ライフサイエンスコーパス: tight control

1 ly for fasting glucose and body mass index ("tight controls").

2 oliferation and tumorigenesis, is subject to tight control.

3 ial energetic response at a time of normally tight control.

4 amily members to keep hTERT expression under tight control.

5 ostimulatory ligands is believed to be under tight control.

6 ween those with usual control and those with tight control.

7 nd molecular mechanisms responsible for this tight control.

8 ke growth factor I receptor (IGF1R) is under tight control.

9 gamma synthesis or that such cells are under tight control.

10 ent immune response, they must be kept under tight control.

11 formance within or across institutions under tight control.

12 tantial reduction of future stroke risk with tight control (0.49; 0.34-0.69), but those with establis

13 id not experience stroke risk reduction with tight control (0.92; 0.83-1.03).

14 llow-up, 286 patients (12.7%) who maintained tight control, 249 (12.6%) who had usual control, and 43

15 less-tight control and 488 women assigned to tight control (31.4% and 30.7%, respectively; adjusted o

16 vere Crohn's disease who were managed with a tight control algorithm, using clinical symptoms and bio

17 ere similar among 493 women assigned to less-tight control and 488 women assigned to tight control (3

18 s for irreversible degradation must be under tight control and is often regulated at the level of sub

19 Tight control and mutual balance of their antagonistic a

20 ntigen-presenting cells (APCs) is subject to tight control and responds to inflammatory stimuli such

21 e and function of the cardiac wall are under tight control and, when the control is upset, can result

22 is and activity of the regulators, to ensure tight control and, where required, irreversible commitme

23 cose metabolic rates while glucose was under tight control as compared with loose control (3.2 +/- 0.

24 d for treatment, such as treat to target and tight control based on therapeutic monitoring and early

25 not surprising that these channels are under tight control by a series of inhibitory extracellular io

26 This process is under tight control by arginase 1 and is of functional importa

27 As such, MOMP is subject to tight control by Bcl-2 family proteins.

28 ecursors with high avidity to NY-ESO-1 under tight control by CD4(+)CD25(+) regulatory T (Treg) cells

29 tro and in vivo These results establish that tight control by ESE3/EHF over the Lin28/let-7 axis is a

30 ow matriptase activates prostasin under this tight control by HAI-1.

31 eals AD as a metabolic disease that is under tight control by JNK3.

32 ein abundance suggests this process is under tight control by miRNAs at the onset of fertilization.

33 The BMP-initiated signaling pathway is under tight control by processes including regulation of the l

34 PRR complexes are under tight control by protein phosphatases, E3 ligases, and o

35 that pluripotency and self-renewal are under tight control by specific molecular networks.

36 gastric cancer (GC) and, therefore, requires tight control by suppressive counter mechanisms.

37 ulates iNKT cell autoreactivity based on the tight control by the APC cytoskeleton of the sizes and d

38 noxin mRNA and protein levels are under tight control by the cell cycle.

39 folded protein domains, are also subject to tight control during evolution.

40 ation of these activators, chaperones ensure tight control, dynamic range, and rapid reversible trans

41 icantly higher proportion of patients in the tight control group achieved the primary endpoint at wee

42 105 (86%) of 122 patients in the tight control group and 100 (82%) of 122 patients in the

43 ients (25 events in 14 [14%] patients in the tight control group and eight events in six [6%] patient

44 ure criteria, which differed between groups (tight control group before and after random assignment:

45 anagement group and 32 (26%) patients in the tight control group discontinued the study, mostly becau

46 CR20 response at 48 weeks were higher in the tight control group than in the standard care group (odd

47 inical management group, 0.9 years [SD 1.7]; tight control group, 1.0 year [2.3]) were randomly assig

48 s (18 [15%]), and headache (18 [15%]) in the tight control group, and worsening Crohn's disease (35 [

49 -control group and 27.5% of the women in the tight-control group (P<0.001).

50 developed in 40.6% of the women in the less-tight-control group and 27.5% of the women in the tight-

51 c blood pressure that was higher in the less-tight-control group by 4.6 mm Hg (95% CI, 3.7 to 5.4).

52 he all-cause mortality rate was 11.0% in the tight-control group vs 10.2% in the usual-control group

53 e care units did not confirm the benefits of tight control, however, and the most recent study sugges

54 Patients were categorized as having tight control if they could maintain their systolic BP a

55 Despite the normally tight control in cell numbers in this region in adults,

56 nonreceptor tyrosine kinases are kept under tight control in cells, but exposure to several differen

57 isone in an MTX-based treatment strategy for tight control in early RA improves patient outcomes.

58 f the host, suggesting the requirement for a tight control in the regulation of transposable element

59 ver, and the most recent study suggests that tight control increases mortality rates.

60 Such tight control may be due to the incorporation of Drosoph

61 S gene transcription and further underscores tight control mechanisms regulating the expression of th

62 occurs during myogenesis and highlights the tight control mechanisms that are utilized for the regul

63 re enrolled and randomly assigned to receive tight control (n=101) or standard care (n=105).

64 Tight control of 8-oxoG bypass during DNA replication is

65 bly transfected with p14(ARF) cDNA under the tight control of a doxycycline-inducible promoter.

66 ma) cells expressing wild-type p53 under the tight control of a tetracycline-responsive promoter was

67 line that stably expresses luciferase under tight control of a tetracycline-responsive promoter.

68 In the striatum, the sparse firing and tight control of action potential timing is in contrast

69 ipin were observed, suggesting that there is tight control of acylation of these phospholipids in the

70 Advantages of this setup include tight control of all bilayer components, which is compel

71 ses rapidly at INRs greater than 4.0 to 5.0, tight control of anticoagulant therapy to maintain the I

72 Tight control of antigen-receptor gene rearrangement is

73 ng to signal transduction and suggest that a tight control of ATPase activity by the CARDs prevents R

74 Tight control of B cell differentiation into plasma cell

75 Tight control of blood glucose concentration in people w

76 xtent to which intensive insulin therapy and tight control of blood glucose improve outcome after isc

77 Many studies of tight control of blood glucose in critically ill patient

78 tremely elevated blood glucose levels, early tight control of blood glucose may permit this insulin-h

79 g overfeeding may improve outcomes more than tight control of blood sugars.

80 The tight control of both biosynthesis of, and cellular resp

81 A tight control of BR homeostasis is vital for modulating

82 This study reveals that tight control of brain volume is exerted through a large

83 l, and post-translational levels, suggesting tight control of C/EBPdelta content and function.

84 Our results thus show that the tight control of Ca(2+) influx by the TRPM4 channel is c

85 nd alpha7-nAChR offers a novel mechanism for tight control of calcium dynamics in neurons.

86 Here, we report tight control of cardiomyocyte hypertrophy through miR-3

87 Tight control of cardiomyocyte proliferation is essentia

88 he underlying molecular mechanism behind the tight control of CD86 is not completely understood.

89 e neural crest cell (NCC) migration requires tight control of cell adhesions, cytoskeletal dynamics a

90 Tight control of cell proliferation is essential for pro

91 One means by which signaling is regulated is tight control of cell surface CD70, which is expressed o

92 Tight control of cell/tissue identity is essential for a

93 nscription into the operon, thereby ensuring tight control of cellular NusA levels.

94 Tight control of charge transport from a visible light s

95 terior-to-anterior cytokinesis, suggesting a tight control of CIF2 protein abundance.

96 termination efficiency demonstrated loss of tight control of conjugation function.

97 Our data suggest that tight control of CYCD activity in the central cell and i

98 These data clearly point to the need for tight control of disease activity without reliance on co

99 ts with rheumatoid arthritis--for sustained, tight control of disease activity--compared with routine

100 Our findings support the importance of tight control of DNA metabolism for beta-cell integrity

101 en dATP and ribonucleotide reductase ensures tight control of dNTP concentration.

102 Treatment strategies for tight control of early rheumatoid arthritis (RA) are hig

103 st anti-oxidant defence system and maintains tight control of EGSH despite substantial oxidative chal

104 Our findings indicate tight control of eIF4E phosphorylation through modulatio

105 We propose that tight control of ERK signalling strength by MKP3 is impo

106 autoinhibitory switch mechanism that allows tight control of ESCRT-III assembly.

107 s fire near the peak of CA1 theta, under the tight control of excitatory inputs that arise at a speci

108 esponses, including autoimmunity; therefore, tight control of expression is critical for proper homeo

109 ranslational organization of RNase H1 allows tight control of expression of RNase H1 in mitochondria,

110 for regulation of gene expression indicate a tight control of expression of the cat-1 gene within the

111 Tight control of extracellular and intracellular inorgan

112 These results indicate that the tight control of FtsA, and probably FtsQ, by cell cycle

113 ystem that affords for modular, tunable, and tight control of gene expression in vivo.

114 e-efficient selection of mass cultures, with tight control of gene expression provided by the Tc-regu

115 ulation is a powerful mechanism that enables tight control of gene expression, via integration of mul

116 providing a novel mechanism for maintaining tight control of gene expression.

117 rough an indirect control mechanism ensuring tight control of gene expression.

118 imeric repressor system was shown to exert a tight control of green fluorescent protein expression in

119 Also, tight control of HbA1c levels in patients with type 2 di

120 The tight control of heat shock gene expression has prompted

121 Thus, tight control of Hedgehog pathway activity throughout em

122 Our results indicate that the tight control of HIF transient dynamics has important fu

123 ults in embryonic lethality, indicating that tight control of Hif-mediated adaptive responses to hypo

124 -1 gene transcription and contributes to the tight control of HO-1 gene regulation in the setting of

125 Understanding such tight control of host defense requires the elucidation o

126 hat Y. pestis YopJ and YopM can both exert a tight control of host IL-1beta/IL-18 production to benef

127 e observations suggest a role for E47 in the tight control of HSC proliferation and energy metabolism

128 hTERT promoter are known to be important for tight control of hTERT in normal tissues, but the molecu

129 ) is driven by a RHO-like GTPase that allows tight control of hydrogen peroxide (H(2)O(2)) production

130 ether an insulin infusion should be used for tight control of hyperglycemia in critically ill childre

131 The effects of less-tight versus tight control of hypertension on pregnancy complications

132 Based on these findings, we propose that tight control of IkappaBbeta protein by p65 is necessary

133 We conclude that tight control of IL23 mRNA stability by TTP is critical

134 Early intervention and tight control of inflammation optimise outcomes in rheum

135 ility to switch between treatments to ensure tight control of inflammation.

136 This tight control of iTreg differentiation dictated by Ag do

137 hysiological processes in plants, making the tight control of its endogenous levels and spatiotempora

138 ance, in terms of interaction with the host, tight control of its in vivo expression might be particu

139 expressed without slowing growth, suggesting tight control of its powerful protein-remodeling activit

140 These effects are mediated through tight control of lipid localization, as overexpression o

141 inally, we show that this is achieved by the tight control of local excitation and inhibition by peri

142 or catabolic inactivation of RA required for tight control of local RA concentrations, is significant

143 ts and solubilisation rates might indicate a tight control of LytB activity to prevent unrestrained b

144 We propose that the tight control of mDia2 expression and ubiquitin-mediated

145 ion is an energy-demanding process requiring tight control of metabolism and redox state.

146 The tight control of metal homeostasis in cells depends on t

147 thway upstream of DNMT1, thus disturbing the tight control of methylation-sensitive genes, which are

148 Not surprisingly, a tight control of miR-155 expression is required to avoid

149 ulatory pathway or both, we demonstrate that tight control of MutS levels in stationary phase contrib

150 ion of digital and analogue processes allows tight control of Myc expression at the population and si

151 ivated K(+) channel activity, thus providing tight control of myogenic tone in the microcirculation.

152 and substrate adaptors cooperatively provide tight control of neddylation and cullin-RING-ligase acti

153 Therefore, tight control of niche number, size and function is nece

154 esponses, and suggest that the host requires tight control of NK cells under these conditions.

155 Tight control of nodulation and infection is required to

156 eath areas also were found, highlighting the tight control of organ growth within and between phytome

157 d shed light on the mechanisms mediating the tight control of p100 processing.

158 may prevent morbidity in patients requiring tight control of Paco2.

159 Finally, we show that tight control of ParA filament dynamics is essential for

160 1 protein, play key role in proteostasis via tight control of partitioning and recycling of misfolded

161 nt role for various TLRs in cooperation with tight control of pathogens penetrating into Peyer patche

162 ticentre trials contradicted the benefits of tight control of patients' blood glucose and results sho

163 as well as the PDCD4 transcript to maintain tight control of PDCD4 levels.

164 Tight control of peripheral vitamin C concentration is p

165 Therefore, tight control of PKR activity is essential for regulated

166 opment of postsurgical fibrosis is under the tight control of positive and negative T cell costimulat

167 Thus, our results demonstrate tight control of PP2A expression, and provide an explana

168 ur studies suggested mechanisms of LCMT-1 in tight control of PP2A function, important for the cell c

169 ly regulate T and B cell responses to ensure tight control of productive T-B cell interactions.

170 HSC function depends on the tight control of proliferation and the balance between s

171 This approach offers tight control of protein functions and improved detectio

172 ase of GDP from eIF2gamma and thereby ensure tight control of protein synthesis initiation.

173 Tight control of psoriatic arthritis disease activity th

174 These functions rely on a tight control of RA distribution within embryonic tissue

175 ion of the pancreatic field are dependent on tight control of RA signaling.

176 wardly rectifying potassium channels enforce tight control of resting membrane potential in excitable

177 The Tight Control of Rheumatoid Arthritis study previously d

178 ganization of cAMP signaling begins with the tight control of second messenger synthesis.

179 n yeast, mitochondrial function requires the tight control of several metabolic processes such as coe

180 rowth, metabolism, and cell division through tight control of signaling via two complexes, TORC1 and

181 as a strategy to define nanostructures with tight control of size, shape and orientation has been wi

182 Tight control of Smad level and activity is critical for

183 E regulation by Ca(2+) ions not only enables tight control of SOCE by the SR membrane, but also provi

184 the Na(+),K(+)-ATPase activity leading to a tight control of sodium reabsorption.

185 es a unique mechanistic insight into how the tight control of spatial segregation is critical in the

186 ncover a new feature of BIR and propose that tight control of ssDNA accumulated during this process i

187 These data suggest that a tight control of Std fimbrial expression mediated by Ros

188 remove SUMOs from targets, contributing to a tight control of SUMOylated proteins.

189 Tight control of synapse formation ensures that neurons

190 Tight control of systolic BP among patients with diabete

191 Tight control of T follicular helper (Tfh) cells is requ

192 Tight control of T(FH) numbers maintains self tolerance.

193 Tight control of T-cell proliferation and effector funct

194 the bacterial heat shock response where the tight control of the amount of heat shock proteins is ac

195 oredoxin (aptamers) were expressed under the tight control of the arabinose-inducible P(BAD) promoter

196 ir normal controls by placing each under the tight control of the arabinose-regulated P(araB) promote

197 arbon dioxide into organic matter requires a tight control of the ATP/NADPH ratio which, in other pho

198 mote neural development and signaling, hence tight control of the concentration of cellular DISC1 in

199 ential function of BER not only necessitates tight control of the continuous availability of basic co

200 It ensures very tight control of the derepression of cell death by the c

201 comprise an unusual operon in which separate tight control of the distal gene (kilB) by the KorB repr

202 d arrestin binding may more generally permit tight control of the duration of GPCR activity.

203 f-renewal of embryonic stem cells requires a tight control of the expression of several key stemness

204 s unique transcriptional mechanism assures a tight control of the homeostasis of VLDL-derived fatty a

205 pombe, the regulatory logic that governs the tight control of the key meiosis-inducing genes in these

206 the cell devotes many genes/proteins to keep tight control of the level of intracellular free Ca(2+).

207 eractions in three-dimensions while allowing tight control of the microenvironment and real-time moni

208 egulation of chromatin remodelers allows for tight control of the naive-to-primed pluripotency transi

209 Tight control of the number and distribution of crossove

210 oreactor system, which allowed for rapid and tight control of the operating conditions.

211 The mechanism for tight control of the robust catalytic potential of PARP-

212 Many of these processes require tight control of the size and shape of cytoskeletal stru

213 erfering RNA expression system that allows a tight control of the specific gene silencing by RNAi.

214 taphase plate formation and thinning require tight control of the state of the mechanical linkage bet

215 nducible cell lines expressing PS2 under the tight control of the tetracycline-responsive transactiva

216 These data provide the first indication that tight control of the turnover of positive as well as neg

217 onal roles speak to the need for maintaining tight control of their concentration within cells.

218 lex network of transcription factors ensures tight control of their expression.

219 The tight control of their fusion and fission, a process ter

220 ve unique homeostatic abilities, maintaining tight control of their local environment through interco

221 re very unstable, which is important for the tight control of their temporal and spatial expression p

222 bute to HSV latency and reactivation through tight control of these LAT-encoded miRNAs and their vira

223 pregnancy, but underscore the necessity for tight control of this signaling molecule to avoid unwarr

224 e reactivation by deubiquitination, allowing tight control of thyroid hormone action.

225 However, the mechanisms that ensure the tight control of tissue-specific alternative splicing ar

226 caution is required for vector spillover and tight control of tissue-specific gene expression.

227 for its function, and suggest a mechanism of tight control of TLR3 signaling and thus immunity.

228 ns within individual sensory ganglia despite tight control of total number in all ganglia.

229 Tight control of transposon activity is essential for th

230 A tight control of viral replication by the host innate im

231 Ocean's 'organic carbon pump' has exerted a tight control on atmospheric CO2, and thus global climat

232 The forest canopy exerts a tight control on biotic N input at a period of high prod

233 We aimed to assess the effect of tight control on early psoriatic arthritis using a treat

234 ression of COX subunits exerted a relatively tight control on oxidative phosphorylation.

235 K approximately = 10(12) M(-1)) and exerts a tight control on the CB7 concentration available to inte

236 nts were randomly assigned at a 1:1 ratio to tight control or clinical management groups, stratified

237 from dephosphorylation in vitro, suggesting tight control over activity in vivo.

238 To ensure a quick response yet maintain tight control over AP-1 target genes, AP-1 activity is l

239 systems that gel only on mixing, which gives tight control over assembly.

240 eed to develop sustainable synthesis routes, tight control over chemical releases during production,

241 Adipocytes maintain tight control over circulating plasma levels, suggesting

242 ts suggest that TGF-beta signaling may exert tight control over COL7A1 by offsetting the balance betw

243 Thus, cells exert tight control over cytosolic metal concentrations, even

244 programming its in vivo retention, providing tight control over embedded drug release kinetics.

245 lators in multi-input motifs (MIMs) provides tight control over expression of target genes.

246 ession of the genes that encode the enzymes, tight control over gene expression and consistent expres

247 These mutations cooperate to deregulate the tight control over gene expression that is otherwise see

248 S. aureus must ensure tight control over its cellular levels as both high leve

249 The intraerythrocytic parasite itself exerts tight control over its internal Na(+), K(+), Cl(-), and

250 th intergenic regions and introns suggests a tight control over length expansion of non-coding region

251 ung volume changes, emphasizing the need for tight control over lung volume when performing hyperpola

252 Additionally, Ptc(+/-) NSCs maintain tight control over mitosis and do not further augment pr

253 eous fraction, but they exert a powerful and tight control over neuronal activity and consequently mo

254 We propose that, rather than exerting tight control over parameters, the auditory system uses

255 In conjunction with a tight control over pore sizes, inverse opal scaffolds ha

256 ring a number of different Ag particles with tight control over shape, as well as a wide variety of A

257 udy indicates that GABA(B) receptors exert a tight control over spatial learning by modulating neuron

258 Mitochondria must maintain tight control over the electrochemical gradient across t

259 tions as a negative regulator that imposes a tight control over the level of innate immune response a

260 epts of triterpene biosynthesis, which posit tight control over the mechanistic pathway through catio

261 as well as better LE and LipE by exercising tight control over the molecular weight and lipophilicit

262 Nervous system function requires tight control over the number of synapses individual neu

263 Tight control over the segregation of endoderm, mesoderm

264 Immune homeostasis is dependent on tight control over the size of a population of regulator

265 with subnanometer precision and allow for a tight control over their biochemical functionality, e.g.

266 synthesize intermetallic nanocrystals with a tight control over their size and shape.

267 Both systems rely on tight control over triggering the concerted refolding of

268 We postulated that such tight control permits a paracrine function of vitamin C.

269 in nucleation by the Arp2/3 complex is under tight control, remaining inactive until stimulation by n

270 Furthermore, tight control significantly increases episodes of hypogl

271 A tight control strategy for RA implies monthly visits to

272 ents were randomly assigned to an MTX-based, tight control strategy starting with either MTX and pred

273 l for proper function, and evolution of this tight control system may have been favored by reduction

274 Women were randomly assigned to less-tight control (target diastolic blood pressure, 100 mm H

275 rget diastolic blood pressure, 100 mm Hg) or tight control (target diastolic blood pressure, 85 mm Hg

276 Developmental errors are minimized by the tight control that imprinted genes have on regulation of

277 These include the tight control that somatic support cells exert on every

278 normal growth, these proteins are subject to tight control through at least two mechanisms.

279 oles and its plasma level in humans requires tight control to avoid bone loss (insufficiency) or vasc

280 h, the regulation of these pathways requires tight control to prevent DNA errors and potentially onco

281 The sigma(54)-factor imposes tight control upon the RNAP by creating a regulatory swi

282 risk of all-cause mortality was 22.8% in the tight control vs 21.8% in the usual control group (adjus

283 verall maternal complications, although less-tight control was associated with a significantly higher

284 To test this action in vivo, normal oral tight control was bypassed by parenteral ascorbate admin

285 ly assigned in a 1:1 ratio to receive either tight control (with review every 4 weeks and with escala