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1  is dominated by the ground plane (0 degrees tilt).
2 on and in neither case is responsible for TM tilt.
3 e support our finding of a stimulus-relevant tilt.
4 gating by a combination of both dilation and tilt.
5 detected on OCT and 65% of eyes had no optic tilt.
6 <1 cm) lateral translation at fixed latitude tilt.
7 f visual gratings according to their average tilt.
8  peripapillary RPE displacement, OCD, or ONH tilt.
9 ovskite induced by O-octahedral rotation and tilt.
10 s following either nose-up or nose-down body tilts.
11 ressure dependent changes in the tetrahedral tilts.
12 s head orientation when the patient was roll-tilted.
13 re and vasoconstriction in POTS women during tilting.
14  sampling revealed a soft potential for TM1a tilting.
15 tortion and, in the alpha chain, Fe-His bond tilting.
16 m with the smaller cesium, due to octahedral tilting.
17 re more complex than simple dilation or bond tilting.
18 we also show that the transmembrane helix is tilted ~13 degrees from the lipid bilayer normal, and ex
19  in ICP (supine, 15 +/- 2 vs. 24 h head-down tilt, 15 +/- 4 mmHg).
20 explore their near-equilibrium behavior in a tilted 2D gravitational column.
21 MSNA were measured during supine and upright tilt (30 deg and 60 deg for 5 min each) in 9 Asians (32
22 h a virtual visual environment, participants tilted a virtual table through continuous wrist flexion/
23     Here, we study a metasurface composed of tilted achiral meta-atoms with no spatial variation of t
24                              We measured the tilt after-effect following adaption to perceptually res
25 identification can still produce significant tilt after-effects in adults with amblyopia.
26                                 Nanoparticle tilting after binding of chiral amino acids is proposed
27  orientation selective detectors producing a tilt aftereffect (TAE).
28 e vertical lines seem oppositely tilted (the tilt aftereffect).
29 ized behavioral stressors, including head-up tilt and 15-minute cycle exercise.
30 ck bilayers (DErPC and DEiPC), it started to tilt and became slightly deformed, and finally it became
31   This approach to quantify local octahedral tilt and correlate it with strain can be applied to char
32  a potent detection technique that decouples tilt and curvature and simultaneously relaxes the requir
33          We report changes in the octahedral tilt and lattice spacing in both materials, together wit
34  trimer is wider than all other HAs due to a tilt and opening of the HA1 subunits of the head domain.
35 e greater shifts in axial A-IOL location and tilt and pupil diameter.
36  the Mcm2-7 hexamer in the DH-dsDNA needs to tilt and shift laterally.
37               Instabilities such as baseline tilt and shift, shift in peak position as well as sharp
38 figurations are characterized by large axial tilt and small eccentricities of Earth's elliptical orbi
39 chirality (63,21)@(65,32) with 16-20 degrees tilt and strain up to 1% in the outer shell.
40 ot track arising from the interplay of plume tilt and the lateral advection of plume sources.
41          This group also encoded mixtures of tilt and translation signals.
42                    In particular, 30 degrees tilt and twist GBs are corresponding to energy minima.
43 cs simulations explored that both 30 degrees tilt and twist GBs are highly mobile associated with col
44                             Both symmetrical tilt and twist GBs over the entire range of rotation ang
45 udy of dislocation structures of both <0001> tilt and twist grain boundaries (GBs) in Magnesium.
46 he design model, despite an unexpected CDRH3 tilt and VH/VL interface deviation, which indicates that
47 mtosecond light pulse, including pulse front tilt and wavefront rotation.
48 hows that two single hexamers, arranged in a tilted and twisted fashion through interdigitated amino-
49 hese structural changes are known to involve tilting and bending of various transmembrane helices.
50 iding in addition to the previously reported tilting and bending.
51 yl regions leads to confined lipid headgroup tilting and conformational rearrangements.
52                        MSNA increased during tilting and it was markedly lower in Asians than Caucasi
53   Interaction with the receptor causes fiber tilting and opening of the internal tail channel by untw
54 type gate-activating mutations that reveal a tilting and straightening of the M4 inner transmembrane
55         We show that the Braun's lipoprotein tilts and bends, and thereby lifts the cell wall closer
56                         Adduction temporally tilts and displaces the prelaminar ONH and peripapillary
57 moduli from the distributions of microscopic tilts and splays of the lipid components.
58 he water/lipid interface, to calculate lipid tilts and splays, as well as to fit the corresponding di
59 olfaction, a lesser chronotropic response to tilt, and a longer duration of illness.
60 rresponding to gating by dilation, gating by tilt, and gating by a combination of both dilation and t
61 he slope ratio between the IOL and iris, IOL tilt, and optic surface changes were determined and corr
62 pling from variations in molecular geometry, tilt, and order.
63          The children showed neck pain, head tilt, and reduction in neck mobility.
64                             We conclude that tilt- and translation-selective signals, which reflect n
65 be the pore size, pore angle, mesh rotation, tilt angle (branch droop) and layering (branch overlap).
66 phatidylglycerol (POPG), as expected, with a tilt angle close to 90 degrees .
67 we show for the first time that the pyrazine tilt angle does not play a role in determining the stren
68 ncorporates angular refinement to reduce the tilt angle error.
69                                Moreover, the tilt angle of an assumed helical portion of the peptide
70 nd H2 ranges from 35 to 69 degrees , and the tilt angle of Cav182-136 is 27 +/- 6 degrees .
71           The connector group determines the tilt angle of the Fc unit which in turn affects the pack
72 performed to design optimum device geometry, tilt angle, and cell throughput that is more than 20 tim
73 ral joint alignment (bisect offset, patellar tilt angle, and Insall-Salvati ratio), trochlear morphol
74                              Analysis of the tilt-angle dependency of the intensities associated with
75                                       Fibril tilt-angle distribution was investigated by combining th
76 work, we introduce a unique configuration of tilted-angle standing surface acoustic waves (taSSAW), w
77                              Our method uses tilted-angle standing surface acoustic waves.
78 splay water contact angles >160 degrees with tilt angles <2 degrees .
79  hexadecane contact angles >150 degrees with tilt angles <5 degrees , whilst the superhydrophobic coa
80 per lipid, the bilayer height, and the chain tilt angles and has important consequences for other bil
81 cy towards water and oils with extremely low tilt angles due to the smooth liquid-liquid contact betw
82                               The calculated tilt angles for PGLa are in excellent agreement with rec
83                                The Pf1 helix tilt angles in bilayers composed of two different lipids
84 old surface, ellipsometry and PM IRRAS yield tilt angles of 29 +/- 4 degrees (monolayers of type A) a
85 ture (NEXAFS) spectroscopy yielded molecular tilt angles of 33-43 degrees .
86 ane contact angles exceeding 155 degrees and tilt angles of less than 4 degrees .
87                        The values of maximum tilt angles were similar, with possible implication of c
88 imaging condition to measure TiO6 octahedral tilt angles, unit-cell-by-unit-cell, in perovskite-based
89 nverse cosine function of the magnetic field tilt angles, which demonstrates the two-dimensional natu
90 nd unique biological object from a series of tilted angles, but it is challenging to image a single p
91 ng various patterns or slide off at designed tilting angles at specified positions on a superhydropho
92                                       Such a tilted anisotropy breaks the symmetry of the problem and
93                                          The tilted array of Raman scattering signals is dispersed by
94 nfocal Raman microspectroscopy featuring the tilted-array technique is demonstrated.
95 , epitaxial strain, and octahedral rotations/tilts as dominating mechanisms for the large net magneti
96  10(20) Omega mum for 21 degrees mismatch in tilt (asymmetric) GBs.
97 a, the NMR analysis showed that MAG2 becames tilted at an angle of 120 degrees , and its azimuthal ro
98 four alpha-helices in the a-subunit that are tilted at approximately 30 degrees to the plane of the m
99  series of transmission electron micrographs tilted at different angles in vitreous ice: cryo-Transmi
100 ts such that the magnetic easy axis slightly tilts away from the direction, normal to the film plane.
101 exists an unusual atomic shuffling along the tilt axis, which greatly assists SCM to operate in the e
102                                    Head down-tilt bed rest (HDBR) serves as a microgravity analog bec
103 nged simulated microgravity (6 deg head-down tilt bedrest).
104 e issues through a Bayesian energy landscape tilting (BELT) scheme for computing Bayesian hyperensemb
105 membrane and cytosolic domain (TM/CT) with a tilted beta3 TM/CT that leads to activation when disrupt
106 . 36 +/- 16 bursts min(-1) ML phase at 5 min tilt), burst incidence or total activity, nor any differ
107 otonation of His(14) is an increase in helix tilt, but GWALP23-H14 remains in a transmembrane orienta
108 frozen Lethocerus muscle confirmed the axial tilt; but strongly bound myosin heads also showed an une
109 s monolayer (type B), the molecular axes are tilted by 40-45 degrees to a structure similar to those
110 ith their cytoskeleton-binding beta-subunits tilted by applied force.
111 ections, to give ambiguous information about tilt; by selectively desensitizing one or other of the b
112 ly gravity-centered representation of object tilt can be achieved directly from the population activi
113                 Thus, miR-29b expression may tilt cells from extrinsic to intrinsic mechanisms of apo
114 al or drug-induced accommodation, as well as tilt changes with respect to natural lens and accommodat
115 kable prediction that perceived direction of tilt (clockwise or counterclockwise) of a test pattern c
116 to a fully upright orientation, with a helix tilt close to 180 degrees , they must make up the actual
117 ths, there were changes in posterior corneal tilt, coma, and hexafoil in the PCRI group.
118 d detection was mildly impaired in head-down tilt compared with upright position in the combined subj
119  catalytic flavin in a previously unobserved tilting conformation.
120 ther' subunit nanoparticle spawns a slightly tilted, consequential 'daughter' nanoparticle, which by
121 ixing structures from different species to a tilt-corrected 2-nm three-dimensional map of frozen-hydr
122 ear the interface region, which results in a tilted Cu2O/Cu interface with concomitant Cu2O island ro
123 agreement was only fair to moderate for disc tilt, cup depth, and disc size (kappaw = 0.46-0.49).
124              Twenty-one eyes (35%) had optic tilt detected on OCT and 65% of eyes had no optic tilt.
125 cific lesions included tessellation (31.7%), tilted disc (28.1%), peripapillary atrophy (7.0%), staph
126                            No eye featured a tilted disc syndrome.
127                                              Tilt-dominated grain boundaries have been investigated i
128 ely when they were heading in a tilted-up or tilted-down direction.
129  examine this question by studying the field-tilt-driven crossover from predominantly edge-state tran
130 nsity is elevated at 90 degrees /270 degrees tilt due to vertical surfaces (trees, walls).
131 e cryogenic electron microscopy by employing tilts during data collection.
132                                 We used dual-tilt electron tomography to produce en-face views of dya
133 r organelles or whole cells from a series of tilted electron cryo-microscopy (cryo-EM) images.
134 tching energy is significantly less than the tilt energy of an unstretched distal monolayer.
135  the ends of the ladder with the presence of tilted external magnetic field and four-Majorana interac
136 nance (SPR) optical fiber biosensor based on tilted fiber Bragg grating technology for direct detecti
137  The sensor architecture lies on gold-coated tilted fiber Bragg gratings (Au-coated TFBGs) photoimpri
138  this work uses nanometric-scale gold-coated tilted fiber Bragg gratings (TFBGs) interrogated by ligh
139                            Using excessively tilted fiber grating (Ex-TFG) inscribed in standard sing
140  measured when supine, during 60 deg upright tilt for 45 min or until presyncope, and during the cold
141                               The 30 degrees tilt GB is characterized with an array of Shockley parti
142 interstitials are annihilated at small-angle tilt GBs (STGBs) in SiC.
143 f equilibrium and metastable [100] symmetric tilt GBs are carried out to explore the energetics of va
144 ion (SCM) of typical [100] group symmetrical tilt GBs in bcc W using atomistic simulations.
145 e at the specific lattice planes, and with a tilted geometry, provide the relaxation pathway: the Ti(
146 ously that in transparent media, pulse front tilt gives rise to the directional asymmetry of the ultr
147 l investigation of a metasurface composed of tilted gold nanowires.
148 ly [001] textured MgO films contain numerous tilt grain boundaries.
149 roscopy (STEM) of a [1-10]/(110) 4.8 degrees tilt grain boundary reveals that the interface is compos
150 ere adapted by a prolonged presentation of a tilted grating.
151 on, and a cardiac chronotropic response upon tilt &gt; 10 beats per minute.
152 d severe axial twisting instead of waving on tilted hard-agar surfaces.
153  in supine, sitting, and 9 degrees head-down tilt (HDT) positions.
154  supine, sitting, and in 9 degrees head-down tilt (HDT).
155 ttern of orthostatic symptoms during head-up tilt (HUT) in patients with orthostatic intolerance duri
156                      Earth's orbit and axial tilt imprint a strong seasonal cycle on climatological d
157 e, observers were asked to judge the average tilt in a circular array of high-contrast gratings, rela
158 aparietal area (CIP) visually encodes object tilt in nonegocentric coordinates defined relative to th
159 OL positioning without any significant optic tilt in patients with glued IOL fixation.
160 es the importance of octahedral rotation and tilt in perovskites, for influencing surface reactivity,
161                           Furthermore, axial tilt in the surface thin films (thickness approximately
162 mensional US data were resectioned in planes tilted in 5 degrees increments away from a central plane
163 ocular summation and difference signals were tilted in opposite directions, to give ambiguous informa
164 heral resistance were higher during rest and tilting in the ML than EF phase; however, heart rate, st
165 erent layers, specifically a second stage of tilt, increased rotation about the O2-C2 dihedral, and a
166  focal volume by the gradient force from the tilted intensity front and the thermocapillary force cau
167   We demonstrate that the laser pulse with a tilted intensity front deposits energy more efficiently
168 ntensity modulation of a diffraction spot on tilting is a fingerprint of the thickness, and changes i
169 um independent of bending, lateral shift, or tilting is missing.
170 tiple images taken at different angular beam tilts, it is possible to image a majority of nanoparticl
171 u2O7 where we find that the octahedra become tilted, leading to two phase transitions.
172 e in the orbital angular momentum (OAM) of a tilted light beam eclipsed by a moving object, lateral m
173 nt (the motion aftereffect), and exposure to tilted lines can make vertical lines seem oppositely til
174 e charges on the C-terminus of the obliquely tilted MAG2 peptides neutralize some of the cationic gro
175         This paper explores a simple method-"tilted MagLev"-to increase the range of densities that c
176  the warmest configuration occurs at minimum tilt, maximum eccentricity, and a perihelion passage dur
177            These calculations show that head tilting may be attributed to specific steric interaction
178 ic epithelial cells, which typically feature tilted metaphase spindles, lack this anaphase flattening
179               Membrane rupture is induced by tilted microindentation, a technique used to perform mec
180 magneto-hydrodynamic instability, known as a tilt mode, which poses a central obstacle to further fie
181 article, we proposed a penalized Exponential Tilt Model (pETM) using network-based regularization tha
182 ave also developed a generalized exponential tilt model that captures both mean and variance signals
183 ect real-space correlation of the octahedral tilt modulation with the superstructure geometry and lat
184 method to determine the bending rigidity and tilt modulus, for lipidic assemblies of arbitrary lipid
185      In addition, theC. elegansNdc80 complex tilts more toward the adjacent protofilament.
186 latform, can undergo remarkable pivoting and tilting motions that appear buffered by N-glycan decorat
187 a-turn; there is a rise of 16.6-16.7 A and a tilt of 36.1-36.6 degrees between consecutive pentamers.
188 on of an autofocus unit that compensates the tilt of a slide in the Z-axis in real time, we increase
189  different models result from changes to the tilt of chains in different layers, specifically a secon
190 oplasmic surface, consistent with an outward tilt of helix B.
191 ause of a approximately 2 A displacement and tilt of M2 relative to M1.
192 cholesterol and the amide of PSM rotates the tilt of the amide plane, which primes it for more robust
193                  The kink, which reduces the tilt of the C-terminal helical domain relative to the bi
194  characterized by a approximately 10 degrees tilt of the head.
195 arm hypothesis, which predicts a large axial tilt of the lever arm domain during the actin-attached w
196 face are intimately tied to the rotation and tilt of the RuO6 octahedra.
197 tation patterns, we controlled the perceived tilt of the test pattern.
198 ich are characterized by a distinct vertical tilt of their axes.
199                                       As the tilt of this rigid barrier is varied, we find Medicago t
200 ace when CGS21680 is bound, due to an inward tilt of TM2 in that region.
201 ation of E14 leads to extensive rotation and tilt of transmembrane helices 1-3 in conjunction with re
202 ffraction at commensurate pressures reveal a tilting of the Cu spins out of the plane with a critical
203 utS in the sliding clamp conformation, where tilting of the MutS subunits across each other pushes DN
204 d repulsion forcing a wider C-Pd-C angle and tilting of the NHC plane in cis-[Pd(IPr)2(eta(2)-O2)].
205                  Induced asymmetry involving tilting of the nonamer-binding domain dimer of RAG1 upon
206 (the C(o) side), leading to a characteristic tilting of the phenyl ring around its C(i)-C(p) axis.
207                                            A tilting of the pre-TCRbeta when bound to the pMHC ligand
208 hains along the b-axis occurs mainly through tilting of the Si-O-Si dihedral angle rather than shorte
209 rate from the EC region; and (iii) concerted tilting of TM1b and TM6a toward TM3 and TM8 to close the
210 f TANGO1 molecules in the ring are initially tilted onto COPII coats but appear to be pushed apart as
211 as strongly correlated Bloch oscillations in tilted optical lattices.
212 re most were translation-selective and a few tilt- or gravitoinertial acceleration-selective.
213  PROPPIN sits in a perpendicular or slightly tilted orientation on the membrane.
214                 TM3 was selected because its tilted orientation, relative to the membrane, allows its
215 The peptides remain mostly helical and adopt tilted orientations.
216 rigami metamaterials with controllable local tilting orientations on demand through prescribed notche
217 of motion from the in-plane component of the tilted oscillating field.
218 distorted and the thiophene ring is strongly tilted out of the plane of the macrocycle.
219 shows one of the protomers to be rotated and tilted outward at the tip end, leading to a breaking of
220 the mountain blocks display large uplift and tilting over a breadth of only about 10 km.
221 in the ORA between the eyes with and without tilt (P = 0.762).
222  +/- 6 vs. 49 +/- 3 bursts min(-1) at 60 deg tilt; P = 0.003).
223 bilized with a non-equilibrium amplitude and tilt pattern of the corner-connected NiO6 octahedral--th
224                                The forbidden tilt pattern we observe arises through coupling to hydra
225  is due to competition between two different tilt patterns of the [M(CN)6 ](3-) ions.
226 ontrolling the relative stabilities of these tilt patterns offers a potential means to tune the explo
227 the number of doubly occupied sites when the tilt per site is tuned to integer fractions of the Mott
228  to protect the dependent eye in the lateral tilt position may reduce the risk of severe corneal inju
229 ients underwent surgery in the right lateral tilt position with ocular protection but reported irrita
230 re combined, the rats developed a limp and a tilted posture that correlated in direction and magnitud
231 error of the target object center during the tilting process through a closed-loop proportional-integ
232 r and/or wider than the cell's height into a tilted, quasidiagonal x-z position.
233  discharge rates, which consistently encoded tilt, rather than translational head movements.
234 hibited significant progressive temporal ONH tilting reaching 3.1 +/- 0.4 degrees in 30-degree adduct
235 y and image analysis based on random conical tilt reconstruction to obtain a three-dimensional (3D) s
236  and a strategy for accounting for electrode tilt relative to the substrate.
237  the monkeys' vocal developmental landscape, tilting, rotating or shifting it in different ways.
238 h a systematic coarse grid sampling of helix tilts/rotations ( approximately 13 trillion transmembran
239 strate a violation of established octahedral tilt rules in the double perovskite analogue (NH4)2SrFe(
240 ure of biological specimens from tomographic tilt series acquired in the scanning transmission electr
241 t retrieves 3D structural information from a tilt series of 2D projections, and is gradually becoming
242 echnology for acquiring electron tomographic tilt series of cyanophage-infected cyanobacterial cells
243 e-dimensional structural information using a tilt series of two-dimensional images.
244          Acquiring three or four tomographic tilt series takes approximately 12 h on a JEM2200FS elec
245  is a novel method of fine alignment for the tilt series.
246 this mapping is achieved using a large-angle tilt-series of electron diffraction patterns.
247 ating ET data acquisition without using beam tilt/shift processes.
248 method could reduce the accumulation of beam tilt/shift that used to compensate the error from the me
249    These unusual features of the twisted and tilted single hexamers suggest a concerted mechanism for
250 ht, providing a transmission response of the tilted SRRs patterned on its surface that is free of any
251     The simulations suggest a robust, highly tilted state for membrane-embedded synaptobrevin with a
252 ch are then stretched to produce an array of tilted surface elements which can be controlled to withi
253 ion as measured by fall in blood pressure on tilt-table testing (R = -0.63, P < 0.001).
254 uction of either "isolated" or "nonisolated" tilted-target-sputtered sub-2 nm platinum nanoparticles
255 e past year), and a cardioinhibitory head-up tilt test (bradycardia <40 beats/min for 10 s or asystol
256 e analyzed findings of the Bielschowsky head-tilt test, the Parks 3-step test, and reversal of the hy
257 nce in patients age >/=40 years with head-up tilt test-induced vasovagal syncope compared with sham p
258             We have investigated the role of tilt testing (TT) in predicting recurrences.
259 ergy more efficiently when writing along the tilt than when writing against, producing either an isot
260  from immune checkpoint inhibitor therapy to tilt the balance in favor of the immune system.
261                    The change is realized by tilting the balance between its production and scavengin
262 d to a reprogramming of the immune response, tilting the balance between the immune system and cancer
263 ate that EHD2 adopts an open conformation by tilting the helical domains upon membrane binding.
264                       The exchange occurs by tilting the imine inside the complex and thereby switchi
265                                              Tilting the MagLev device relative to the gravitational
266  perovskite lattice in two distinct ways: by tilting the MX6 octahedra or by simply contracting the l
267                      This is accomplished by tilting the phase front of waves through a two-dimension
268 anoscale magnetic fields is possible without tilting the specimen.Beyond high resolving power, electr
269 f BNNSs and can be inter-converted by simply tilting the TEM specimen following designated directions
270 tored in filament deformation (i.e., strain) tilts the fragmentation-annealing reaction free-energy p
271 th the rapidly moving Pacific plate strongly tilts the Hawaiian plume and leads to lateral separation
272 ines can make vertical lines seem oppositely tilted (the tilt aftereffect).
273                  After 10 minutes of head-up tilt, the heart rate was lower with the ITD versus sham
274  ago, during an interval of decreasing axial tilt, the orbital component in global temperature record
275                                 Cancer cells tilt their energy production away from oxidative phospho
276                                           To tilt this balance toward elimination, we targeted LRV1 u
277                              Situations that tilt this balance toward TLR7 promote inappropriate resp
278           Ankle sway was increased by slowly tilting this platform in a random fashion, or decreased
279  and as a consequence maintain their spindle tilt through cytokinesis.
280  at baseline while supine and during head-up tilt to 70 degrees for 10 minutes.
281 ngle triangular-lattice PC Bragg lasers that tilt to opposite directions by taking advantage of the s
282  apparent when confined spindles rotate from tilted to parallel positions while MDCK cells progress f
283 r and a nearby surface causes the swimmer to tilt toward the surface and the velocity gradient associ
284 ar to those of Purkinje cells, thus encoding tilt, translation or mixtures of these signals.
285 and GWALP23-H14 helices exhibit well defined tilted transmembrane orientations in dioleoylphosphatidy
286  semimetals with Dirac/Weyl cones either not tilted (type I) or tilted (type II).
287 rac/Weyl cones either not tilted (type I) or tilted (type II).
288  more accurately when they were heading in a tilted-up or tilted-down direction.
289  the opposite trend: they show no octahedral tilting upon Cs-substitution but only a contraction of t
290                                   They first tilt upward with respect to the surface, still keeping t
291 continuum of representations in which planar tilt was encoded in a gravity-centered reference frame i
292  the extra degree of freedom associated with tilting we have performed first principles hybrid densit
293              To identify the origins of head tilting, we analyse 781 additional simulations in which
294 and marked the first time that deflation and tilt were captured in real time by a new seafloor cabled
295 due to its increased octahedral rotation and tilting, which results in enhanced electron-correlation,
296 ng through a 4 x 4 confocal pinhole array is tilted with a periscope.
297 ribution of the valleys along a small circle tilted with respect to the equator is found to correspon
298 pon nail plucking injury, the homeostasis is tilted with these SCs dominantly delivering progeny to t
299 ible damage, provided that the nanotwins are tilted within about 15 degrees of the loading axis.
300 k field images recorded at different angular tilts yields insight into the character of nanoparticle

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