1 blockers/inhibitors (edaravone and lazaroids/
tirilazad).
2 Desmethyl
tirilazad (
20 mg/kg) and 100 mg/kg deferoxamine inhibit
3 Desmethyl
tirilazad (
20 mg/kg) improves neurologic exam, but 3 mg/
4 nisms of cytoprotective action may exist for
tirilazad and the antioxidant gossypol.
5 unlikely that the antioxidant properties of
tirilazad are involved in the suppression of motor nerve
6 ssigned to receive either 20 mg/kg desmethyl
tirilazad at -15 mins followed by 8 mg/kg/hr for 90 mins
7 High-dose desmethyl
tirilazad improves neurologic function after hypoxic isc
8 a significant increase in r, suggesting that
tirilazad intercalates into the membrane bilayer and pro
9 Desmethyl
tirilazad is a lipid-soluble free radical quencher.
10 Tirilazad itself caused a significant increase in r, sug
11 Enhanced relative survival with
tirilazad mesylate also was seen in cultures containing
12 However,
tirilazad mesylate attenuated sepsis-induced acute lung
13 Pretreatment with the
tirilazad mesylate did not change P. aeruginosa sepsis-i
14 Tirilazad mesylate enhanced relative ganglion cell survi
15 ith the 21-aminosteroid antioxidant compound
tirilazad mesylate has been previously shown to retard t
16 The lipid peroxidation blocker
tirilazad mesylate inhibits retinal ganglion cell death
17 Treatment with
tirilazad mesylate significantly attenuated hypoxemia an
18 cantly greater when it was co-incubated with
tirilazad mesylate than with diluent control (91.8% +/-
19 hibition, and the effect on cell survival of
tirilazad mesylate was assessed.
20 The
tirilazad mesylate-treated group received a 5-mg/kg bolu
21 Neither desmethyl
tirilazad nor deferoxamine improves pathologic results.
22 roves neurologic exam, but 3 mg/kg Desmethyl
tirilazad or 100 mg/kg deferoxamine does not.
23 f cells with lipophilic antioxidants such as
tirilazad or gossypol.
24 assigned to receive either 3 mg/kg desmethyl
tirilazad or vehicle at -15 and 90 mins.
25 Tirilazad pretreatment caused a dose-related suppression
26 In the present study, we examined
tirilazad'
s effects (7.7, 13.0 or 30.0 mg/kg twice daily
27 y because of its antioxidant action, whereas
tirilazad'
s protection is mediated not only via its anti
28 Rather, it is proposed that
tirilazad suppresses delayed motor nerve terminal Ca2+ c