ライフサイエンスコーパス: tissue specificity

1 ing and tissue-specific genes based on their tissue specificity.

2 ing regulatory nucleotide sequence determine tissue specificity.

3 ilitate fine-tuning of receptor activity and tissue specificity.

4 ht into the genetic determinants of host and tissue specificity.

5 f mice expressing human SLAM with human-like tissue specificity.

6 ation molecule (SLAM, CD150) with human-like tissue specificity.

7 ost different in skew if they have different tissue specificity.

8 al step in defining the viral host-range and tissue specificity.

9 these genes as candidates for biomarkers for tissue specificity.

10 o striking, we considered the possibility of tissue specificity.

11 d a distinct pattern of genomic location and tissue specificity.

12 aracterize them and determine their cell and tissue specificity.

13 tage of an organism, and often show striking tissue specificity.

14 a quantitative role but was not required for tissue specificity.

15 Multiple TFs work in concert to achieve tissue specificity.

16 s of a given species, such as host range and tissue specificity.

17 the alternative polyadenylation signals has tissue specificity.

18 of epidermal genes, thus exerting intrinsic tissue specificity.

19 volutionary rates are highly correlated with tissue specificity.

20 ied in all tissues, there are clear cases of tissue specificity.

21 oupled sequences that unambiguously modulate tissue specificity.

22 lncRNA properties such as low abundance and tissue specificity.

23 anges are associated with tumorigenesis, not tissue specificity.

24 pressor elements led to the apparent loss of tissue specificity.

25 clusters, some of which showed tumor and/or tissue specificity.

26 ene products and without a unique pattern of tissue specificity.

27 tected only in normal testis, supporting its tissue specificity.

28 tification of tissue expression profiles and tissue specificity.

29 ression cassettes with predictable stage and tissue specificity.

30 the bacterial adhesin intimin contributes to tissue specificity.

31 luminal progenitor cells to oncogenesis and tissue specificity.

32 actors initiate disease and what directs its tissue specificity.

33 d the roles that AS may play in diseases and tissue specificity.

34 CR, which expressed in a network manner with tissue specificity.

35 concepts such as gene dosage-sensitivity and tissue specificity.

36 genomic background and then predicting their tissue specificity.

37 temic side effects due to the drugs' lack of tissue specificity.

38 d key transcription factors controlling this tissue specificity.

39 s, pilRNA expression is dynamic and displays tissue specificity.

40 on genes in mouse than in human, which poses tissue specificity.

41 ted 84,301 developmental enhancers and their tissue specificity.

42 e loss of hCD79b transcriptional activity or tissue specificity.

43 , their phylogenetic similarities, and their tissue specificity.

44 nous hormonal homeostasis, again with strong tissue specificity.

45 n about their transcriptional regulation and tissue specificity.

46 sociation analysis approaches by considering tissue specificity.

47 effectors of omega-3 fatty acids with marked tissue specificity.

48 stly change 3' UTR isoform ratios to achieve tissue specificity.

49 ble levels, 162 microRNAs exhibited striking tissue-specificity.

50 ciation analysis approaches fail to consider tissue-specificity.

51 s, anther tapetum, and seed coat with unique tissue-specificity.

52 ntrinsic properties rather than merely their tissue specificities.

53 HBV infection has both host and tissue specificities.

54 o new members of the Rh family with distinct tissue specificities.

55 as illustrated by their excessive degree of tissue specificity (80%).

56 s found to be accurate for 69% of identified tissue specificities and for 80% of expression profiles.

57 y linked genes with three mutually exclusive tissue specificities and interdigitated control elements

58 These data are evidence for divergent tissue specificities and targeting of multigene families

59 ed AtMLO genes showed similar or overlapping tissue specificity and analogous responsiveness to exter

60 Taken together, the remarkable prostate-tissue specificity and androgen-dependent expression of

61 he existence of TFAP2 coactivators that have tissue specificity and are important for ductal developm

62 us ovarian and breast cancer, confirming the tissue specificity and cell surface localization.

63 organ structure is essential in maintaining tissue specificity and cellular differentiation.

64 Both tissue specificity and electrophysiological studies stro

65 -II splice variants were compiled with their tissue specificity and exon usage.

66 ed protein sequence of PSGR and its prostate tissue specificity and expression profile in human prost

67 We define tissue specificity and expression-pattern specificity ac

68 ny interesting phenotypes such as virulence, tissue specificity and host range, for which it would be

69 ngs provide insights into both the basis for tissue specificity and into possible therapeutic opportu

70 iled analysis of the roles of repeat length, tissue specificity and level of expression in the neurod

71 ation pathway impacts on current concepts of tissue specificity and models of active chromatin domain

72 lant color) alleles of r have nonoverlapping tissue specificity and nonhomologous 5' flanking sequenc

73 ggesting that adaptive immunity controls the tissue specificity and persistence of CHIKV infection.

74 an lead to suboptimal performance, a lack of tissue specificity and potential toxicity.

75 hought to account at least partially for the tissue specificity and progressive nature of the symptom

76 ate transporters showed a complex pattern of tissue specificity and regulation by sulfur nutritional

77 ses (ACs), a group of enzymes with different tissue specificity and regulation.

78 gene expression and to diagnose the probable tissue specificity and role of transcription factors.

79 approach can be broadly applied to increase tissue specificity and sensitivity of differential expre

80 ocess can be usefully analyzed in respect to tissue specificity and synergy.

81 alleles are necessary but not sufficient for tissue specificity and the clinical syndrome.

82 otassium channels provides information about tissue specificity and the complex regulation of genes e

83 cell biology but often with debate over the tissue specificity and the efficacy of inactivation.

84 c1 and tps26 maize orthologs differ in their tissue specificity and their induction by insect herbivo

85 splantation, with the aim of identifying the tissue specificity and types of immunogenic non-HLA anti

86 on-biased, and likely contributes toward the tissue-specificity and progressive nature of the symptom

87 ds the unusual genetics, and most likely the tissue-specificity and progressive nature of the symptom

88 oantigen-specific T cells may allow study of tissue-specificity and subsequent alloantigen identifica

89 ith vastly different clinical presentations, tissue specificities, and ages of onset.

90 ict both the presence of enhancers and their tissue specificity, and are thus a feature that can be e

91 are expressed with overlapping cellular and tissue specificity, and coding region mutations can caus

92 nsequences at enhancers depend on cell type, tissue specificity, and constraints at associated promot

93 tliers test for ranking genes based on their tissue specificity, and correlated this ranking with NXS

94 a treatment modality with targeted delivery, tissue specificity, and therapy tailored to address mech

95 This tissue specificity appears to be governed by the relativ

96 terms of sequence and expression levels, but tissue specificities are often conserved.

97 rol of the process of mineralization and its tissue specificity are important steps in the search for

98 ell lines, showing that their host range and tissue specificity are largely determined by events occu

99 However, the mechanisms underlying such tissue specificity are unknown.

100 However, these networks do not account for tissue specificity, are limited to protein-coding genes,

101 g a score test-based approach where we model tissue-specificity as a random effect and investigate an

102 ique in not only its structure, but also its tissue specificity, as it is the first member to be foun

103 Here, we present a method for predicting tissue specificity based on quantitative deregulation of

104 romoters by adapting a quantitative index of tissue-specificity based on Polr2a occupancy.

105 ing elements (CNEs) likely to have a desired tissue-specificity based on the expression of nearby gen

106 e proximal promoter of the alphaIIb gene for tissue specificity, but also characterizes the distal or

107 at these receptors are unlikely to determine tissue specificity, but rather, may play a wider role in

108 hat the proximal promoter was sufficient for tissue specificity, but that a region 2.5 to 7.1 kb upst

109 controlled by multiple enhancers have higher tissue specificity, but the regulating enhancers are les

110 tested for antigen specificity by ELISA, for tissue specificity by immunohistochemistry, for affinity

111 tion (8/10) were reported to have a matching tissue specificity by independent studies in the publish

112 A new study sheds light on this tissue specificity by showing that binding of clock acti

113 Analysis for tissue specificity by using the Northern blot and revers

114 roid membrane receptor: plausible structure, tissue specificity, cellular distribution, steroid bindi

115 genetic effects, we characterize patterns of tissue specificity, compare local and distal effects, an

116 and red cob (WR pattern), and this switch in tissue-specificity correlated with increased transgene m

117 to solid tumor development and indicate that tissue specificity defines functional significance for t

118 umulated in an age-dependent manner, but the tissue specificity did not obviously correlate with cell

119 e exists that the intronic promoter provides tissue specificity different from that of the primary pr

120 r-infrared (NIR) fluorophores with different tissue specificities driven by their inherent chemical s

121 hat they have evolved different functions or tissue specificities following duplications.

122 degradation in the nucleus to ensure narrow tissue specificity for a gene (e.g., that for FR-alpha)

123 rexpressed autoantigen genes for SSc and its tissue specificity for fibroblasts, cDNA microarrays of

124 thelial lineage, could provide the locus and tissue specificity for histone methylation and chromatin

125 the genus contrasts with stringent host and tissue specificity for individual species and pathovars.

126 nsplantation, donor exosomes with respective tissue specificity for islet beta cells and renal epithe

127 umulates in the liver, suggesting a striking tissue specificity for ribose metabolism.

128 o influence the level of expression bias and tissue specificity for some allelic combinations.

129 nfounding effects (e.g. temporal regulation, tissue specificity, genetic background) are not consider

130 n of at least nine enhancers with individual tissue specificities in the digit anlagen, growth plates

131 al conditions including the mechanism of its tissue specificity in any organism.

132 These sites showed tissue specificity in degree of hydroxylation and a patt

133 y show that individual TFs can contribute to tissue specificity in different tissues by interacting w

134 We discovered that tissue specificity in ER activation was due to differenc

135 Accounting for tissue specificity in global integration of functional g

136 (Xenopus laevis) and has the most restricted tissue specificity in mammals, whereas beta, gamma, and

137 ocal" immune cells play a role in regulating tissue specificity in relation to disease heterogeneity

138 action of the genome is expressed with great tissue specificity in the adult, demonstrating the need

139 Tissue specificity in the distribution of AMPK subtypes

140 ed or divergent B lineage characteristics or tissue specificity in these animals.

141 osity in the BRCA1 locus could contribute to tissue specificity in tumor development.

142 therapeutics in their lack of pharmacologic tissue specificity in vivo.

143 Northern blot analysis to detect tissue specificity indicates that the human and mouse ge

144 ar and membrane proteins are associated with tissue specificity, indicating a potential role for them

145 Additional analysis shows that tissue specificity is due to abnormal activation of the

146 We demonstrate that tissue specificity is not sacrificed in an ADV backbone

147 ific COX deficiency, but the reason for such tissue specificity is unknown.

148 owever, in both cases, the basis of neuronal tissue specificity is unknown.

149 Tissue-specificity is an important aspect of many geneti

150 but not airway epithelium; we conclude that tissue specificity likely contributes to the effect of n

151 Recently, studies have suggested this tissue specificity may be linked to inhibition of estrog

152 es of torsinA dysfunction, demonstrating how tissue specificity may result from differential suscepti

153 Tissue specificity may result from the presence of more

154 een transcriptional and post-transcriptional tissue specificity mechanisms in cereal globulin genes.

155 numerous tumors, we sought to understand how tissue specificity might factor into their functional si

156 This may help to explain the tissue specificity observed for many viruses.

157 in preputial gland to 97% in testes, and the tissue-specificity observed in vivo was retained in cult

158 Notably, the tissue specificities of these genes include known target

159 he results show a strong correlation between tissue specificity of a gene and the propensity of its p

160 Our finding highlights the tissue specificity of a gene network regulated by a miRN

161 onses at high temperature, suggesting either tissue specificity of ABA signaling or a role of ABA in

162 remains controversial partly because of the tissue specificity of ACAD9 expression: high in liver an

163 Advantage has been taken of the relative tissue specificity of adenovirus for liver, and the gene

164 exon-intron structure, alternative splicing, tissue specificity of alternative splice forms, and prot

165 The molecular basis for tissue specificity of beta-catenin-dependent oncogenesis

166 ed their additional exons, as well as tested tissue specificity of both previously reported and novel

167 Here, we investigate the tissue specificity of both the global levels and locus-s

168 Here, we highlight the tissue specificity of BRAF and EGFR alterations and impl

169 The reason for this tissue specificity of BRCA1 carcinomas must be found if

170 , these results provide important aspects of tissue specificity of BRCA1-mediated suppression of brea

171 Our work elucidates the basis of the tissue specificity of BRCA1-related tumor predisposition

172 The tissue specificity of cancers that arise from malfunctio

173 bryonic stem (ES) cells, we investigated the tissue specificity of CTCF binding sites.

174 We have studied the in vivo function and tissue specificity of Dcas, the Drosophila ortholog of C

175 matically characterize the global extent and tissue specificity of developmental expression programs

176 r, this simple hypothesis cannot explain the tissue specificity of disorders caused by homoplasmic mt

177 e I hypersensitive sites (DHSs) with similar tissue specificity of DNase-seq signal patterns.

178 Tissue specificity of embryonic Fpn1 dysregulation was e

179 Indeed, we show that (i) tissue specificity of enhancers and nearby gene expressi

180 h in PTSD, important limitations include the tissue specificity of epigenetic modifications, the phen

181 ce of nearby transposable elements (TEs) and tissue specificity of expression increased the odds of A

182 The tissue specificity of expression of the mouse gene also

183 Tissue specificity of expression of these genes, along w

184 hydroxybenzaldehyde, than with tricetin, the tissue specificity of expression suggests it may be a ca

185 Marked tissue specificity of expression was observed in Zn-depl

186 Consistent with the tissue specificity of expression, complete sequencing an

187 immunotherapeutic agents because of unusual tissue specificity of expression, uniquely safe profile

188 in-like and CDK-like proteins showing strong tissue specificity of expression.

189 However, this does not account for the tissue specificity of FSHD pathology, which requires sta

190 To better understand the tissue specificity of FV replication and host immunologi

191 and second, it yields information about the tissue specificity of gene expression by the use of nati

192 The tissue specificity of gene expression is imparted by an

193 The tissue specificity of genes is known to correlate positi

194 ortant implications for our understanding of tissue specificity of glucocorticoid action including th

195 The molecular factors that govern tissue specificity of glucocorticoids, however, are poor

196 dentifies critical elements required for the tissue specificity of hEPCR and suggests a mechanism for

197 We present evidence that tissue specificity of Hh targets depends on transcriptio

198 interplay of these components may determine tissue specificity of hormone action.

199 ning to be understood, as are aspects of the tissue specificity of hormone action.

200 ease genes alone cannot explain the observed tissue specificity of human diseases.

201 rkers by analyzing numeric approximations of tissue specificity of human genes.

202 nd among-cell selection may also explain the tissue specificity of human mitochondrial defects.

203 robust platform for deciphering the complex tissue specificity of human mitochondrial-based disorder

204 lly characterize this phenomenon, we analyze tissue specificity of imprinting from allelic expression

205 Tissue specificity of imprinting is widespread, and gend

206 izing the infection process, determining the tissue specificity of infection, and the spatial migrati

207 izing the infection process, determining the tissue specificity of infection, the spatial migration o

208 -ras(LA2) allele, we have uncovered dramatic tissue specificity of K-ras(G12D)-dependent p19(Arf) up-

209 elationship and the basis for the pronounced tissue specificity of laminopathies are poorly understoo

210 The relevance of tissue specificity of microvascular endothelial cells (M

211 ssing and translation may be involved in the tissue specificity of mitochondrial DNA disease mutation

212 that miRNA expression broadly contributes to tissue specificity of mRNA expression in many human tiss

213 Tissue specificity of NECI-CAT expression demonstrated t

214 We examined the tissue specificity of nine BK alpha alternative exons an

215 tion in these families may shed light on the tissue specificity of oxidative phosphorylation disorder

216 Tissue specificity of PARP-DBD expression in human tumor

217 ation disorders or modulate the severity and tissue specificity of pathogenic mitochondrial DNA mutat

218 n of Ppp1cc2, and recapitulate the wild-type tissue specificity of PPP1CC2 in transgenic mice.

219 We have shown previously that this tissue specificity of Ras isoforms is defined by the Ras

220 ntal in primary function is unknown, and the tissue specificity of recapitulated gene expression rema

221 Analysis of the tissue specificity of reflectin subtypes reveals that tu

222 To study the timing and tissue specificity of retrotransposition, we created tra

223 a previously unknown factor involved in the tissue specificity of SCA7 and that trichostatin A may a

224 n to identify factors that contribute to the tissue specificity of SCA7.

225 framework to explain the age dependence and tissue specificity of the ADLD disease phenotype.

226 at auxin may be responsible for the observed tissue specificity of the AtPGM promoter.

227 ts, we provide genetic evidence for gene and tissue specificity of the Brahma chromatin remodeling co

228 Tissue specificity of the bullfrog rem2 gene showed that

229 islet allograft rejection and highlights the tissue specificity of the chemokine/chemokine receptor s

230 branes selectively in neurons, mimicking the tissue specificity of the human disease and providing a

231 hophysiological mechanisms that underlie the tissue specificity of the m.3243A > G mutation, and impo

232 The striking tissue specificity of the muscle mtDNA mutations detecte

233 ndependent apoptotic effects and mechanisms, tissue specificity of the p53 response, a molecular unde

234 These findings indicate that the tissue specificity of the pp52 promoter is determined by

235 In this investigation, we have compared the tissue specificity of the small heat shock protein (shsp

236 erized genes and assessing the frequency and tissue specificity of their expression in silico.

237 The tissue specificity of these DHSs mirrored the activity o

238 ribosomopathies and attempt to reconcile the tissue specificity of these disorders with the ubiquitou

239 To explore the tissue specificity of these eQTLs and hence to quantify

240 on factor-binding sites, which determine the tissue specificity of these genomic assays.

241 Tissue specificity of these linkages was examined in mic

242 as no more than 2,500 cpm, demonstrating the tissue specificity of this construct.

243 noglobulin G (IgG) seem incongruous with the tissue specificity of this disease.

244 To test tissue specificity of this nongenomic signaling mechanis

245 We have investigated the tissue specificity of this pathway in body size regulati

246 pha alters energy metabolism in vivo and the tissue specificity of TNF-alpha action are unclear.

247 the pathway genes was perturbed, whereby the tissue specificity of transcripts was altered.

248 ting that factors other than Env mediate the tissue specificity of tumor induction by ENTV.

249 s variation provides one explanation for the tissue specificity of tumor suppression by p53.

250 oteins Lkb1 and Tsc1/Tsc2 may underlie their tissue specificity of tumor suppressor action.

251 idespread implications for understanding the tissue specificity of tumor suppressor gene phenotypes.

252 A2BP1 play an important role in determining tissue specificity of UGCAUG-mediated alternative splici

253 ression Atlas 2 data allow the cataloging of tissue-specificities of the predicted SREs.

254 The results indicate that tissue-specificity of an isolated enhancer may be quite

255 Cell and tissue-specificity of cytokine action appears to be dete

256 Statistical methods leveraging the tissue-specificity of DNA methylation for deconvoluting

257 Tissue-specificity of enhancer candidates is defined bas

258 model by measuring the number, identity, and tissue-specificity of functional regulatory targets for

259 we investigate the relationship between the tissue-specificity of gene expression and the type of pr

260 n syringyl monomer content and abolishes the tissue-specificity of its deposition.

261 gated the intriguing question related to the tissue-specificity of malignant conversion in VHL diseas

262 estigated the relative expression levels and tissue-specificity of NCF2 5'-UTR variant mRNAs and thei

263 by sub-optimal expression levels or improper tissue-specificity of particular promoters, or rely on t

264 ontributes toward the progressive nature and tissue-specificity of the symptoms.

265 hen used in vivo reporter assays to test the tissue-specificity of these enhancers, chromatin configu

266 For the same set of proteins, the curated tissue specificity offered in SWISS-PROT was accurate in

267 tire collections of enhancers with a defined tissue specificity or conservation depth.

268 differences in isoform dependence arise from tissue specificity or from the nature of the oncogenic s

269 We found that tissue-specificity plays a crucial part in the function

270 Neuropsychiatric side effects and lack of tissue specificity precluded clinical use of first-gener

271 ed real time PCR (rtPCR) to characterize its tissue specificity, regional brain expression, and brain

272 The reasons for this tissue specificity remain unknown, although biliary epit

273 Although some of these show tissue specificity (roots or leaves), none exhibit recip

274 iated with mitochondrial dysfunction and the tissue specificity seen in many mitochondrial disorders.

275 Furthermore, complex indels display strong tissue specificity (such as VHL in kidney cancer samples

276 cRNAs show remarkably strong conservation of tissue specificity, suggesting that it is selectively ma

277 is more strongly correlated with measures of tissue specificity than nonreproductive genes, suggestin

278 w avenues of research into toxic effects and tissue specificity that are necessary to allow their suc

279 ular factors that vary depending on dose and tissue specificity, the activation of NF-kappaB appears

280 Despite this high level of tissue specificity, the cis-regulatory elements that con

281 Tissue specificity, the traditional predictor of gene fu

282 sion system greatly facilitates changing the tissue-specificity, the transgene expressed, or the cell

283 other neurodegenerative disorders exhibiting tissue-specificity, thereby guiding the search for effec

284 ving both basal transcriptional activity and tissue specificity to cone photoreceptors and pinealocyt

285 the role of p53 and p21 in determination of tissue specificity to DNA damage in vivo, we compared th

286 ms may be important in conferring target and tissue specificity to its transcriptional activity.

287 l mouse small intestine tissues and a strong tissue-specificity to the process.

288 Tissue-specificity values facilitated high-throughput an

289 mental and cell-type-specific functions, yet tissue specificity was established for only a small frac

290 This tissue specificity was greatly altered via alternative s

291 duced pigment in vegetative tissues, but the tissue-specificity was different from B-Bolivia, suggest

292 To understand this tissue specificity, we compared early mutant huntingtin-

293 oxLDL-induced cytotoxicity and determine its tissue specificity, we have used Chinese hamster ovary (

294 Expression strength and tissue specificity were maintained over five transgenic

295 s in transcriptional factors/regulators show tissue specificity, whereas histone modifiers are often

296 Our results reveal striking tissue specificity with distinct regulation of target p5

297 Evaluation of mRNA prevalence and tissue specificity, with particular focus on adult tissu

298 There was striking tissue-specificity, with predominantly amino acids affec

299 sence of alternative promoters with distinct tissue specificity within many protein-coding genes.

300 ron 5/intron 6 ship1 genomic segment and its tissue specificity within transgenic mice expressing GFP