ライフサイエンスコーパス: tier

1 exed to Western immunoblotting as the second tier.

2 lla typhi were included in the high-priority tier.

3 standards, including all certifications from Tier 0 up to Partial Zero Emission Vehicle.

4 a(-1) yr(-1) and were best predicted by IPCC Tier 1 and DeltaEF emission factor approaches.

5 , and membrane-bound HIV-1 Env gp140 induced tier 1 and tier 2 neutralizing antibodies in a mouse mod

6 ith serious bleeding who does not respond to Tier 1 and Tier 2 therapies.

7 Env) vaccine candidates elicit predominantly tier 1 and/or autologous tier 2 virus neutralizing antib

8 i, a facultative intracellular bacterium and tier 1 biothreat, causes the fatal zoonotic disease glan

9 a into a genomic resource on par with ENCODE tier 1 cell lines and, importantly, is the only current

10 rgovernmental Panel on Climate Change (IPCC) Tier 1 default estimates of carbon storage with this tre

11 e fires, which are 58-7% of the current IPCC Tier 1 default value for all fires.

12 between Tier 2 autologous neutralization and Tier 1 heterologous neutralization, as well as overall T

13 Compared to estimates from the IPCC Tier 1 linear model, our updated N2 O emissions range fr

14 rgovernmental Panel on Climate Change (IPCC) tier 1 method has a SOC change factor of 1 (no SOC loss)

15 s and multiple effector functions, including tier 1 neutralization, antibody-dependent cellular cytot

16 he immunization regimen that correlated with Tier 1 neutralization.

17 Tier 1 options (rituximab, thrombopoietin receptor agoni

18 We exhaust all Tier 1 options before proceeding to Tier 2, which compri

19 2 drugs not alone but in combination with a Tier 1 or a second Tier 2 drug with a different mechanis

20 Since the organism is considered a tier 1 select agent according to the Centers for Disease

21 t MHF, and MARV is therefore classified as a Tier 1 select agent and a category A bioterrorism agent.

22 (LPS) of Francisella tularensis bacteria, a Tier 1 Select Agent of bioterrorism.

23 Burkholderia pseudomallei is a CDC tier 1 select agent that causes melioidosis, a severe di

24 Bacillus anthracis is a tier 1 select agent with the potential to quickly cause

25 antivirals and vaccines, EBOV is listed as a tier 1 select-agent risk group 4 pathogen.

26 y titers against homologous and heterologous tier 1 SIVs.

27 ad significantly weaker NAb activity against tier 1 subtype B viruses (P = 0.003 for SF-162 and P = 0

28 d NAb response against primary infecting and tier 1 subtype B viruses are more susceptible to superin

29 , but each has disadvantages relative to the tier 1 tests.

30 her ratio of tier 2 autologous titers versus tier 1 V3-sensitive titers than BG505 SOSIP.664.

31 layed earlier affinity maturation, achieving tier 1 virus neutralization compared with animals immuni

32 ially protective maternal plasma V3-specific tier 1 virus-neutralizing responses was dependent on the

33 ave serum neutralization activity limited to tier 1 viruses and antibody-dependent cytotoxicity respo

34 alizing responses against easy-to-neutralize tier 1 viruses were associated with reduced risk of peri

35 filtration model to predict residential AER (Tier 1), infiltration factors (Tier 2), indoor concentra

36 es (two in tier 3, 14 in tier 2, and four in tier 1).

37 neutralizing activity against primary HIV-1 tier 1, 2, and 3 strains and present a low rate of somat

38 Fifty-nine genes were ranked in tier 1, 44 in tier 2, 68 in tier 3, and 70 in tier 4.

39 ased on the strength of evidence as follows: tier 1, genes with 3 or more de novo pathogenic loss-of-

40 al sensitivities to antibody neutralization; tier-1 isolates are sensitive, whereas tier-2 isolates a

41 blocking glycans eliminated the induction of tier-1 NAbs to V3-epitopes.

42 erted two glycans into the dominant site for tier-1 NAbs, the gp120 V3 region, to block the induction

43 mers suppress elicitation of V3-directed and tier-1 neutralizing antibodies and induce robust autolog

44 vergent atypically neutralization-sensitive (tier-1) viruses.

45 forms and modulate their stability to bestow tier-1-like properties on primary tier-2 strains.

46 ite mutations in Env can convert tier-2 into tier-1-like viruses.

47 antibody responses against highly sensitive Tier 1A isolates and weaker neutralizing antibody respon

48 cellular cytotoxicity (ADCC), and low-titer tier 1B and tier 2 neutralizing antibody responses.

49 ddition, we report firm correlations between Tier 2 autologous neutralization and Tier 1 heterologous

50 nodes of vaccinated macaques correlated with Tier 2 autologous neutralization.

51 ly, DS-SOSIP.4mut elicited a higher ratio of tier 2 autologous titers versus tier 1 V3-sensitive tite

52 nces (envs) induced neutralizing Abs against Tier 2 autologous viruses expressing cognate envelope (E

53 sponse potently neutralized the heterologous tier 2 clade B viral strain RHPA, which was used to desi

54 but in combination with a Tier 1 or a second Tier 2 drug with a different mechanism of action.

55 We often prescribe Tier 2 drugs not alone but in combination with a Tier 1

56 neutralizing activities against >50% of the tier 2 global HIV-1 isolates tested.

57 neutralizing activities against heterologous tier 2 HIV-1 isolates.

58 autoantibodies significantly correlated with tier 2 HIV-1 neutralization, and anti-H2A antibody clone

59 generate neutralizing antibody responses to tier 2 HIV-1 strains with alum treatment alone in the ab

60 Similar results were also obtained with tier 2 HIV-1 viruses using a human anti-gp41 nnAb, 246D.

61 ld-type mice also leads to the production of tier 2 HIV-1-neutralizing antibodies, which increase in

62 adly neutralizing antibodies (bnAbs) against tier 2 HIV-1.

63 of about 115 against a panel of heterologous Tier 2 isolates.

64 ence, 64, 2000 and 253) and the updated IPCC Tier 2 model were ranked highest in EU (RMSPE = 11.0% an

65 uantity, quality, and kinetics of autologous tier 2 nAb development.

66 s immunization protocol induced reproducible tier 2 nAb responses after only two immunizations 8 week

67 ane-bound HIV-1 Env gp140 induced tier 1 and tier 2 neutralizing antibodies in a mouse model.

68 totoxicity (ADCC), and low-titer tier 1B and tier 2 neutralizing antibody responses.

69 ntly blocks diverse HIV-1 strains, including tier 2 or 3 strains, transmitted founders, quasispecies,

70 ltiple subtypes of HIV-1 isolates, including tier 2 or 3 strains, transmitted founders, quasispecies,

71 antibody-mediated neutralization against 11 tier 2 or 3 viruses was assessed in 163 clade B spontane

72 o emissions accounting and will support IPCC Tier 2 reporting of fire emissions.

73 no or limited neutralizing activity against tier 2 strains.

74 ndards Institute (CLSI) document M23-defined tier 2 study.

75 bleeding who does not respond to Tier 1 and Tier 2 therapies.

76 Here, we examined whether tier 2 virus NAb and V1/V2-specific non-NAb could be eli

77 well as weak and/or sporadic cross-reactive tier 2 virus NAb responses with unknown specificity.

78 ecificity of vaccine-elicited cross-reactive tier 2 virus NAb responses, we performed single memory B

79 V2 cap, demonstrating a means to accomplish tier 2 virus neutralization by penetrating the dense N-g

80 , nearly 20% (6/33) displayed cross-reactive tier 2 virus neutralization, which recapitulated the ser

81 A modest fraction of the Tier 2 virus neutralizing activity appeared to target th

82 licit predominantly tier 1 and/or autologous tier 2 virus neutralizing antibody (NAb) responses, as w

83 roved neutralizing responses to heterologous tier 2 viruses in nearly all study participants.

84 on as detected using a standardized panel of tier 2 viruses.

85 t sensitive viruses, not the more resistant "tier 2" isolates that dominate circulating strains.

86 bodies against the neutralization-resistant (tier 2) 16055 virus following inoculation of liposome-ar

87 s CZA97.012 from a neutralization-resistant (tier 2) clade C virus.

88 ibodies (NAbs) against relatively resistant (tier 2) primary viruses.

89 idential AER (Tier 1), infiltration factors (Tier 2), indoor concentrations (Tier 3), personal exposu

90 ifty-nine genes were ranked in tier 1, 44 in tier 2, 68 in tier 3, and 70 in tier 4.

91 our different subtypes (two in tier 3, 14 in tier 2, and four in tier 1).

92 e novo pathogenic loss-of-function variants; tier 2, genes with 2 de novo pathogenic loss-of-function

93 aust all Tier 1 options before proceeding to Tier 2, which comprises a host of immunosuppressive agen

94 als using a large, multi-subtype panel of 30 tier 2-3 Env-pseudotyped viruses.

95 This Tier 2-oriented carbon stock assessment provides a scien

96 nal center formation, and the elicitation of tier-2 autologous neutralizing antibodies.

97 vating germinal center B cells and eliciting tier-2 autologous neutralizing antibodies.

98 e induction of the more desired responses to tier-2 epitopes.

99 Single-site mutations in Env can convert tier-2 into tier-1-like viruses.

100 tion; tier-1 isolates are sensitive, whereas tier-2 isolates are more resistant.

101 A large panel of diverse tier-2 isolates from clades B and C was analyzed.

102 zing antibodies and induce robust autologous tier-2 neutralization, unlike a first-generation trimer.

103 Two tier-2 QC reproducibility studies of bedaquiline DST wer

104 A tier-2 reproducibility study was conducted in eight part

105 to bestow tier-1-like properties on primary tier-2 strains.

106 autologous NAb responses against resistant (Tier-2) viruses in several animal models.

107 bodies against the neutralization-resistant (tier-2), sequence-matched virus and more broadly active

108 ation of high levels of somatic mutation and tier-2-neutralizing antibodies resembling the authentic

109 epitope modification, elicited heterologous tier-2-neutralizing responses.

110 We reserve Tier 3 strategies, which are of uncertain benefit and/or

111 ion factors (Tier 2), indoor concentrations (Tier 3), personal exposure factors (Tier 4), and persona

112 viruses from four different subtypes (two in tier 3, 14 in tier 2, and four in tier 1).

113 s were ranked in tier 1, 44 in tier 2, 68 in tier 3, and 70 in tier 4.

114 e novo pathogenic loss-of-function variants; tier 3, genes with 1 de novo pathogenic loss-of-function

115 nd from football games within eight football tiers (3 to 10) in England, and to extrapolate this to a

116 neutralized even the difficult-to-neutralize tier-3 pseudoviruses with great potency (GMT > 600).

117 rations (Tier 3), personal exposure factors (Tier 4), and personal exposures (Tier 5) for ambient PM2

118 ovo pathogenic loss-of-function variant; and tier 4, genes with only inherited (or unknown inheritanc

119 ier 1, 44 in tier 2, 68 in tier 3, and 70 in tier 4.

120 re factors (Tier 4), and personal exposures (Tier 5) for ambient PM2.5.

121 The polarity of the N-tier ahead of the C-tier places the leading Pol epsilon

122 IAs as first-tier tests and when used in two-tiered algorithms, including a modified two-tiered testi

123 pain increases PACAP expression at multiple tiers along the spinoparabrachioamygdaloid tract.

124 ic helicases, is shaped like a ring with two tiers, an N-tier ring composed of the N-terminal domains

125 REVIEW We used a two-tiered analytic approach including both completed studie

126 Here, we show that calbindin-positive dorsal tier and calbindin-negative ventral tier SNc dopaminergi

127 penetrates into the central channel of the N-tier and the unwound leading single-strand DNA traverses

128 of-systems approach that is causal, modular, tiered, and scalable, as well as new educational and org

129 Its tiered approach allows for building models at different

130 al growth model and telemedicine system in a tiered approach may reduce the number of clinical ROP in

131 We employed a tiered approach that first examined processes influencin

132 maximum cumulative ratio (MCR) as part of a tiered approach to evaluate and prioritize the risk of a

133 Ebola Response Team"), and a framework for a tiered approach to hospital preparedness.

134 To describe a tiered approach to ROP screening (TARP) for identifying

135 The tiered approach to ROP screening was associated with a r

136 We use a tiered approach to treat patients who require therapy to

137 nchoring the coding region rbcL in multigene tiered approach, the combination rbcL + matK + ITS yield

138 tosolic domains, which assemble into a three-tiered architecture.

139 segregated columns exist in a "next-higher" tier area, V3.

140 Efforts to develop a standardized 2-tier assay system for the detection of antiretinal antib

141 EIA in test-to-test comparisons or as first-tier assays in STTT or MTTT with few exceptions.

142 ility and limitations in screening and early tier assessments.

143 CRC screening tests are ranked in 3 tiers based on performance features, costs, and practica

144 All candidate genes were ranked into 4 tiers based on the strength of evidence as follows: tier

145 The tiered cardiac CT protocol included a calcium scan follo

146 We used a three-tiered categorisation based on the WHO definition of uns

147 In contrast, the three-tier clinical-genomic risk groups had 10-year distant me

148 t the genefu R/Bioconductor package, a multi-tiered compendium of bioinformatics algorithms and gene

149 ated to one of three hypothetical scenarios: tiered consent and controlled data sharing; broad consen

150 were also comparable to those from a higher tier consumer model (ConsExpo 4.1) for the surface clean

151 s, and a C-tier of C-terminal domains; the C-tier contains the motor.

152 In principle, either tier could translocate ahead of the other during movemen

153 arms have been assembled into two- and three-tiered covalent stacks through imine formation.

154 Here, we present a two-tiered CRISPR-mediated chemical-genetic strategy for tar

155 We stratified the priority list into three tiers (critical, high, and medium priority), using the 3

156 s agreed that an ideal assay should have a 2-tier design and that Western blot and immunohistochemist

157 n in comparison to other commonly used first-tier diagnostic methods, such as non-invasive cfDNA scre

158 ted GHG emissions between the eight football tiers during the 2012/13 season.

159 formularies cover their medications in a low tier (eg, "Preferred"), (2) for patients without insuran

160 factures one of the most commonly used first-tier EIAs in the United States, the combined IgM/IgG Vid

161 t these antigens could be used in a simple 1-tier ELISA that is faster to perform, easier to interpre

162 rforming the testing in a clinically focused tiered fashion would be 6.1% more sensitive and 17.7% le

163 red in Europe and reduce the need for higher-tier fate and effects tests.

164 annual GHG emission of spectators from the 8 tiers for the 2012/13 season was estimated at 56,237 ton

165 ng inhibitor Dusp4 within the first two cell tiers from the margin.

166 a (LGG) as a model, we employ a unique multi-tiered genomic dissection strategy using 540 patients fr

167 Thus, large-scale and multi-tiered genomic three-dimensional reorganization is requi

168 ate significant differences between football tiers' GHG emissions, H(7) = 46.474, p < 0.001.

169 e complications were graded as per Clavien 5 tier grading and major morbidity (grade III b, grade IV

170 nd furcation defects, using a well-known six-tiered hierarchical model for diagnostic efficacy.

171 ysis of network topology reveals (i) a three-tiered hierarchy initiating at master regulators, (ii) h

172 every class are created and delineates a two-tiered hierarchy of class switch pathways.

173 The developmental shift to an adult "two-tier" hierarchy challenges current dogma and provides a

174 ning approach in combination with a multiple tier high throughput experimental screen utilizing two c

175 l for 18 additional genes that were ranked 1 tier higher because of this cross-disorder approach was

176 A algorithm and modified criteria for second-tier IgG immunoblots, were also evaluated.

177 rgovernmental Panel on Climate Change (IPCC) Tier II guidelines to quantify the evolution of CH4 emis

178 positive or equivocal, is followed by second-tier immunoblotting.

179 ) algorithm is applied that utilizes a first-tier immunofluorescence assay or enzyme immunoassay (EIA

180 Ss) for potential endocrine activity can use tiered in silico and in vitro models.

181 Tiered interventions in each arm were specified and impa

182 rand DNA traverses the channel through the N-tier into the C-tier motor, 5'-3' through CMG.

183 CMD, with muscle biopsy reserved as a second-tier investigation.

184 red testing (STTT) algorithm where the first tier is typically an enzyme immunoassay (EIA) that if po

185 -breaking studies in science end up in lower-tier journals.

186 es of the test; (3) strengthening functional tiered laboratory networks and systems to expand access

187 ve range, but has spread rapidly in northern-tier lakes in the United States, where it can interfere

188 nts demonstrated the generalizability of the tiered learning architecture, in that its use was found

189 opose a machine learning architecture called tiered learning for prediction of ATC codes that relies

190 Tiered learning utilizes this observation to constrain t

191 The prediction accuracy obtained with tiered learning was found to be either comparable or bet

192 In March, 2016, the UK Government proposed a tiered levy on sugar-sweetened beverages (SSBs; high tax

193 ception rates from 1994-98 to 2009-13 by top-tier local authorities in England, in relation to Teenag

194 This limitation stems from their two-tiered measurement protocol that combines slow ( approxi

195 the central nervous system (CNS) via a three-tier mechanism.

196 This two-tiered mechanism globally orchestrates developmental gen

197 cal confirmation of Lyme disease (LD) is a 2-tier method recommended by the CDC in 1995.

198 The results call for the development of two-tier models for the evolution of cooperation.

199 es the channel through the N-tier into the C-tier motor, 5'-3' through CMG.

200 A tiered, multilevel data-integration approach was used, w

201 Here, we describe the development of a tiered museum-based program at the University of Califor

202 gh concentration (>1.6 x 10(22) cm(-3) ) and tiered nature of its anionic electrons, which offers gui

203 s, integrates interaction pairs into a multi-tiered network analysis, and ultimately predicts disease

204 transporters in the mediodorsal and ventral tier nuclei.

205 composed of the N-terminal domains, and a C-tier of C-terminal domains; the C-tier contains the moto

206 features maintained in the controlled-access tier of dbGaP.

207 into Mexico and decrease across the northern tier of North America, while counts for the high tercile

208 to protein destabilization, suggesting a new tier of regulation in WUS protein regulation.

209 ately contacts the downstream amino-terminal tier of the MCM motor ring.

210 l activity of drugs and diseases at multiple tiers of biological action, and is therefore a useful ap

211 ully completed 274 interactions across all 3 tiers of China's rural health system, interacting with p

212 Multiple tiers of enhancer suboptimization produce specific, but

213 establishing functional laboratories at all tiers of health systems in developing countries, strengt

214 compatibility score, which uses 4 escalating tiers of hierarchal severity to derive a total score for

215 stal is a great challenge in reaching higher tiers of nanocatalyst design.

216 reforms encouraging first contact with lower tiers of the health system can improve efficiency only w

217 ng mechanism whereby the N-terminal and AAA+ tiers of the MCM work in concert to translocate on singl

218 substance-by-substance approach and using a Tier One cumulative assessment based on the lowest acute

219 This involved biochemical, cell-based, and tier-one ADME techniques.

220 A Multi-Tiered Parallel Framework (CUDAMPF) implemented on CUDA-

221 The polarity of the N-tier ahead of the C-tier places the leading Pol epsilon below CMG and Pol al

222 In this study we present a novel two tier platform; i) a peptide delivery system, termed RALA

223 stemic embolic events, or death by assigning tiered points for higher concentrations of the biomarker

224 Surprisingly, the new N-tier to C-tier polarity of translocation reveals an unforeseen qua

225 neurons that modulates nociception in a two tier process: (1) directly by release of OT from axons o

226 ur data show that membrane repair is a multi-tiered process involving immediate, cell-intrinsic mecha

227 The three-tier proteoform identification and characterization work

228 l preferences within medical students to the tier ranking of their medical schools and their expected

229 Using a three-tier reef fish food web and intermittent-flow respiromet

230 , is shaped like a ring with two tiers, an N-tier ring composed of the N-terminal domains, and a C-ti

231 re, the N-tier ring is pushed ahead by the C-tier ring during CMG translocation, opposite the current

232 Therefore, the N-tier ring is pushed ahead by the C-tier ring during CMG

233 We suggest that these N-tier ring movements cause the DNA strand separation and

234 tructure found in the active helicase, the N-tier ring of the Mcm2-7 hexamer in the DH-dsDNA needs to

235 sections of the surgical specimens using a 4-tiered scale (scores 1-4).

236 Based on this research, we recommend a tiered screening approach wherein a) QSAR is used to ide

237 We have employed TIER-seq (transiently inactivating an endoribonuclease f

238 atories but who test negative by reference 2-tiered serologic analysis.

239 hema migrans lesion or a positive standard 2-tiered serologic result in a patient with symptoms compa

240 The conventional 2-tiered serologic testing protocol for Lyme disease (LD),

241 Thus, existing 2-tier serology-based assays yield low sensitivities (29%-

242 lowed by immunoblot, with that of standard 2-tiered serology for the diagnosis of Lyme disease.

243 e dorsal tier and calbindin-negative ventral tier SNc dopaminergic neurons in mice comprise functiona

244 s delineated brain regions into structurally tiered spatial groups and we observed striking enrichmen

245 PLN) began building in the late 1980s on a 3-tiered structure of 146 laboratories with different and

246 er credit, diversify participation, create a tiered structure, and build community.

247 ative conformational coupling in these multi-tiered structures.

248 tments to produce chemically organized multi-tiered structures.

249 rate is strongly dependent on the number of tiers, suggesting cooperative conformational coupling in

250 /high would be reclassified by the new three-tier system and 67% of patients would be reclassified fr

251 am review decreased, suggesting that the two-tier system led to earlier recognition of reversible pat

252 (very-low- to very-high-risk) by the new six-tier system.

253 A combination of alpha and beta provides a tiered system for quantitatively assessing the probe eff

254 Here, a novel multi-tiered systems biology approach was used to predict meta

255 of microRNA-124 (miR-124), determined with a tiered systems biology approach, is responsible for incr

256 g) in a cohort of 337 ID subjects as a first-tier test and compared it with a standard clinical evalu

257 rformance of the C6 EIA alone and as a first-tier test followed by immunoblot, with that of standard

258 support the adoption of genomics as a first-tier test for individuals with ID.

259 standard whole-cell sonicate EIA as a first-tier test for the diagnosis of Lyme disease and has been

260 valuation of their performance in a simple 1-tier test for the serological confirmation of LD.

261 The first-tier test is a low-specificity enzyme-linked immunosorbe

262 to interpret, and less expensive than the 2-tier test method and which is better at detecting Borrel

263 markedly better (80% versus 63%) than the 2-tier test method in detecting anti-Borrelia antibodies i

264 ng these two recombinant antigens with the 2-tier test method.

265 red testing (MTTT) approach where the second-tier test was a C6 EIA.

266 The two methods (DbpA/C6-OspC versus 2-tier test) were equivalent in identifying sera from nega

267 capsule colonoscopy every 5 years is a third-tier test.

268 The two tier testing strategy was applied to 78 samples obtained

269 ad sensitivity similar to that of standard 2-tiered testing (79.8% vs 81.6% for standard 2-tiered tes

270 c (99.3%-99.5%) compared with conventional 2-tiered testing (99.5% specificity; P = .6-1.0).

271 Several modified two-tiered testing (MTTT) algorithms, including a 2-EIA algo

272 -tiered algorithms, including a modified two-tiered testing (MTTT) approach where the second-tier tes

273 in early LD, we evaluated several modified 2-tiered testing (MTTT) protocols, which use 2 assays desi

274 Specifically, a standardized two-tiered testing (STTT) algorithm is applied that utilizes

275 approach for Lyme disease is a standard two-tiered testing (STTT) algorithm where the first tier is

276 cteristics for the currently recommended two-tiered testing algorithm (TTTA).

277 (aged </=21 years) undergoing conventional 2-tiered testing for Lyme disease at a single hospital-bas

278 city of our 10-antigen panel compared to two-tiered testing in detecting early B. burgdorferi infecti

279 A clinically directed tiered testing strategy can increase sensitivity and imp

280 lar specificity compared with conventional 2-tiered testing, obviating the need for Western blots.

281 iered testing (79.8% vs 81.6% for standard 2-tiered testing; P = .71) with slightly lower specificity

282 gies (LYT versus LYM/LYG) when used as first-tier tests (sensitivity, 83 to 85%; specificity, 85 to 8

283 d to include molecular-based assays as first-tier tests and the success of these assays depends on th

284 ssess the performance of these EIAs as first-tier tests and when used in two-tiered algorithms, inclu

285 The first-tier tests are colonoscopy every 10 years and annual fec

286 immunosorbent assay (ELISA), and the second-tier tests are higher-specificity IgG and IgM Western bl

287 The second-tier tests include CT colonography every 5 years, the FI

288 tocols, which use 2 assays designed as first-tier tests sequentially, without the need of Western blo

289 results between individual first- and second-tier tests, although the overall agreement of the differ

290 y, bioMerieux launched its dissociated first-tier tests, the Vidas Lyme IgM II (LYM) and IgG II (LYG)

291 ssignment, were ranked across 3 hierarchical tiers: time to death, time to rehospitalization for hear

292 Surprisingly, the new N-tier to C-tier polarity of translocation reveals an unfo

293 To address this, we deploy a three-tiered transcriptomic meta-analysis that functions at th

294 Safety and feasibility of the tiered treatment protocol were confirmed.

295 A Tier Two assessment using a trophic level approach was a

296 patients would be reclassified from NCCN six-tier (very-low- to very-high-risk) by the new six-tier s

297 sualizations are implemented either as multi-tier web server applications that require significant ma

298 s disease, and the calbindin-positive dorsal tier, which is relatively resilient.

299 populations: the calbindin-negative ventral tier, which is vulnerable to neurodegeneration in Parkin

300 Second, testing should proceed via tiers with iterative feedback that informs experiments a