ライフサイエンスコーパス: tissue stem cell

1 ial in part through its rejuvenation of aged tissue stem cells.

2 arguably the most extensively characterized tissue stem cells.

3 ypes are transcriptionally similar to normal tissue stem cells.

4 research in cell adhesion, inflammation, and tissue stem cells.

5 s have been shown to originate in epithelial tissue stem cells.

6 rine cells in vivo, suggesting that they are tissue stem cells.

7 ce of cancer cells with properties of normal tissue stem cells.

8 least some BCCs can arise from hair follicle tissue stem cells.

9 ion or infection usually first occurs in the tissue stem cells.

10 nd tissue because they do not develop ground tissue stem cells.

11 ing that these cells have features of normal tissue stem cells.

12 ing and plasticity, features associated with tissue stem cells.

13 are slow cycling in vivo, a known feature of tissue stem cells.

14 he early oncologic processes and the role of tissue stem cells.

15 nt spheroids previously shown to derive from tissue stem cells.

16 agenic events that generate cancers in human tissue stem cells.

17 of a decline in the restorative capacity of tissue stem cells.

18 nd germ cells are continuously maintained by tissue stem cells.

19 believed to originate from transformation of tissue stem cells.

20 s and in its possible derivation from normal tissue stem cells.

21 ce for unprecedented transdifferentiation of tissue stem cells.

22 d the potential plasticity of HSCs and other tissue stem cells.

23 about the possible totipotency of some adult tissue stem cells.

24 ise attributed to an intrinsic plasticity of tissue stem cells 9.

25 Adult tissue stem cells adjust to environmental changes.

26 enchymal transition (EMT) in both epithelial tissue stem cells and breast cancer cells.

27 similarities and differences between normal tissue stem cells and cancer stem cells (CSCs) have been

28 vely kill SCs holds promise for rejuvenating tissue stem cells and extending health span.

29 prime instigators of a functional decline of tissue stem cells and of mitochondrial dysfunction that

30 We proposed that epithelial tissue stem cells and their cancer stem cell (CSC) count

31 are postembryonic determinants of the ground tissue stem cells and their lineage.

32 utrient-sensing pathways active in mammalian tissue stem cells and their relevance to normal and canc

33 Cancers are thought to arise in tissue stem cells, and similar to healthy tissue, are th

34 mming, and hematopoietic and skeletal muscle tissue stem cells, and we discuss the implications for r

35 Tissue stem cells are responsible for replenishing and m

36 ent lineage-tracing studies, we propose that tissue stem cells are routinely lost and replaced in a s

37 ived stem cells (BMDC) and not from resident tissue stem cells as previously believed.

38 om bone marrow stem cells (BMSC) and adipose tissue stem cells (ASC) of humans and rhesus macaques we

39 arabiosis rejuvenates the performance of old tissue stem cells at some expense to the young, but whet

40 ave challenged this paradigm by showing that tissue stem cells can differentiate to unexpected cell l

41 Differentiating tissue stem cells can self-assemble into structures that

42 Adult tissue stem cells can serve two broad functions: to part

43 Tissue stem cells contribute to tissue regeneration and

44 function in mouse models, indicating that a tissue stem cell defect may underlie the pathophysiology

45 Tissue stem cells divide to self-renew and generate diff

46 In many tissues, stem cells divide less often than their progeny

47 Adult organisms rely on tissue stem cells for maintenance and repair.

48 Tissue stem cells form the cellular base for organ homeo

49 a hallmark of dyskeratosis congenita, impair tissue stem cell function in mouse models, indicating th

50 A temporal decline in tissue stem cell functionality may be a key component of

51 The detailed understanding of adult tissue stem cells has significance for both regenerative

52 have some phenotypic similarities with adult tissue stem cells, has been suggested to contribute to t

53 Local tissue stem cells have been described in airways of the

54 Analogies between TICs and normal tissue stem cells have led to the proposal that activati

55 for its complete function in DNA repair and tissue stem cell homeostasis.

56 ntegral to the regulation of energy balance, tissue/stem cell homeostasis, and disease pathogenesis.

57 Wnts are also key drivers of most types of tissue stem cells in adult mammals.

58 m1 expression identifies distinct connective tissue stem cells in both the bone (OCR stem cells) and

59 indicating that a similar process occurs in tissue stem cells in dyskeratosis congenita patients.

60 or the maintenance of diverse populations of tissue stem cells in mice.

61 s an alternative for region-restricted adult tissue stem cells in regenerative medicine.

62 lls to send mitogenic signals to neighboring tissue stem cells in response to estrogen and progestero

63 ayed the ability of mTert-driven GFP to mark tissue stem cells in testis, bone marrow (BM), and intes

64 gr5 are known markers of adult and embryonic tissue stem cells in various organs.

65 tophagy genes in the regulation of different tissue stem cells, including neural stem/progenitor cell

66 hown to promote self-renewal in a variety of tissue stem cells, including neuronal stem cells and hem

67 at lncRNAs exert critical functions in adult tissue stem cells, including skin, brain, and muscle, as

68 nfection, mutation, or epigenetic change-the tissue stem cell is involved in the generation of cancer

69 t to which cancer stem cells resemble normal tissue stem cells is a critical issue if targeted therap

70 rentiation of specific cell types from adult tissue stem cells is a major challenge in developmental

71 tion in stem cell biology is how the fate of tissue stem cells is initially determined during develop

72 t to test because the identity of most adult tissue stem cells is not known.

73 The literature on isolation of adult tissue stem cells is vast and disparate.

74 that supports expansion of several types of tissue stem cells, is a candidate therapeutic target for

75 pled receptor-5 (LGR5) is expressed in adult tissue stem cells of many epithelia, and its overexpress

76 esis are that (a) tumors originate in either tissue stem cells or their immediate progeny through dys

77 lls must be phenotypically similar to normal tissue stem cells or whether they can retain the identit

78 wever, it is unclear whether it functions in tissue stem cells other than blood.

79 arises from the transformation of a resident tissue stem cell, our results show that EMT can produce

80 Thus, there is no "one size fits all" adult tissue stem cell paradigm.

81 Tissue stem cells play a key role in tissue maintenance.

82 rate subphyla, collectively demonstrate that tissue stem cells rather than pluripotent blastema cells

83 hich aging is caused in part by a decline in tissue stem cell regenerative function.

84 AML1 is a transcription factor implicated in tissue stem cell regulation and belongs to the small Run

85 em cells, but their roles in development and tissue stem cells remain unclear.

86 These observations establish that adult tissue stem cells reside within the CD62L(+) Tcm cell co

87 Mechanisms of tissue stem cell (SC) quiescence control are important f

88 Malignant transformation of tissue stem cells (SC) may be the root of most cancer.

89 Adult tissue stem cells (SCs) reside in niches, which orchestr

90 Adult tissue stem cells (SCs) reside in niches, which, through

91 Cancers and tissue stem cells (SCs) share similar molecular pathways

92 Adult tissue stem cells self-renew and differentiate in a way

93 The possibility that other adult tissue stem cells show similar heterogeneity and mechani

94 evealed substantial upregulation of an adult tissue stem-cell signature, activated Wnt signalling, an

95 ese results indicate that, similar to normal tissue stem cells, subsets of CSCs in some tumours conta

96 echanistic insight into the dynamics between tissue stem cell subtypes and demonstrates that p63 regu

97 le is known about how growth factors control tissue stem cell survival and proliferation.

98 s whether malignancy arises in self-renewing tissue stem cells that suffer oncogene activation or in

99 dult mammalian tissues, could regulate adult tissue stem cells through modulating niche signaling and

100 rns, which separated them clearly from other tissue stem cells with lower developmental potency.