ライフサイエンスコーパス: tight junction protein

1 ion, demonstrating a novel function for this tight junction protein.

2 ssion of Claudin-2, a cation-channel-forming tight junction protein.

3 , produce collagen VIII, and express ZO-1, a tight-junction protein.

4 d by Muller cells, and zonula occludens-1, a tight-junction protein.

5 ITC)-labeled markers, and immunostaining for tight junction proteins.

6 roteolytic activity on basement membrane and tight junction proteins.

7 sed by disruptions in adherens junctions and tight junction proteins.

8 licating electrostatic interactions with the tight junction proteins.

9 ssion and altered localization of intestinal tight junction proteins.

10 c activation and tyrosine phosphorylation of tight junction proteins.

11 oproteinase 9 expression and reduced loss of tight junction proteins.

12 Src family kinases/FAK, and down-regulating tight junction proteins.

13 dysregulated expression and localization of tight junction proteins.

14 mma attenuated HIV-mediated dysregulation of tight junction proteins.

15 companied by decreased surface expression of tight junction proteins.

16 naling pathways leading to the disruption of tight junction proteins.

17 audin-3 and -4, members of a large family of tight junction proteins.

18 ns in cell morphology and mislocalization of tight junction proteins.

19 luorescence indicated expression of multiple tight junction proteins.

20 with immunofluorescence labeling of various tight junction proteins.

21 pical surface, overlapping with adherens and tight junction proteins.

22 affold various transmembrane and cytoplasmic tight junction proteins.

23 reased intestinal permeability and decreased tight junction proteins.

24 essed for barrier function and expression of tight junction proteins.

25 lation of adhesion molecules and decrease in tight junction proteins.

26 PDZ-domain protein that associates with many tight junction proteins.

27 s the epithelium without gross alteration in tight-junction proteins.

28 pe and organisation caused by truncations in Tight Junction Protein 1a (ZO-1a).

29 vo requires an intracellular scaffold called Tight Junction Protein 1b (Tjp1b).

30 the mRNA expression of cadherin-1 (CDH1) and tight junction protein 2 (TJP2), two primary components

31 ransporters ABCB4, ABCB11, ATP8B1, ABCC2 and tight junction protein 2 (TJP2).

32 how that protein-truncating mutations in the tight junction protein 2 gene (TJP2) cause failure of pr

33 (DSC)2, occludin (OCLN), desmoglein (DSG)1, tight junction protein 2, and gap junction protein alpha

34 Among these were tight junction protein-2 (2.2-fold increase, P = .019),

35 RB6-8C5, but not 1A8, display: 1) intact BBB tight junction proteins; 2) reduced CNS vascular permeab

36 Pals1 binds Patj (Pals1-associated tight-junction protein), a multi-PDZ-domain protein that

37 ermeability by inhibiting IL-6 and modulates tight junction proteins after ischemia.

38 The expression of several tight junction proteins also was decreased, whereas the

39 rocyte activation, cerebral endothelial cell tight junction protein alterations and CNS vascular perm

40 diaphragms by demonstrating the presence of tight junction proteins, although slit diaphragms lack t

41 Here we identify the angiomotin-family tight junction protein AMOTL2 as a novel activator of LA

42 Here we identify IFITM1 as a hepatocyte tight junction protein and a potent anti-HCV effector mo

43 Expression of tight junction protein and regular morphology was observ

44 on of COX-2 is involved in the disruption of tight junction proteins and BBB integrity, mice were pre

45 that CD8 T cells initiate disruption of BBB tight junction proteins and CNS vascular permeability in

46 hat are coordinated with other transmembrane tight junction proteins and cytosolic scaffold proteins.

47 1) form tight junctions, 2) express typical tight junction proteins and electrolyte transporters, 3)

48 nal epithelium by decrease/redistribution of tight junction proteins and endoplasmic reticulum stress

49 EP-1 can modify the phosphorylation state of tight junction proteins and play a role in regulating pe

50 ced the loss of endothelial cell markers and tight junction proteins and preserved BBB function.

51 BBB by regulating the proper localization of tight junction proteins and raise the possibility that e

52 MMPs degrade extracellular matrix and cleave tight-junction proteins and cytokines, modulating their

53 e protein (CLAMP), which resembles mammalian tight-junction proteins and localizes to secretory organ

54 We found that claudin-1, a tight junction protein, and small proline-rich (Sprr2) p

55 enced by enhanced permeability, reduction of tight junction proteins, and expression of matrix metall

56 , analyzed levels of messenger RNAs encoding tight junction proteins, and performed H&E staining and

57 ransfer constant in brain regions, and IL-6, tight junction proteins, and plasmalemma vesicle protein

58 C, the protease-activated receptor PAR2, the tight junction proteins, and the profilaggrin polypeptid

59 he N terminus were enriched in transmembrane tight junction proteins, and those proximal to the C ter

60 ecrease in TER, comparable redistribution of tight-junction proteins, and secretion of more IL-8 than

61 Transepithelial electrical resistance and tight junction protein architecture were studied in cult

62 In addition, we show that tight-junction proteins are disintegrated in the PCFT mu

63 hich zonal occludens-1 and claudin-3, apical tight-junction proteins, are mislocalized.

64 MMP9 expression, and changes in endothelial tight junction proteins as well as adhesion molecules.

65 hesion through focal adhesion, adherens, and tight junction proteins as well as integrin signal trans

66 tudy identified occludin (OCLN), an integral tight junction protein, as one of the key factors for HC

67 This reflects substantial reductions in tight junction proteins associated with "leaky" nephron

68 romise the steady-state distribution of most tight junction proteins but results in increased transep

69 Claudin-18.1 is the only known lung-specific tight junction protein, but its contribution to airway b

70 luorescent assessments of zonula occludens-1 tight junction protein cellular distribution were conduc

71 Unlike its homologous tight junction protein cingulin, paracingulin has been i

72 The tight junction protein claudin 1 (Cldn-1) has been repor

73 ch as the microRNAs miR-217 and miR-122, the tight junction protein claudin c, the gene fam136a, and

74 followed by pathway analysis implicated the tight junction protein claudin-1 (CLDN1) in melanoma pro

75 with decreases in the intestinal epithelial tight junction protein claudin-1 (CLDN1).

76 ng numerous host cell factors, including the tight junction protein claudin-1 (CLDN1).

77 cytes, and it was recently reported that the tight junction protein claudin-1 is a critical HCV entry

78 Expression of the tight junction protein claudin-1 is dysregulated in colo

79 duces down-regulation of the barrier-forming tight junction protein claudin-1.

80 To elucidate the role of the tight junction protein claudin-10 in TAL function, we ge

81 expression of CLDN10, the gene encoding the tight junction protein Claudin-10, show enhanced paracel

82 a human disorder caused by mutations in the tight junction protein claudin-16.

83 tion of the permeability-associated, "leaky" tight junction protein claudin-2 at intercellular juncti

84 was decreased induction of the pore-forming tight junction protein claudin-2 in STAT6(-/-) mice.

85 Despite loss of the tight junction protein claudin-2, KO mice had preserved

86 -22-dependent upregulation of the epithelial tight junction protein claudin-2.

87 pithelial integrity indicated by loss of the tight junction protein claudin-3 was not observed during

88 I/R injury caused a loss of the tight junction protein claudin-3, which was ameliorated

89 hether differences in lung expression of the tight junction protein claudin-4 are associated with alv

90 d reduced expression of the endothelial cell tight junction protein claudin-5 (Cldn5) and abnormal bl

91 tenin and attachment to the promoter for the tight junction protein claudin-5, with concomitant reduc

92 breakdown and downregulation of the specific tight junction proteins claudin-1 and -3 in adult brain

93 ain 042 induced aberrant localization of the tight junction proteins claudin-1 and, to a lesser degre

94 the Langerhans cell marker Langerin and the tight junction proteins Claudin-1, Claudin-7, and ZO-2.

95 nied by altered ileal mRNA expression of the tight junction proteins claudin-2 and occludin.

96 13 correlated with altered expression of the tight junction proteins claudin-2, occludin, and ZO-1.

97 e, we identify the endothelial transmembrane tight junction proteins claudin-5 (CLN-5) and occludin (

98 The tight junction proteins claudin-5 and occludin showed re

99 scavenger receptor class B member I, and the tight-junction proteins claudin-1 and occludin have been

100 a reduction of the cerebral endothelial cell tight-junction proteins claudin-5 and occludin.

101 an gene mutations have been reported in four tight junction proteins (claudin 1, 14, 16, and zona occ

102 neutrophil accumulation, and localization of tight junction proteins (claudin-1, ZO-1) were visualize

103 e recently reported that the expression of a tight junction protein, claudin-1, is increased during c

104 and a very weak nominal association with the tight junction protein, claudin-5, has previously been i

105 increased BBB integrity (elevated levels of tight-junction protein, Claudin 5, and reduced S100B lev

106 Interestingly, we identified the tight junction protein claudin1 as a regulator of these

107 h is linked to significant downregulation of tight junction protein claudin5 in Lrp5(-/-) vessels.

108 The tight junction proteins claudins are abnormally regulate

109 stress alters BBB integrity through loss of tight junction protein Cldn5, promoting peripheral IL-6

110 ral analysis revealed distinct intercellular tight junction protein complexes and immunocytochemistry

111 studies have revealed an important role for tight junction protein complexes in epithelial cell pola

112 icipates physiologically in the formation of tight-junction protein complexes, we examined whether mo

113 This effect was unrelated to changes in tight junction protein content.

114 In the kidney, tight junction proteins contribute to segment specific s

115 Furthermore, tight junction proteins could be major targets of drug d

116 ative strategies directly targeting specific tight junction proteins could prove to be less toxic to

117 n or intracellular redistribution of several tight junction proteins, did not affect degradation of c

118 urther mechanistic studies show that reduced tight junction proteins, diminished AQP4 expression, and

119 e permeability of HBMEC as well as prevented tight junction protein down-regulation of ZO-1, claudin-

120 oduct 2-deoxy-d-ribose cooperatively repress tight junction proteins, driving permeability.

121 ates paracellular permeability by remodeling tight junction protein dynamic behavior and intermolecul

122 emodeling contributes to barrier regulation, tight junction protein dynamic behavior was assessed by

123 In this study, we measure tight junction protein dynamics in live confluent Madin-

124 s accompanied by increased expression of the tight junction protein e-cadherin and sustained down reg

125 , epithelial cytokeratins (e.g., CK-19), and tight junction proteins (e.g., ZO-1), and impaired their

126 It uses some claudin tight junction proteins (eg, claudin-4) as receptors to

127 molog in zebrafish elevated transcription of tight junction protein-encoding genes and increased zebr

128 metalloproteinases (MMPs), which degrade the tight junction proteins essential for maintaining BBB in

129 hesion molecule-A (JAM-A) is an adherens and tight junction protein expressed by endothelial and epit

130 ne with inducible expression of claudin-8, a tight junction protein expressed in the collecting duct.

131 lt was of focal nature and led to changes in tight junction protein expression and architecture.

132 flammatory diseases by regulating intestinal tight junction protein expression and barrier function.

133 OX-2 in the ileum is a critical modulator of tight junction protein expression and intestinal barrier

134 ts of occludin peptide on cellular toxicity, tight junction protein expression and localization, and

135 Tight junction protein expression was measured by Wester

136 Barrier function and tight junction protein expression were assessed.

137 Alterations of tight junction protein expression were associated with i

138 MET-1 also preserved cecum tight junction protein expression, and reduced S. typhim

139 concentrations of Hcy showed a reduction of tight junction protein expression, increased FITC dextra

140 tic laminin decreases aquaporin-4 (AQP4) and tight junction protein expression.

141 blood-brain barrier (BBB) and alterations of tight junction protein expression.

142 e represses permeability-promoting claudin-2 tight-junction protein expression through an IL-10RA-dep

143 ed for changes in gut permeability, BTL, and tight-junction protein expression, immune cell recruitme

144 ctions (matrilysis) as well as adherence and tight junction proteins for degradation.

145 , we identified a homozygous mutation in the tight-junction protein gene JAM3 in a large consanguineo

146 nd/or redistribution of three representative tight junction proteins (ie, zonula occludens-1, Occludi

147 Our studies identify a novel role of a tight junction protein in the development and progressio

148 t for more sophisticated in vivo analysis of tight junction proteins in renal functions.

149 ous glucocorticoids alters the expression of tight junction proteins in the cerebral cortex of sheep.

150 These caused deregulation of tight junction proteins in the endothelia.

151 ded to be higher, whereas gene expression of tight junction proteins in the ileum was significantly d

152 e a novel in vivo model to study the role of tight junction proteins in the remodeling of the biliary

153 d the cell-surface distribution of these two tight junction proteins in various hepatic cell lines, i

154 the hypoxia-induced decrease of occludin, a tight junction protein, in the OIR rat retina and in cul

155 The expression of other tight junction proteins (including ZO-1) was not associa

156 e markers in adult progenitor cells included tight junction proteins, integrins, cadherins, cell adhe

157 egrated model in which dynamic regulation of tight junction protein interactions determines barrier f

158 ted diarrhea results from NF-kappaB-mediated tight junction protein internalization and increased par

159 nes of clinical significance such as OCLN, a tight junction protein involved in hepatitis C viral ent

160 he sub-cellular distribution of adherens and tight junction proteins is perturbed in mutant lung epit

161 Whether slit diaphragms also contain tight junction proteins is unknown.

162 at junctional adhesion molecule A (JAM-A), a tight junction protein, is a key negative regulator of c

163 on and cellular distribution of claudin-1, a tight junction protein, is dysregulated in colon cancer

164 Claudin 3, a tight junction protein, is transiently incorporated into

165 e water channel protein, Aquaporin-3 and the tight junction protein isoform, ZO-1 alpha+.

166 strated that rat slit diaphragms contain the tight junction proteins JAM-A (junctional adhesion molec

167 o hepatocytes, we depleted expression of the tight junction protein junctional adhesion molecule-A (J

168 wn as MARVELD2), which encodes a tricellular tight junction protein known as tricellulin, lead to non

169 Transmembrane tight junction proteins known as claudins are essential

170 ere used to examine gut barrier function and tight junction protein levels during 48-hour starvation

171 lso rapidly affected CPE cell morphology and tight junction protein levels.

172 f inflammatory cytokines, and alterations in tight junction protein localization and expression at th

173 ion reverses the gut barrier dysfunction and tight junction protein losses due to a lack of enteral f

174 ribute to smaller infarction, changes in the tight junction proteins may lead to the greater edema fo

175 sa include the transcriptional regulation of tight junction proteins, metabolic regulation of barrier

176 Regulation of PKC activity and tight junction protein modifications may have therapeuti

177 ptake assay, quantitative RT-PCR analysis of tight junction proteins, myosin light chain kinase, and

178 to Tat diminished the expression of several tight junction proteins, namely, occludin, zonula occlud

179 expressed significant levels of Claudin-1, a tight junction protein needed for HCV infection of Huh-7

180 We provide evidence that the tight junction protein occludin (encoded by the OCLN gen

181 It has been previously determined that the tight junction protein occludin (OCLN) is essential for

182 l host factors, the tetraspanin CD81 and the tight junction protein occludin (OCLN), explain, at leas

183 vascular endothelial cells degraded both the tight junction protein occludin (p < 0.05) and the adher

184 TNF-alpha induced a relocalization of tight junction protein occludin and increased the latera

185 We provide evidence that the tight junction protein occludin contributes to the regul

186 In cultured monolayers, endocytosis of the tight junction protein occludin correlated with barrier

187 dence for IL-17A-dependent regulation of the tight junction protein occludin during epithelial injury

188 modulator of METH-induced redistribution of tight junction protein occludin in brain endothelial cel

189 d that ischemia induced rapid degradation of tight junction protein occludin in cerebromicrovessels.

190 s study was to determine the function of the tight junction protein occludin in the control of permea

191 hough the C-terminal cytoplasmic tail of the tight junction protein occludin is heavily phosphorylate

192 Localization of the tight junction protein occludin was determined by immuno

193 Immunoblotting further showed that tight junction protein occludin was downregulated in ind

194 l lamina components, adhesion molecules, the tight junction protein occludin, and matrix metalloprote

195 re used to evaluate levels of cytokines, the tight junction protein occludin, and mucosal inflammatio

196 hedding of heparan sulfate (DeltaHS) and the tight junction protein occludin.

197 rved levels of the cerebral endothelial cell tight junction protein occludin.

198 lular calcium and the internalization of the tight junction protein occludin.

199 domain has the same arch-shaped fold as the tight junction protein occludin.

200 ription factor NF-kappaB and stabilizing the tight junction protein occludin.

201 not quality decreased the expression of the tight junction proteins occludin and claudin-1 in the sm

202 on of DSS than control mice, and loss of the tight junction proteins occludin and claudin-2 from inte

203 n astrocytic protein, and down-regulation of tight junction proteins Occludin and Claudin5, collectiv

204 trapping mutant of DEP-1 interacts with the tight junction proteins occludin and ZO-1 in a tyrosine

205 adherens junction protein beta-catenin, and tight junction proteins occludin and ZO-1 was unchanged,

206 sorganization and the mislocalization of the tight junction proteins occludin and ZO-1, suggesting th

207 xpression and localization of the intestinal tight junction proteins occludin and ZO-1.

208 tocin-induced diabetes inhibited the loss of tight junction proteins occludin and zona occludin- 1 (Z

209 rmeability correlated with disruption of the tight-junction protein occludin and decreased the number

210 d cysts, which was associated with increased tight junction protein (occludin and zonula occludens-1)

211 s (Lgr5 and Bmi1), whereas the expression of tight junction proteins (occludin and claudin) in 13% CP

212 -insoluble membrane fractions confirmed that tight junction proteins (occludin, claudin-1 and zona oc

213 tion of the BBB manifested by the absence of tight junction proteins (occludin, claudin-5, ZO-1 and J

214 genase-2 (COX-2) and decreased expression of tight junction proteins, occludin and zonula occludens-1

215 re, IL-25 restores the reduced expression of tight junction proteins, occludin, junction adhesion mol

216 Tight junction proteins OCLN1 and TJP1were downregulated

217 cells and tissues may reflect differences in tight junction protein or lipid composition or post-tran

218 es not affect the progressive degradation of tight junction proteins or paracellular BBB leakage.

219 e further observed significant disruption of tight junction protein organization only in the ileum bu

220 ad and evolutionarily conserved role for the tight junction protein PALS1 in the biogenesis of adhere

221 lasma membrane, where it associates with the tight-junction proteins Pals1/PATJ and E-cadherin.

222 ition, Atg9 interacted with PALS1-associated tight junction protein (Patj), which associates with TSC

223 Z domain-containing protein Pals1-associated tight junction protein (PATJ), which has been described

224 even 1 (PALS1)/Stardust and PALS1-associated tight junction protein (PATJ).

225 c-Met transduction did not change tight junction protein patterns, suggesting unaltered ep

226 The claudin family of tight junction proteins plays an important role in regul

227 rical resistance and increased the amount of tight junction protein present in membrane fractions.

228 Tight junction proteins regulate the paracellular transp

229 n cell polarity, as apical, basolateral, and tight junction proteins remain properly localized.

230 show that SPRY2 downregulates genes encoding tight junction proteins such as claudin-7 and occludin a

231 r permeability and reduces the expression of tight junction proteins such as occludin and zonula occl

232 stood but appear to involve dysregulation of tight-junction proteins such as claudins.

233 ificant upregulation of luminal keratins and tight-junction proteins such as claudins.

234 However, other tight junction proteins, such as claudin-1, ZO-1, and oc

235 onocytes resulted in decreased expression of tight junction proteins, such as junctional adhesion mol

236 nfiltration, and higher expression levels of tight junction proteins, such as zonula occludens-1 and

237 Occludin is a transmembrane tight junction protein that contributes to diverse cellu

238 hesion molecule-A (JAM-A) is a transmembrane tight junction protein that has been shown to regulate b

239 Claudin-3 (CLDN3) is a tight junction protein that is overexpressed in 90% of o

240 Claudin-2 is a tight junction protein that mediates paracellular water

241 Junctional adhesion molecule-A (JAM-A) is a tight junction protein that serves as a receptor for reo

242 required for the expression of claudin-1, a tight junction protein that was recently identified as a

243 Here, we report marvelD3, a novel tight junction protein that, like occludin and tricellul

244 Epithelial barrier function is maintained by tight junction proteins that control paracellular fluid

245 Claudins are tight junction proteins that have been implicated in mai

246 rier function requires targeted insertion of tight junction proteins that have distinct selectively p

247 Claudins form a large family of tight junction proteins that have essential roles in the

248 volves the formation of complexes containing tight junction proteins that include claudins and, somet

249 Claudins are tight junction proteins that play a key selectivity role

250 to evaluate the role of occludin, one of the tight junction proteins that regulate BBB functions in H

251 Claudins are tetraspan transmembrane tight-junction proteins that regulate epithelial barrier

252 ta provide a link between the trafficking of tight junction proteins through endosomes and contact-in

253 roteins and altered membrane localization of tight junction proteins through Galpha12/Src signaling p

254 breakdown of type IV collagen and decreases tight junction protein (TJP) expression in a co-culture

255 Increased fluorescein staining and decreased tight junction protein Tjp1 expression demonstrated that

256 ludes the entire wild-type gene encoding the tight junction protein TJP2 (ZO-2).

257 The contribution of tight junction proteins to barrier function is well esta

258 also shows good functional expression of key tight junction proteins, transporters, receptors and enz

259 The tight junction protein tricellulin marks these sites and

260 es a loss of capillary endothelial cells and tight junction proteins, two critical components of the

261 spheroid surface exhibits high expression of tight junction proteins, VEGF-dependent permeability, ef

262 time, and the expression of transporters and tight junction proteins was investigated by conventional

263 we showed that the HBMEC expression of ZO-1 (tight junction protein) was increased by co-cultivation

264 in-containing protein PATJ (Pals1-associated tight junction protein) was not per se crucial for the m

265 for epithelial-to-mesenchymal transition and tight junction proteins were assessed in exposed cells.

266 stinal epithelial permeability and levels of tight junction proteins were examined by permeable fluor

267 In the absence of JAM-A, other tight junction proteins were mislocalized, and pseudocan

268 IL-17A and MMPs, and elevated the levels of tight junction proteins, which improved the BBB integrit

269 the balance in favor of the kinase such that tight junction proteins would regain their phosphorylati

270 trical resistance and mislocalization of the tight junction protein ZO-1 after calcium switch.

271 repressed the translation of mRNAs encoding tight junction protein ZO-1 and adherens junction E-cadh

272 tic cobblestone morphology and expression of tight junction protein ZO-1 and pump protein Na+/K+ ATPa

273 strated delayed membrane localization of the tight junction protein ZO-1 consistent with a defect in

274 The tight junction protein ZO-1 is known to link the transme

275 Moreover, the tight junction protein ZO-1 is mislocalized in the tal1-

276 Here, we demonstrate that the tight junction protein ZO-1 regulates tension acting on

277 sion molecules (including E-cadherin and the tight junction protein ZO-1), gain of mesenchymal bioche

278 regulator of migration through targeting the tight junction protein ZO-1.

279 positively correlated with the expression of tight junction protein ZO-1.

280 A contributed to BBB breakdown by disrupting tight junction protein ZO-1.

281 lial permeability and down-regulation of the tight junction proteins ZO-1 and claudin-1.

282 e III toxins altered the distribution of the tight junction proteins ZO-1 and occludin and were able

283 nges detected included redistribution of the tight junction proteins ZO-1 and occludin to lateral mem

284 unocytochemistry confirmed expression of the tight junction proteins ZO-1 and occludin.

285 o reduce barrier function and influenced the tight junction proteins ZO-1 and occludin.

286 ls and expression and phosphorylation of the tight junction proteins ZO-1 and occludin.

287 arrier in mice by reducing the levels of the tight junction proteins ZO-1, occludin and claudin-5 bet

288 t oxalate permeability, but knockdown of the tight-junction protein ZO-1 enhanced permeability to oxa

289 s manifested by EC apoptosis and loss of the tight-junction protein ZO-1.

290 utrophil infiltration, and a preservation of tight junction proteins (ZO-1 and occludin) composing th

291 microscopy using specific antibodies against tight junction proteins, ZO-1, and claudin-1 and by meas

292 yosin heavy chain IIB, paxillin, Sec61 beta, tight junction protein ZO1, and Tom20.

293 rotein (PSD-95)/Drosophila discs-large (dlg)/tight-junction protein (ZO1)] have been shown to control

294 DCK renal epithelial cells, silencing of the tight junction protein zona occludens 2 (ZO-2 KD) induce

295 thelial cell (hBMEC) monolayer integrity and tight junction protein zona occludens-1, while the resul

296 vessel basal lamina protein laminin, and the tight junction protein zona occludens-1.

297 The expression of tight junction proteins zona occludens-1, occludin, clau

298 These cells express the tight junction proteins zonula occludens 1 (ZO-1) and oc

299 y of the ileum and reduced expression of the tight junction proteins zonula occludens-1, occludin, an

300 ee Hb (HbG) on the expression of endothelial tight junction proteins (zonula occludens 1, claudin-5,