ライフサイエンスコーパス: tight junction

1 d cytosolic translocation of CLDN14 from the tight junction.

2 gistic effect of ethanol and acetaldehyde on tight junction.

3 adherin and the formation of ZO-1 containing tight junctions.

4 yanate-dextran 4 kDa, and mRNA expression of tight junctions.

5 down through perforin-mediated disruption of tight junctions.

6 m and is involved in the organization of the tight junctions.

7 ain the blood-testis barrier formed by their tight junctions.

8 r leakage, and better maintained endothelial tight junctions.

9 ing cytokinesis and is mediated by sustained tight junctions.

10 acellular leak and rearrangement of alveolar tight junctions.

11 the formation/reorganization of adherens and tight junctions.

12 actin nucleation-promoting factor N-WASP to tight junctions.

13 rrier properties and mechanical stability of tight junctions.

14 dothelial transcytosis rather than a loss of tight junctions.

15 ithelial polarity and the normal assembly of tight junctions.

16 l growth factor signaling and preserves BMEC tight junctions.

17 ovokes loss of endothelial cell coverage and tight junctions.

18 k between alpha-toxin and the degradation of tight junctions.

19 cell cultures on permeable supports 1) form tight junctions, 2) express typical tight junction prote

20 ial cells (ECs), which are connected through tight junctions, adherens junctions, and stabilizing bas

21 a group of 105 genes encoding functions for tight junction, adherent, and cell migration.

22 mbly and function of epithelial adherens and tight junctions (AJs and TJs).

23 of Crtc-sNPF signaling disrupted epithelial tight junctions, allowing resident gut flora to promote

24 cule-1 (PECAM-1), plays an important role in tight junction among endothelia cells, leukocyte traffic

25 atment partially reversed the degradation of tight junction and adherens junction both in vivo and in

26 in localization of adhesion proteins at the tight junction and basal ES at the Sertoli cell BTB.

27 cancer that is based on the dysregulation of tight junction and epithelial polarity master genes via

28 on, c) increased apoptosis, d) alteration of tight junction and neuronal damage.

29 ood-brain barrier permeability and modulated tight junction and PLVAP protein expression in fetal bra

30 ce was maintained by the interaction between tight junctions and a submembraneous network of actomyos

31 ction in the ability to mediate formation of tight junctions and actin-based protrusions, bind atypic

32 ll GTPase protein that is a key component of tight junctions and adherens junctions.

33 ced loss of zonula occludens-1 (ZO-1) at the tight junctions and alterations in F-actin cytoskeletal

34 bearing the humanized alleles formed normal tight junctions and did not exhibit any immunologic abno

35 ggering Rho GTPase signals that modulate RPE tight junctions and enhance RPE barrier function.

36 nel protein localization within synapses and tight junctions and function to scaffold intracellular s

37 pericytes in xenograft models disrupted BTB tight junctions and increased vascular permeability.

38 lation of JAM-C promotes its localization to tight junctions and inhibits transwell migration of A549

39 ngual epithelium as cations permeate through tight junctions and leave their larger and less permeabl

40 hat form blood-CNS barriers have specialized tight junctions and low rates of transcytosis to limit t

41 lls form a blood-retina barrier by virtue of tight junctions and low transcytosis.

42 ithelial lineage such as cell-cell adhesion, tight junctions and markers of differentiation.

43 cient for strengthening mammalian epithelial tight junctions and preserving cell polarity and barrier

44 e that a dynamic interplay among E-cadherin, tight junctions, and EMT exists and mediates an importan

45 over, ultrastructure of corneodesmosomes and tight junctions appeared normal, immunohistochemistry fo

46 l airspaces of the lung, alveolar epithelial tight junctions are crucial to regulate airspace fluid.

47 ntirely through transcytosis, as specialized tight junctions are functional as early as vessel entry

48 ens junctions and bicellular and tricellular tight junctions are maintained and remodeled during cell

49 Furthermore, GTP-bound Rap1 promoted tight junction assembly, and loss of Rap1B led to loss o

50 DbpA mediates tight junction-associated activities in tubular epitheli

51 GRHL2), in mice led to reduced expression of tight junction-associated barrier components, reduced co

52 epithelial cells (IECs) fail to express the tight junction-associated protein claudin-7.

53 We conclude that USP53 is a novel tight junction-associated protein that is essential for

54 hich correlated with a reduced expression of tight junction-associated proteins and increased numbers

55 ates expression and distribution of selected tight junctions-associated claudins.

56 Assembly and sealing of the tight junction barrier are critically dependent on the p

57 long cytoplasmic process that can cross the tight junction barrier to reach the lumen.

58 ns that mediate LPS modulation of intestinal tight junction barrier using in vitro and in vivo model

59 The defective intestinal tight junction barrier was shown to be an important fact

60 re multifunctional and have an impact on the tight junction barrier while the non-LEE-encoded protein

61 y, and disease have focused on BBB and BCSFB tight junctions but not the corresponding endothelial an

62 nol and acetaldehyde synergistically disrupt tight junctions by a mechanism involving calcium, oxidat

63 ission electron microscopy and expression of tight junctions by confocal microscopy.

64 of intercellular adhesive structures such as tight junctions, cadherin-based adherens junctions, and

65 ar channels and speculate that modulation of tight junction channel gating kinetics may be an unappre

66 get genes, encoding structural components of tight junctions (Claudins and ZO proteins), adherens jun

67 EPAC-Rap1 signaling pathway may regulate the tight junction complex of the BRB and may restore barrie

68 enance of the apically restricted actomyosin-tight junction complex.

69 cells, suggesting that USP53 is part of the tight junction complex.

70 pression of claudin-4, a protein involved in tight junction complexes, is widely dysregulated in epit

71 ation of ZO-1 mRNA, which encodes a critical tight junction component.

72 Analysis of the levels of tight junction components demonstrates that claudin-2 pr

73 ng as evidenced by de novo expression of the tight junction components ZO-1 and E-cadherin and the fo

74 Tight junction components ZO-1, claudin 5, and occludin

75 red expression and localization of principle tight junction components, and that epidermal differenti

76 The collecting duct epithelium forms tight junctions composed of barrier-enforcing claudins a

77 crucial for mechanotransduction, but whether tight junctions contribute to the regulation of cell-cel

78 s) inducing barrier integrity impairment and tight junction damage.

79 Blood-brain barrier disruption and tight junction damages were observed in the presence of

80 The organization and integrity of epithelial tight junctions depend on interactions between claudins,

81 paracellular ion transport and cause a novel tight junction disease characterized by a non-BS, non-GS

82 e sensitized Caco-2 cells to ethanol-induced tight junction disruption and barrier dysfunction, where

83 -dependently increased acetaldehyde-mediated tight junction disruption and barrier dysfunction.

84 RNA blocked ethanol and acetaldehyde-induced tight junction disruption and barrier dysfunction.

85 ration) and BTB function (i.e., basal ES and tight junction disruption, making the barrier leaky), in

86 ZO-1 depletion led to tight junction disruption, redistribution of active myos

87 acetaldehyde-induced barrier dysfunction and tight junction disruption.

88 ehydrogenase attenuated acetaldehyde-induced tight junction disruption.

89 acetaldehyde-induced barrier dysfunction and tight junction disruption.

90 -2 mimic activity in response to bacteria or tight-junction disruption.

91 L-4 prevented mucosal barrier disruption and tight junction downregulation in a mouse model of house

92 e between neighbors, and two new tricellular tight junctions flank the midbody following cytokinesis.

93 ys (i.e., mitogen-activated protein kinases, tight junctions, focal adhesion, transforming growth fac

94 Intercellular tight junctions form selectively permeable barriers that

95 zed superfibronectin is sufficient to induce tight junction formation and apicobasolateral polarizati

96 had no inhibitory effect on wound closure or tight junction formation following injury.

97 that astrocytes of the glia limitans induce tight junction formation in response to inflammatory cue

98 hosphorylation was reduced in lungs of mice, tight junction formation increased, and protein concentr

99 in alpha5beta1 clustering and is followed by tight junction formation, as determined by ZO-1 localiza

100 1, claudin-4, and claudin-8-key proteins for tight junction formation.

101 The blood-nerve barrier (BNB), formed by tight junction-forming microvessels within peripheral ne

102 as mucus layer modifications and hydration, tight junction fortification and the production of a bro

103 age and association studies identified three tight junction genes from the kidney--claudin-14, -16, a

104 epressor Snail1, which impedes expression of tight junction genes.

105 vated receptor gamma (Ppargamma) pathway and tight-junction genes.

106 ngs support a key role of JAM-A in promoting tight junction homeostasis and lung barrier function by

107 sphingomyelinase is linked to degradation of tight junctions in endothelial cells in vitro, which is

108 proliferation, maturation, and formation of tight junctions in Sertoli cells, thus confirming a requ

109 and zonula occludens 2 localization to lung tight junctions in situ along with a delay in up-regulat

110 ut the effects of IL-22 on the regulation of tight junctions in the intestinal epithelium.

111 y, alpha-toxin induces severe degradation of tight junctions in the lung and causes lung edema in viv

112 e C zeta-mediated internalization of surface tight junctions in the pulmonary epithelium.

113 les through the pericellular capillaries and tight junctions in the taste bud.

114 at the corners of polarized epithelia where tight junctions in vertebrates or septate junctions (SJ)

115 ice, while IL-17 release impaired enterocyte tight junctions, increased enterocyte apoptosis, and red

116 vel and tissue-specific role of claudin-3, a tight junction integral protein, in inhibiting colon can

117 ic effect of ethanol and acetaldehyde on the tight junction integrity in Caco-2 cell monolayers.

118 Ethanol up to 150 mM did not affect tight junction integrity or barrier function, but it dos

119 f BBB integrity and permeability by altering tight junction integrity, promoting the displacement of

120 independently disrupted polarized epithelial tight junction integrity.

121 ional, blood-brain barrier model exemplifies tight-junction integrity.

122 proinvasive functions when it relocates from tight junctions into the cytonuclear compartment.

123 re, we provide evidence that the tricellular tight junction is important for paracellular water perme

124 Whether the tight junction is permeable to water remains highly cont

125 by brain endothelial cells interconnected by tight junctions is essential for the homeostasis of the

126 ion of Par3, which is normally restricted to tight junctions, is sufficient to alter apical membrane

127 h Kindlin-2 does not associate directly with tight junctions, its downregulation also destabilizes th

128 ops by protease-mediated lysis of epithelial tight junctions, leading to accelerated cell death; desq

129 size-reductive proliferation and subsequent tight junction maturation in a dominant manner.

130 Thus, impairment of both adherens and tight junctions may contribute to enhanced leakiness of

131 apse microscopy reveals strikingly decreased tight junction membrane contact dynamics in knockout cel

132 Claudins are tight-junction membrane proteins that function as both p

133 ysis confirmed that ALCAM is associated with tight junction molecule assembly at the BBB, explaining

134 ast, wild-type mice showed no change in lung tight junction morphologic features in response to mild

135 oss individual claudin-2 channels within the tight junction of cultured canine renal tubule or human

136 se kidney, ILDR1 is localized to tricellular tight junctions of the distal tubules.

137 The barrier properties of tight junctions of the stria vascularis appeared intact

138 re cytotoxic and exhibited up to 175% higher tight junction-opening capacity than did protein nanopar

139 induce apoptosis, oxidative stress, loss of tight junctions or production of IL-8 after 24 hours, bu

140 unction, either by strengthening endothelial tight junctions or suppressing endothelial vesicular tra

141 We report a novel trans-tight junction patch clamp technique that detects flux a

142 n in tumor endothelium, activating TIE-2 and tight junction pathways and normalizing vessel structure

143 cells that include the Nrf2, AMP kinase, and tight junction pathways.

144 KO mice, with rescue of the endothelial gene tight junction, pericyte coverage and extracellular-matr

145 anning ion conductance microscopy to resolve tight junction permeabilities with submicrometer precisi

146 entrations, causes an increase in intestinal tight junction permeability (TJP) via a TLR4-dependent p

147 i cells was shown to induce the Sertoli cell tight junction permeability barrier disruption via chang

148 nction ultrastructural complexity but reduce tight junction permeability; and 3) no claudin hemichann

149 interactions are a novel target to regulate tight-junction permeability.

150 ion of Cx43 indeed resealed the Sertoli cell tight junction-permeability barrier based on a functiona

151 loss of plastin 3 perturbed the Sertoli cell tight junction-permeability barrier, mediated by changes

152 Chronic alcohol abuse weakens alveolar tight junctions, priming the lung for acute respiratory

153 ition, Atg9 interacted with PALS1-associated tight junction protein (Patj), which associates with TSC

154 Z domain-containing protein Pals1-associated tight junction protein (PATJ), which has been described

155 breakdown of type IV collagen and decreases tight junction protein (TJP) expression in a co-culture

156 pe and organisation caused by truncations in Tight Junction Protein 1a (ZO-1a).

157 vo requires an intracellular scaffold called Tight Junction Protein 1b (Tjp1b).

158 the mRNA expression of cadherin-1 (CDH1) and tight junction protein 2 (TJP2), two primary components

159 ransporters ABCB4, ABCB11, ATP8B1, ABCC2 and tight junction protein 2 (TJP2).

160 (DSC)2, occludin (OCLN), desmoglein (DSG)1, tight junction protein 2, and gap junction protein alpha

161 luorescent assessments of zonula occludens-1 tight junction protein cellular distribution were conduc

162 The tight junction protein claudin 1 (Cldn-1) has been repor

163 ng numerous host cell factors, including the tight junction protein claudin-1 (CLDN1).

164 with decreases in the intestinal epithelial tight junction protein claudin-1 (CLDN1).

165 expression of CLDN10, the gene encoding the tight junction protein Claudin-10, show enhanced paracel

166 -22-dependent upregulation of the epithelial tight junction protein claudin-2.

167 pithelial integrity indicated by loss of the tight junction protein claudin-3 was not observed during

168 I/R injury caused a loss of the tight junction protein claudin-3, which was ameliorated

169 d reduced expression of the endothelial cell tight junction protein claudin-5 (Cldn5) and abnormal bl

170 stress alters BBB integrity through loss of tight junction protein Cldn5, promoting peripheral IL-6

171 hesion molecule-A (JAM-A) is an adherens and tight junction protein expressed by endothelial and epit

172 lt was of focal nature and led to changes in tight junction protein expression and architecture.

173 concentrations of Hcy showed a reduction of tight junction protein expression, increased FITC dextra

174 Our studies identify a novel role of a tight junction protein in the development and progressio

175 lso rapidly affected CPE cell morphology and tight junction protein levels.

176 l host factors, the tetraspanin CD81 and the tight junction protein occludin (OCLN), explain, at leas

177 vascular endothelial cells degraded both the tight junction protein occludin (p < 0.05) and the adher

178 We provide evidence that the tight junction protein occludin contributes to the regul

179 dence for IL-17A-dependent regulation of the tight junction protein occludin during epithelial injury

180 d that ischemia induced rapid degradation of tight junction protein occludin in cerebromicrovessels.

181 ription factor NF-kappaB and stabilizing the tight junction protein occludin.

182 domain has the same arch-shaped fold as the tight junction protein occludin.

183 Occludin is a transmembrane tight junction protein that contributes to diverse cellu

184 Claudin-2 is a tight junction protein that mediates paracellular water

185 Junctional adhesion molecule-A (JAM-A) is a tight junction protein that serves as a receptor for reo

186 repressed the translation of mRNAs encoding tight junction protein ZO-1 and adherens junction E-cadh

187 Here, we demonstrate that the tight junction protein ZO-1 regulates tension acting on

188 yosin heavy chain IIB, paxillin, Sec61 beta, tight junction protein ZO1, and Tom20.

189 DCK renal epithelial cells, silencing of the tight junction protein zona occludens 2 (ZO-2 KD) induce

190 We found that claudin-1, a tight junction protein, and small proline-rich (Sprr2) p

191 Claudin-18.1 is the only known lung-specific tight junction protein, but its contribution to airway b

192 and a very weak nominal association with the tight junction protein, claudin-5, has previously been i

193 molog in zebrafish elevated transcription of tight junction protein-encoding genes and increased zebr

194 ssion of Claudin-2, a cation-channel-forming tight junction protein.

195 e represses permeability-promoting claudin-2 tight-junction protein expression through an IL-10RA-dep

196 ed for changes in gut permeability, BTL, and tight-junction protein expression, immune cell recruitme

197 increased BBB integrity (elevated levels of tight-junction protein, Claudin 5, and reduced S100B lev

198 d by Muller cells, and zonula occludens-1, a tight-junction protein.

199 neutrophil accumulation, and localization of tight junction proteins (claudin-1, ZO-1) were visualize

200 It uses some claudin tight junction proteins (eg, claudin-4) as receptors to

201 nd/or redistribution of three representative tight junction proteins (ie, zonula occludens-1, Occludi

202 s (Lgr5 and Bmi1), whereas the expression of tight junction proteins (occludin and claudin) in 13% CP

203 ermeability by inhibiting IL-6 and modulates tight junction proteins after ischemia.

204 1) form tight junctions, 2) express typical tight junction proteins and electrolyte transporters, 3)

205 nal epithelium by decrease/redistribution of tight junction proteins and endoplasmic reticulum stress

206 BBB by regulating the proper localization of tight junction proteins and raise the possibility that e

207 MMP9 expression, and changes in endothelial tight junction proteins as well as adhesion molecules.

208 romise the steady-state distribution of most tight junction proteins but results in increased transep

209 breakdown and downregulation of the specific tight junction proteins claudin-1 and -3 in adult brain

210 ctions (matrilysis) as well as adherence and tight junction proteins for degradation.

211 d the cell-surface distribution of these two tight junction proteins in various hepatic cell lines, i

212 on of DSS than control mice, and loss of the tight junction proteins occludin and claudin-2 from inte

213 n astrocytic protein, and down-regulation of tight junction proteins Occludin and Claudin5, collectiv

214 es not affect the progressive degradation of tight junction proteins or paracellular BBB leakage.

215 show that SPRY2 downregulates genes encoding tight junction proteins such as claudin-7 and occludin a

216 Epithelial barrier function is maintained by tight junction proteins that control paracellular fluid

217 to evaluate the role of occludin, one of the tight junction proteins that regulate BBB functions in H

218 ta provide a link between the trafficking of tight junction proteins through endosomes and contact-in

219 time, and the expression of transporters and tight junction proteins was investigated by conventional

220 for epithelial-to-mesenchymal transition and tight junction proteins were assessed in exposed cells.

221 ransfer constant in brain regions, and IL-6, tight junction proteins, and plasmalemma vesicle protein

222 n or intracellular redistribution of several tight junction proteins, did not affect degradation of c

223 urther mechanistic studies show that reduced tight junction proteins, diminished AQP4 expression, and

224 oduct 2-deoxy-d-ribose cooperatively repress tight junction proteins, driving permeability.

225 sa include the transcriptional regulation of tight junction proteins, metabolic regulation of barrier

226 ptake assay, quantitative RT-PCR analysis of tight junction proteins, myosin light chain kinase, and

227 However, other tight junction proteins, such as claudin-1, ZO-1, and oc

228 nfiltration, and higher expression levels of tight junction proteins, such as zonula occludens-1 and

229 spheroid surface exhibits high expression of tight junction proteins, VEGF-dependent permeability, ef

230 reased intestinal permeability and decreased tight junction proteins.

231 essed for barrier function and expression of tight junction proteins.

232 roteolytic activity on basement membrane and tight junction proteins.

233 MMPs degrade extracellular matrix and cleave tight-junction proteins and cytokines, modulating their

234 e protein (CLAMP), which resembles mammalian tight-junction proteins and localizes to secretory organ

235 a reduction of the cerebral endothelial cell tight-junction proteins claudin-5 and occludin.

236 lasma membrane, where it associates with the tight-junction proteins Pals1/PATJ and E-cadherin.

237 ificant upregulation of luminal keratins and tight-junction proteins such as claudins.

238 Claudins are tetraspan transmembrane tight-junction proteins that regulate epithelial barrier

239 trial of a novel therapeutic agent targeting tight junction regulation in patients with CeD who are s

240 lial resistance, decreased expression of the tight junction scaffold protein zonula occludens 1, and

241 oordinating interactions among claudins, the tight junction scaffold, and the cytoskeleton.

242 lity of another claudin to interact with the tight-junction scaffold.

243 USP53 colocalizes and interacts with the tight junction scaffolding proteins TJP1 and TJP2 in pol

244 hways involved in mitochondrial function and tight junction signaling.

245 leads to aberrant microtubule organization, tight junction stabilization and impaired wound closure

246 nces in Claudin-10 membrane localization and tight junction strand formation, indicating that these a

247 ay not fully recapitulate that of epithelial tight junction strands, this is the first direct demonst

248 tein 2 (TJP2), two primary components of the tight junction strands.

249 ore, Mgc regulates adherens junction but not tight junction structure, and the ability to regulate ad

250 scence was used to evaluate the integrity of tight junction structures in cultured epithelial cells.

251 ain of nNOS to claudin-3 and claudin-14, two tight junction tetraspan membrane proteins that are esse

252 elial barrier is maintained by expression of tight junctions that connect adjacent epithelial cells a

253 iquitinating enzyme and a novel component of tight junctions that is necessary for sensory hair cell

254 l retractions and a subsequent modulation of tight junctions through dephosphorylation of VE-cadherin

255 Dysfunction of cell-cell tight junction (TJ) adhesions is a major feature in the

256 mechanisms of intestinal mucosa, a defective tight junction (TJ) barrier has been postulated as a key

257 Tight junction (TJ) defects have recently been associate

258 in altered cytoskeletal structure, increased tight junction (TJ) formation and reduced barrier permea

259 The tight junction (TJ) has a key role in regulating paracel

260 ole of LKB1 in the maintenance of functional tight junction (TJ) in vivo.

261 causes an increase in intestinal epithelial tight junction (TJ) permeability by activating myosin li

262 ) cause an increase in intestinal epithelial tight junction (TJ) permeability, the mechanisms that me

263 sistance, apoptosis signaling molecules, and tight junction (TJ) protein phosphorylation in response

264 dherens junction (AJ) protein E-cadherin and tight junction (TJ) protein Zonula Occludens-1 (ZO-1).

265 METH administration decreased expression of tight junction (TJ) proteins and increased BBB permeabil

266 Tight junction (TJ) proteins are known to be involved in

267 ry of HCV and other pathogens is mediated by tight junction (TJ) proteins, but successful therapeutic

268 determine whether HIF influenced epithelial tight junction (TJ) structure and function.

269 ar seal between epithelial cells, called the tight junction (TJ), is built by several membrane protei

270 laudin family of proteins is integral to the tight junction (TJ), the apical cell-cell adhesion and a

271 immunoblotting, immunofluorescence analysis, tight junction (TJ)-permeability assessment, and overexp

272 by RNAi in Sertoli cells with an established tight junction (TJ)-permeability barrier perturbed the T

273 PFOS perturbed the Sertoli cell tight junction (TJ)-permeability barrier, causing disrup

274 (+), Ca(2+), and Mg(2+) reabsorption via the tight junction (TJ).

275 ), comprised of brain endothelial cells with tight junctions (TJ) between them, regulates the extrava

276 equires restricted positioning of functional tight junctions (TJ) to the most suprabasal viable layer

277 nation between cell-cell adherens junctions, tight junctions (TJ), and the perijunctional actomyosin

278 Delivery occurs adjacent to tight junctions (TJ), suggesting that it recognizes a re

279 olves paracellular passage regulated through tight junctions (TJ).

280 resistance (TEER) measurements without other tight-junction (TJ) formation parameters.

281 Tight junctions (TJs) are barrier forming structures of

282 formation of a paracellular barrier made by tight junctions (TJs) between CNS endothelial cells (ECs

283 st 27 in humans and mice, polymerize to form tight junctions (TJs) between epithelial cells, in a tis

284 Tight junctions (TJs) form a barrier on the apical side

285 dial component is a network of interlamellar tight junctions (TJs) unique to central nervous system m

286 cytes open the BBB by disrupting endothelial tight junctions (TJs), but the mechanisms that control a

287 Endothelial cells lining SC elaborate tight junctions (TJs), down-regulation of which may wide

288 nimals demonstrated well preserved capillary tight junctions (TJs).

289 gral membrane proteins and are components of tight junctions (TJs).

290 vant after extending their dendrites through tight junctions to acquire antigens and migrating to reg

291 Claudins are tight-junction transmembrane proteins that act as parace

292 s, specialized structures called tricellular tight junctions (tTJs) and tricellular adherens junction

293 malian inner ear, bicellular and tricellular tight junctions (tTJs) seal the paracellular space betwe

294 claudin-16 and -19 cis interaction increase tight junction ultrastructural complexity but reduce tig

295 BB permeability, possibly by stabilizing BBB tight junction via Robo4 mediated Rac1 activation.

296 Reestablishment of tight junctions was compromised in EM and CX epithelial

297 ily protein that constitutes the backbone of tight junctions, was identified as a novel target of IL2

298 l barrier function is defined principally by tight junctions, which, in turn, depend on the regulated

299 macromolecular and bacterial movement across tight junctions, while increased intestinal permeability

300 d control LC dendrites docked with epidermal tight junctions with equal efficiencies and ingested sur