ライフサイエンスコーパス: tight

1 orphyrin, except when the strap is short and tight.

2 conserved in all three domains of life as a tight 3',5'-cAMP-binding protein.

3 Second, the expression of a tight adherence (tad) pilus locus was elevated in NT.

4 The mucoadhesive layer is responsible for tight adhesion of the whole system to the oral mucosa af

5 This mechanism leads to tight allosteric coupling between gates, preventing them

6 f the endothelial glycocalyx layer (EGL) and tight and adherens junction markers with plasma leakage.

7 V infection did not affect the expression of tight and adherens junction proteins such as ZO-1, claud

8 icals in high-risk patients, combined with a tight and frequent control of inflammation, and adjustme

9 er by approximately 7 degrees , resulting in tight and loose axial subunit packing in the rod and hoo

10 re used in the clinic to treat leukemia, but tight and selective inhibitors are not available for Bcl

11 nterestingly, this interaction was unusually tight ( approximately 260 nm) for an Hsp70-client intera

12 These results support the hypothesis of a tight association between hypoxia and angiogenesis.

13 al reconstruction microscopy (STORM) shows a tight association of CIZ1 with Xist RNA at the single-mo

14 ed that genes within a SM pathway would form tight associations (modules) with each other in coexpres

15 iately precedes the catalytic domain and has tight associations with it.

16 increases myogenesis but also regulates the tight balance of protein synthesis and degradation.

17 hat allows a flexible protein to stabilize a tight bending of DNA.

18 The most effective compound 19 is a tight binder of MDM2 and activates p53 in cancer cells t

19 ptides named "avathrin." Avathrin is a fast, tight binding competitive inhibitor with an affinity of

20 d protein (RAP) as a model ligand due to its tight binding interaction.

21 rotomer to disrupt that protomer's TPR-U-box tight binding interface, swiftly exposing and activating

22 Such tight binding of the structured mutant (omega6) affects

23 man placental lactogen (hPL), a specific and tight binding PRLR ligand, to magnetic resonance imaging

24 e, conformational selection between weak and tight binding states of A1 takes precedence and drives n

25 l titration calorimetry experiments revealed tight binding to McpX(PR) with dissociation constants (K

26 fferent Dirac systems by means of continuum, tight-binding and ab-initio calculations.

27 ed through the coupled-mode theory under the tight-binding approximation and the rigorous band struct

28 ons, and demonstrate its feasibility through tight-binding calculations of the band structure.

29 a cyclopropyl unit may add to the armory of tight-binding inhibitor designs.

30 SPI-1 was characterized as a high-affinity, tight-binding inhibitor of Arabidopsis subtilase SBT4.13

31 dies also revealed that 5-formylTHF, a slow, tight-binding inhibitor of serine hydroxymethyltransfera

32 , enzyme kinetic evaluation revealed a slow, tight-binding mechanism of inhibition, which is unpreced

33 We develop a tight-binding model to characterize the effective Hamilt

34 reover, exploring the parameter space of the tight-binding models that describe them we find photores

35 Tight-binding PNP inhibitors show exceptionally long lif

36 Rubisco is prone to inhibition by tight-binding sugar phosphates, whose removal is catalyz

37 the major iron source and emphasizing iron's tight biogeochemical coupling to major nutrients, a more

38 tions of OPACs with the dentin matrix create tight biointerfaces with hydrophobic methacrylate adhesi

39 role in brain angiogenesis and in ensuring a tight blood-brain barrier.

40 on-covalently crosslink actin filaments into tight bundles.

41 es are proposed to be the result of loose or tight cation-dienolate ion pairs.

42 direct experimental evidence showing that a tight cavity can generate a stronger binding affinity to

43 mitotic rounding, geometric cues imposed by tight cell packing prevail and cells divide along their

44 onsumption by a Clark electrode in an oxygen-tight cell.

45 idual epithelial or endothelial cells into a tight cellular sheet requires stringent control of cell

46 from humans and fish revealed they formed a tight clade distinguished by 93 single-nucleotide polymo

47 f CD to concentrate carotenoids and prevents tight clustering of CD within carotenoid bodies.

48 tric growth in thickness leads to impossibly tight coiling.

49 hycoerythrobilin (PEB) in vitro leading to a tight complex that can also be formed in Escherichia col

50 XRCC4 and DNA Ligase 4 (LIG4) form a tight complex that provides DNA ligase activity for clas

51 ated by the inhibitor securin, which forms a tight complex with separase and may also stabilize this

52 Tda2 forms a tight complex with the polyproline motif-rich protein Ai

53 Cholesterol is a critical nutrient requiring tight constraint in the endoplasmic reticulum (ER) due t

54 Thus the phenomenology puts tight constraints on the form of the order parameter in

55 Fine astrocytic processes are in tight contact with neurons and blood vessels and shape e

56 vere Crohn's disease who were managed with a tight control algorithm, using clinical symptoms and bio

57 icantly higher proportion of patients in the tight control group achieved the primary endpoint at wee

58 105 (86%) of 122 patients in the tight control group and 100 (82%) of 122 patients in the

59 anagement group and 32 (26%) patients in the tight control group discontinued the study, mostly becau

60 s (18 [15%]), and headache (18 [15%]) in the tight control group, and worsening Crohn's disease (35 [

61 Advantages of this setup include tight control of all bilayer components, which is compel

62 Tight control of blood glucose concentration in people w

63 The tight control of both biosynthesis of, and cellular resp

64 This study reveals that tight control of brain volume is exerted through a large

65 Our findings support the importance of tight control of DNA metabolism for beta-cell integrity

66 en dATP and ribonucleotide reductase ensures tight control of dNTP concentration.

67 Tight control of extracellular and intracellular inorgan

68 hysiological processes in plants, making the tight control of its endogenous levels and spatiotempora

69 or catabolic inactivation of RA required for tight control of local RA concentrations, is significant

70 ion is an energy-demanding process requiring tight control of metabolism and redox state.

71 The tight control of metal homeostasis in cells depends on t

72 ulatory pathway or both, we demonstrate that tight control of MutS levels in stationary phase contrib

73 and substrate adaptors cooperatively provide tight control of neddylation and cullin-RING-ligase acti

74 eath areas also were found, highlighting the tight control of organ growth within and between phytome

75 1 protein, play key role in proteostasis via tight control of partitioning and recycling of misfolded

76 es a unique mechanistic insight into how the tight control of spatial segregation is critical in the

77 ncover a new feature of BIR and propose that tight control of ssDNA accumulated during this process i

78 mote neural development and signaling, hence tight control of the concentration of cellular DISC1 in

79 A tight control of viral replication by the host innate im

80 nts were randomly assigned at a 1:1 ratio to tight control or clinical management groups, stratified

81 eous fraction, but they exert a powerful and tight control over neuronal activity and consequently mo

82 We propose that, rather than exerting tight control over parameters, the auditory system uses

83 In conjunction with a tight control over pore sizes, inverse opal scaffolds ha

84 synthesize intermetallic nanocrystals with a tight control over their size and shape.

85 Cell motility depends on tight coordination between the microtubule (MT) and acti

86 This tight coordination by a network of conserved residues de

87 the intestinal epithelial barrier relies on tight coordination of cell proliferation and migration,

88 rganelles can strongly correlate, reflecting tight coordination of their functions.

89 F-mediated PM induction in NMPs functions in tight coordination with canonical Wnt signaling during t

90 The tight correlation between the number of tissue-specific

91 Tight coupling between below-ground autotrophic respirat

92 temporal responses to carbachol demonstrated tight coupling between force development and RLC phospho

93 he action of these peptides likely relies on tight coupling between membrane partitioning, alpha-heli

94 ble by conventional techniques, reflecting a tight coupling between O2 production and consumption by

95 , which is required for stringent gating and tight coupling of ion and substrate fluxes in the GABA t

96 ses via Ca(2+)-triggered exocytosis requires tight coupling of L-type Ca(2+) channels to release-read

97 The tight coupling of these events poses a dual conundrum: m

98 The tight coupling with motor neurons suggests that Renshaw

99 this kind of cyclic heat engines satisfy the tight-coupling condition.

100 g) and (2) constriction of the inner pore by tight criss-crossing of the cytoplasmic ends of the S6 a

101 structure reveals that YbAnbu subunits form tight dimers, held together in part by the Anbu specific

102 Recent animal studies showed physiologically tight disynaptic connections between the cerebellum and

103 the stability of inactivated states is under tight evolutionary control, but that in Nav1.1 faster re

104 t maintained tissue architecture yet allowed tight experimental control.

105 pproach achieves the long-standing goal of a tight feedback cycle between computation and experiment

106 n dynamics and plant development and reveals tight feedback regulation at both the transcriptional an

107 riety of important deterministic equiangular tight frames (ETFs) and tight non-ETFs, we consider the

108 We further show a tight functional coupling between CaV1.3 calcium influx

109 pecific intramolecular cycloadditions, under tight functional group control, that facilitate selectiv

110 Tight gas sandstone samples are imaged at high resolutio

111 ggest that transcripts in placenta are under tight genetic control, and that placental gene networks

112 The Alignable Tight Genomic Clusters (ATGCs) database is a collection

113 dren with hyperglycemia did not benefit from tight glycemic control targeted to a blood glucose level

114 In multicenter studies, tight glycemic control targeting a normal blood glucose

115 r DNA strands and then closes to establish a tight grip on the DNA template.

116 e helical domains of each Cya monomer form a tight hairpin, bringing the two catalytic domains into a

117 of the six VAT subunits to constrict into a tight helix that grips an 80 A stretch of unfolded prot

118 mplex surface appendages that have evolved a tight, hierarchical regulation of expression.

119 ntent, the liver secretes triglyceride under tight homeostatic control.

120 starting from their zygotic state involves a tight integration of the myriad biochemical signaling in

121 eling emphasis on combinations of marks, its tight integration with downstream functional enrichment

122 PEPC hetero-octameric complex, arises from a tight interaction between 107-kD plant-type PEPC and 118

123 ntal and clinical investigations indicates a tight interaction between metabolism and circadian timek

124 ance of innate immunity and, especially, the tight interaction between the innate and the adaptive im

125 ormed discrete, small (20-140 Kb) domains of tight interaction that corresponded to locations bound b

126 nal of early flooding stress, most likely in tight interaction with the other gases.

127 In summary, our findings suggest a tight interdependency between Gag structural proteins an

128 ion in patients, which is characterized by a tight interplay between pathogen and host, and can there

129 ich nucleophiles add to the iminium-chloride tight ionic pair.

130 Dysfunction of cell-cell tight junction (TJ) adhesions is a major feature in the

131 in altered cytoskeletal structure, increased tight junction (TJ) formation and reduced barrier permea

132 The tight junction (TJ) has a key role in regulating paracel

133 ) cause an increase in intestinal epithelial tight junction (TJ) permeability, the mechanisms that me

134 Tight junction (TJ) proteins are known to be involved in

135 laudin family of proteins is integral to the tight junction (TJ), the apical cell-cell adhesion and a

136 immunoblotting, immunofluorescence analysis, tight junction (TJ)-permeability assessment, and overexp

137 (+), Ca(2+), and Mg(2+) reabsorption via the tight junction (TJ).

138 in localization of adhesion proteins at the tight junction and basal ES at the Sertoli cell BTB.

139 Furthermore, GTP-bound Rap1 promoted tight junction assembly, and loss of Rap1B led to loss o

140 EPAC-Rap1 signaling pathway may regulate the tight junction complex of the BRB and may restore barrie

141 ng as evidenced by de novo expression of the tight junction components ZO-1 and E-cadherin and the fo

142 s) inducing barrier integrity impairment and tight junction damage.

143 Blood-brain barrier disruption and tight junction damages were observed in the presence of

144 paracellular ion transport and cause a novel tight junction disease characterized by a non-BS, non-GS

145 ration) and BTB function (i.e., basal ES and tight junction disruption, making the barrier leaky), in

146 L-4 prevented mucosal barrier disruption and tight junction downregulation in a mouse model of house

147 had no inhibitory effect on wound closure or tight junction formation following injury.

148 that astrocytes of the glia limitans induce tight junction formation in response to inflammatory cue

149 hosphorylation was reduced in lungs of mice, tight junction formation increased, and protein concentr

150 in alpha5beta1 clustering and is followed by tight junction formation, as determined by ZO-1 localiza

151 vel and tissue-specific role of claudin-3, a tight junction integral protein, in inhibiting colon can

152 re, we provide evidence that the tricellular tight junction is important for paracellular water perme

153 Whether the tight junction is permeable to water remains highly cont

154 ysis confirmed that ALCAM is associated with tight junction molecule assembly at the BBB, explaining

155 n in tumor endothelium, activating TIE-2 and tight junction pathways and normalizing vessel structure

156 i cells was shown to induce the Sertoli cell tight junction permeability barrier disruption via chang

157 ition, Atg9 interacted with PALS1-associated tight junction protein (Patj), which associates with TSC

158 breakdown of type IV collagen and decreases tight junction protein (TJP) expression in a co-culture

159 vo requires an intracellular scaffold called Tight Junction Protein 1b (Tjp1b).

160 ransporters ABCB4, ABCB11, ATP8B1, ABCC2 and tight junction protein 2 (TJP2).

161 with decreases in the intestinal epithelial tight junction protein claudin-1 (CLDN1).

162 expression of CLDN10, the gene encoding the tight junction protein Claudin-10, show enhanced paracel

163 -22-dependent upregulation of the epithelial tight junction protein claudin-2.

164 pithelial integrity indicated by loss of the tight junction protein claudin-3 was not observed during

165 d reduced expression of the endothelial cell tight junction protein claudin-5 (Cldn5) and abnormal bl

166 concentrations of Hcy showed a reduction of tight junction protein expression, increased FITC dextra

167 l host factors, the tetraspanin CD81 and the tight junction protein occludin (OCLN), explain, at leas

168 d that ischemia induced rapid degradation of tight junction protein occludin in cerebromicrovessels.

169 domain has the same arch-shaped fold as the tight junction protein occludin.

170 Claudin-18.1 is the only known lung-specific tight junction protein, but its contribution to airway b

171 and a very weak nominal association with the tight junction protein, claudin-5, has previously been i

172 ssion of Claudin-2, a cation-channel-forming tight junction protein.

173 It uses some claudin tight junction proteins (eg, claudin-4) as receptors to

174 nd/or redistribution of three representative tight junction proteins (ie, zonula occludens-1, Occludi

175 s (Lgr5 and Bmi1), whereas the expression of tight junction proteins (occludin and claudin) in 13% CP

176 nal epithelium by decrease/redistribution of tight junction proteins and endoplasmic reticulum stress

177 BBB by regulating the proper localization of tight junction proteins and raise the possibility that e

178 ctions (matrilysis) as well as adherence and tight junction proteins for degradation.

179 on of DSS than control mice, and loss of the tight junction proteins occludin and claudin-2 from inte

180 es not affect the progressive degradation of tight junction proteins or paracellular BBB leakage.

181 for epithelial-to-mesenchymal transition and tight junction proteins were assessed in exposed cells.

182 ptake assay, quantitative RT-PCR analysis of tight junction proteins, myosin light chain kinase, and

183 nfiltration, and higher expression levels of tight junction proteins, such as zonula occludens-1 and

184 spheroid surface exhibits high expression of tight junction proteins, VEGF-dependent permeability, ef

185 roteolytic activity on basement membrane and tight junction proteins.

186 hways involved in mitochondrial function and tight junction signaling.

187 leads to aberrant microtubule organization, tight junction stabilization and impaired wound closure

188 nces in Claudin-10 membrane localization and tight junction strand formation, indicating that these a

189 ay not fully recapitulate that of epithelial tight junction strands, this is the first direct demonst

190 BB permeability, possibly by stabilizing BBB tight junction via Robo4 mediated Rac1 activation.

191 KO mice, with rescue of the endothelial gene tight junction, pericyte coverage and extracellular-matr

192 GRHL2), in mice led to reduced expression of tight junction-associated barrier components, reduced co

193 epithelial cells (IECs) fail to express the tight junction-associated protein claudin-7.

194 resistance (TEER) measurements without other tight-junction (TJ) formation parameters.

195 ional, blood-brain barrier model exemplifies tight-junction integrity.

196 e represses permeability-promoting claudin-2 tight-junction protein expression through an IL-10RA-dep

197 increased BBB integrity (elevated levels of tight-junction protein, Claudin 5, and reduced S100B lev

198 MMPs degrade extracellular matrix and cleave tight-junction proteins and cytokines, modulating their

199 lasma membrane, where it associates with the tight-junction proteins Pals1/PATJ and E-cadherin.

200 equires restricted positioning of functional tight junctions (TJ) to the most suprabasal viable layer

201 nation between cell-cell adherens junctions, tight junctions (TJ), and the perijunctional actomyosin

202 Delivery occurs adjacent to tight junctions (TJ), suggesting that it recognizes a re

203 olves paracellular passage regulated through tight junctions (TJ).

204 Tight junctions (TJs) form a barrier on the apical side

205 cytes open the BBB by disrupting endothelial tight junctions (TJs), but the mechanisms that control a

206 Endothelial cells lining SC elaborate tight junctions (TJs), down-regulation of which may wide

207 gral membrane proteins and are components of tight junctions (TJs).

208 s, specialized structures called tricellular tight junctions (tTJs) and tricellular adherens junction

209 ll GTPase protein that is a key component of tight junctions and adherens junctions.

210 bearing the humanized alleles formed normal tight junctions and did not exhibit any immunologic abno

211 ggering Rho GTPase signals that modulate RPE tight junctions and enhance RPE barrier function.

212 pericytes in xenograft models disrupted BTB tight junctions and increased vascular permeability.

213 lation of JAM-C promotes its localization to tight junctions and inhibits transwell migration of A549

214 hat form blood-CNS barriers have specialized tight junctions and low rates of transcytosis to limit t

215 lls form a blood-retina barrier by virtue of tight junctions and low transcytosis.

216 ntirely through transcytosis, as specialized tight junctions are functional as early as vessel entry

217 ission electron microscopy and expression of tight junctions by confocal microscopy.

218 The collecting duct epithelium forms tight junctions composed of barrier-enforcing claudins a

219 The organization and integrity of epithelial tight junctions depend on interactions between claudins,

220 sphingomyelinase is linked to degradation of tight junctions in endothelial cells in vitro, which is

221 ut the effects of IL-22 on the regulation of tight junctions in the intestinal epithelium.

222 y, alpha-toxin induces severe degradation of tight junctions in the lung and causes lung edema in viv

223 at the corners of polarized epithelia where tight junctions in vertebrates or septate junctions (SJ)

224 proinvasive functions when it relocates from tight junctions into the cytonuclear compartment.

225 Thus, impairment of both adherens and tight junctions may contribute to enhanced leakiness of

226 se kidney, ILDR1 is localized to tricellular tight junctions of the distal tubules.

227 induce apoptosis, oxidative stress, loss of tight junctions or production of IL-8 after 24 hours, bu

228 unction, either by strengthening endothelial tight junctions or suppressing endothelial vesicular tra

229 of intercellular adhesive structures such as tight junctions, cadherin-based adherens junctions, and

230 ys (i.e., mitogen-activated protein kinases, tight junctions, focal adhesion, transforming growth fac

231 ion of Par3, which is normally restricted to tight junctions, is sufficient to alter apical membrane

232 h Kindlin-2 does not associate directly with tight junctions, its downregulation also destabilizes th

233 macromolecular and bacterial movement across tight junctions, while increased intestinal permeability

234 l growth factor signaling and preserves BMEC tight junctions.

235 ovokes loss of endothelial cell coverage and tight junctions.

236 k between alpha-toxin and the degradation of tight junctions.

237 adherin and the formation of ZO-1 containing tight junctions.

238 yanate-dextran 4 kDa, and mRNA expression of tight junctions.

239 mory, consistent with previous evidence of a tight link between these potentials and working memory c

240 ors in the centromeric KIR region and are in tight linkage disequilibrium.

241 lobal carbon cycles that is characterized by tight linkages between methane-utilizing (methanotrophic

242 g autophagy, and illustrate the existence of tight mechanistic links between the cellular stress resp

243 tion reversibly in either direction requires tight mechanochemical coupling between the catalytic dom

244 ein, binds to its motor domain and induces a tight microtubule-binding state in dynein.

245 inary reversible acid responsiveness enables tight mucosal bacterial adherence while also allowing an

246 Kinetics studies of m4-1BB disclosed a very tight nanomolar binding affinity to m4-1BBL with an unex

247 This requires tight negative genetic correlations between direct genet

248 sed to prime hydrolysis by destabilising the tight networks of polysaccharides intertwining cellulose

249 ministic equiangular tight frames (ETFs) and tight non-ETFs, we consider the distribution of singular

250 Since a large amount of nanopores exist in tight oil reservoirs, fluid transport in nanopores is co

251 performance with simple planar fractures in tight oil reservoirs.

252 formance with complex fracture geometries in tight oil reservoirs.

253 Tight packing of the major virion glycoprotein (VP1) is

254 Meiotic progression depends on tight physical and functional coupling of recombination

255 lator of liver development and highlight how tight quantitative control of hepatic cell differentiati

256 al for ATP production in all organisms, with tight regulation by multiple metabolites.

257 ng to their unique homeostatic phenotype and tight regulation by the central nervous system (CNS) mic

258 y and sensory function, homeostasis requires tight regulation in specific compartments or niches.

259 This tight regulation includes regulating the activation of T

260 the molecular mechanisms responsible for its tight regulation is not fully understood.

261 Tight regulation of Bcl6 expression, an essential transc

262 Here we show that tight regulation of buffered intracellular metal concent

263 In this study, we show that tight regulation of endogenous PDGFRalpha activity is re

264 Endotoxin tolerance requires tight regulation of genes occurring at the transcription

265 Tight regulation of integrin activity is paramount for d

266 ated import, export and storage proteins for tight regulation of the zinc concentration have evolved.

267 Tight regulation of this branchpoint is essential, but t

268 tly enriched in dopamine neurons, suggesting tight regulation of X-linked gene expression to ensure s

269 in life and their crucial function requires tight regulation.

270 animals, sleep pressure is under continuous tight regulation.

271 and growth, demonstrating rapid evolution of tight regulatory control for down-regulation of growth a

272 EMENT Neurovascular coupling, defined as the tight relationship between activated neurons and hemodyn

273 nferred from fossil leaf cuticles based on a tight relationship between LMA and cuticle thickness obs

274 ological and in vivo studies have revealed a tight relationship between tau pathology and cognitive i

275 ween conditioning and robustness and use its tight relationship to define quantitative thresholds for

276 potentially harmful requiring mechanisms for tight repression and substrate-specific activation.

277 s lagging due to the limits in materials and tight requirements for optical applicaitons.

278 Production of oil from shale and tight reservoirs accounted for almost 50% of 2016 total

279 he cells re-aggregated within hours, forming tight retinal organoids.

280 Nop15 are highly flexible, but essential for tight RNA binding.

281 tacked perpendicular to the fibril axis into tight self-associating sheets.

282 ticle sizes from 0.9 to 1.4 nanometers, with tight size distributions.

283 AMP/PKA signalling is compartmentalised with tight spatial and temporal control of signal propagation

284 intracellular trafficking network linked to tight spatial control of active Src and FAK levels, and

285 gulate diverse cellular processes depends on tight spatial control of its activity.

286 cell cycle exit, granules initially retain a tight spatial organization, yet their size distribution

287 perate in cellular lipid metabolism and form tight structural associations, which were first observed

288 ce in the CCS-mass 2D spectrum, suggesting a tight structure-function relationship for each class of

289 cution of mitotic cell division requires the tight synchronisation of numerous biochemical pathways.

290 key innovative feature of this source is the tight three-dimensional confinement of the optical pump

291 Because most FSH is constitutively secreted, tight transcriptional regulation is critical for maintai

292 rs of highly packed residues that facilitate tight transmembrane helix association.

293 tacted with controlled volumes of air in air-tight tubes containing oxygen-sensors and are further ag

294 helices unfold and the alpha2 helices form a tight two-helix coiled-coil.

295 ver, it has not been yet discerned whether a tight U-turn or an alternative conformation, such as a V

296 The newly developed tight UF hollow fiber membranes display huge potential f

297 The tight UF hollow fibers also exhibit robust performance i

298 The newly developed tight UF hollow fibers not only possess a small mean por

299 Cell development requires tight yet dynamic control of protein production.

300 As examples, we present them as tight yet reversible immobilization reagents for surface