ライフサイエンスコーパス: tighten

1 s regulations on other emissions sources are tightened.

2 ated inside the implants, and abutments were tightened.

3 he NMR spectrum indicative of conformational tightening.

4 becomes less dynamic and exhibits structural tightening.

5 stinct from nucleosome breathing, sliding or tightening.

6 the membrane was largely responsible for the tightening.

7 ased constraints on the first conformational tightening.

8 ntubation (transient or permanent) or eyelid tightening.

9 tress fiber formation and induces junctional tightening.

10 SL annular (SLAC) or inter-PM (PAPS) suture tightening (4 to 5 mm of cinching for 5 seconds during i

11 pknotted protein, it is possible to untie or tighten a knotted polypeptide and even convert a slipkno

12 eatherization efforts targeted solely toward tightening a building envelope led to 20% more serious a

13 The latter tightens a monolayer of airborne contaminants to yield l

14 NADP+ binding in the reductase also tightened affinity of these inhibitors for P-450 BM3 (Kd

15 partially dehydrating phosphate oxygens and tightening all interfaces to form RO.

16 th biplane videofluoroscopy before and after tightening an adjustable Paneth-type mitral annuloplasty

17 These bonds must be tightened and highlighted as we work toward our common g

18 erve that the fibre-soil interfacial bond is tightened and the measurement range of the fibre is exte

19 ID domain protein confers position-dependent tightening and loosening of guide-strand-target interact

20 terium exchange experiments have highlighted tightening and loosening of protein structures upon liga

21 Tightening and loosening show that ligand binding respec

22 ss based on the trade-off between structural tightening and restraint of conformational mobility.

23 After AFR, skin tightening and symptomatic relief were reported.

24 asmic funnel of SecY, and by the coordinated tightening and widening of SecA's clamp above the SecY p

25 onine, the inhibitor of N-glycan processing, tightens and stabilizes cell-cell junctions as detected

26 It also predicts that Arg(73) tightens and stabilizes the actin and that Glu(73) cause

27 66 and GFP is longer than 36 residues, ClpXP tightens and translocates the knot before it reaches GFP

28 pulled by the termini, the knot can only get tightened, and any attempt at untying results in failure

29 The pore opens upon tightening, and closes upon disengagement, of the cataly

30 P complex (K(D)(GDP) = 9.4 +/- 3.2 mM) which tightened approximately 500-fold in the presence of Mn2+

31 investigation as it was previously found to tighten binding to both dihydrofolate and NADPH by appro

32 tructures, closes around the product further tightening binding.

33 Addition of these Q67H mutations tightens binding 40-fold, and the catalytic efficiency (

34 ons to determine if the Q67H mutation, which tightens binding approximately 100-fold to both dihydrof

35 ecosystem health, unless steps are taken to tighten biosecurity worldwide.

36 2.3+/-0.1 to 2.3+/-0.1), and decreased after tightening both sutures (STRING-1+2, 2.3+/-0.2 to 1.3+/-

37 es the setup of the catalytic triad but also tightens both subsites to achieve better binding.

38 accurate energies even with the drastically tightened bound.

39 s in leading markets have been progressively tightened, but current diesel vehicles emit far more NOx

40 le microtubules into loose bundles that are "tightened" by the other.

41 of Mertk synergized with interferon-beta to tighten cell junctions and prevent virus transit across

42 Histone deacetylases (HDACs) tighten chromatin structure and repress gene expression

43 and Pro102, in turn, not only stabilize the tightened conformation of the [2Fe-2S] cluster binding l

44 er complex formation followed by two slower, tightening conformational changes.

45 derived calcium signals to the mitochondria, tightened connections, synthetic or naturally observed u

46 ly attributable to allosteric conformational tightening, consistent with IM-MS data.

47 We hypothesized that tTS would tighten control of transgene expression in rtTA-based sy

48 ations of the membrane-permeant dB-cAMP 1 mM tightened coupling in almost all cell pairs.

49 Prolonged hypobaric hypoxia significantly tightened coupling modes GC/NE, NE/GC, and NE/NE but red

50 -0.1 to 1.2+/-0.1; P<0.05) when STRING-1 was tightened, did not change after tightening STRING-2 (2.3

51 Paneth suture tightening during circumflex occlusion also decreased en

52 ures in terms of modular fragments: the TEF (Tightened End Fragments), and the calculation at each po

53 C strategies is further demonstrated against tightening environmental standards (to the strictest lev

54 Though CD73 tightens epithelial barriers, its role in the ischemic b

55 te that overexpression of VAPB or PTPIP51 to tighten ER-mitochondria contacts impairs, whereas small

56 past 2 decades and recent recommendations to tighten federal regulation of electroconvulsive therapy

57 ion by serving among all of the factors that tighten gene expression.

58 e, and whether owners experience facilitated tightened glycaemic control, and wider psychosocial bene

59 2+-binding affinity of S100A1 is found to be tightened (greater than threefold) when TRTK12 is bound.

60 st that the closed conformation results from tightened hydrophobic interactions that exclude water fr

61 e sharp cristae edges, whereas trimeric OPA1 tightens ICS outlets.

62 onal estimates of climate sensitivity can be tightened if reconstructions of Northern Hemisphere temp

63 K(D) 1.45 +/- 0.30 mm, and this binding was tightened in the T.SOS.HCII complex, characterized by K(

64 This undergoes conformational tightening in line with the solution Tmelt = 348 K befor

65 high-throughput environment, to reduce bias, tighten insert size distribution and reliably obtain hig

66 structural analysis identified an extensive, tightened intramolecular H-bonding network in bound PMI

67 tic vesicles corral a central exocytic zone, tightening it to a vertex that establishes the polarity

68 15 degree bending in the inner bundle gate, tightening its diameter and shifting the narrowest point

69 of tumors associated with KSHV/HHV8, further tightens its association with malignancy, and suggests a

70 in monomer; an effect that may contribute to tightening lateral interactions between protofilaments a

71 t be the key to improved N retention through tightening linkages between plants and microbes and redu

72 Recently, a strongly and optimally tightened lower bound on the exchange energy was proved

73 Therefore, an overall structural tightening mechanism is not supported by the data.

74 sion of two VL domains into a single protein tightens MG binding over 1000-fold to low picomolar affi

75 rs' budgets for helping to fight the disease tighten, national governments and external funding partn

76 r mechanism of mechanical unfolding and knot tightening of AFV3-109.

77 lthough these findings have helped lead to a tightening of air-quality standards, their validity with

78 een receiving increased attention due to the tightening of ambient air quality standards.

79 Tightening of any STRING sutures did not affect anterior

80 e and during acute ischemia before and after tightening of each STRING using transesophageal echocard

81 onin is enhanced by more than 2000-fold upon tightening of EI to form EI*, from K(i) = 530 nM (EI) to

82 ased inflammatory response is accompanied by tightening of endothelial cell junctions and reduction i

83 Interestingly, we discovered that tightening of ER-mitochondria contacts by overexpression

84 vo model for organogenesis, we show that the tightening of hindgut curvature that normally occurs bet

85 (cat) for isomerization of GAP, suggesting a tightening of interactions between the side chain of Lys

86 g of Ca(2+) to carbonyl groups and/or strong tightening of interlipid H-bonds to levels beyond those

87 IL-15-mediated tightening of intestinal epithelial monolayers correlate

88 ect of phosphite was accompanied by apparent tightening of its interactions within the active site at

89 bound to PIP 2 in lipid bilayers indicate a tightening of ligand-protein interactions relative to th

90 Such mutual tightening of metal and substrate binding suggests the f

91 ket, and the underlying mechanism could be a tightening of Na(+) binding at Na(+) site II, possibly v

92 bouquet formed through a gradual, continuous tightening of telomeres over approximately 6 h.

93 Tightening of the annuloplasty sutures, even beyond the

94 ll three measurements gave rise to a similar tightening of the apparent Kd value compared with pure P

95 Here we show that tightening of the ascending branch of the Hadley Circula

96 a short "synthetic linker" (<5 nm) leads to tightening of the associations.

97 These results imply selective tightening of the barrier in patients exposed to the wid

98 mpositional shift in soil biota, preceded by tightening of the belowground networks, corresponds with

99 Entropy of activation may reflect tightening of the contact between the associated protein

100 ackbone amide nitrogen atoms that results in tightening of the Cys39-Cys48 metal cluster binding loop

101 derived largely from changes associated with tightening of the dimer interface.

102 residue I174 to serine results in an overall tightening of the hinge region, resulting in aberrant pr

103 with a two-step binding mechanism, in which tightening of the initial encounter complex (EI) results

104 ow which the structure is compressed through tightening of the inter-tetrahedral bond angle, resultin

105 Our results imply a tightening of the interaction between L7 and L10 relativ

106 Diminished cavity size and tightening of the LAA orifice may play a role in the red

107 derived largely from changes associated with tightening of the ligand-antibiotic interface.

108 ajor mode of MT stabilization by MSAs is the tightening of the longitudinal interactions between two

109 = 21 microM) and PRPP each caused a 2.5-fold tightening of the other's binding.

110 s before and during circumflex ischemia, and tightening of the Paneth suture.

111 This indicates that the pain-related tightening of the patients orbits was matched by partici

112 s occur in vivo, the present results imply a tightening of the selective blood-brain barrier with chr

113 thus appears that the binding of heme and a tightening of the structure around the heme stabilize th

114 mechanism of stabilization, resulting in the tightening of the tertiary and quaternary hexamer struct

115 o or beta(nuc) values, indicating a putative tightening of the usual S(N)2 transition states (anti-Ha

116 ded by FasIII can be sufficient to drive the tightening of tube curvature observed.

117 the former Soviet Union, and the progressive tightening of U.S. sanctions, Cuba's model health care s

118 r Zn(II) concentration, we show how a modest tightening of Zn(II) affinity, plus weakened DNA affinit

119 ion to the enthalpy of binding derived from "tightening" of the protein structure.

120 -Ca(2+)-channel topology whose developmental tightening optimizes synaptic transmission.

121 anges in cell-substrate adherence, cell-cell tightening or cytoskeletal remodeling.

122 t previously been considered in terms of the tightening, or loosening, of receptor structures that re

123 ents are the equilibrium between relaxed and tightened organizations of the hydrogen-bonding network

124 range, with a cholesteric state arising with tightening pitch as temperature deviates from this point

125 tent permanently; 34% (n = 22) had an eyelid-tightening procedure with 50% success, and 15% (n = 10)

126 the data that are consistent with structural tightening relate to defined regions and are close to th

127 They imply that the barriers are tightened selectively (efflux transporter upregulation)

128 proper orientation in the epithelium, and a "tightened" Sertoli cell TJ permeability barrier, support

129 slipknot was untied during unfolding, and no tightened slipknot conformation was observed.

130 ing it from shrinking and the formation of a tightened slipknot conformation.

131 s with broadened specificity, receptors with tightened specificity, and receptors that lack activatio

132 er complex is followed by two conformational tightening steps reported by fluorescence quenches.

133 Forward and reverse rates for both tightening steps were unaffected by 6-aminohexanoic acid

134 STRING-1 was tightened, did not change after tightening STRING-2 (2.3+/-0.1 to 2.3+/-0.1), and decrea

135 anges in network connectivity strengthen and tighten synchronous connectivity near foci-a mechanism t

136 been proposed to operate through structural tightening that improves all of the functional group int

137 ature, whereby the DNA reduces the degree of tightening that is observed in its absence, thereby prom

138 h between distinct open and closed states to tighten the active site and avail catalysis.

139 Many TJ proteins are known to tighten the cell structure and maintain a barrier.

140 neracy by identifying a lensing object would tighten the constraints on the mass in MACHOs.

141 We suggest that Cra helps to tighten the control of adhE transcription under aerobic

142 ate (vitamin C) has previously been shown to tighten the endothelial barrier and maintain barrier int

143 opose that, via PTGS, disiRNAs could help to tighten the expression of epigenetically activated TEs a

144 e of prior information that could be used to tighten the focus of a range of health-related research

145 A new generation of humanized mice aims to tighten the gap between mouse and human, such that MS-as

146 interdomain bonds are critical, because they tighten the interaction with ATP in the E2.P phosphoryl

147 residues in the interstices of the TtCM x S tighten the intersubunit hydrophobic interactions compar

148 d data and alternative surveys that can help tighten the link between surveillance activities and int

149 nd Trp436, Gln440, Glu443 and Arg444 tend to tighten the nucleotide-binding pocket when non-cognate n

150 e at the cell membrane, which contributes to tighten the PI3Kalpha Ras binding domain/K-Ras4B interac

151 marily from diffuse structural changes which tighten the protein structure around the 8-oxo-nucleotid

152 a similar induction of P-glycoprotein, which tightened the BBB, thereby increasing the neuroprotectio

153 icated that, with both isozymes, Mg(2+) ions tightened the binding of NADH, and by binding to the coe

154 n vivo increased P-glycoprotein activity and tightened the blood-brain barrier to methadone, reducing

155 uring restitution, both CXCL12 and TGF-beta1 tightened the monolayer by decreasing the paracellular s

156 Mechanistically, PFKFB3 inhibition tightened the vascular barrier by reducing VE-cadherin e

157 Future distributions may result in tightening the acceptance levels of quantification and t

158 oth the wild-type and mutant structures thus tightening the active site.

159 g baseline conditions, then before and after tightening the annuloplasty suture during proximal left

160 on in response to inflammatory cues, thereby tightening the border to limit the number of activated T

161 of MurA with PEP fulfills dual functions by tightening the complex with UNAM for the efficient feedb

162 escribe some of these new functions that are tightening the connection between autophagy and acquired

163 yme fail to undergo immortalization, further tightening the connection between telomere maintenance a

164 On tightening the degree of confinement, a transition is ob

165 le external stimulation is held constant are tightening the experimental link between consciousness a

166 Tightening the grid of microsatellite markers under this

167 led chromophores in condensed phase systems, tightening the inferred relations between the spatial an

168 on and ischemia due to coronary occlusion by tightening the link between cardiac systolic performance

169 .1+/-0.4 to 0.4+/-0.4, mean+/-SD, P<0.05) by tightening the Paneth annuloplasty suture.

170 It is also found that substrate binding tightens the active site and restricts the conformationa

171 The gamma-rotation tightens the ATP-bound alphabetaTP interface, as require

172 mechanism in which binding of one substrate tightens the binding of the other substrate to produce a

173 auses concerted movement of SDL2 and thereby tightens the binding pocket for the internal ligand.

174 Addition of 9-deazaadenine tightens the binding to 0.10 microM whereas added adenin

175 Thus, CAR activation selectively tightens the blood-brain barrier by increasing transport

176 ngthens the interaction between subunits and tightens the catalytic site loops.

177 DNA binding further tightens the narrow distal pocket and slightly weakens t

178 geal joints (MTPJs) prior to push off, which tightens the plantar soft tissues to convert the foot in

179 the glutenin network during pasta processing tightens the protein network and results in lower cookin

180 Fourth, ISW1a tightens the spacing to canonical repeat lengths.

181 nded length of this tail suggests that ClpXP tightens the trefoil knot against GFP, which prevents GF

182 On activation, outward S4 motion tightens the VSD-pore linker, perturbing linker-S6-helix

183 chinery and hijack the actin cytoskeleton to tighten their interaction with the gut epithelium, while

184 creased aridity and/or drought frequency may tighten them.

185 n of either the larger Ser (22) or Met (108) tightens this interaction, pulling alpha2 and alpha5 tow

186 ulated E-cadherin localization and monolayer tightening through Rho-associated protein kinase activat

187 ro substrate concentration (K(a)Mn2+), which tightened to 0.32 +/- 0.18 mM when extrapolated to infin

188 tic abutments were fixed to the implants and tightened to 20 Ncm without counter torque.

189 ope of 1.6) is indicative of further complex tightening to the closed conformation.

190 ation site binds with a Kd of 3.2 microM and tightens to 0.75 microM in the presence of 9-deazaadenin

191 The difference between loosening and tightening torque value was also measured.

192 onse of AML patients to therapy; however, to tighten treatment correlates within genetically defined

193 otted protein AFV3-109 is transformed into a tightened trefoil knot by applied pulling force.

194 s and the slipknot can be transformed into a tightened trefoil knot involving approximately 13 amino

195 Addition of SAM tightened up the cosubstrate pocket in both proteins and

196 t binding of two distinct Ca(2+) ions causes tightening up of the regions that surround the anion hol

197 1 cm(-1) upon magnesium binding is due to a "tightening up" (in the sense of a more rigid molecule wi

198 ition mechanism is proposed, wherein slower "tightening up" of the initial encounter complex occurs.

199 fficient) for thermodynamic feasibility; 2), tighten V(max) and V(min) constraints to enclose the rem

200 suture annuloplasty that could be reversibly tightened was anchored to each fibrous trigone and exter

201 negatively charged lipid indicated that the tightening was largely electrostatic.

202 ine and the bilayers, while this interaction tightened when POPE (1-hexadecanoyl-2-(9-Z-octadecenoyl)

203 crevice, and that this crevice is closed or tightened when S1 is in the S1** MgADP.Pi state.

204 a cage around the distally bound anion that tightens when substrate binds and an active site loop cl

205 ot in the unfolded state that can be further tightened with higher forces.