ライフサイエンスコーパス: tissue macrophage

1 ithout increased vascular inflammation (ED1+ tissue macrophages).

2 ction can be sustained for several months by tissue macrophage.

3 s of peripheral blood monocytes and resident tissue macrophages.

4 bone marrow precursors, blood monocytes, and tissue macrophages.

5 finition, not terminally differentiated like tissue macrophages.

6 nctly and universally associated with mature tissue macrophages.

7 1(op/op) mice, which have reduced numbers of tissue macrophages.

8 electively expressed PPARgamma among resting tissue macrophages.

9 rences and expression pattern in the pool of tissue macrophages.

10 asis and thus represent a central feature of tissue macrophages.

11 severe depletion of resident osteoclasts and tissue macrophages.

12 solated mouse monocytes compared with mature tissue macrophages.

13 KKepsilon) in liver, adipocytes, and adipose tissue macrophages.

14 1), such as plasmacytoid dendritic cells and tissue macrophages.

15 but not monocytes, dendritic cells or other tissue macrophages.

16 was required to rapidly replenish destroyed tissue macrophages.

17 ynthesized and secreted by liver, brain, and tissue macrophages.

18 igh-fat diet showed no reductions in adipose tissue macrophages.

19 and restraining the inflammatory products of tissue macrophages.

20 apacity to infect non-dividing cells such as tissue macrophages.

21 reas, and heart but decreased iron levels in tissue macrophages.

22 sociated with storage of glucocerebroside in tissue macrophages.

23 positive, and a small percentage are mature tissue macrophages.

24 ammatory monocytes, and increased numbers of tissue macrophages.

25 ctivating factor acetylhydrolase (PAF AH) in tissue macrophages.

26 nificantly increased replicative capacity in tissue macrophages.

27 hancement of viral spread within nondividing tissue macrophages.

28 CSF-1 dependent, bone marrow-derived adipose tissue macrophages.

29 ting monocytes or from migration of resident tissue macrophages.

30 pe responses and/or deactivating parasitized tissue macrophages.

31 pe that impart high replicative capacity for tissue macrophages.

32 the establishment of persistent infection in tissue macrophages.

33 ls and lymphocytes, but not to B-1a cells or tissue macrophages.

34 ithelial cells, and a subsequent increase in tissue macrophages.

35 e 1 (HIV-1) infects CD4(+) T lymphocytes and tissue macrophages.

36 ted reservoir of infectious HIV-1 virions in tissue macrophages.

37 and precursors of resident and inflammatory tissue macrophages.

38 dentify yolk sac EMPs as a common origin for tissue macrophages.

39 hemoattractant activity for F4/80(+)CD11c(-) tissue macrophages.

40 embryonic-derived but not postnatal-derived tissue macrophages.

41 pilosebaceous follicles and colocalized with tissue macrophages.

42 s in the frequency of M1- or M2-like adipose tissue macrophages.

43 e pathophysiology is manifested primarily in tissue macrophages.(1) In this issue of Blood, Campeau a

44 HIV-expressing cells were associated with tissue macrophages, a target of HIV infection.

45 Mechanisms involved in adipose tissue macrophage accrual continue to be elusive.

46 nce regarding dietary cholesterol on adipose tissue macrophage accrual, systemic inflammation and its

47 ay for erythrophagocytosis in the context of tissue macrophage accumulation and inflammation involvin

48 Stat3 in T cells in DIO mice affects adipose tissue macrophage accumulation and M2 phenotype.

49 and IL-13, in the induction of inflammatory tissue macrophage accumulation and/or hemophagocytosis.

50 eas overexpression of SirT1 prevents adipose tissue macrophage accumulation caused by chronic high-fa

51 t decreases blood glucose levels and adipose tissue macrophage accumulation in a high-fat, diet-fed m

52 ctors that potentially contribute to adipose tissue macrophage accumulation in obesity.

53 ice transgenic for IL-4 production developed tissue macrophage accumulation, disruption of splenic ar

54 i-IL-4 complexes, lead to substantial YM1(+) tissue macrophage accumulation, erythrophagocytosis with

55 lesterol added resulted in increased adipose tissue macrophage accumulation, local inflammation and c

56 s influence diet-induced obesity and adipose tissue macrophage accumulation, mice that were either wi

57 tion, indicating a possible role for adipose tissue macrophage activation.

58 atory response, resident and newly recruited tissue macrophages adhere to extracellular matrix and ce

59 is probably life-long since targeted cells (tissue macrophages) allow residual parasites to persist.

60 Distinct populations of tissue macrophages also acquire context-specific functio

61 Depletion of visceral tissue macrophages also did not alter central nervous sy

62 nt anti-inflammatory effects with regards to tissue macrophage and neutrophil density following ureth

63 marked reduction in pro-inflammatory adipose tissue macrophages and activated CD8+ T cells.

64 lammatory cytokines in both isolated adipose tissue macrophages and adipocytes.

65 Microglia are the brain's tissue macrophages and are found in an activated state s

66 First, we show an altered distribution of tissue macrophages and blood monocytes in the absence of

67 y alveolar macrophages, in contrast to other tissue macrophages and blood monocytes.

68 lso show that CD44ICD promotes the fusion of tissue macrophages and bone marrow-derived macrophages.

69 HIV infects tissue macrophages and brain microglia, which express lo

70 earance of senescent neutrophils by resident tissue macrophages and DCs helps to set homeostatic leve

71 lia, whereas monocytes, dermal, and lymphoid tissue macrophages and DCs were unaffected.

72 Monocytes are circulating precursors for tissue macrophages and dendritic cells (DCs) but are not

73 tion with, and/or infection of CD4(+)CCR5(+) tissue macrophages and dendritic cells (DCs) play import

74 Furthermore, we determined that tissue macrophages and dendritic cells within the liver

75 Recruited monocytes differentiate into tissue macrophages and dendritic cells, which sample ant

76 ious subsets, which are able to give rise to tissue macrophages and dendritic cells.

77 s used for identifying the complex origin of tissue macrophages and discuss the relative contribution

78 Its expression on tissue macrophages and epithelial cells suggests importa

79 venger receptor-induced apoptosis in primary tissue macrophages and in macrophage apoptosis in advanc

80 tment reduced peripheral blood monocytes and tissue macrophages and inhibited macrophage function in

81 d plays a role in the maintenance of adipose tissue macrophages and insulin resistance once obesity a

82 an enzyme predominantly expressed in mature tissue macrophages and is implicated in several disease

83 In contrast, tissue macrophages and monocyte-derived macrophages in v

84 e characterized by cholesterol deposition in tissue macrophages and prevalent atherosclerosis.

85 However, unlike tissue macrophages and similar to DCs, they homeostatica

86 row-derived progenitor cells into monocytes, tissue macrophages and some dendritic cell (DC) subtypes

87 f osteopontin in the accumulation of adipose tissue macrophages and the development of insulin resist

88 The selective expression of CR3 by tissue macrophages and the requirement of TLR2 inside-ou

89 type lectin, CD209, known to be expressed on tissue macrophages and to mediate the uptake of M. lepra

90 m for stromal cells (fibrocytes and possibly tissue macrophages) and CD8(+) T and CD21(+) B lymphocyt

91 eplication in fibrocytes (possibly including tissue macrophages) and T and B lymphocytes in the prese

92 een inflammation, cholesterol oxidation, the tissue macrophage, and atherosclerosis.

93 including the osteopetrotic, hematopoietic, tissue macrophage, and reproductive phenotypes.

94 ), CD4(+), CD8(+), and CD25(+)) lymphocytes, tissue macrophages, and dendritic cells (Iba-1(+) and CD

95 IV-1 uses mononuclear phagocytes (monocytes, tissue macrophages, and dendritic cells) as a vehicle fo

96 ving rise to B and T lymphocytes, monocytes, tissue macrophages, and dendritic cells.

97 ransduction in dendritic cells, osteoclasts, tissue macrophages, and microglia.

98 sue inflammation, M1 polarization of adipose tissue macrophages, and the development of insulin resis

99 (SHIVs) during infections of rhesus monkeys, tissue macrophages are able to sustain high levels (>10(

100 Resident tissue macrophages are activated by the fungal pathogen

101 Tissue macrophages are an important cellular reservoir f

102 Although tissue macrophages are anatomically distinct from one an

103 Tissue macrophages are critical contributors to HIV path

104 The origins of tissue macrophages are diverse, with evidence for local

105 ifferentiation of blood-borne monocytes into tissue macrophages are incompletely defined.

106 To determine whether tissue macrophages are productively infected, we used 3

107 rom adipose tissue demonstrates that adipose tissue macrophages are responsible for almost all adipos

108 In tissues, macrophages are exposed to metabolic, homeostat

109 we review evidence on the pathogenic role of tissue macrophages as long-term viral reservoirs in vivo

110 Tissue macrophages assume a distinct phenotype, designat

111 ocytes given to MCP-1 KO recipients, adipose tissue macrophage (ATM) accumulation is reduced by ~40%,

112 Obesity is associated with increased adipose tissue macrophage (ATM) infiltration, and rodent studies

113 the expansion of adipose tissue and adipose tissue macrophage (ATM) polarization, in the current stu

114 Adipose tissue macrophage (ATM) recruitment and activation play

115 etes has been known for decades, and adipose tissue macrophage (ATM)-associated inflammation has rece

116 Here, we studied whether human adipose tissue macrophages (ATM) modulate cancer cell function.

117 lation of classically activated (M1) adipose tissue macrophages (ATMs) and the expression of proinfla

118 These adipose tissue macrophages (ATMs) are inflammatory and promote l

119 Adipose tissue macrophages (ATMs) are key players orchestrating

120 o-inflammatory cytokines secreted by adipose tissue macrophages (ATMs) contribute to chronic low-grad

121 We further showed that adipose tissue macrophages (ATMs) in lipodystrophy and obesity a

122 Here, we show that adipose tissue macrophages (ATMs) in obese mice secrete miRNA-co

123 s that NPY regulates the function of adipose tissue macrophages (ATMs) in response to dietary obesity

124 Adipose tissue macrophages (ATMs) infiltrate adipose tissue duri

125 We have examined the hypothesis that adipose tissue macrophages (ATMs) interact with and regulate the

126 Polarized activation of adipose tissue macrophages (ATMs) is crucial for maintaining adi

127 Although recent studies show that adipose tissue macrophages (ATMs) participate in the inflammator

128 Adipose tissue macrophages (ATMs) play a critical role in obesit

129 Adipose tissue macrophages (ATMs) play an important role in the

130 ever, the functional role of IRF4 in adipose tissue macrophages (ATMs) remains unclear, despite high

131 ere we characterized the response of adipose tissue macrophages (ATMs) to weight loss and fasting in

132 and functional characteristics of adipocyte tissue macrophages (ATMs), in obese patients undergoing

133 en into account the heterogeneity of adipose tissue macrophages (ATMs), nor have they examined how ag

134 infiltration of increased numbers of adipose tissue macrophages (ATMs).

135 displayed cytotoxic activity toward adipose tissue macrophages (ATMs).

136 , we demonstrate that in microglia and other tissue macrophages, beta-amyloid initiates a CD36-depend

137 cent paradigm shifts in our understanding of tissue macrophage biology.

138 ired for the development and distribution of tissue macrophages but is involved in the generation of

139 be specified, as they could be monocytes or tissue macrophages, but most likely dendritic cells.

140 Infection of tissue macrophages by X4 HIV-1 may be highly relevant in

141 omplexity is added by the new knowledge that tissue macrophages can be derived either from a resident

142 Tissue macrophages can be derived from embryonic progeni

143 novel transgenic mouse (CD11b-DTR) in which tissue macrophages can be specifically and selectively a

144 Adipose tissue macrophages can contribute to the systemic proinf

145 l adipose tissue macrophage content (adipose tissue macrophages; CD11b(+), CD11c(+), Ly6C(hi)) concom

146 eatment with clodronate liposomes to deplete tissue macrophages, comparing the sites of (99m)Tc-EC20

147 Tissue macrophages comprise a heterogeneous group of cel

148 DPP-4i reduced visceral adipose tissue macrophage content (adipose tissue macrophages; C

149 or insulin action is associated with adipose tissue macrophage content (ATMc) and/or markers of macro

150 mice also had increased body fat and adipose tissue macrophage content, elevated plasma interleukin-6

151 e systemic inflammation or increased adipose tissue macrophage content, were reversed when plasma ins

152 a framework in which to consider how adipose tissue macrophages contribute to the remodeling events i

153 eripheral monocytes associated with death of tissue macrophages correlates with AIDS progression in m

154 ques, increasing monocyte turnover reflected tissue macrophage damage by SIV and was predictive of te

155 overt inflammation, constitutively maintain tissue macrophage/DC populations.

156 productive, hematopoietic tooth eruption and tissue macrophage defects of CSF-1-deficient, osteopetro

157 The recent recognition that tissue macrophages derive from different sources, couple

158 in the steady state, the dogma remains that tissue macrophages derive from monocytes.

159 While tissue macrophages derive from one of a small number of

160 and suggest that the relocation of iron from tissue macrophages during infection may contribute to an

161 poietic deletion of Ntn1 facilitates adipose tissue macrophage emigration, reduces inflammation and i

162 earance of infused enzyme by the MR on fixed tissue macrophages, especially Kupffer cells.

163 f diet-induced obesity, we show that adipose tissue macrophages exhibit reduced migratory capacity, w

164 Tissue macrophage export of iron occurs concurrent with

165 Reciprocally, adipose tissue macrophages express IL-17 and IL-22 receptors, ma

166 ba-1(+) and CD83(+)), with a small number of tissue macrophages expressing CD163 and CD204 scavenger

167 PM(2.5) increased adipose tissue macrophages (F4/80(+) cells) in visceral fat expr

168 Second, aside from being immune sentinels, tissue macrophages form integral components of their hos

169 The differentiation of resident tissue macrophages from embryonic precursors and that of

170 We assessed gene expression in tissue macrophages from various mouse organs.

171 Tissue macrophages function to maintain homeostasis and

172 ctional, and phenotypic heterogeneity within tissue macrophages has altered our understanding of thes

173 Adipose tissue macrophages have been proposed as a link between

174 Since then, monocytes and tissue macrophages have emerged as key sentinels of infe

175 Macs is followed by their specification into tissue macrophages, hereby generating the macrophage div

176 Understanding the mechanisms that dictate tissue macrophage heterogeneity should explain why simpl

177 -wide analysis of gene expression in adipose tissue macrophages highlights the transforming growth fa

178 from the marrow through the blood to become tissue macrophages, histiocytes, and dendritic cells.

179 um enzyme levels through M-CSF regulation of tissue macrophage homeostasis without concomitant histop

180 factor-1 receptor (CSF-1R) kinase regulates tissue macrophage homeostasis, osteoclastogenesis, and P

181 irus with in vivo cell tropism primarily for tissue macrophages; however, in vitro the virus can be a

182 of apoptotic cells is an innate function of tissue macrophages; however, its role in disease progres

183 e functional and phenotypic heterogeneity of tissue macrophages in different anatomic sites and as a

184 cells fail to recapitulate the phenotype of tissue macrophages in key respects, including that they

185 Our results reveal an unanticipated role for tissue macrophages in mesoangioblast function.

186 at altering the proinflammatory capacity of tissue macrophages in progressively HIV-infected individ

187 al macrophages represent the largest pool of tissue macrophages in the human body and a critical inte

188 erleukin 4 and the alternative activation of tissue macrophages in the organismal response to diverse

189 vidence suggesting local self-maintenance of tissue macrophages in the steady state, the dogma remain

190 ytes do not show significant contribution to tissue macrophages in the steady state.

191 nounced proinflammatory signature of adipose tissue macrophages in type 2 diabetic obese patients, ma

192 nce, to our knowledge, of HIV persistence in tissue macrophages in vivo.

193 tes engage different complement receptors on tissue macrophages in vivo.

194 CD11c+ and B220+ dendritic cells and F4/80+ tissue macrophages in vivo.

195 report that activation of different types of tissue macrophages, including microglia, by lipopolysacc

196 (IL-37tg) exhibit reduced numbers of adipose tissue macrophages, increased circulating levels of adip

197 ion of several pro-inflammatory cytokines in tissue macrophages, induction of the anti-inflammatory c

198 Adipose tissue macrophage infiltration and inflammation were als

199 y cytokine, mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance, i

200 Kinetics of adipose tissue macrophage infiltration was characterized by fluo

201 tion, adipocyte apoptosis, prevented adipose tissue macrophage infiltration, and protected against th

202 g of the failing myocardium reverses adipose tissue macrophage infiltration, inflammation, and adipon

203 utaneous fat is inversely related to adipose tissue macrophage infiltration.

204 correlated with the degree of IR and adipose tissue macrophage infiltration.

205 tissue factor-PAR2 signaling reduced adipose tissue macrophage inflammation, and specific pharmacolog

206 Lung tissue macrophage inflammatory protein-2, keratinocyte-d

207 sma lipids, increases autophagy, and orients tissue macrophages into an anti-inflammatory phenotype i

208 pronounced polarization of liver and adipose tissue macrophages into an M1 phenotype.

209 The reduction of synovial tissue macrophages is a reliable biomarker for clinical

210 y also suggest that its function in resident tissue macrophages is limited.

211 (MoM), we demonstrate that HIV infection of tissue macrophages is rapidly suppressed by ART, as refl

212 clearance is primarily the function of fixed tissue macrophages (Kupffer cells) that line the hepatic

213 CL2(-/-) mice, despite no changes in adipose tissue macrophage levels, suggests that CCL2 has effects

214 ) primarily infects blood monocytes (MO) and tissue macrophages (M phi).

215 n, Fas ligation on circulating monocytes and tissue macrophages may induce proinflammatory cytokine r

216 Resident tissue macrophages mediate early innate immune responses

217 f efferocytosis by resident murine and human tissue macrophages (Mo).

218 the origin and differentiation cues for many tissue macrophages, monocytes, and dendritic cell subset

219 Tissue macrophages (Mphis) and dendritic cells (DCs) pla

220 cally and functionally distinct from mammary tissue macrophages (MTMs).

221 rmed with DNA isolated from ischemic muscle, tissue macrophages (Mvarphis), and endothelial cells.

222 at monocytes are the immediate precursors of tissue macrophages needs to be refined based upon eviden

223 probably seldom eradicates all parasites in tissue macrophages; nevertheless, most T cell-intact pat

224 acrophage progenitor frequency and decreased tissue macrophage nitric oxide and IL-12 production in r

225 These findings support the theory that tissue macrophage numbers are regulated through local pr

226 Adipose tissue macrophage numbers increase in obesity and partic

227 Tissue macrophage numbers vary during health versus dise

228 ication-competent virus was rescued from the tissue macrophages obtained from these animals.

229 much less is known about microglia, resident tissue macrophages of the brain that originate from a di

230 Microglial cells are the resident tissue macrophages of the CNS and are widely recognized

231 As the tissue macrophages of the CNS, microglia are critically

232 Thus, tissue macrophages, once infected, have the characterist

233 light of recent advances in understanding of tissue macrophage ontogeny, their capacity for self-rene

234 ently, it has become evident that most adult tissue macrophages originate during embryonic developmen

235 rain macrophages but are distinct from other tissue macrophages owing to their unique homeostatic phe

236 ence that obesity-related changes in adipose tissue macrophage phenotype could be mediated by adipocy

237 Our investigations reveal that the tissue macrophage phenotype is under discrete tissue-sel

238 s of cells, including mast cells, monocytes, tissue macrophages, platelets, eosinophils, endothelial

239 trated ER stress-induced rewiring of adipose tissue macrophage polarization by IRE1alpha activation,

240 e the nature, functions, and interactions of tissue macrophage populations within their microenvironm

241 properties that distinguish them from other tissue macrophage populations, we have optimized serum-f

242 is required for efficient HIV replication in tissue macrophages present in human spleens and tonsils.

243 In this study, we show that tissue macrophages present in the fetal mouse lung media

244 rion sequestration and destruction via local tissue macrophages, prion trafficking by B and dendritic

245 Tissue macrophages provide innate defense against GAS, a

246 ant and positive correlation between adipose tissue macrophage quantification at MR imaging and P904

247 l variance in mice was correlated to adipose tissue macrophage quantification by using monoclonal ant

248 With tissue insult, resident tissue macrophages rapidly efflux to lymph nodes where t

249 LR1-positive plasmacytoid dendritic cell and tissue macrophage recruitment to sterile sites of tissue

250 nclude that CCL2 is not critical for adipose tissue macrophage recruitment.

251 may contribute to obesity-associated adipose tissue macrophage recruitment.

252 As immune sentinels, tissue macrophages regulate immune activation and inflam

253 Here we show that adipose tissue macrophages regulate the age-related reduction in

254 oxide content (r = 0.87, P < .0001), adipose tissue macrophage-related inflammation at immunohistoche

255 itial events of monocyte migration to become tissue macrophages remain poorly understood.

256 ocytes, whereas dendritic cells and resident tissue macrophages remained unaltered.

257 approaches that could promote elimination of tissue macrophage reservoirs.

258 Our results reveal unique intra-tissue macrophage specialization and identify neuro-immu

259 Factors that govern tissue macrophage specialization are emerging.

260 We have identified a new tissue macrophage subset in the thymus and have discover

261 fy Ly6C as a marker of functionally discrete tissue macrophage subsets and support a model of selecti

262 but the transcriptional basis for producing tissue macrophage subsets remains unknown.

263 ervations support a model according to which tissue macrophage subtype specification is distinct from

264 eptor of the Ig superfamily (CRIg), found on tissue macrophages such as synovial macrophages, has pro

265 of Siglec-1 in circulating SSc monocytes and tissue macrophages suggests that type I IFN-mediated act

266 Tissue macrophages synthesize neutrophil chemoattractant

267 Renal tissue macrophages, T cells, and neutrophils produce var

268 light marked heterogeneity in the origins of tissue macrophages that arise from hematopoietic versus

269 addition to CD4 T lymphocytes, HIV-1 infects tissue macrophages that can actively accumulate infectio

270 These results define a lineage of tissue macrophages that derive from the YS and are genet

271 ry X4 HIV-1 isolates can productively infect tissue macrophages that have terminally differentiated i

272 n resulted in a phenotypic change in adipose tissue macrophages that was characterized by upregulatio

273 h lpr/lpr and B6 mice had similar numbers of tissue macrophages, the loss of Fas in M-CSF-deficient m

274 review, we discuss the different origins of tissue macrophages, the transcription factors regulating

275 with the discovery of an important role for tissue macrophages, these new findings are helping to re

276 Like many tissue macrophages, they self-maintain locally.

277 IL-4 was sufficient to drive accumulation of tissue macrophages through self-renewal.

278 We postulate that the failure of tissue macrophages to remove senescent erythrocytes led

279 reduced, further confirming polarization of tissue macrophages toward an anti-inflammatory phenotype

280 n adipose tissue and polarization of adipose tissue macrophages toward an M2 alternatively activated

281 formed to evaluate the kinetics and monocyte/tissue macrophage turnover in Indian rhesus macaques (Ma

282 ilin-1 was diminished on blood monocytes and tissue macrophages under proinflammatory conditions.

283 veal that a distinct process exists in which tissue macrophages undergo rapid in situ proliferation i

284 attractive target for delivering antigens to tissue macrophages via Sn-mediated endocytosis.

285 Activation of NF-kappaB in tissue macrophages was assessed in mice that expressed a

286 b-PI3Kgamma(-/-) mice, the number of adipose tissue macrophages was similar to control, but displayed

287 s demonstrated that both circulating PMN and tissue macrophages were altered under inflammatory condi

288 Adipose tissue macrophages were detected and quantified with a 4

289 In contrast, epidermal Langerhans cells and tissue macrophages were largely preserved.

290 anemia of inflammation, iron accumulated in tissue macrophages, whereas a relative paucity of iron w

291 rominent players in this process are adipose tissue macrophages, which are a specialized leukocyte pr

292 d promotes alternative activation of adipose tissue macrophages, which are required for the increased

293 Moreover, skin-resident tissue macrophages, which encounter S. mansoni excretory

294 y promoted alternative activation of adipose tissue macrophages, which secrete catecholamines to indu

295 okines and decreased accumulation of adipose tissue macrophages, which were also preferentially biase

296 nitors and the independent myeloid system of tissue macrophages, whose regulation by local microenvir

297 y activates the production of NPY in adipose tissue macrophages with autocrine and paracrine effects.

298 Infiltrating cells included tissue macrophages, with an HLA-DR(+)CD14(+)CD45(+)CD68(

299 g to the accumulation of glucocerebroside in tissue macrophages within multiple organs.

300 ations like neutrophils and F4/80(+) adipose tissue macrophages without any alterations in the freque