ライフサイエンスコーパス: timer

1 within a specific window of the sporulation timer.

2 The trans ring thus serves as a variable timer.

3 represents a unique mechanism for a genetic timer.

4 as an evolutionarily conserved developmental timer.

5 logs, tim-1 and kin-20, in the developmental timer.

6 ts, and thus involves a neuroblast-intrinsic timer.

7 sRed, resulted in a mutant named Fluorescent Timer.

8 a time course expected if Id4 is part of the timer.

9 rse expected if the proteins are part of the timer.

10 t evidence that p27 is part of the intrinsic timer.

11 r to be controlled by an autonomous maternal timer.

12 th, and suggesting a role as a developmental timer.

13 terminal ATPase acts as an input-independent timer.

14 vated caspase-8 with a K48-ubiquitin shutoff timer.

15 d by Hox proteins and an internal neuroblast timer.

16 ing screen identified miR-124 as a candidate timer.

17 rolled by the quantity of wax present in the timer.

18 ucing the timing factor in maturation of the timer.

19 echanisms that could potentially function as timers.

20 work for the study of emergent developmental timers.

21 dely conserved molecular gears of these 24-h timers.

22 Genome Biology, Li and colleagues introduced TIMER, a gene expression deconvolution approach for stud

23 Circadian clocks are endogenous timers adjusting behaviour and physiology with the solar

24 This timer also controls daily rhythms in gene expression and

25 Although mixing a timer and an adder can sometimes attenuate size variatio

26 at the overexpression of p27 accelerates the timer and that the increases in both p27 and p18 that oc

27 ectricity to power small electronic devices (timers and calculators) for several tens of hours.

28 rolling liquid, including autonomous fluidic timers and fluidic logic.

29 Because both the fluidic timers and paper-based assays depend on the wicking rate

30 ic far-red fluorescent proteins, fluorescent timers and photoconvertible fluorescent labels.

31 r, procaspase-9 autoprocessing activates the timer, and the rate at which the processed caspase-9 dis

32 This model successfully reproduces sizer, timer, and the restriction point features of the eukaryo

33 hore formation in DsRed, TagRFP, fluorescent timers, and PAmCherry.

34 Some timers appear to operate in a largely cell-autonomous fa

35 Fluidic timers are 97% accurate (with respect to the time requir

36 ed, but the mechanisms underlying biological timers are still unclear.

37 These "fluidic timers" are composed of paraffin wax and a signaling fea

38 isms in plants appear to use their circadian timers as the ruler by which the day/night length is mea

39 p1 (p27) is a component of this TH-regulated timer, as it increases as OPCs proliferate and is requir

40 the wicking rate of the sample, the fluidic timers automatically calibrate themselves (relative to t

41 s, and suggests an inextricable link between timer-based models of size control and heavy-tailed cell

42 - counteracts protein dilution to facilitate timer behavior.

43 This response requires an endogenous timer called the circadian clock to measure the duration

44 Timers can balance proliferation with differentiation to

45 d its overexpression in OPCs accelerates the timer, causing the cells to differentiate prematurely.

46 the interaction between melatonin-regulated timer cells and adjacent prolactin-secreting cells, whic

47 otein dilution poses stringent challenges to timer circuits by continually diluting out timer compone

48 o timer circuits by continually diluting out timer components in proliferating cells (Figure 1A, righ

49 e first evidence for an intrinsic cell cycle timer controlling duration and patterning activity of a

50 ysone signal can function as a developmental timer coordinating development within the imaginal disc.

51 occurs after reaching a size threshold), and timer (division occurs after a fixed time from birth).

52 In the Ngn3-Timer embryos, green-dominant cells could be readily det

53 in network provides an intrinsic destruction timer, enabling long-range coordination of actin network

54 ER-associated degradation (ERAD), acts as a timer enzyme, modifying N-linked sugar chains of glycopr

55 od (an overt expression of the photoperiodic timer) evolves independently of the rhythmic response to

56 ements, indicating that a stimulus-dependent timer exploits arousal to time gaze-shifts.

57 By acting as a timer for cell cycle exit, p27(Kip1) curtailed the progr

58 oters may provide an intrinsic developmental timer for dendrite/synapse gene expression.

59 undance in freshly harvested seeds acts as a timer for seed dormancy release, which functions largely

60 hosphate release, and to provide an internal timer for the age of the filament.

61 osphorylation of the CII domain provides the timer for the hydrolysis in the CI domain.

62 he peptidyl-prolyl isomerase Pin1 provides a timer for the lifetime of conventional PKC isozymes, con

63 e that ribosome collisions serve as a robust timer for translational quality control pathways to reco

64 Fast-FT is a fluorescent timer (FT) engineered from DsRed-like fluorescent protei

65 spase-9 processing, as well as the molecular timer function of the apoptosome.

66 atile or oscillatory dynamics can facilitate timer functions [3,4].

67 The timer gene provides a simple mechanism to coordinate pat

68 The networks operate through a timer gene, the level of which measures developmental pr

69 Timers help cells defer their responses to stimuli, ofte

70 A cell-intrinsic timer helps control when rodent oligodendrocyte precurso

71 An intracellular timer in oligodendrocyte precursor cells is thought to h

72 and Mash1 may be part of the cell-intrinsic timer in the precursor cells.

73 rt of the mechanism that sets the neurogenic timer in these cells.

74 s is similar to sleep regulated by circadian timers in insects and mammals, and sleep in response to

75 ure time and are likely to extend to similar timers in many other precursor cell types.

76 '-endo nucleotides may function as molecular timers in many RNA folding and ligand recognition reacti

77 uggest that miRNAs may act broadly as linear timers in vertebrate neuronal development.

78 rine cells, we developed a mouse model (Ngn3-Timer) in which DsRed-E5, a fluorescent protein that shi

79 cycle once it reaches a critical size, and "timer," in which the cell attempts to grow for a specifi

80 Depending on the order of FPs in the timer, incomplete proteasomal degradation either shifts

81 RFPs with a large Stokes shift, fluorescent timers, irreversibly photoactivatable and reversibly pho

82 The timer is regulated via a special repressilator-like inhi

83 An intracellular timer is thought to help control the timing of oligodend

84 that although the striatum serves as a 'core timer', it is part of a distributed timing system involv

85 18/INK (p18), may also be a component of the timer: it increases as OPCs proliferate, and its overexp

86 hore retention, suggesting an autoregulated, timer-like mechanism.

87 transcription factors and the developmental timer lin-14 cause not only a loss of zig gene expressio

88 models: dimer <--> tetramer <--> hexamer and timer <--> hexamer, equally consistent with the data.

89 tent with the hypothesis that the circannual timer may reside within the PT thyrotroph and is encoded

90 The cellular timer mechanisms that regulate such changes are, however

91 omes, whereas MAD3 acts as a crucial meiotic timer, mediating a prophase delay in every meiosis.

92 nthetic gene network acting as a predictable timer, modifiable by component choice.

93 Removal of the ENSA/Greatwall (EG) timer module eliminates this second threshold, as well a

94 oint (sizer) and the size-independent clock (timer) observed in many cell cycle experiments.

95 inesis until exit from mitosis; however, the timer of cytokinesis has not been experimentally defined

96 e cis ring constitutes a second, nonvariable timer of the chaperonin cycle.

97 ues serve, through deamidation, as molecular timers of biological events.

98 tors form dimers, which assemble into stable timers of dimers.

99 lication checkpoint activities are important timers of the undisturbed cell cycle before, but not aft

100 clude that specific assemblies, particularly timers, of naturally secreted Abeta oligomers are potent

101 eveals a biphasic mode of growth: a relative timer phase before constriction where cell growth is cor

102 xplore mixer models of size control, where a timer phase precedes/follows an adder, as has been propo

103 t that depends inversely on the noise in the timer phase.

104 rocaspase-9 sets the overall duration of the timer, procaspase-9 autoprocessing activates the timer,

105 y regulates the neuroblast temporal identity timer: prolonged Hunchback expression keeps the neurobla

106 egies based on radiolabeling or fluorescence timer proteins, allowed us to formally demonstrate the p

107 Cellular 'timers' provide an important function in living cells.

108 We conclude that two distinct "timers" regulate neuroblast gene expression: a hunchback

109 Circadian clocks are biochemical timers regulating many physiological and molecular proce

110 rcadian clock and the seasonal photoperiodic timer remains a subject of intense controversy.

111 ls expressing the 7.5-kb hPhox2a fluorescent timer reporter differentiated to equal numbers of catech

112 a MitoTimer reporter gene from the existing Timer reporter gene.

113 ast gene expression: a hunchback --> Kruppel timer requiring cytokinesis, and a Kruppel --> pdm1 -->

114 eset buttons, batteries, or maintenance; the timer simply starts once the sample is added to the devi

115 e rather than using an independent 2-hr-long timer started at the beginning of S phase.

116 Characterization of the timer suggests that it might be held inactive in eggs by

117 ction as an intrapituitary "pacemaker-slave" timer system.

118 Tandem fluorescent protein timers (tFTs) report on protein age through time-depende

119 idence is also emerging for a cell-intrinsic timer that alters the properties of each neuroblast with

120 p27 accumulation is part of a cell-intrinsic timer that arrests the cell cycle and initiates differen

121 regulatory process by acting as a molecular timer that co-ordinates membrane targeting with the synt

122 4C are functionally linked components of the timer that controls abscission in multiple physiological

123 transcription factor is a critical intrinsic timer that controls the onset of SC differentiation by r

124 Previous work identified a developmental timer that controls the stability of cyclin A protein in

125 The circadian clock is the endogenous timer that coordinates physiological processes with dail

126 anism for a genetic circuit to function as a timer that could be used in the engineering of synthetic

127 s demonstrate that p27 is part of the normal timer that determines when oligodendrocyte precursor cel

128 is directly linked to an autonomous maternal timer that drives the early embryonic cell cycles until

129 t Pin1 is a unique, dose-dependent molecular timer that enhances Rta protein function, but inhibits l

130 orphosis suggests that larvae possess a molt timer that establishes a minimal time to metamorphosis.

131 4 transcription is part of the intracellular timer that helps determine when oligodendrocyte precurso

132 Thus IRE1 activity is governed by a timer that may be important in switching the UPR from th

133 ccessibility is controlled by the biological timer that measures the nucleo-cytoplasmic (N:C) ratio,

134 isomerization acts as an effective molecular timer that plays significant roles in biological and pat

135 early embryo to function as a developmental timer that preserves naivete and prevents premature dele

136 terochronic genes constitute a developmental timer that specifies temporal cell fate selection.

137 The timer that triggers this cell death is yet to be identif

138 stablishment is controlled by the biological timers that control the onset of the MBT.

139 Circadian clocks are endogenous timers that enable plants to synchronize biological proc

140 enabling phytochromes to function as thermal timers that integrate temperature information over the c

141 conclusion that Aux/IAAs are auxin-initiated timers that synchronize developmental transitions.

142 Thus, E5 is a "fluorescent timer" that can be used to monitor both activation and d

143 ulsed positive feedback loop to implement a "timer" that operates over timescales much longer than a

144 This pathway serves as a molecular 'timer' that sets the lifespan of DCs and regulates the m

145 n, the Galpha subunit's intrinsic activation timer (the rate of GTP hydrolysis) is regulated spatiall

146 activate procaspase-3) dictates how fast the timer 'ticks' over.

147 leotide bound to actin filaments serves as a timer to control actin filament turnover during cell mot

148 Thus MAM may function as a timer to couple transcription activation with disassembl

149 This autocrine mechanism could serve as a timer to determine the frequency of pulsatile GnRH relea

150 a library of different chemical tests and a timer to indicate when the tests are completed.

151 nter, but also exploit an intrinsic interval timer to initiate physiological recrudescence following

152 The trans-proline sets a molecular timer to maintain the binding-active state long enough f

153 as OPCs proliferate and is required for the timer to operate accurately.

154 t Claspin may also respond to an independent timer to trigger the MBT and activation of cell cycle ch

155 r Ypt1p-mediated vesicular transport or as a timer to turn off Ypt1p-mediated membrane fusion but onl

156 ction with a Cdh2 tandem fluorescent protein timer transgenic line, we observed that Cdh2-EGFP molecu

157 3) A decision gate that is coupled to the timer via a special repressilator-like loop.

158 ersed in the bath throughout scanning, and a timer was used to synchronize lip movements with the 4D

159 Using chimeric fluorescent timers, we show that synaptic vesicle-associated protein

160 nslation could appear to be a core circadian timer when the true pacemaker is an embedded biochemical

161 de slightly better accuracy than an external timer when used to track an assay that measured the leve

162 The timer, when expressed as a static spatial gradient, func

163 functions as a proteolytic-based 'molecular timer', wherein the intracellular concentration of proca

164 tokinesis, and a Kruppel --> pdm1 --> castor timer which is cell cycle independent.

165 tion module (Spo0A dynamics) is modeled as a timer whose clock rate is adjusted by a stress-sensing u

166 2) A sporulation timer whose clock rate is regulated by cell stress and p

167 that the levels of p27 matter in the way the timer works.