ライフサイエンスコーパス: tightly

1 lustrates the need to control Notch activity tightly.

2 in the selectivity filter that binds Ca(2+) tightly.

3 MtrF binds alpha-Fe2O3 specifically, but not tightly.

4 he more structural role of the CN(-) ligands tightly anchoring the (2FeH) unit to the protein environ

5 ococcus pneumoniae protein domain, binds CFH tightly and increases accessibility of CCPs 19 and 20.

6 t a waist belt (a weight-lifter belt applied tightly and inflated to a constant cuff pressure of 50 m

7 eIF4G601-1196 binds BTE tightly and supports efficient translation.

8 vector Anopheles gambiae that specifically, tightly, and quickly binds and inhibits thrombin.

9 targets nonspecifically before folding to a tightly associated conformation, but the microscopic det

10 Cancer chemoresistance and metastasis are tightly associated features.

11 nces in signal production and perception are tightly associated with changes in social behavior in ha

12 Zebrafish pontin mutants display phenotypes tightly associated with cilia defects, and cilia motilit

13 Because it is tightly associated with cloud forests (with climatically

14 drives primarily near surface warming and is tightly associated with increasing water vapor over dese

15 g pathway and VEGF pathway, were found to be tightly associated with liver cancer.

16 T-XM results were tightly associated with SAFB MFI values.

17 's sarcoma-associated herpesvirus (KSHV), is tightly associated with the development of Kaposi's sarc

18 The FP neck is tightly associated with the flagellum via a series of cy

19 rity and accumulation of mutations have been tightly associated with the onset of neurodevelopmental

20 n brain, imbalances in 3R:4R ratio have been tightly associated with the pathogenesis of several neur

21 Adenylyl cyclase type 9 (AC9) is found tightly associated with the scaffolding protein Yotiao a

22 ared, suggesting that these compartments are tightly associated.

23 he most prevalent metabolic disorders and it tightly associates with obesity, type 2 diabetes, and ca

24 ts of the guanine riboswitch class that most tightly bind the nucleoside 2'-deoxyguanosine.

25 e absence of ATP the transporter and the SBP tightly bind.

26 ly long residence and rearrangement times of tightly binding complexes.

27 olecule/protein crystal structures to design tightly binding ligands with appropriately positioned el

28 TBCD from bovine tissues and showed that it tightly binds the small GTPase ARL2 but appears to be in

29 Similarly, all lines exhibited increases in tightly bound (1-->4)-beta-galactan.

30 l stabilization compared to the noncovalent, tightly bound antagonist-GPCR complex of iodopindolol an

31 n vitro COCP efficiently transfers otherwise tightly bound carotenoid to the full-length OCP apoprote

32 How tightly bound charge transfer (CT) excitons dissociate a

33 Light absorbed in the organic layers forms tightly bound excitons that are split into free electron

34 to FAD-dependent monooxygenases, contains a tightly bound FAD prosthetic group, and is required for

35 ular mechanism by which CITED2 displaces the tightly bound HIF-1alpha from their common cellular targ

36 ionally active chloroplast DNA together with tightly bound protein factors can be purified by gel fil

37 alters the mechanism by which RecBCD removes tightly bound protein obstacles from DNA.

38 w affinity site (QL), passing electrons to a tightly bound quinone cofactor at a high affinity site (

39 however, identifying extracellular proteins tightly bound to insoluble lignocellulose in these micro

40 yntaxin-1 still adopts a closed conformation tightly bound to Munc18-1, whereas the syntaxin-1 linker

41 med weak interactions with the NPs, PhOH was tightly bound to the NP surface.

42 In the absence of Ca(2+), Tn that is tightly bound to Tpm binds actin and holds the Tpm stran

43 f an exonic ribonucleoprotein complex with a tightly bound U1 but not U2 snRNP.

44 cellulose microfibrils in the onion wall is tightly bound with extended xyloglucan chains and that s

45 bventricular zone neuroblasts are aligned in tightly bundled chains within a meshwork of astrocytes;

46 ing its neighboring ligand binding domain to tightly clamp the two polypeptides together.

47 g arc that terminates in two beta-sandwiches tightly clasping the glucosyltransferase domain.

48 terminal catalytic domain of human A3B has a tightly closed active site, and rearrangement of the sur

49 Tightly clustered inositol trisphosphate receptors (IP3R

50 a liquid phase could explain how SVs remain tightly clustered without being stably bound to a scaffo

51 tin modification and cellular metabolism are tightly connected.

52 This supports an ancient and tightly conserved genetic origin of stomata.

53 atory concept executed by coiled-coil MDs to tightly control AAA+ chaperone activity.

54 albumin and the somatostatin positive cells, tightly control both up-to-down and down-to-up state tra

55 at is modified, reorganized, and degraded to tightly control its properties during growth and develop

56 ATEMENT Parvalbumin-positive (PV(+)) neurons tightly control pyramidal cell output.

57 cts were found in two experiments: One using tightly controlled artificial environments as stimuli, t

58 Gliotactin levels are tightly controlled at the mRNA level and at the protein

59 n governing cell function, with their levels tightly controlled at transcriptional and post-transcrip

60 ribution of cholesterol among organelles are tightly controlled by a combination of mechanisms involv

61 t with diurnal variation, metabolism is also tightly controlled by cell-autonomous circadian clock.

62 iments revealed that presynaptic function is tightly controlled by ER Ca(2+) content.

63 indicates that vitamin A homeostasis must be tightly controlled by ISX to maintain immunity and toler

64 ty and plasticity of excitatory circuits are tightly controlled by local inhibitory interneurons in a

65 nthesis in the endoplasmic reticulum (ER) is tightly controlled by multiple mechanisms to regulate ce

66 FOXP1 SUMOylation is tightly controlled by neuronal activity, in which synaps

67 l neurons through CaMKIV signaling, which is tightly controlled by neuronal activity.

68 ntenance and dissolution of pluripotency are tightly controlled by phosphorylation.

69 tion, and shape of the synaptic response was tightly controlled by plasma membrane glutamate transpor

70 KEY POINTS: Body Na(+) content is tightly controlled by regulated urinary Na(+) excretion.

71 Blood glucose levels are tightly controlled by the coordinated action of at least

72 The STKR1 activity is tightly controlled by their regulatory glycine-serine ri

73 We demonstrate that nucleosome sliding is tightly controlled by two regulatory domains: the DNA-bi

74 Phosphoenolpyruvate carboxylase (PEPC) is a tightly controlled cytosolic enzyme situated at a crucia

75 he early stages of neonatal development is a tightly controlled event involving coordinated intrahepa

76 oding variation, but given the importance of tightly controlled gene expression for normal brain deve

77 The position of the mitotic spindle is tightly controlled in animal cells as it determines the

78 s, both mTORC1 and mTORC2 kinase activity is tightly controlled in cells.

79 ll polarity, the activity of CDC42 GTPase is tightly controlled in maintaining normal hematopoietic s

80 f protein substrates, their activity must be tightly controlled in time and space.

81 t is regulated by inductive signals that are tightly controlled in time and space.

82 The BM niche comprises a tightly controlled microenvironment formed by specific t

83 These properties are regulated by tightly controlled networks of gene expression, which in

84 Synapse formation and growth are tightly controlled processes.

85 Cdk enzymatic activity is tightly controlled through cyclin interactions, posttran

86 s that microRNAs (miRNAs) contribute to this tightly controlled tissue- and stage-specific gene expre

87 A prediction is that the activity of Hda is tightly controlled to ensure that replication initiation

88 naling molecules, and their activity must be tightly controlled to prevent cancer, immune disorders,

89 y fire' kindled by the host response must be tightly controlled to prevent it from spreading and caus

90 These switches are normally tightly controlled, but in RAS-related diseases, such as

91 Thus, expression of p21 has to be tightly controlled, which is achieved by numerous mechan

92 the host and the microbiome is extensive and tightly controlled.

93 Hence, the cellular iron balance must be tightly controlled.

94 Therefore, ubiquitin ligases need to be tightly controlled.

95 ment provides key regulatory signals for and tightly controls cardinal features of hematopoietic stem

96 The organisation of these structures tightly controls intracellular calcium dynamics.

97 , a genetic toolbox has been identified that tightly controls stomatal development and patterning.

98 ciates with the ECM and the cell surface and tightly controls the bidirectional flow of information b

99 elium serves as a size-selective barrier and tightly controls the fluid exchange from the circulation

100 Ste23 and Cym1 tightly cooperate to ensure the correct functioning of t

101 tion and community-wide data underscores the tightly coordinated in situ metabolism of the keystone N

102 ation of differentiation programs need to be tightly coordinated so that different cell types are gen

103 rray of signaling molecules and pathways are tightly coordinated to support spermatogenesis.

104 multiple dynamic physiological processes are tightly coordinated while interacting with a dense and e

105 brain function, neural activity needs to be tightly coordinated within the brain network.

106 ibodies and possibly, anti-THSD7A antibodies tightly correlate with disease activity.

107 nes have inverse expression levels, which is tightly correlated with greater root biomass contents.

108 thylation dynamics of the Dmrt1 promoter are tightly correlated with temperature and could mediate th

109 t limitation; (ii) activation of sigma(F) is tightly correlated with, and preceded by, Spo0A P reachi

110 nsider diversification and duplication to be tightly correlated.

111 ssimilation and below-ground respiration are tightly coupled and provides evidence of the mechanism a

112 g TA targeting to the membrane, and reveal a tightly coupled channel of communication between the TA-

113 ystems with lower export potential have more tightly coupled communities.

114 We defined 147,888 blocks of tightly coupled CpG sites, called methylation haplotype

115 ely, our study uncovers a previously unknown tightly coupled positive feedback signalling loop betwee

116 These findings reveal EEG correlates of tightly coupled sensorimotor processing in the human bra

117 n that an initial transcriptomic response is tightly coupled to an ensuing proteomic response.

118 nfolded client proteins in a process that is tightly coupled to ATP binding and hydrolysis.

119 Ds) are essential for energy homeostasis and tightly coupled to cellular metabolism.

120 The changes in encoding, tightly coupled to CS occurrences, consist of either inc

121 ion making process as confidence ratings are tightly coupled to decision accuracy.

122 Expansion of PG is tightly coupled to growth of a bacterial cell and requir

123 Cell growth and proliferation are tightly coupled to metabolism, and dissecting the signal

124 We find that cortical blebbing is tightly coupled to MRTF nuclear shuttling to promote the

125 Maximal topoisomerase II expression was tightly coupled to S phase and G2/M phase via both trans

126 ate metabolites and macromolecular sinks are tightly coupled to the cell cycle in a marine diatom, an

127 hough most models of saccade programming are tightly coupled to underlying neurophysiology, none have

128 Because oocyte differentiation is tightly coupled with the onset of meiosis, it is of sign

129 These steps are typically tightly coupled with the primary intermediate, nitrite,

130 reast tumours, and its expression levels are tightly coupled with those of glypican-1 across breast c

131 ween years within species and hence were not tightly coupled.

132 ndings indicate that proteolytic degradation tightly couples RGS2 transcription, protein levels, and

133 Even pockets as tightly defined and as deeply studied as that of the mus

134 motion, and reproduction are fundamental and tightly entwined aspects of human behavior.

135 the Bessel beam coupled with the ability to tightly focus it through a high NA lens allowed precise,

136 Recently, acoustic tweezers based on tightly focused ultrasound microbeam have attracted cons

137 By manipulating a tightly focussed beam of energetic ions, often gallium (

138 Subjective confidence reports tightly followed the predictions derived from the ideal

139 The existence of tightly-integrated cross-talk through multiple signaling

140 tia nigra and striatopallidal pathways might tightly interact downstream to dopamine receptors, likel

141 The blood-retinal barrier (BRB) consists of tightly interconnected capillary endothelial cells cover

142 ndscapes of tumor genomes and epigenomes are tightly interconnected.

143 segments where side chains from amino acids tightly interdigitate in a dry interface.

144 Chromatin structure is tightly intertwined with transcription regulation.

145 Confidence and actions are normally tightly interwoven-if I am sure that it is going to rain

146 e the appropriate chemical structure to bind tightly into the CB7 cavity.

147 Nun fits tightly into the TEC by taking advantage of gaps between

148 phic scales, short-distance interactions and tightly knit sub-networks dominate the dynamics of patho

149 While the two variants are tightly linked in Caucasians, we separated their effects

150 nd population differentiation rates are more tightly linked in tropical species than in temperate spe

151 y, one of the major kinases in cells that is tightly linked to anabolic and catabolic pathways.

152 However, epithelial cell division must be tightly linked to cell death to preserve barrier functio

153 Increasing age is tightly linked to decreased thickness of the human neoco

154 an papillomavirus (HPV) replication cycle is tightly linked to epithelial cell differentiation.

155 lieved that gamma oscillations in cortex are tightly linked to local hemodynamic activity.

156 and nucleic acids present in a cell, and is tightly linked to metabolism, proliferation and gene exp

157 The downregulated genes were tightly linked to regulation of the cell cycle.

158 processes in adipose tissue compartments is tightly linked to severe metabolic disorders, including

159 Physiological functions of S1P are tightly linked to shear stress, the key biophysical stim

160 vironment, as epigenetic mechanisms are both tightly linked to the genome and environmentally respons

161 metabolic fluxes, these variations were not tightly linked to the genome structure of the lines.

162 Hz coherence between cortex and periphery is tightly linked to the presence of approximately 20 Hz bu

163 amplified polymorphic sequence (CAPS) marker tightly linked to the Prs locus and demonstrated its pot

164 heightened ERK signaling activity in aRG is tightly linked to the temporal formation and the relativ

165 Mitochondrial function is tightly linked to their morphology: healthy mitochondria

166 ugh genetic fine-mapping, we define a set of tightly linked variants likely to contain the causal all

167 n H1 subtype expression and localization are tightly linked with chromatin remodeling and might be cr

168 activity and cytadherence among isolates was tightly linked with degree of tissue inflammation in hos

169 levels in weaned male mutant beta-cells were tightly linked with hyperglycemia, decreased beta-cell p

170 Variation around the tightly-linked light response genes PHYC and FRS10 corre

171 Eukaryotic mRNA decay is tightly modulated by RNA-binding proteins (RBPs) and mic

172 is critical for reward/reinforcement and is tightly modulated by the laterodorsal tegmentum (LDT).

173 lobe and distributed heteromodal areas were tightly nested.

174 ssue of the N/MC individuals were nearly all tightly non-mac-tropic, contrasting with previous data f

175 The formation and function of synapses are tightly orchestrated by the precise timing of expression

176 Organismal stress initiates a tightly orchestrated set of responses involving complex

177 granule genesis in Pseudomonas aeruginosa is tightly organized under nitrogen starvation.

178 ceptor outer segment filled with hundreds of tightly packed "disc" membranes.

179 erein each receptor-binding domain is either tightly packed at the membrane-distal apex or rotated in

180 The double-stranded DNA is tightly packed in the capsid as a left-handed superhelix

181 omatase clusters were also more abundant and tightly packed in the NCM of males as compared to female

182 ed motions, whereas most form the centers of tightly packed internal regions.

183 and myosin II filaments were organized into tightly packed linear arrays oriented along the axis of

184 ms of starch, cellulose, and chitin can have tightly packed organizations of polymer chains with low

185 Btbd7 knockout results in more tightly packed outer bud cells, which display stronger E

186 e cytoplasmic protein interactions mediate a tightly packed state.

187 mammals, taste buds typically contain 50-100 tightly packed taste-receptor cells (TRCs), representing

188 (alanine to phenylalanine) in the predicted, tightly packed TM domain dimer interface.

189 ls a C1r2s2 with its serine protease domains tightly packed together in the center of C1 and an intri

190 l six transmembrane helices of CmTMEM175 are tightly packed within each subunit without undergoing do

191 t function as a molecular "OR logic gate" to tightly regulate energy and glucose metabolism.

192 sensing network that allows Ncrassa cells to tightly regulate gene expression in response to environm

193 Nuclear pore complexes tightly regulate nucleo-cytoplasmic transport, controlli

194 During development, mesenchymal progenitors tightly regulate the balance between self-renewal and di

195 eukaryotic cells, and LD-associated proteins tightly regulate their dynamics.

196 chi is tightly regulated and depends on environmental condition

197 es indicate that proteasome function is also tightly regulated and determines whether a ubiquitylated

198 ch on HR, little is known about how it is so tightly regulated and how it can be contained spatially

199 The HPV life cycle is tightly regulated and intimately linked to the different

200 commensal microbes and the immune system are tightly regulated and maintain intestinal homeostasis, b

201 s pattern-triggered immunity, translation is tightly regulated and poorly correlated with transcripti

202 The production of biosurfactants is tightly regulated at the transcriptional level by the qu

203 of the proper number of nephrons requires a tightly regulated balance between renal progenitor cell

204 Their spatial and temporal availability is tightly regulated by a set of specific lipid kinases and

205 rly, oxidative balance in the vasculature is tightly regulated by a wealth of pro- and antioxidant sy

206 , suggesting that neuronal NMNAT2 levels are tightly regulated by cAMP signaling.

207 l role in Ad pathogenesis and is known to be tightly regulated by cholesterol-rich "lipid rafts." Col

208 Cellular synthesis of TSP-1 is tightly regulated by different intermediate biomolecules

209 Mineralization of bones and teeth is tightly regulated by levels of extracellular inorganic p

210 called an appressorium, whose development is tightly regulated by MAPK signaling pathways following t

211 ed activation mechanism for TRPC4/5 channels tightly regulated by NHERF1/2 interaction.

212 Microtubule-based axonal transport is tightly regulated by numerous pathways, ensuring appropr

213 minent features of this kinase is that it is tightly regulated by proteasomal degradation.

214 PMEs are therefore tightly regulated by proteinaceous inhibitors (PMEIs), s

215 The NALP3 inflammasome is tightly regulated by recently discovered control mechani

216 The membrane lipid composition is tightly regulated by the cell, maintaining a homeostasis

217 hicken and mouse embryos, PAPC expression is tightly regulated by the clock and wavefront system in t

218 e, an intricate process in seed formation is tightly regulated by the DNA binding activity of protago

219 The biological activity of IL-1 is tightly regulated by the specific receptor antagonist (I

220 al migration, highlighting the importance of tightly regulated CAMK2 auto-phosphorylation in neuronal

221 xpressed constitutively in cells, unlike the tightly regulated ChaC1.

222 y proteins involved in T3SS construction are tightly regulated due to its role in pathogenesis and mo

223 undle production and that myosin activity is tightly regulated during ovulation to produce an optimal

224 The levels of dNTPs are tightly regulated during the cell cycle and depend on th

225 Centrosome numbers are tightly regulated during the cell cycle.

226 Thus, T cells must be tightly regulated from their development onward.

227 s a highly coordinated process that requires tightly regulated gene expression programmed by transcri

228 an others to transcriptional activation, and tightly regulated genes may cause target gene silencing

229 icity-transducing effector whose activity is tightly regulated in cis by the globular C-terminal doma

230 oietic CDRs points to sets of genes that are tightly regulated in leukemic transformations and common

231 Hence, expression of RTN1 and RTN3 is tightly regulated in mouse brains.

232 Transgene expression in hPSCs is tightly regulated in response to doxycycline treatment.

233 Although nitrate and nitrite reduction are tightly regulated in response to substrate availability,

234 Mitochondrial oxidation of nutrients is tightly regulated in response to the cellular environmen

235 e of glycolysis in differentiated cells, was tightly regulated in stem cells.

236 MicroRNAs (miRs) are tightly regulated in the immune system, and aberrant exp

237 Cell production and death are tightly regulated in the rapidly renewing gut epithelium

238 Diverse cellular proteins and RNAs are tightly regulated in their subcellular localization to e

239 on principal neuron spike patterns that are tightly regulated in time.

240 cytoplasm, with its import into the nucleus tightly regulated like other members of the IRF family.

241 in inaccurate control of tubule diameter, a tightly regulated parameter with important physiological

242 Embryonic development is driven by tightly regulated patterns of gene expression, despite e

243 Polyamines are tightly regulated polycations that are essential for lif

244 re triggered by the P starvation response, a tightly regulated process in plants.

245 Gut homeostasis is a tightly regulated process requiring finely tuned complex

246 Ubiquitylation is a tightly regulated process that is essential for appropri

247 in DNA double-strand break (DSB) repair is a tightly regulated process to maintain genome integrity.

248 ally designed micro- and nanostructures, and tightly regulated processes, nature demonstrates exquisi

249 Cytosolic sensing of nucleic acids initiates tightly regulated programs to limit infection.

250 ellular turnover and tissue function rely on tightly regulated rates of ISC division and appropriate

251 Plants have evolved tightly regulated signaling networks to respond and adap

252 herefore depends upon highly coordinated and tightly regulated tissue-residing cellular sensors and r

253 Fc-FcgammaR interactions are tightly regulated to control IgG-mediated inflammation a

254 s vital that chemokine receptor signaling is tightly regulated to ensure appropriate responses.

255 nce of myogenic progenitor and stem cells is tightly regulated to ensure appropriate skeletal muscle

256 The innate inflammatory response must be tightly regulated to ensure effective immune protection.

257 of uniporter subunit assembly, which must be tightly regulated to ensure proper mitochondrial respons

258 Gene expression in Plasmodium falciparum is tightly regulated to ensure successful propagation of th

259 Eukaryotic translation is tightly regulated to ensure that protein production occu

260 n-triggering signaling process in T cells is tightly regulated to permit an immune response that is a

261 Inflammation in the CNS must be tightly regulated to respond efficiently to infection wi

262 e myosin II (NMII) motor proteins, which are tightly regulated via the phosphorylation of their assoc

263 The innate immune system is tightly regulated, as excessive inflammation can lead to

264 able elements (TEs) are a prolific source of tightly regulated, biochemically active non-coding eleme

265 ic information encoded by DNA methylation is tightly regulated, but shows a striking drift associated

266 ponses to infectious agents and is therefore tightly regulated.

267 ly considered inaccurate and they need to be tightly regulated.

268 rial behavior, its assembly and activity are tightly regulated.

269 o have deleterious effect on the host and is tightly regulated.

270 etrimental to the host and therefore must be tightly regulated.

271 eioses, although total crossover numbers are tightly regulated.

272 lication to occur, origin activation must be tightly regulated.

273 mmation and leukocyte transmigration must be tightly regulated.

274 ng neuronal commissures whose development is tightly regulated.

275 that this potentially destructive pathway is tightly regulated.

276 kill multiple targets, degranulation must be tightly regulated.

277 role for hydrogen peroxide in the mechanisms tightly regulating NOD-like receptor family, pyrin domai

278 tal - anterior cingulate cortex appears most tightly related to the adolescents' variations in sleep

279 multi-sensory perceptual disambiguation that tightly replicates human performance.

280 Collectively, our results indicate that MAPK tightly suppresses DC migration and augments DC survival

281 In aggregate, our analyses suggested a tightly synchronized diel coupling of viral and cellular

282 ost enzyme activity but binds to GmGIP1 more tightly than does PsXEG1, thus freeing PsXEG1 to support

283 xception of the dibenzylammonium 2b(+)) more tightly than the other derivatives under investigation (

284 e4S](3+) clusters bind to DNA 550 times more tightly than those with [4Fe4S](2+) clusters.

285 The mutants bind more tightly than wild-type BRAF to RAS-GTP, and their bindin

286 articular, alpha-band oscillations have been tightly tied to spatial attention and may not reflect lo

287 specially HspB1 and HspB5, but also B3, bind tightly to a variety of proteins, whereas fewer substrat

288 Drosophila Fhod binds tightly to barbed ends, where it slows elongation in the

289 isoform Munc18a is well-established to bind tightly to both the closed conformation and the N-peptid

290 The analogues were bound tightly to eukaryotic translation initiation factor 4E (

291 like carbamazepine and phenytoin, which bind tightly to fast-inactivated states.

292 A (proliferating cell nuclear antigen) binds tightly to Pol delta and recruits it to the lagging stra

293 We show that RAD52 binds tightly to the RPA-ssDNA complex and imparts an inhibito

294 lular ends of the four S6 segments are drawn tightly together to block ion permeation completely.

295 ctivity between pairs of LGN neurons is more tightly tuned than predictions based simply on receptive

296 oretical studies suggest that moraphology is tightly tuned to minimize wiring and conduction delay of

297 The duration of the behavior correlated tightly with field application.

298 n ventrolateral prefrontal cortex correlates tightly with irrational behavior.

299 teins and lipids such as PIP2 which interact tightly with Kir channels.

300 ed over 2 orders of magnitude and correlated tightly with the concentration of cardiolipin in the equ