ライフサイエンスコーパス: tissue distribution

1 ciency did not affect in vivo MC numbers and tissue distribution.

2 equivalence (NEQ) were also investigated for tissue distribution.

3 ives higher peripheral numbers and increased tissue distribution.

4 elf-renewal and differentiation with a broad tissue distribution.

5 incipal regulator of iron absorption and its tissue distribution.

6 ts in GDR, fasting glucose, FFAs and adipose tissue distribution.

7 iral gene expression and restricted in their tissue distribution.

8 ers are ubiquitous while others show limited tissue distribution.

9 als, toxicity, limited efficacy, and limited tissue distribution.

10 abolic pathways, kinetics of elimination and tissue distribution.

11 eacetylase complex with a broad cellular and tissue distribution.

12 in parallel to affect drug cytotoxicity and tissue distribution.

13 sential for T(reg) cell migration and normal tissue distribution.

14 l cell types, while others have a widespread tissue distribution.

15 howed rapid plasma clearance (0.021 L/h) and tissue distribution.

16 ted with amounts of JCV DNA in urine and its tissue distribution.

17 ariant polypeptides, in addition to a unique tissue distribution.

18 y the pattern of cellular responses by their tissue distribution.

19 ts high affinity, specificity, and selective tissue distribution.

20 RDye) 800CW to study its tumor targeting and tissue distribution.

21 their metabolic stability and improves their tissue distribution.

22 locking activities that vary in strength and tissue distribution.

23 NAs, like messenger RNAs, display restricted tissue distributions.

24 s but have different physiological roles and tissue distributions.

25 d exhibit dissimilar physiological roles and tissue distributions.

26 rface receptors with different functions and tissue distributions.

27 To further improve tumor uptake and normal tissue distribution, a larger hu4D5v8 fragment [(scFv-C(

28 meters (5 mum and 20 mum) to investigate the tissue distribution, accumulation, and tissue-specific h

29 ) weight maintenance, and 3) compare adipose tissue distribution after 1-y maintenance with that of c

30 previously reported abnormalities in adipose tissue distribution after acute weight restoration in ad

31 2L(hi), CD27(hi), KLRG-1(low)) and function (tissue distribution, Ag-driven proliferation, cytokine p

32 XVIIIA, MyoIIA, and SP-R210 have overlapping tissue distribution, all being highly expressed in myelo

33 Interestingly, tissue distribution analysis identified miR-378 to be hi

34 An extensive tissue distribution analysis of 1 in wild-type animals w

35 cific Vgamma2Vdelta2 T cells regarding their tissue distribution, anatomical localization, and correl

36 692/29 has a more restricted normal tissue distribution and a higher antigen threshold for k

37 pharmacokinetics characterized by extensive tissue distribution and a long terminal half-life.

38 t, the first of which is characterization of tissue distribution and access to the site of action; th

39 simultaneous modulation of serum half-life, tissue distribution and activity of a given human IgG1.

40 cell surface proteins exhibiting restricted tissue distribution and apparent tissue modulation.

41 t in discrepancies due to variation in prion tissue distribution and assay sensitivities that limit d

42 ships between visceral adiposity and adipose tissue distribution and beta cell function, insulin resi

43 The NHERFs exhibit some overlap in tissue distribution and binding partners, suggesting red

44 Although its wide tissue distribution and biological functions have been w

45 Pharmacokinetic studies investigated the tissue distribution and blood clearance of the (225)Ac-E

46 we further demonstrate marked divergence in tissue distribution and developmental expression.

47 rties led to the discovery of compounds with tissue distribution and duration of action suitable for

48 se compounds demonstrate preferential ocular tissue distribution and efficacy after oral administrati

49 Mdr1a (Abcb1a) had a profound effect on the tissue distribution and especially the brain accumulatio

50 n (humans, ABCB1; rodents, Abcb1a/b) affects tissue distribution and excretion of (11)C-erlotinib and

51 sion (MATE) transporter 1 contributes to the tissue distribution and excretion of many drugs.

52 this article, we describe Co-RT and present tissue distribution and expression level analysis of sev

53 ort) Sec transcripts are restricted in their tissue distribution and expression levels vary among ind

54 tracted from cartilage; and investigated its tissue distribution and extracellular assembly by immuno

55 g is accompanied by major changes in adipose tissue distribution and function.

56 ent an extended analysis of AE2 variant mRNA tissue distribution and function.

57 Studies of the tissue distribution and gene regulation of ACAD9 and ver

58 olate/antifolate transporter with the widest tissue distribution and greatest activity is the reduced

59 (ILCs), increased the understanding of their tissue distribution and has established essential functi

60 The tissue distribution and histopathology in mice challenge

61 ed corepressor variants that differ in their tissue distribution and in their biochemical properties.

62 of this kind of agent for monitoring in vivo tissue distribution and in vivo stability of a biologica

63 Tissue distribution and in vivo therapeutic activity wer

64 o determine the relationship between adipose tissue distribution and incident hypertension.

65 Previous studies of CLN3P tissue distribution and intracellular localization will

66 Identifying the diverse tissue distribution and intracellular location of NeuPSA

67 The differential tissue distribution and lens expression patterns of thes

68 T and high quality cDNA (hq-cDNA) sequences, tissue distribution and likely intron position inferred

69 emory subset displayed a distinct pattern of tissue distribution and localization within the spleen,

70 een associated with abnormalities in adipose tissue distribution and metabolism.

71 parent conjugate exhibited relatively broad tissue distribution and only modest elimination via excr

72 NA polymerase III transcript with restricted tissue distribution and orthologs in chimpanzee but not

73 D50 data, we dissected the kinetics of viral tissue distribution and pathology in mice challenged wit

74 ical MHC class Ia molecules but with limited tissue distribution and polymorphism.

75 ng expression of CD115, scavenging function, tissue distribution and poor capacity for Ag presentatio

76 nsus on many aspects of HLA-G, including its tissue distribution and receptor binding.

77 1 (11betaHSD1(-/-)) have "healthier" adipose tissue distribution and resist metabolic disease with di

78 e its cellular function, we investigated its tissue distribution and subcellular location.

79 The normal and tumor tissue distribution and the cell line reactivity of AOC3

80 G antibodies with high affinity and adequate tissue distribution and to restore protection against sm

81 The tissue distribution and transcriptional regulation of ut

82 eta subunits (beta1-beta4) show differential tissue distribution and unique functional modulation, re

83 iseases is associated with abdominal adipose tissue distribution and varies between ethnic groups.

84 nografts, [(131)I]MIP-1145 exhibited diffuse tissue distribution and washout from all tissues except

85 evelopment remain unresolved, their distinct tissue distributions and differential activities in coop

86 These Treg subsets have unique tissue distributions and diverse roles in maintaining or

87 er clinical disorders, as indicated by their tissue distributions and inheritance patterns.

88 y available about their antigen specificity, tissue distribution, and biological relevance in chronic

89 l protein hepcidin regulates the absorption, tissue distribution, and extracellular concentration of

90 To assess AMI bioconcentration factors, tissue distribution, and metabolite formation in fish, w

91 n summary, we have determined the structure, tissue distribution, and molecular function of the carti

92 by a determination of drug pharmacokinetics, tissue distribution, and multiple functional measures of

93 decitabine, severely limiting its half-life, tissue distribution, and oral bioavailability.

94 ing in a high tumor uptake, highly favorable tissue distribution, and promising therapeutic profile i

95 tro and in vivo metabolic stability, in vivo tissue distribution, and rates of release of the active

96 ntial as antibiotics, their size, stability, tissue distribution, and toxicity have hampered attempts

97 rious concentrations and infusion durations; tissue distribution; and methods for optimizing delivery

98 For adipose tissue distribution assessment to be clinically useful,

99 erol and differs from the MGAT1 and MGAT3 in tissue distribution at the mRNA level.

100 bly compromising the prediction of erlotinib tissue distribution at therapeutic doses from PET with a

101 of (11)C-erlotinib PET to predict erlotinib tissue distribution at therapeutic doses.

102 High similarity of ocular expression and tissue distribution between the two optineurin proteins

103 lymphoid organs and subsequent non-lymphoid tissue distribution but also their phenotypic diversity.

104 MHHAV has wide tissue distribution but shows tropism for the liver.

105 We believe that given the broad tissue distribution, but contrasting signaling profiles,

106 cells uniquely display an Ag receptor-based tissue distribution, but what defines their preferential

107 Western blot analysis and to identify their tissue distribution by immunofluorescence microscopy.

108 labeled allogeneic splenocytes and monitored tissue distribution by in vivo bioluminescence imaging.

109 easures pulmonary perfusion and corrects for tissue distribution by measuring regional proton density

110 rformed serial necropsies to assess PrP(CWD) tissue distribution by real-time quaking-induced convers

111 get activity, favorable pharmacokinetics and tissue distribution characterize VFV as a promising new

112 xhibited improved pharmacokinetics and liver tissue distribution compared with unmodified oligonucleo

113 ion and pharmacokinetics indicated favorable tissue distribution, controlled pharmacokinetic paramete

114 valuated using measured bioconcentration and tissue distribution data collected in two previous studi

115 both the morphology of guard cells and their tissue distributions differ substantially between Arabid

116 n the gill, heart, and brain, representing a tissue distribution distinct from that found in teleosts

117 al bioavailability (F = 56%) and a favorable tissue distribution drug profile, with high liver to pla

118 fically examined Se assimilation efficiency, tissue distribution, efflux rate, and maternal transfer

119 and mouse resistin have distinct patterns of tissue distribution, experiments were performed using hu

120 afish (Danio rerio), and characterized their tissue distribution, expression levels, and biochemical

121 endowed with unique antigen recognition and tissue distribution features.

122 ractions governing iNKT cell development and tissue distribution have been uncovered recently, buildi

123 reconstruction; analysis of RNA and protein tissue distribution; immunofluorescent and electron micr

124 tional study of dietary patterns and adipose tissue distribution in 74 overweight adolescents (aged:

125 ight for approximately 1 y, visceral adipose tissue distribution in AN patients was not different fro

126 nt properties and, based on apparent limited tissue distribution in Arabidopsis, should be considered

127 To determine the plasma clearance and tissue distribution in mice of the versatile capsid of b

128 (18)F-fluorothymidine ((18)F-FLT) uptake and tissue distribution in mouse models of cancer.

129 er, no studies have extensively analyzed the tissue distribution in other species or compared evoluti

130 ater than 50-fold liver-to-pancreas ratio of tissue distribution in rodent and non-rodent species.

131 ate the two models: (1) observed patterns of tissue distribution in the laboratory and field, (2) the

132 lish Rh-OPTN protein expression profiles and tissue distribution in the rhesus anterior segment, reti

133 ' in different cell types and hence in their tissue distribution in vivo.

134 ncreased energy expenditure; altered adipose tissue distribution, including reduced white adipose acc

135 Tissue distribution indicated preferential partitioning

136 diffusion-weighted images for complimentary tissue distribution information to address the difficult

137 of beta5-tubulin, a minor isotype with wide tissue distribution, inhibits cell division.

138 on process coupled with biologic insights on tissue distributions into account by comparing in vivo r

139 t after achieving a critical threshold, GDNF tissue distribution is more important than dose for trop

140 .5 (chBP2) and E11.5 (chBP1), although their tissue distribution is similar (skin = intestine>lung>he

141 different memory T-cell subsets with diverse tissue distributions is largely unknown.

142 ormone that controls iron absorption and its tissue distribution, is the cause of iron overload in ne

143 e in vivo, demonstrating drug absorption and tissue distribution leading to pharmacological efficacy.

144 n tumor standardized uptake value and normal tissue distribution may determine the most appropriate c

145 1 breast carcinoma cells and in paired-label tissue distribution measurements in mice bearing subcuta

146 gesting a link between the heart and adipose tissue distribution mediated through natriuretic peptide

147 Studies examining the tissue distribution of (1)(4)C-Dp44mT injected intraveno

148 CsA effect on tissue distribution of (11)C radioactivity (AUC ratios)

149 sue)/AUC(plasma)) served as a measure of the tissue distribution of (11)C radioactivity.

150 Tissue distribution of (123)I-MIP-1072 was determined on

151 f accelerator mass spectrometry to trace the tissue distribution of (14)C-labeled proanthocyanidins i

152 On the basis of the measured amounts and tissue distribution of (210)Po, it was estimated that th

153 ve biomarkers, enabling visualization of the tissue distribution of (potentially modified) therapeuti

154 mer implants in saline and bovine serum, (b) tissue distribution of 5-FU and its metabolite, 5-fluoro

155 prehensive investigation of the steady-state tissue distribution of 8c2 in wild-type mice versus thos

156 highest level of Tmem86b, which agreed with tissue distribution of activity.

157 The relative tissue distribution of AMI was consistent at both doses,

158 trations in bronchoalveolar lavage fluid and tissue distribution of an intracellular protein, GADD45-

159 no major effect on the induction or overall tissue distribution of antigen-specific T cells during a

160 orescent protein fluorescence resembling the tissue distribution of APPb mRNA requires both the intro

161 anism that determines the regulation and the tissue distribution of CD1d remains largely unknown.

162 rovides the first information on the precise tissue distribution of CD8 T cells in pancreata from T1D

163 etics, effects on arterial NO signaling, and tissue distribution of cell-free Hb and its scavenger pr

164 d long-term in vivo imaging of viability and tissue distribution of cellular grafts in large animals.

165 emical phenotype determines the severity and tissue distribution of clinical features.

166 ignal transduction and the regulation of the tissue distribution of cytokines/growth factors.

167 ATP1 activation and that FATPs determine the tissue distribution of dietary lipids.

168 latory effect might be due to differences in tissue distribution of DPAT.

169 ffect of P-gp activity and inhibition on the tissue distribution of drugs in a more representative an

170 The potency and tissue distribution of FAAH inhibitors can be imaged in

171 mice and specific antiserum to determine the tissue distribution of FcRn in the adult mouse.

172 However, the wide tissue distribution of ghrelin suggests that it may have

173 Low-density maps of tissue distribution of HBV peptides, such as secapin, ma

174 Tissue distribution of human, mouse, and rat P518/Qrfp a

175 on MR- and MPR-mediated plasma clearance and tissue distribution of infused phosphorylated (P) and no

176 This study investigated the expression and tissue distribution of inositol monophosphatase (IMPA1)

177 The widespread tissue distribution of ion channels, coupled with the pl

178 cidin controls plasma iron concentration and tissue distribution of iron by inhibiting intestinal iro

179 control the dietary absorption, storage, and tissue distribution of iron.

180 In this study, the transport and tissue distribution of lutein and zeaxanthin were examin

181 fficient production, delivery, and effective tissue distribution of lysosomal enzymes.

182 Concerning the strategic tissue distribution of MC and the presence of degranulat

183 tical role in modulating the development and tissue distribution of memory cells induced by parasite

184 le in the clinical assessment of the spatial tissue distribution of metabolites.

185 As the tissue distribution of MiHA affects the clinical outcome

186 quantitative analysis of the composition and tissue distribution of multiple cell populations in lymp

187 specialized mammalian cells, the ubiquitous tissue distribution of NHA2 suggests that H(+)-coupled t

188 Analysis of the tissue distribution of PEAR1 showed that it was most hig

189 BPK model to estimate the toxicokinetics and tissue distribution of PFOA in male rats.

190 successfully predicts the toxicokinetics and tissue distribution of PFOA in rats following exposure v

191 n important role for CXCR3 and CXCL10 in the tissue distribution of preimmune MP cells.

192 exposed deer to CWD prions and monitored the tissue distribution of PrP(CWD) over the first 4 months

193 Together, the tissue distribution of RDH12 and its catalytic propertie

194 Cellular and tissue distribution of Rh-OPTN protein were highly simil

195 However, the cellular and tissue distribution of Se remains largely unknown becaus

196 nd immunohistochemistry was used to evaluate tissue distribution of selected proteins.

197 al signal transduction and regulation of the tissue distribution of signaling molecules.

198 Results indicate that limited tissue distribution of silver detected from AgNPs is due

199 f AgNPs and AgNO3 to mice, and characterized tissue distribution of silver in the sinonasal mucosal e

200 Tissue distribution of small proline-rich proteins (SPRR

201 port here the functional characteristics and tissue distribution of Sodium/Imino-acid Transporter 1 (

202 examined the homing receptor expression and tissue distribution of T reg cells in the steady state a

203 expression correlates with the differential tissue distribution of T-cell subsets during acute coron

204 onal data coupled with the restricted normal tissue distribution of testisin and its overexpression i

205 ed by an increase in both protein levels and tissue distribution of the G1 cell cycle kinase, CDK4.

206 nsgene expression (luciferase) and the local tissue distribution of the labeled plasmid at the inject

207 haracterize the discovered miRNAs, including tissue distribution of the precursors and mature sequenc

208 by PET and CT 4 and 24 h later, and measured tissue distribution of the radiohybridization probes.

209 influence of vitamin D(3), as defined by the tissue distribution of the VDR, has broadened at least 9

210 ss of function of PUT3 demonstrated that the tissue distribution of these metabolites is altered with

211 e-dependent manner because of the dissimilar tissue distribution of these proteins.

212 leotide Polymorphism) and information on the tissue distribution of these proteins.

213 uantitative RT-PCR method, we determined the tissue distribution of these SDF-1 isoforms.

214 In this report we examined the tissue distribution of this JCV receptor-type sialic aci

215 ngly limited phenotype, given the widespread tissue distribution of tricellulin in epithelial cells.

216 nd ST revealed altered expression levels and tissue distribution of TSP-1.

217 This reflects the tissue distribution of TTP lesions in vivo.

218 Thus, by determining the subcellular and tissue distribution of two isoforms, alternative splicin

219 S1P1 receptor also dictates the distinctive tissue distribution of V alpha14-J alpha18 natural kille

220 prevalence (particularly in the UK), altered tissue distribution of vCJD, and the failure of decontam

221 ts as a basis for determining the levels and tissue distribution of vector, noninvasively in living a

222 ease progression by affecting the amount and tissue distribution of viral replication.

223 ch control dietary uptake, reabsorption, and tissue distribution of vitamin C.

224 protein in the heart but does not modify the tissue distribution of wild type beta2-microglobulin.

225 n be used to simulate the toxicokinetics and tissue distribution of xenobiotic substances, such as pe

226 amine the infection potential, kinetics, and tissue distribution of XMRV in an animal model, we inocu

227 a coupled with the overlapping, but distinct tissue distributions of FAAH-1 and FAAH-2 suggest that t

228 The tissue distributions of the three antimicrobials, especi

229 Although the cell and tissue distributions of the three kindlins differ, there

230 he underlying mechanisms may include altered tissue distribution or increased catabolism via pyridoxa

231 wn about the kinetics of the generation, the tissue distribution or the underlying mechanism of clona

232 novel gene is expressed in a more restricted tissue distribution, particularly kidney and brain.

233 or algal toxins and have provided details on tissue distribution, pathways of trophic transfer, and s

234 n these mice, hCD1d is expressed in a native tissue distribution pattern and supports NKT cell develo

235 The tissue distribution pattern of ALT1 and ALT2 proteins la

236 These data correlate well with the tissue distribution pattern of cocaine as visualized wit

237 Similar to the tissue distribution pattern of rat CXCR1, we found murin

238 e identified distinct hepatic expression and tissue distribution patterns of ISGs that segregated wit

239 Tissue distribution patterns of organochlorine pesticide

240 oforms of ACSL and FATP exist with different tissue distribution patterns, intracellular locations, a

241 iNKT functional subsets showed distinct tissue distribution patterns.

242 monkeys, respectively, as well as favorable tissue distribution properties with a liver to plasma ex

243 and possesses favorable pharmacokinetic and tissue distribution properties.

244 imilar intracellular distribution, and broad tissue distribution, Rap1a and 1b are not functionally r

245 h the molecular mechanisms that ensure IL-22 tissue distribution remain poorly understood.

246 ion patterns of SOX9, MITF, and OTX2 yielded tissue distribution remarkably similar to that of BEST1.

247 SPECT/CT images and tissue distribution results revealed that (166)Ho-MSNs a

248 SPECT/CT imaging corroborated the tissue distribution results, demonstrating uptake only i

249 puted tomography imaging was consistent with tissue distribution results.

250 ncomplexed protein; however, the analysis of tissue distribution reveals that the interaction with th

251 An assessment of tissue distribution showed the Cas-PMCA transcript to be

252 ITF isoforms was expressed in a sequence and tissue distribution similar to that observed in mice.

253 Ts) have been identified as important to the tissue distribution, species-specific accumulation, and

254 These data suggest that a combination of tissue distribution, specificity, and kinetic difference

255 Tissue distribution studies 30 min after [(18)F]10 admin

256 Post mortem and real-time tissue distribution studies did not reveal increased cis

257 Tissue distribution studies in hamsters suggest, rather,

258 Tissue distribution studies in mice showed 17.3 +/- 6.3%

259 Tissue distribution studies in mice showed the highest e

260 Tissue distribution studies in mice using [(14)C]-labele

261 On the basis of imaging and tissue distribution studies in several rodent tumor mode

262 Tissue distribution studies in the rat using radiolabele

263 Tissue distribution studies of a series of analogues ([1

264 Tissue distribution studies show that JNJ-28871063 cross

265 Tissue distribution studies were performed at the end of

266 as their in vitro stability and the ex vivo tissue distribution studies.

267 of a cassette dosing strategy for label-free tissue distribution studies.

268 In a preliminary PK/tissue distribution study in healthy mice, the parent co

269 rate recognition, SCF complex formation, and tissue distribution suggest that FBA proteins play diver

270 In keeping with its broad tissue distribution, taurine serves as a modulator of nu

271 SSmuLC-MS/MS) was explored as a quantitative tissue distribution technique for probing compound prope

272 that human SPCA2 (hSPCA2) has a more limited tissue distribution than hSPCA1, with prominent protein

273 creased replication efficiency and a broader tissue distribution than nonlethal isolates from the sam

274 ata provide evidence that MMP-20 has a wider tissue distribution than previously acknowledged.

275 properties such as biotransformation rate or tissue distribution that differ from those of legacy con

276 activated and recruited into the lung with a tissue distribution that differs from that of convention

277 sence of overt inflammation, with a specific tissue distribution that includes the kidney, gastrointe

278 Vitamin D receptors have a broad tissue distribution that includes vascular smooth muscle

279 encoded by the VWA2 gene, has a very similar tissue distribution to the Fraser complex proteins in bo

280 s transmembrane proteins restricted in their tissue distribution, to act as coreceptors along with cl

281 lations that exhibit similar degradation and tissue distribution upon injection but have differential

282 detected as an increase in [(11)C]flumazenil tissue distribution volume (VT).

283 the data and more robust derivations of the tissue distribution volumes (V(T), in mL/g) than a 2-tis

284 Adipose tissue distribution was assessed at baseline and at the

285 fore the administration of (64)Cu-TP3982 and tissue distribution was examined.

286 ssfully applied to two case studies in which tissue distribution was instrumental in advancing projec

287 Its normal tissue distribution was largely restricted to moderate s

288 portantly, in mosquito-infected animals ZIKV tissue distribution was limited to hemolymphatic tissues

289 he suppression of de novo Th1 generation and tissue distribution was mediated by chronic type I IFN (

290 Tissue distribution was similar but not identical betwee

291 Tissue distribution was studied by PET imaging, ex vivo

292 prepared in high specific activity, and its tissue distribution was tested in vivo.

293 ity, body composition, and abdominal adipose tissue distribution were assessed with a frequently samp

294 ellular localization, ocular expression, and tissue distribution were established by immunolabeling.

295 The pharmacokinetic profile and the tissue distribution were investigated by beta-radio imag

296 nterestingly, both the response kinetics and tissue distributions were different when epitopes on VP6

297 ability, displayed a largely non-overlapping tissue distribution with AUF1 and was predominantly expr

298 Epsin 1 and 2 have broad tissue distribution with high-level expression in the br

299 st, smooth muscle MLCK had a more ubiquitous tissue distribution, with the greatest expression observ

300 led highly restricted and mutually exclusive tissue distributions, with striking resolution of layere