of different Lyme disease spirochetes within tick vectors could potentially aid development of novel

288 gene is up-regulated by B. turicatae in the tick versus the mammal, and the encoded protein (BTA121)

289 enetically modified viruses into sustainable tick-vertebrate host transmission cycle in nature.

290 Deer tick virus (DTV), a genetic variant (lineage II) of Powa

291 We also describe a variant of Jingmen tick virus, another Jingmenvirus, sequenced from a Ugand

292 ts, and RNA from each individually extracted tick was deep sequenced to an average depth of 7.3 milli

293 he province of Caceres, where viral RNA from ticks was amplified in 2010.

294 250 adults of this human-biting, generalist tick were collected from contiguous chaparral and grassl

295 GS assay detectedRickettsiaDNA in 45% of the ticks, while the amplification rates of the other three

296 ing unfed ticks compared to the level in fed ticks, while the levels of PotD were similar under the a

297 Evolution has provided ticks with an arsenal of bioactive saliva molecules that

298 Microinjection of ticks with IFNgamma induced IGTPase, and ticks parasitiz

299 he application of quantitative proteomics to ticks with unknown genomes has provided deeper insights

300 ionts (CLEs and FLEs, respectively) occur in ticks worldwide.