ライフサイエンスコーパス: tip cell

1 m cells are controlled by the somatic distal tip cell.

2 amyloplasts sediment along the length of the tip cell.

3 prouting as a result of increased numbers of tip cells.

4 n the retraction of filopodia in endothelial tip cells.

5 s and diminished the directionality of their tip cells.

6 g the retraction of filopodia in endothelial tip cells.

7 eaved CLEC14A binds to sprouting endothelial tip cells.

8 ks due to increased elongation of protonemal tip cells.

9 g and helps to restrict the proliferation of tip cells.

10 s required for RanGAP NE association in root tip cells.

11 nts and divisions of individual ureteric bud tip cells.

12 hairs, but only five were expressed in root tip cells.

13 nsure its correct localization within hyphal tip cells.

14 y are rate-limiting for the growth of hyphal tip cells.

15 ion of microtubule disassembly within hyphal tip cells.

16 ended bead-like structure in interphase root tip cells.

17 and inducing adrenocorticotropin in rostral tip cells.

18 elial cell motility, driving cells to become tip cells.

19 ns of two specific gonadal cells, the distal tip cells.

20 gonad, in the spermatheca and at the distal tip cells.

21 retention of exogenously added auxin in root tip cells.

22 rain in immunofluorescence assays using root tip cells.

23 L to the cell plate in dividing soybean root tip cells.

24 in endothelial cells, including endothelial tip cells.

25 matrix and transfer Dll4 protein to distant tip cells.

26 ing in stalk cells is induced by DLL4 on the tip cells.

27 muli inducing cytosolic Ca(2+) rises in root tip cells.

28 staining in TIPS mesenchymal cells and peri-TIPS cells.

29 type III procollagen mRNA compared with peri-TIPS cells.

30 ative to type I, collagen compared with peri-TIPS cells.

31 prouting, in which a subset of cells, termed tip cells, acquires motile, invasive behaviour and exten

32 progenitors that secrete VEGF-A to stimulate tip cell activity and the pro-angiogenic macrophages tha

33 ed due to cell elastic distortion, offset by tip-cell adhesion, and indeed such a model fits the bare

34 Tip cells also undergo most cell proliferation, daughter

35 TIPS cells also expressed high levels of type III procol

36 the pro-angiogenic macrophages that promote tip cell anastomosis.

37 we find defects in the generation of distal tip cells, anchor cells, and spermatheca; three of the f

38 Tip cell anchorage antagonizes forward-directed, TGF-bet

39 Defects in these features obliterate tip cell anchorage, producing misshapen and misplaced tu

40 ctive interaction between the somatic distal tip cell and the germ line.

41 ic relies on induction by the somatic distal tip cell and the glp-1 signal transduction pathway.

42 caused rapid disassembly of microtubules in tip cells and a 10x reduction in growth rate.

43 l macrophages localize between Dll4-positive tip cells and at vascular branchpoints, and that these m

44 led vegfr3) is expressed in segmental artery tip cells and becomes ectopically expressed throughout t

45 ects caused by a perturbed directionality of tip cells and by loss of cell contacts between tip and s

46 formation of significantly more endothelial tip cells and capillary bridges-some with loops-near the

47 d on astrocytes (ACs), which guide sprouting tip cells and deposit a provisional matrix for sprouting

48 ialisation of endothelial cells into leading tip cells and following stalk cells.

49 Notch regulation, is present on endothelial tip cells and is critical to sprouting angiogenesis.

50 is highly expressed in capillary endothelial tip cells and is involved in suppressing neighboring sta

51 -coenzyme A dehydrogenase activity in villus tip cells and plasma beta-hydroxybutyrate values in port

52 ls and regulates the differentiation between tip cells and stalk cells of neovasculature.

53 including stress fibers in migratory distal tip cells and the proximal gonad sheath, where it become

54 the sEH significantly delayed angiogenesis, tip cell, and filopodia formation, a phenomenon associat

55 stalks, verified that the stalks are free of tip cells, and assessed the ability of tip-free stalks t

56 wild type, inhibition of endocytosis in root tip cells, and cell death in the adjacent elongation zon

57 ing induces sprouty expression in the nearby tip cells, and sprouty acts nonautonomously and in a com

58 s of A. nidulans and in multinucleate hyphal tip cells, and we used a green fluorescent protein-alpha

59 lly "over" existing sprout cells to form new tip-cells; and (2) loss of VE-cadherin activity prevents

60 We found that normal tip cells are bipotential, contributing to both tips and

61 alpha-primase may be isolated from pea shoot tip cells as a large (1.25 x 10(6) Da) multi-protein com

62 ptin mutants affect morphology of the distal tip cells, as well as their migration and guidance durin

63 ced the formation of specialized endothelial tip cells at the edges of the repairing capillary networ

64 ndothelial cells exist in one of two states: tip cells at the growing front and stalk cells in the va

65 ind that, in normal kidneys, most individual tip cells behave as self-renewing progenitors, some of w

66 as a unique function in regulating migratory tip cell behavior during sprouting angiogenesis.

67 Finally, miR-221 promoted tip cell behavior through repression of two targets: cyc

68 arly all sprouting endothelial cells exhibit tip-cell behaviour, leading to excessive numbers of cell

69 is just an occasional instance of groups of tip cells being "left behind" by error in a mainly stalk

70 cells-cells that directly contact the distal tip cell body-relative to cells further proximal, a diff

71 During the pseudoglandular stage, the tip cells both self-renew and contribute descendents to

72 ontrast, Spry2 overexpression eliminated the tip cell branching in the intersegmental vessels.

73 reporter sorted to peroxisomes in lon2 root tip cells but was largely cytosolic in more mature root

74 ssion leads to overproduction of endothelial tip cells by both morphologic and molecular criteria.

75 ation studies indicate that CD45(+) liver SP tip cells can be generated from BM HSCs, suggesting a re

76 In addition, individual Id2(+) tip cells can self-renew and contribute descendents to b

77 rotein, directed biosynthesis only in apical-tip cell clusters of short, procumbent glandular trichom

78 ting cytoskeleton remodelling, migration and tip cell competitiveness.

79 demonstrate that microtubules help balancing tip cell contraction, which is driven by myosin, and is

80 ssing protein 46), phenocopied bcd1-mediated tip cell death.

81 le) and its fast neutron-derived Bgh-induced tip cell death1 mutant, bcd1.

82 ociated cell dispersal." Premitotic ureteric tip cells delaminate from the epithelium and divide with

83 ion of sprouting activity (e.g., endothelial tip cell density, filopodia number) can be obtained.

84 Ablation of the peripheral cap cells and tip cells did not alter root curvature.

85 The growth rate of hyphal tip cells did not change significantly in mitosis.

86 Tip cell differentiation is inhibited through lateral No

87 During angiogenic sprouting, endothelial "tip cells" directionally branch from existing vessels in

88 ip in comparison to experiments in which the tip-cell distance is a constant irrespective of cell siz

89 Ret expression defines a population of UB "tip cells" distinct from cells of the tubular "trunks,"

90 ages of vasculogenesis, during canalogenesis tip cells divide and form branched chains prior to vesse

91 n addition, when notch signaling is blocked, tip cells divide, and both daughter cells take on a tip

92 The distal tip cell (DTC) caps a blind-ended tube; only the distal

93 Analysis of distal tip cell (DTC) migration during gonadogenesis in Caenorh

94 nscription factor required for proper distal tip cell (DTC) migration.

95 Notch pathway signaling from the distal tip cell (DTC) niche to the germline maintains the proge

96 ferative fate is specified by somatic distal tip cell (DTC) niche-germline GLP-1 Notch signaling thro

97 The Caenorhabditis elegans distal tip cell (DTC) provides a niche for germline stem cells

98 single-celled mesenchymal niche, the distal tip cell (DTC), employs GLP-1/Notch signaling and an RNA

99 neurons, vulval precursor cells, the distal tip cell (DTC), intestine, and the lateral hypodermal se

100 etaR signaling cascade in the gonadal distal tip cell (DTC), the germline stem cell niche, where it n

101 only its distal daughter generates a distal tip cell (DTC), which is required for stem cell maintena

102 ific expression of HA-betatail in the distal tip cells (DTC), the cells that direct gonad morphogenes

103 n the gonadal lineage both to specify distal tip cells (DTCs) and in DTC differentiation and function

104 The two specialized C. elegans distal tip cells (DTCs) provide an in vivo model system for the

105 n is found in the hypodermis, muscle, distal tip cells (DTCs), and in neurons.

106 ms are determined by migration of the distal tip cells (DTCs).

107 nd the gonad arm migration led by the distal tip cells (DTCs).

108 uppressing neighboring stalk cells to become tip cells during angiogenesis.

109 with heterozygous deletion of Dll1 had fewer tip cells during angiogenic sprouting of the superficial

110 train to lineage trace the distal epithelial tip cells during either the pseudoglandular or canalicul

111 lay in the retraction and fusion of the tail tip cells during L4 morphogenesis, such that retraction

112 hese pathways might interact to generate new tip cells during retinal angiogenesis.

113 l derived factor-1, was also identified as a tip cell-enriched gene, and we provide evidence for a no

114 n (termed CD45(+) liver side population [SP] tip cells), exhibit a surface phenotype similar to that

115 Distinctive tip cell exploratory behavior, adhesion, and basement me

116 ies, particularly in kidney, have shown that tip cells express a set of genes distinct from those in

117 nocopied defects associated with loss of the tip cell-expressed Flt4 receptor.

118 ngiogenic switch on by promoting endothelial tip cell fate and sprouting and it promotes venous diffe

119 ole of miR-27b in the control of endothelial tip cell fate, branching, and venous specification and d

120 postnatal angiogenesis impaired endothelial tip cell filopodia protrusion, resulting in incomplete f

121 , leads to aberrant extension of endothelial tip cell filopodia, excessive vessel branching and abnor

122 provide an opportunity to selectively target tip cell filopodia-driven angiogenesis to restrict tumor

123 ect in astrocytes, the number of endothelial tip cell filopodias, and the rate of developing retinal

124 filopodia-like protrusions characteristic of tip cells, following stalk cells exhibiting apical-basal

125 found that transposition of RescueMu in root-tip cells follows the cut-and-paste type of transpositio

126 VEGFR-1 deficiency promoted tip cell formation and endothelial cell proliferation an

127 )-directed Notch signaling induces excessive tip cell formation and endothelial proliferation resulti

128 uced retinal endothelial cell proliferation, tip cell formation and neovascularization in vivo.

129 uced retinal endothelial cell proliferation, tip cell formation and neovascularization.

130 ugh in most endothelial beds hypoxia induces tip cell formation and sprouting angiogenesis, here we d

131 e reduced microglial activation and enhanced tip cell formation by A2AR-dependent and -independent me

132 essels, where Dll1 expression coincided with tip cell formation in a spatiotemporal manner.

133 ted signaling was required for the lymphatic tip cell formation in both FGF-2- and VEGF-C-induced lym

134 e VEGFR-3-induced lymphatic endothelial cell tip cell formation is a prerequisite for FGF-2-stimulate

135 and HEY2, thereby repressing VEGF signaling, tip cell formation, and endothelial sprouting.

136 ata identify SYNJ2BP as a novel inhibitor of tip cell formation, executing its functions predominatel

137 Interestingly, increased angiogenesis, tip cell formation, vascular permeability, VEGFR-2 accum

138 of new connections by regulating endothelial tip cell formation.

139 giopoietin-2, ESM1, and Apelin, and impaired tip cell formation.

140 type needs to be actively repressed to allow tip-cell formation.

141 enes that distinguish uniplanar protonematal tip cells from multiplanar gametophore bud cells in the

142 s demonstrate that NRP1 promotes endothelial tip cell function during angiogenesis.

143 Notch signaling regulates tip cell function, and we find that TNF also induces the

144 To identify genes critical to tip cell function, we have developed a method to isolate

145 TNF induces the known tip cell genes platelet-derived growth factor B (PDGFB)

146 ro, culture of ECs on DLL1 induced essential tip cell genes, including Dll4, VEGF receptor 3, and eph

147 In Caenorhabditis elegans, the distal tip cell/germline interaction promotes a mitotic fate an

148 Hyphal tip cells grew approximately 5 times faster than binucle

149 study develops a quantitative framework for tip cell growth and characterizes mechanisms of force ge

150 s results in a shared defect in gametophytic tip cell growth.

151 The hermaphrodite distal tip cell (hDTC) also provides "leader" function to contr

152 In hyphal tip cells, however, microtubules disassembled through mo

153 f UB tip markers, suggesting a shift towards tip cell identity.

154 ments are spatially segregated within hyphal tip cells in a manner that depends upon the integrity of

155 ary to restrict angiogenic cell behaviour to tip cells in developing segmental arteries in the zebraf

156 of C. albicans cell growth and to the hyphal tip cells in growing filaments.

157 ted with filopodia of angiogenic endothelial tip cells in invasive bladder cancer.

158 cell sprouting from spheroids, formation of tip cells in the sprouting assay, expression of alphavbe

159 Genes enriched in tip cells include ESM-1, angiopoietin-2, and SLP-76.

160 Six genes with expression in ureteric tip cells, including Wnt11, were downregulated, whereas

161 a suggested feedback loop that links VEGF-A tip cell induction with delta-like 4 (Dll4)/notch-mediat

162 cting system of the mature kidney, while the tip cells interact with the adjacent cells of the metane

163 esion, and indeed such a model fits the bare-tip/cell interaction, in agreement with earlier work.

164 and impairs differentiation of ureteric bud tip cells into trunk cells.

165 angiogenesis initially depend on endothelial tip cell invasion, which is followed by a series of matu

166 The putative posterior distal tip cell is then eliminated in all but one species by pr

167 zed subtype of endothelial cell known as the tip cell is thought to be involved in the detection and

168 wing blood vessels, sprouting of endothelial tip cells is inhibited by Notch signaling, which is acti

169 ination, thought to be regulated by anterior tip cells, is selectively suppressed by mild hypoxia by

170 Moreover, our analysis of the tip cell lamellipodia revealed the diversity in their in

171 orphogenetic process that involves polarized tip cells leading stalk cells to form new capillaries.

172 The outgrowth of multipotent tip cells leaves behind differentiated progeny that form

173 or (EGF) signalling from the distally placed tip cell lineage, which sets up a distal-to-proximal gra

174 on the anterior tubules, we demonstrate that tip cells make transient contacts with alary muscles at

175 rrelates with decreased expression of the EC tip cell markers apelin and Dll4 and is associated with

176 Therefore, the male distal tip cell (mDTC) serves as a niche but not as a leader.

177 s an important regulatory node through which tip cell migration and proliferation are controlled duri

178 ic ring assay indicated that TLR9 suppressed tip cell migration and recruitment of mural cells and ad

179 n ADAMTS family protease required for distal tip cell migration in C. elegans.

180 In this study we examine the contribution of tip cell migration rate and stalk cell proliferation rat

181 properties of FN and HS promote directional tip cell migration, whereas FN integrin-binding function

182 onger intersegmental vessels and exacerbated tip cell migration.

183 unctions are required for nuclear and distal tip cell migrations, but only one is required for nuclea

184 a novel role for this receptor in mediating tip cell morphology and vascular patterning in the neona

185 Third, the distal tip cell niche extends processes that nearly encircle ad

186 , whether Dll4-containing exosomes influence tip cells of existing capillaries is unknown.

187 synthesize protective acylated sugars in the tip cells of glandular trichomes on stems and leaves.

188 e Arp2/3 complex subunit ARPC1 in elongating tip cells of protonemal filaments of the moss Physcomitr

189 Here, we show that the tip cells of Six1(-/-) UB fail to form an ampulla for br

190 reticulum (ER) and cell cycle arrest in root tip cells of stt3a seedlings, as determined by expressio

191 Hyphal tip cells of the fungus Aspergillus nidulans are useful

192 tium and in the migrations of the two distal tip cells of the gonad.

193 lial growth factor A (VEGF-A) in endothelial tip cells of the mouse retina.

194 ere abundant throughout the length of hyphal tip cells of the mutant.

195 gene are expressed in the sheath and distal tip cells of the somatic gonad, the gut and other non-go

196 In Drosophila development, tip cells of the tracheal system lead the migration of e

197 n receptor UNC5B is expressed by endothelial tip cells of the vascular system.

198 with one gene (named Sl-ASAT3) expressed in tip cells of type I trichomes where acylsugars are made.

199 lastid displacement and induced curvature in tip cells of WT and wwr protonemata.

200 riving GFP expression showed fluorescence in tips cells of long, slender trichomes that is consistent

201 ter canalicular stage, the distal epithelial tip cells only contribute descendents to the alveoli.

202 by being either positioned at the sprouting tip cells or tethered along the vessel walls.

203 ur key findings are that when an endothelial tip cell penetrates BrM: 1) RPE with normal epithelial j

204 TNF promotes angiogenesis by inducing an EC tip cell phenotype and the expression of jagged-1, a lig

205 mental data illustrate that induction of the tip cell phenotype is dependent on the protein VEGF-A; h

206 Addition of Dll4 exosomes confers a tip cell phenotype on the endothelial cell, which result

207 hrough VEGFR2, but in addition by inducing a tip cell phenotype through an NFkappaB-dependent pathway

208 ls divide, and both daughter cells take on a tip cell phenotype, resulting in increased branching thr

209 posit that endothelial cells default to the tip-cell phenotype when Notch is inactive.

210 providing spatial and temporal control over "tip cell" phenotype during angiogenic sprouting.

211 tes angiogenesis by inducing an endothelial "tip cell" phenotype.

212 show that Kif26b and Daam1 depletion impairs tip cell polarization and destabilizes extended vascular

213 expression, which suggests an increase in EC tip cell population.

214 P1-expressing endothelial cells attained the tip cell position when competing with NRP1-negative endo

215 ing has been activated are excluded from the tip-cell position.

216 lial cells did not efficiently contribute to tip cell positions in developing sprouts.

217 cell proliferation and migration, as well as tip cell potential in mosaic blood vessels.

218 ithin this cluster of cells to segregate the tip cell precursor, in which proneural gene expression s

219 s exposed in its monomer form on endothelial tip cells prior to adherens junction formation.

220 These distal tip cell processes are likely to play a critical role in

221 Furthermore, miR-221 was required for tip cell proliferation and migration, as well as tip cel

222 were found within dividing cells in the root tip cell proliferation zone.

223 g, and also regulates migration of capillary tip cells, proliferation of trunk cells, and gene expres

224 a-miR-132 to developing mouse eyes disrupted tip cell Ras activity and prevented angiogenic sprouting

225 endothelial sprout, it causes filopodia and tip cell retraction.

226 ar endothelial growth factor (VEGF)-mediated tip cell selection and subsequent angiogenic sprouting.

227 ood vessel formation starts with endothelial tip cell selection and vascular sprout migration, follow

228 the protein VEGF-A; however, the process of tip cell selection is not fully understood.

229 al (Semaphorin3E-Plexin-D1) that accelerates tip cell selection rate, yielding a dense network.

230 environments; (2) a VEGF gradient increases tip cell selection rate.

231 Dll1 acts as an extrinsic cue involved in tip cell selection, which directs vessel sprouting and b

232 ive imaging, we demonstrate that the rate of tip-cell selection determines the length of linear sprou

233 Reiterations of endothelial-tip-cell selection, sprout extension and anastomosis are

234 Anterior portions of the tail tip cells show the first evidence of retractions and fus

235 ngly, proper oocyte growth depends on distal tip cell signaling involving the redundant function of G

236 ption-polymerase chain reaction (qRT-PCR) of tip cells sprouting in vitro.

237 or more factors that promote the endothelial tip cell state and inhibit angiogenesis.

238 nhibited the expression of genes enriched in tip cells, such as angiopoietin-2, ESM1, and Apelin, and

239 overlap is more extensive than predicted for tip cell switching, and it sets up a longitudinal cell-c

240 vessel branching (angiogenesis), endothelial tip cells (TCs) lead sprouting vessels, extend filopodia

241 s harbor distinct stem cell types, including tip cells that divide in single planes to generate filam

242 forming sprouts are composed of specialized tip cells that guide the sprout and trunk cells that pro

243 specification of endothelial cells into the tip cells that lead new blood vessel sprouts is coordina

244 In interphase root tip cells, the fluorescent protein fusions labeled micro

245 step of the migration is the ability of the tip cell to carry out proteolysis, we have estimated cel

246 st time that Dll4-containing exosomes causes tip cells to lose their filopodia and trigger capillary

247 but the molecular signaling pathways used by tip cells to mediate tissue vascularization remain large

248 gous bridging phenomenon linking endothelial tip cells together during formation of polygonal endothe

249 these ceRNAs appears to reduce PTEN levels, tipping cells toward cancer progression.

250 e host's mid-region, whereas donor allantoic tip cells typically returned to the tip, often colonizin

251 time-lapse analysis reveals that endothelial tip cells undergo a stereotypical pattern of proliferati

252 ates the cell-fate decision between vascular tip cells versus stalk cells.

253 NDINGS: Experimental data extends beyond the tip cell vs. stalk cell paradigm, and involves numerous

254 growth rate and a decreased thickness of the tip cell wall, causing tip bursts.

255 etailed analysis of pea (Pisum sativum) root tip cell walls.

256 Enrichment of jagged-1 in tip cells was confirmed by immunofluorescent staining as

257 ibition to antagonize filopodia formation in tip cells was context-dependent, suggesting a mechanism

258 ature and, the appearance and density of the tip cells were similar in bim+/+ and bim-/- mice.

259 located from the NE in undifferentiated root-tip cells, whereas NE targeting in differentiated root c

260 py was used to directly visualize the distal tip cell which extends tentacle-like processes that dire

261 Each first gives rise to one distal tip cell (which promotes arm growth and germ line prolif

262 ptins are also expressed in migrating distal tip cells, which are leaders for gonad arm extension.

263 ated at the tip of branches, consistent with tip cells, which emerged from established vessels to for

264 om a specialised subset of tubule cells, the tip cells, which express the protease Rhomboid and are t

265 cyclin cDNA clone, cycZm2w, from maize root tip cells, which fits best into group A2 of current plan

266 L4-Notch signaling controls the selection of tip cells, which guide new sprouts, and trailing stalk c

267 types of cells make up the new vasculature: tip cells, which migrate in response to gradients of vas

268 ily is required for RanGAP targeting in root tip cells, while both families are dispensable in other

269 comparison of RNA extracted from endothelial tip cells with that of endothelial stalk cells using mic