ライフサイエンスコーパス: tidal volume

1 Mechanical ventilation with low tidal volume.

2 ty index and the coefficient of variation of tidal volume.

3 odal, tsDCS induced a persistent increase in tidal volume.

4 currents by hypoxia were unaffected by high tidal volume.

5 forces) contribute a negligible fraction of tidal volume.

6 ng aeration and the regional distribution of tidal volume.

7 e respiratory system (r = .58), but not with tidal volume.

8 ceiving mechanical ventilation with very low tidal volume.

9 by titration of the respiratory rate and/or tidal volume.

10 sk of ICU mortality compared with subsequent tidal volumes.

11 with saline lavage and augmented using large tidal volumes.

12 in patients receiving ventilation with lower tidal volumes.

13 001), whereas we detected no association for tidal volume (1.05, 0.98-1.13; p=0.179).

14 3%; 95% CI, 1.01-1.05; P = 0.004), decreased tidal volume (-1.7 ml; 95% CI, -3.3 to -0.2; P = 0.03),

15 were mechanically ventilated using moderate tidal volume (12 ml/kg).

16 rtery disease, or acute hemorrhage (1B); low tidal volume (1A) and limitation of inspiratory plateau

17 Low tidal volume (2.9-4 ml/kg ideal body weight) and poor co

18 identified by prior work: 1) lung-protective tidal volume, 2) appropriate setting of positive end-exp

19 mL/kg), and mechanical ventilation with high tidal volume (20 mL/kg).

20 volume ventilation (high tidal volume group, tidal volume 25 mL/kg, zero positive end-expiratory pres

21 inflation; high-stretch group received high tidal volume (30-32 mL/kg) with positive end-expiratory

22 With increasing tidal volume (4, 6, 8, and 10 mL/kg), the change in intr

23 trong for mechanical ventilation using lower tidal volumes (4-8 ml/kg predicted body weight) and lowe

24 Adding extracorporeal CO2 removal at tidal volume 6 mL/kg decreased PaCO2 by 21% (95% CI, 17-

25 Baseline corresponded to tidal volume 6 mL/kg of predicted body weight without ex

26 ariation, and cardiac index were recorded at tidal volume 6 mL/kg predicted body weight and 1 minute

27 nd-expiratory occlusion test obtained during tidal volume 6 mL/kg predicted body weight did not predi

28 d-expiratory occlusion test was performed at tidal volumes 6 and 8 mL/kg predicted body weight and af

29 trol group), mechanical ventilation with low tidal volume (6 mL/kg), and mechanical ventilation with

30 generated tidal volume values (n = 600; mean tidal volume = 6 mL/kg), with a 30% coefficient of varia

31 n, i.e., mechanical ventilation with eupneic tidal volume (7 mL .kg) at low end-expiratory lung volum

32 cols for 3 hours: control group received low tidal volume (7 mL/kg) with positive end-expiratory pres

33 p < 0.01), possibly as a result of a higher tidal volume (7.2 mL/kg [6.7-8.8] vs. 5.8 [5.1-6.8]; p =

34 two-thirds of patients with ARDS received a tidal volume 8 of mL/kg or less of predicted body weight

35 low tidal volume ventilation (control group, tidal volume 9 mL/kg, positive end-expiratory pressure 5

36 th moderate-to-severe hypoxemia, the expired tidal volume above 9.5 mL/kg predicted body weight accur

37 In these patients, the expired tidal volume above 9.5 mL/kg predicted body weight predi

38 ure levels (until day 7) and lower delivered tidal volume after 3 days on extracorporeal membrane oxy

39 Increased tidal volume after cathodal tsDCS opens up the perspecti

40 The fraction of the total tidal volume allocated for alveolar inflation is 34 +/-

41 It has been suggested that use of lower tidal volumes also benefits patients who do not have ARD

42 ventilation may be associated with increased tidal volume and alveolar pressure that could contribute

43 riability index, coefficient of variation of tidal volume and apnoea-hypopnoea index were increased i

44 This effect was due to both decreased tidal volume and breathing frequency.

45 High tidal volume and cecal ligation and perforation increase

46 sure distribution, how this is influenced by tidal volume and chest compliance, and its interaction w

47 m H2O) were noted, with significantly higher tidal volume and compliance at PEEP10 and PEEP5 than PEE

48 Furthermore, increased tidal volume and decreased chest compliance decreased st

49 Increased tidal volume and decreased chest wall compliance both in

50 ECCO2R enables reductions in tidal volume and driving pressure, key determinants of v

51 urs with matched lung strains (ratio between tidal volume and functional residual capacity) but diffe

52 compared with a ventilation strategy of low tidal volume and high positive end-expiratory pressure,

53 ist ventilation increased the variability of tidal volume and improved oxygenation and venous admixtu

54 We assessed expired tidal volume and its association with noninvasive ventil

55 ort), arterial blood gases, airway pressure, tidal volume and its coefficient of variation, respirato

56 ammation than atelectrauma at comparable low tidal volume and lower driving pressure, suggesting that

57 Lung-protective ventilation with lower tidal volume and lower plateau pressure improves mortali

58 A relationship between tidal volume and mortality in mechanically ventilated ch

59 There was no association between tidal volume and mortality when tidal volume was dichoto

60 12 mL/kg also showed no association between tidal volume and mortality.

61 pressure, respiratory carbon dioxide levels, tidal volume and peroneal nerve muscle sympathetic activ

62 the ventilation protocol, noncompliance with tidal volume and plateau pressure targets was associated

63 yndrome Network protocol recommends limiting tidal volume and plateau pressure; it also recommends in

64 Tidal volume and positive end-expiratory pressure had no

65 Tidal volume and respiratory rate were recorded from the

66 itude of the peak coherence function between tidal volume and RSNA frequency spectra.

67 sis was to determine the association between tidal volume and the occurrence of pulmonary complicatio

68 ect harmful forms of OTV including excessive tidal volumes and common forms of patient-ventilator asy

69 Effects of two study interventions (lower tidal volumes and fluid-conservative hemodynamic managem

70 rgeting lung recruitment with the use of low tidal volumes and high positive end-expiratory pressure.

71 nly during mechanical ventilation with large tidal volumes and limitedly to subpleural alveoli.

72 prolonged mechanical ventilation with large tidal volumes and normal end-expiratory lung volume.

73 Protective mechanical ventilation with lower tidal volumes and PEEP reduces compounded postoperative

74 g-protective ventilation with the use of low tidal volumes and positive end-expiratory pressure is co

75 igh respiratory drive and breathe with large tidal volumes and potentially injurious transpulmonary p

76 ute ventilation), 0.25 mL/kg (airway opening tidal volume), and 13.7% (plethysmography tidal volume)

77 Minute ventilation, tidal volume, and breathing frequency were measured befo

78 Transcutaneous carbon dioxide, tidal volume, and minute ventilation may assist in refin

79 studies, the parameters of respiratory rate, tidal volume, and minute volume were measured using whol

80 ventilation settings (i.e. plateau pressure, tidal volume, and positive end-expiratory pressure) on I

81 n inability to increase breathing frequency, tidal volume, and, thus, minute ventilation in response

82 ediator-but not functional-responses to high tidal volume are augmented by subthreshold sepsis primin

83 Significantly smaller tidal volumes are achieved at higher frequencies (>6 Hz)

84 ion; and atelectasis group received the same tidal volume as control but neither positive end-expirat

85 2 patients with ARDS with 11,558 twice-daily tidal volume assessments (evaluated in milliliter per ki

86 ether 1) mechanical ventilation with eupneic tidal volume at low end-expiratory lung volume causes pl

87 rolonged mechanical ventilation with eupneic tidal volume at low end-expiratory lung volume followed

88 om that of mechanical ventilation with large tidal volume at normal end-expiratory lung volume.

89 The median (interquartile range) expired tidal volume averaged over all noninvasive ventilation s

90 proved in the intervention group (use of low tidal volumes, avoidance of heavy sedation, use of centr

91 /kg predicted body weight and after reducing tidal volume back to 6 mL/kg predicted body weight.

92 ing a simple algorithm targeting the expired tidal volume between 6 and 8 mL/kg of predicted body wei

93 and carbon dioxide, minute ventilation, and tidal volume (both at airway opening and by inductive pl

94 hoalveolar lavage and plasma mediators; high tidal volume but not cecal ligation and perforation impa

95 Priming of high tidal volume by cecal ligation and perforation intensifi

96 A low or moderate expired tidal volume can be difficult to achieve during noninvas

97 r mechanical ventilation, which, with higher tidal volume, can cause ventilator-associated lung injur

98 Mechanical ventilation with large tidal volume caused the appearance of plasma membrane di

99 e, positive end-expiratory pressure, DeltaP, tidal volume, Cdyn, and PaO2/FIO2 were collected at acut

100 ined by transiently increasing tidal volume (tidal volume challenge) are superior to pulse pressure v

101 to 8 mL/kg predicted body weight, that is, "tidal volume challenge," the changes in pulse pressure v

102 redicted body weight and 1 minute after the "tidal volume challenge." The tidal volume was reduced ba

103 Tidal volume changes (DeltaV(T)) followed the same trend

104 ptor activity (major breathing frequency and tidal volume changes did not alter vagal tone or sympath

105 In addition, oscillatory tidal volume changes were assessed at each pressure step

106 ry pressure of at least 5 cm of water, and a tidal volume close to 6 ml per kilogram of predicted bod

107 ed that C-26 mice have a significantly lower tidal volume compared to controls under basal conditions

108 reover, a 1 ml/kg PBW increase in subsequent tidal volumes compared with the initial tidal volume was

109 ng tidal volume), and 13.7% (plethysmography tidal volume) compared with total lung capacity levels.

110 gnificant dynamic hyperinflation and greater tidal volume constraints (P<0.05).

111 ate gas exchange is achieved with very small tidal volumes cycling at a high mean airway pressure.

112 ; or 7) cecal ligation and perforation, high tidal volume, dexamethasone.

113 am, high tidal volume, saline; 5) sham, high tidal volume, dexamethasone; 6) cecal ligation and perfo

114 atory lung volume increased (P < 0.001), and tidal volume did not change (P = 0.44); the ratio of tid

115 olume change (sVol), defined as the regional tidal volume divided by the regional end-expiratory gas

116 decrease in the rib cage contribution to the tidal volume during phasic REM sleep becomes a critical

117 8 mL/kg predicted body weight, and the mean tidal volume during the first 72 hours after acute respi

118 xpiratory pressure, DeltaP [PIP minus PEEP], tidal volume, dynamic compliance [Cdyn]) or oxygenation

119 Selecting a smaller initial tidal volume for non-white patients and patients with hi

120 Sixty tidal volumes for each ventilator settings were analyzed

121 and stroke volume variation after increasing tidal volume from 6 to 8 mL/kg predicted body weight pre

122 and stroke volume variation after increasing tidal volume from 6 to 8 mL/kg predicted body weight wer

123 hypothesized that with transient increase in tidal volume from 6 to 8 mL/kg predicted body weight, th

124 here was a reduction in emergency department tidal volume from 8.1 mL/kg predicted body weight (7.0-9

125 Tidal volume gradients between the 2 groups did not infl

126 roup, and in 31% of the patients in the high tidal volume group (adjusted odds ratio [low vs high tid

127 nhibitor 3-aminobenzamide (10 mg/kg IP, high tidal volume group + 3-aminobenzamide group, n = 7).

128 /kg predicted body weight), an "intermediate tidal volume group" (> 7 and < 10 mL/kg predicted body w

129 10 mL/kg predicted body weight), and a "high tidal volume group" (>/= 10 mL/kg predicted body weight)

130 entilation, patients were assigned to a "low tidal volume group" (tidal volumes </= 7 mL/kg predicted

131 roup, in 28% of patients in the intermediate tidal volume group, and in 31% of the patients in the hi

132 monia occurred in 23% of patients in the low tidal volume group, in 28% of patients in the intermedia

133 n = 15), high tidal volume ventilation (high tidal volume group, tidal volume 25 mL/kg, zero positive

134 lume group (adjusted odds ratio [low vs high tidal volume group], 0.72; 95% CI, 0.52-0.98; p = 0.042)

135 ion, the following are recommended: 1) avoid tidal volumes > or =10 mL/kg body weight; 2) keep platea

136 mechanical ventilation with the use of lower tidal volumes has been found to improve outcomes of pati

137 With tidal volume held constant, negligible changes occurred

138 might further justify implementation of low tidal volume/high positive end-expiratory pressure venti

139 erapy, mechanical ventilation with injurious tidal volumes, hospital-acquired aspiration, and volume

140 in the KF reduced respiratory frequency and tidal volume in anaesthetized rats.

141 aphragmatic stimulation generated sufficient tidal volumes in all STIM animals.

142 n minutes]: OR, 1.14, 95% CI, 1.05-1.24; and tidal volume [in milliliters per kilogram of predicted b

143 om "very high" to more "clinically relevant" tidal volumes induce similar pathophysiologies in health

144 Mechanical ventilation at high tidal volume induces reactive oxygen species production

145 bution due to the change in lung height with tidal volume inflation are probably bigger contributors

146 A low expired tidal volume is almost impossible to achieve in the majo

147 emic respiratory failure, and a high expired tidal volume is independently associated with noninvasiv

148 Ventilation with low tidal volumes is associated with a lower risk of develop

149 Protective mechanical ventilation with low tidal volumes is standard of care for patients with acut

150 Comparing patients ventilated with tidal volume less than 7 mL/kg and greater than 10 mL/kg

151 r than 10 mL/kg or greater than 12 mL/kg and tidal volume less than 8 mL/kg and greater than 10 mL/kg

152 In total, 54.4% of patients received a tidal volume less than 8 mL/kg predicted body weight, an

153 urgery, and received ventilation with higher tidal volumes, lower positive end-expiratory pressure le

154 e treated with low tidal volume ventilation (tidal volume < 6.5 mL/kg predicted body weight) at some

155 Exclusion criteria were: Arrhythmia, tidal volume <8 mL/kg, left ventricular ejection fractio

156 were assigned to a "low tidal volume group" (tidal volumes </= 7 mL/kg predicted body weight), an "in

157 The current study elucidated the effects of tidal volume lung inflation [functional residual capacit

158 Tidal volume lung inflation results in structural change

159 hesion molecule-1 protein levels in the high-tidal volume lungs (p < 0.0001).

160 High stress despite low tidal volumes may worsen lung injury and increase risk o

161 n (5% in 1998 to 14% in 2010), a decrease in tidal volume (mean 8.8 ml/kg actual body weight [SD = 2.

162 High tidal volume mechanical ventilation and the resultant ex

163 When compared with low-tidal volume mechanical ventilation, high-tidal volume v

164 filtrates" on the chest radiograph report, a tidal volume of >8 mL/kg predicted body weight (based on

165 during controlled mechanical ventilation at tidal volume of 4, 6, 8, and 10 mL/kg with normal and de

166 DS with lung-protective ventilation, using a tidal volume of 6 mL per kg of predicted bodyweight and

167 lavage, the LTVV group was ventilated with a tidal volume of 6 mL/kg and progressively higher positiv

168 prototypical patient receiving 8 days with a tidal volume of 6 ml/kg PBW, the absolute increase in IC

169 t (ventilator-induced lung injury) lung with tidal volume of approximately 3 mL/kg and 1) high positi

170 during controlled mechanical ventilation at tidal volumes of 4, 6, 8, and 10 mL/kg with normal and d

171 tional assist ventilation at comparable mean tidal volumes of 6 mL/kg.

172 ent populations to understand the effects of tidal volume on patient outcome.

173 mechanical ventilation strategies using low tidal volume or high levels of positive end-expiratory p

174 g for PaO2/FIO2 and either driving pressure, tidal volume, or plateau pressure and positive end-expir

175 In scenarios with variation in tidal volume over the 8-day period, mortality was higher

176 intervention phase was associated with lower tidal volume (P < 0.01), higher positive end-expiratory

177 and/or sedatives and ventilator parameters (tidal volume per ideal body weight, positive end-expirat

178 risk of hospital death based on quantiles of tidal volume, positive end-expiratory pressure, plateau

179 th significant changes (p < 0.01 for all) in tidal volume, positive end-expiratory pressure, respirat

180 also correlated significantly on oscillatory tidal volume/pressure relationships (mean r = 0.81 +/- 0

181 text]e/[Formula: see text]co2, dead space to tidal volume ratio (Vd/Vt), and arterial to end-tidal CO

182 0.80 to -0.84; P < 0.001) but not dead space/tidal volume ratio.

183 olume of nondependent and dependent regions, tidal volume reaching nondependent and dependent lung (V

184 ger photoplethysmographic arterial pressure, tidal volume, respiratory carbon dioxide concentrations

185 Changes in PaO2/Fio2 ratio, tidal volume, respiratory rate, mean airway pressure, pl

186 Secondary outcomes included tidal volume, respiratory rate, minute volume, dynamic l

187 piratory rate, accompanied by an increase in tidal volume, resulting in little change in minute volum

188 nonventilated, dexamethasone; 4) sham, high tidal volume, saline; 5) sham, high tidal volume, dexame

189 one; 6) cecal ligation and perforation, high tidal volume, saline; or 7) cecal ligation and perforati

190 Higher tidal volumes shortly after ARDS onset were associated w

191 inhibition, (2) nonlinear complexity of the tidal volume signal (related to medullary ventilatory co

192 Based on the tertiles of tidal volume size in the first 2 days of ventilation, pa

193 Tidal volume, static compliance, tidal impedance variati

194 ed with mechanical ventilation using the low tidal volume strategy as per the Acute Respiratory Distr

195 lity, but these levels are not influenced by tidal volume strategy.

196 Even when not increasing tidal volume, strong spontaneous effort may potentially

197 -expiratory pressure to avoid atelectasis, a tidal volume that is limited to less than 5-7 cc/kg per

198 lable high-frequency ventilators may deliver tidal volumes that approach the magnitude of those deliv

199 ndent to dependent regions without change in tidal volume) that was caused by spontaneous breathing d

200 We investigated the association of tidal volume, the level of PEEP, and driving pressure du

201 variation obtained by transiently increasing tidal volume (tidal volume challenge) are superior to pu

202 Lowering tidal volume to 4 mL/kg reduced minute ventilation from

203 Inspiratory pressure was adjusted to control tidal volume to 5-7 mL/kg, maintaining a plateau pressur

204 lume did not change (P = 0.44); the ratio of tidal volume to DeltaPes (an estimate of dynamic lung co

205 ation and lung aeration by redistribution of tidal volume to dependent lung regions.

206 n of the abdomen, expressed as percentage of tidal volume to evaluate expiratory flow limitation.

207 elluft, which occurred despite limitation of tidal volume to less than 6 ml/kg.

208 , and estimate the respiration rate (RR) and tidal volume (TV) from analysis of electrocardiographic

209 d Hering-Breuer mechanoreflex, and increased tidal volume under normal conditions.

210 Tidal volumes up to 20 mL/kg are unlikely to induce subs

211 esthetized mice were ventilated with various tidal volumes up to 40 mL/kg.

212 There is substantial variability in tidal volumes used in these studies and no certainty abo

213 r supine sheep were mechanically ventilated (tidal volume V(T) = 8 mL/kg, respiratory rate adjusted t

214 acing under normocapnic conditions increased tidal volume (V(T)) and each inspiration was preceded by

215 y driving pressure (DP(AW)), the quotient of tidal volume (V(T)), and respiratory system compliance (

216 ositive end-expiratory pressures (PEEPs) and tidal volumes (V(T)s) were selected.

217 th basis as a sequence of randomly generated tidal volume values (n = 600; mean tidal volume = 6 mL/k

218 oportional assist ventilation yielded higher tidal volume variability than pressure support ventilati

219 injection) 3 days consecutively before high tidal volume ventilation (30 mL/kg, 4 hrs) at day 4.

220 ts were ventilated for 120 minutes using low tidal volume ventilation (control group, tidal volume 9

221 -expiratory pressure 5 cm H2O, n = 15), high tidal volume ventilation (high tidal volume group, tidal

222 venty patients (19.3%) were treated with low tidal volume ventilation (tidal volume < 6.5 mL/kg predi

223 The entire cohort received low tidal volume ventilation 11.4% of the time patients had

224 examining this association in the era of low tidal volume ventilation and a fluid conservative strate

225 y distress syndrome patients receiving lower tidal volume ventilation and to determine the factors th

226 Interventions that improve adoption of low tidal volume ventilation are needed.

227 Nine (29%) in the low-tidal volume ventilation arm did not meet predetermined

228 her evidence for early implementation of low tidal volume ventilation as well as new insights into th

229 High tidal volume ventilation during pneumonia/sepsis induces

230 bal lung stress varies considerably with low tidal volume ventilation for acute respiratory distress

231 ected to normal (7 mL/kg) or high (28 mL/kg) tidal volume ventilation for another 2 hrs.

232 zed mice were ventilated with injurious high tidal volume ventilation for periods up to 180 minutes.

233 ncy percussive ventilation group and the low-tidal volume ventilation group had similar demographics

234 frequency percussive ventilation and the low-tidal volume ventilation groups in mean (+/- sd) ventila

235 Although low tidal volume ventilation has been shown to reduce mortal

236 High tidal volume ventilation impaired phenylephrine- and ace

237 Previous studies reported poor low tidal volume ventilation implementation.

238 ow-tidal volume mechanical ventilation, high-tidal volume ventilation increased lung edema score and

239 d 34% waited more than 72 hours prior to low tidal volume ventilation initiation.

240 ely recognition of ARDS and adherence to low tidal volume ventilation is important for reducing morta

241 However, the effect of the timing of low tidal volume ventilation is not well understood.

242 Low tidal volume ventilation lowers mortality in the acute r

243 acute lung injury patients receiving lower tidal volume ventilation often have a plateau pressure t

244 ve end-expiratory pressure, n = 14), or high tidal volume ventilation plus the poly-(adenosine diphos

245 percussive ventilation with contemporary low-tidal volume ventilation strategies.

246 However, the low-tidal volume ventilation strategy failed to achieve vent

247 years after publication of the landmark low tidal volume ventilation study, use remains poor.

248 % were associated with increased odds of low tidal volume ventilation use.

249 ine the rate, quality, and predictors of low tidal volume ventilation use.

250 In unadjusted analysis, high tidal volume ventilation was associated with an increase

251 In multivariable modeling, high tidal volume ventilation was the strongest risk factor f

252 tilation) group and ventilated with 4-hr low tidal volume ventilation with spontaneous breathing or w

253 ur attending physicians (6.2%) initiated low tidal volume ventilation within 1 day of acute respirato

254 as 34 physicians (52.3%) never initiated low tidal volume ventilation within 1 day of acute respirato

255 ancements in critical care, aside from lower tidal volume ventilation, accounted for this improvement

256 that compared low with high PEEP during low tidal volume ventilation, an increase in the level of PE

257 Modifiable risk factors, including high tidal volume ventilation, are associated with its develo

258 ing trials, early exercise and mobility, low tidal volume ventilation, conservative fluid management,

259 Among patients who received low tidal volume ventilation, the mean (SD) percentage of ac

260 Women were less likely to receive low tidal volume ventilation, whereas sepsis and FIO2 greate

261 ventilation-based strategy (n = 31) or a low-tidal volume ventilation-based strategy (n = 31).

262 r clinical outcomes when compared with a low-tidal volume ventilation-based strategy in burn patients

263 High tidal volume ventilation-induced pulmonary vascular dysf

264 n predicting fluid responsiveness during low tidal volume ventilation.

265 ably predict fluid responsiveness during low tidal volume ventilation.

266 pressure greater than 30 cm H2O received low tidal volume ventilation.

267 put monitoring, and receiving controlled low tidal volume ventilation.

268 most threefold greater driving pressure (and tidal volume) versus spontaneous breathing (28.0 +/- 0.5

269 ng injury and profoundly susceptible to high tidal volume VILI, with increases in microvascular perme

270 ion of the RTN to breathing frequency (FR ), tidal volume (VT ) and minute volume (VE ) by inhibiting

271 od pressure, respiratory frequency (fR ) and tidal volume (VT ) were recorded in 28 conscious adult m

272 increased both breathing frequency (fR ) and tidal volume (VT ) whereas, in REM sleep, hypercapnia in

273 hypocapnic; central CO2 response slopes for tidal volume (VT ), breathing frequency (fb ) and rate o

274 Tidal volume (VT) and volume of gas caused by positive e

275 The protective role of a small tidal volume (VT) has been established, whereas the adde

276 stress Syndrome (ARMA) trial in 2000, use of tidal volume (VT) less than or equal to 6 mL/kg predicte

277 g regions (Vt%dep and Vt%(nondep)), regional tidal volumes (Vt(dep) and Vt(nondep)), and antero-poste

278 nspiratory (plateau) airway pressures, lower tidal volumes (VT), and higher positive end-expiratory p

279 s included ventilatory management (including tidal volume [VT] expressed as mL/kg predicted bodyweigh

280 d by a wide variety of changes in the depth (tidal volume, VT ) and number of breaths (respiratory fr

281 Lower tidal volumes (Vts) attenuate extrapulmonary organ injur

282 Tidal volume was 6 mL/kg in both groups.

283 an PaO2/FIO2 was 99 mm Hg +/- 41 mm Hg, mean tidal volume was 7.6 mL/kg +/- 1.8 mL/kg predicted body

284 uent tidal volumes compared with the initial tidal volume was associated with a 15% increase in morta

285 An increase of 1 ml/kg PBW in initial tidal volume was associated with a 23% increase in ICU m

286 Expired tidal volume was averaged and respiratory and hemodynami

287 tion between tidal volume and mortality when tidal volume was dichotomized at 7, 8, 10, or 12 mL/kg.

288 y weight [7.6-10.2]; p = 0.001), and expired tidal volume was independently associated with noninvasi

289 Mean tidal volume was kept at approximately 6 mL/kg in all mo

290 nute after the "tidal volume challenge." The tidal volume was reduced back to 6 mL/kg predicted body

291 Tidal volume was set at 8 ml/kg, and respiratory rate wa

292 At the end of recruitment, tidal volume was significantly higher (p = 0.002) and ox

293 The mean expired tidal volume was significantly higher in patients who fa

294 Tidal volume was subsequently reduced to 4 mL/kg for the

295 hout ARDS, protective ventilation with lower tidal volumes was associated with better clinical outcom

296 ninvasive ventilation sessions (mean expired tidal volume) was 9.8 mL/kg predicted body weight (8.1-1

297 nation, heart rate, transcutaneous PCO2, and tidal volume were simultaneously recorded at each airway

298 Tidal volumes were lower in conventional mechanical vent

299 We tested a strategy that combines the low tidal volume with lower respiratory rates and minimally

300 ransfected mice during inspiration increased tidal volume without altering inspiratory duration, wher