ライフサイエンスコーパス: tissue transglutaminase

1 tin recognition site within this sequence of tissue transglutaminase.

2 dependent on excess activity of cell surface tissue transglutaminase.

3 l digestion and that have been deamidated by tissue transglutaminase.

4 cells requires deamidation of the protein by tissue transglutaminase.

5 ucts of physiological digestion of gluten by tissue transglutaminase.

6 highly specific substrate for deamidation by tissue transglutaminase.

7 bly occurring as a result of cell leakage of tissue transglutaminase.

8 s to immobilized maltose-binding protein and tissue transglutaminase.

9 ts with a monoclonal antibody raised against tissue transglutaminases.

10 lization of antibodies against epidermal and tissue transglutaminases.

11 830 children tested positive for IgA against tissue transglutaminase (1.0%; 95% confidence interval,

12 e (14%), and anti-IgA autoantibodies against tissue transglutaminase (12%).

13 tory of celiac disease or antibodies against tissue transglutaminase 2 (controls), healthy family mem

14 (~30%) to both human Factor XIII (FXIII) and tissue transglutaminase 2 (hTG2).

15 Tissue transglutaminase 2 (TG2) has been of particular i

16 Tissue transglutaminase 2 (TG2) is a multifunctional pro

17 Tissue transglutaminase 2 (TG2) is overexpressed in epit

18 isease patients, who have antibodies against tissue transglutaminase 2 in the absence of villous atro

19 st results (for levels of antibodies against tissue transglutaminase-2 and deamidated gliadin peptide

20 , distinct from the two CD hallmark antigens tissue transglutaminase-2 and deamidated gliadin, exhibi

21 s between fibrillar collagens, introduced by tissue transglutaminase-2, are necessary for the self-as

22 le as 60 microU of purified guinea pig liver tissue transglutaminase (4.2 ng or 54 fmol of enzyme).

23 ed nonmitochondrial autoantibody was against tissue transglutaminase (57.1% of ALF patients).

24 Reducing tissue transglutaminase activity in collagen gels contai

25 /-0.35 to 13.93+/-4.21 U/mg DNA in cytosolic tissue transglutaminase activity was seen.

26 of 60 to 120 kJ per m2 resulted in increased tissue transglutaminase activity when measured either in

27 en and transforming growth factor beta1, and tissue transglutaminase activity.

28 zing agent maitotoxin to increase endogenous tissue transglutaminase activity.

29 induced in cortical neurons (ie, cyclin D3, tissue transglutaminase, alpha1-antichymotrypsin, and ST

30 These effects are specific for tissue transglutaminase and are not shared by its functi

31 uding serologic tests for antibodies against tissue transglutaminase and deamidated gliadin peptide,

32 strates and/or modulators of enzymes such as tissue transglutaminase and ecto-protein kinases that mo

33 ntion of the profibrotic cleavage substrates tissue transglutaminase and endoglin accompanied MMP-14

34 lder were tested for CD based on analysis of tissue transglutaminase and endomysial antibodies.

35 ed on results of serum tests for IgA against tissue transglutaminase and endomysium or on both a heal

36 pgli), as well as for IgA antibodies against tissue transglutaminase and endomysium.

37 The number of cells showing increases in tissue transglutaminase and its cross-link product, epsi

38 It was shown recently that tissue transglutaminase and presumably plasma transgluta

39 In conclusion, IGFBP-1 is a substrate for tissue transglutaminase and Tg leads to the formation of

40 Sera were tested for tissue transglutaminase and, if abnormal, for endomysial

41 ee or four antibody tests including IgA anti-tissue transglutaminase and/or IgA anti- endomysium perm

42 est results (IgA/IgG gliadin, endomysium, or tissue transglutaminase) and compared them with 213,208

43 st three of which, namely, TGase 1, TGase 2 (tissue transglutaminase), and TGase 3, are present in th

44 ad antibodies against gliadin, 1.22% against tissue transglutaminase, and 0.61% against endomysium (P

45 d peroxidase, gastric parietal cells (PCAs), tissue transglutaminase, and 21-hydroxylase was tested u

46 slinking of VEGF165, catalysed by the enzyme tissue transglutaminase, and associates with MVs through

47 entromere, chromatin, soluble liver antigen, tissue transglutaminase, and deaminated gliadin peptides

48 s (IgA anti-dpgli, IgG anti-dpgli, IgA anti- tissue transglutaminase, and IgA anti-endomysium) yielde

49 though high levels of autoantibodies against tissue transglutaminase (anti-TG2) are strongly indicati

50 d of 10 years and analyzed for antibodies to tissue transglutaminase (anti-TG2A) using a radiobinding

51 Serum samples were analyzed for anti-tissue transglutaminase (anti-tTG) concentrations at age

52 iations between levels of antibodies against tissue transglutaminase (anti-tTG, a marker of celiac di

53 (ACPAs), antinuclear antibodies (ANAs), anti-tissue transglutaminase antibodies (AGTAs), and anti-thy

54 oped and optimized for determination of anti-tissue transglutaminase antibodies (anti-tTG) in human s

55 nd specific screening serologic tests (anti- tissue transglutaminase antibodies IgA [anti-TTG] and ed

56 Positivity for IgA tissue transglutaminase antibodies was detected in 97%.

57 els of soluble E-selectin (sE-sel), IgA anti-tissue transglutaminase antibodies, and serum IL-8 level

58 he sensitivities of Simtomax, endomysial and tissue-transglutaminase antibodies were compared in 133

59 It captures the target tissue transglutaminase antibody (anti-tTG), and finally

60 c screening for celiac disease using the IgA tissue transglutaminase antibody (IgA tTG) and, if posit

61 were younger (P = .03), had lower titers of tissue transglutaminase antibody (P = .001), and less fr

62 estigations revealed a slightly elevated IgA tissue transglutaminase antibody level in the setting of

63 Tissue transglutaminase appears to have a significant ro

64 t domain revealed that amino acids 81-140 of tissue transglutaminase are involved in fibronectin bind

65 In addition the levels of tissue transglutaminase, as determined by quantitative i

66 wed up for up to 20 years for development of tissue transglutaminase autoantibodies (tTGA).

67 llowed from birth were screened annually for tissue transglutaminase autoantibodies (tTGAs).

68 were defined as being positive for islet or tissue transglutaminase autoantibodies at 2 consecutive

69 he TEDDY study who were tested for islet and tissue transglutaminase autoantibodies, respectively.

70 hese results suggest that a risk of islet or tissue transglutaminase autoimmunity need not influence

71 Tissue transglutaminase belongs to the multigene transgl

72 Transglutaminase 2 (TG2, a.k.a. tissue transglutaminase) belongs to a family of transglu

73 The protein cross-linking enzyme tissue transglutaminase binds in vitro with high affinit

74 Thus, induction of tissue transglutaminase by all-trans-RA and, surprisingl

75 Both factor XIIIa and tissue transglutaminase catalyzed the polymerization of

76 The results suggest that tissue transglutaminase-catalyzed covalent linkages invo

77 The glutamate at P6, which is formed by tissue transglutaminase-catalyzed deamidation, is an imp

78 alysis, showing a parallel increase in renal tissue transglutaminase content.

79 nt upon transglutamination, we determined if tissue transglutaminase could catalyze this reaction and

80 -linking pattern similar to that observed in tissue transglutaminase cross-linked fibrin(ogen) with m

81 ell death with dying cells showing extensive tissue transglutaminase cross-linking of intracellular p

82 Adhesive function of tissue transglutaminase does not require its cross-linki

83 nsor based on the covalent immobilization of tissue transglutaminase enzyme in its open conformation

84 roduce cornified envelope precursors and the tissue transglutaminase enzyme that cross-links them.

85 New diagnostic options include the tissue transglutaminase enzyme-linked immunosorbent assa

86 This observed association between tissue transglutaminase, epsilon-(gamma-glutamyl) lysine

87 Retinoid and interleukin-6 inductions of tissue transglutaminase expression are mediated by speci

88 Furthermore, simvastatin decreased tissue-transglutaminase expression and IMV inward remode

89 r and extracellular compartments elicited by tissue transglutaminase following exposure to ultraviole

90 to Ala significantly reduced the affinity of tissue transglutaminase for fibronectin, indicating that

91 cular mechanisms mediating the regulation of tissue transglutaminase gene expression by TGF-beta fami

92 GF-beta1, BMP2, and BMP4 regulation of mouse tissue transglutaminase gene expression requires a compo

93 t retinoid-dependent expression of the mouse tissue transglutaminase gene is mediated by a versatile

94 oids regulate the transcription of the mouse tissue transglutaminase gene via activation of regulator

95 he regulation of the expression of the human tissue transglutaminase gene.

96 lating the tissue-specific expression of the tissue transglutaminase gene.

97 t G protein, Gh, that can also function as a tissue transglutaminase, has been described.

98 estinal inflammatory disease, and studies on tissue transglutaminase have generated significant new i

99 en in coeliac disease, and to explore if the tissue transglutaminase homologues found in other organi

100 Human tissue transglutaminase (hTG2) is a multifunctional enzy

101 patients with concentrations of IgA against tissue transglutaminase (IgA-TTG) >10-fold the upper lim

102 ational modification of proteins mediated by tissue transglutaminase II (TGase), a GTP-binding protei

103 Tissue transglutaminase II (TGase-II), which is capable

104 mboxane receptor (TP), but also functions as tissue transglutaminase II (tTG).

105 ed formation of noncovalent MK multimers nor tissue transglutaminase II covalent multimerization of M

106 the role of the protein cross-linking enzyme tissue transglutaminase in changes associated with the e

107 n between gluten, immune responsiveness, and tissue transglutaminase in coeliac disease.

108 udy, we have investigated the involvement of tissue transglutaminase in the development of kidney fib

109 eriments clearly demonstrate localization of tissue transglutaminase in the nucleus that can be activ

110 dehydrogenase is less strongly inhibited by tissue transglutaminase in the presence of constructs co

111 3-phosphate dehydrogenase is inactivated by tissue transglutaminase in the presence of glutathione S

112 patients have circulating antibodies against tissue transglutaminase; in children, European guideline

113 disease assay using an assay for IgA against tissue transglutaminase; in subjects with positive test

114 Overexpression of tissue transglutaminase increases its amount on the cell

115 nied by the cross-linking of fibronectin and tissue transglutaminase into nonreducible high molecular

116 Tissue transglutaminase is a calcium-dependent enzyme th

117 Tissue transglutaminase is a calcium-dependent transamid

118 Tissue transglutaminase is a calcium-dependent, protein

119 Tissue transglutaminase is expressed at low levels in th

120 stoma SH-SY5Y cells demonstrated that 93% of tissue transglutaminase is localized to the cytosol.

121 The expression of tissue transglutaminase is regulated by a variety of mol

122 rring in rats submitted to SNx suggests that tissue transglutaminase may play an important role in th

123 Together our results demonstrate that tissue transglutaminase mediates the interaction of inte

124 nt with earlier reports indicating that host tissue transglutaminase modification of gliadin enhances

125 s regulation was paralleled by a decrease in tissue transglutaminase mRNA in MC3T3 E1 cells.

126 GTP-binding protein/transglutaminases (tissue transglutaminases or TGases) have been implicated

127 dehydrogenase complex also is inactivated by tissue transglutaminase plus glutathione S-transferase c

128 Retinoid-dependent activation of the tissue transglutaminase promoter depends on both a proxi

129 rs in CV-1 cells demonstrated that the mouse tissue transglutaminase promoter is activated by ligand

130 - (BMP) and BMP4-dependent inhibition of the tissue transglutaminase promoter.

131 ly conserved between the human and the mouse tissue transglutaminase promoters and a distal region th

132 s been the discovery of a potential role for tissue transglutaminase, recently found to be the autoan

133 hances gliadin-specific CD T-cell responses, tissue transglutaminase specifically deamidated Q65 in t

134 molecular methodologies to demonstrate that tissue transglutaminase (TG) activates downstream NF-kap

135 Tissue transglutaminase (TG) is a Ca2+-dependent acyltra

136 Tissue transglutaminase (TG) is an enzyme that stabilize

137 Following incubation with pure tissue transglutaminase (Tg), IGFBP-1 formed covalently

138 g for the inducible enzyme/adhesion molecule tissue transglutaminase (TG), we demonstrate coordinate

139 lcium-dependent protein crosslinking enzyme, tissue transglutaminase (TG2) but no direct link between

140 The ubiquitous cross-linking enzyme tissue transglutaminase (TG2) has been implicated in irr

141 Gluten lacks such peptides, but tissue transglutaminase (TG2) introduces negatively char

142 Tissue transglutaminase (TG2) is a multifunctional Ca(2+

143 Tissue transglutaminase (TG2) is a multifunctional enzym

144 Tissue transglutaminase (TG2) is involved in Ca(2+)-depe

145 c expression of the pro-inflammatory protein tissue transglutaminase (TG2) reprograms the transcripti

146 e activity of the matrix crosslinking enzyme tissue transglutaminase (TG2) via S-nitrosylation in you

147 GPR56 inhibits melanoma growth and binds to tissue transglutaminase (TG2), a major crosslinking enzy

148 Tissue transglutaminase (TG2), an enzyme involved in cel

149 Tissue transglutaminase (TG2), an enzyme that catalyzes

150 c breast cancer cells express high levels of tissue transglutaminase (TG2), but established no direct

151 te the performance of antibody tests against tissue transglutaminase (TG2), deamidated gliadin peptid

152 associated with the sulfhydryl-rich protein tissue transglutaminase (TG2), thereby endowing the memb

153 umor cell lines expressed elevated levels of tissue transglutaminase (TG2).

154 of circulating autoantibodies to the enzyme tissue transglutaminase (TG2).

155 We show that GPR56 binds specifically to tissue transglutaminase, TG2, a widespread component of

156 ptoms and levels of immunoglobulin A against tissue-transglutaminase (TGA-IgA) 10-fold or more the up

157 Tissue transglutaminase (TGase) catalyzes transfer of ga

158 Tissue transglutaminase (TGase) exhibits both a GTP bind

159 Retinoic acid (RA) is a potent activator of tissue transglutaminase (TGase) expression, and it was r

160 Tissue transglutaminase (TGase) has been implicated in n

161 Tissue transglutaminase (TGase) is a Ca(2+)-dependent en

162 Tissue transglutaminase (TGase) is a Ca2+-dependent enzy

163 Tissue transglutaminase (TGase) is a dual function enzym

164 Tissue transglutaminase (TGase) is involved in the regul

165 However, tissue transglutaminase (TGase) provides an interesting

166 disease (AD), we investigated the ability of tissue transglutaminase (TGase) to convert human recombi

167 a model system for investigating the role of tissue transglutaminase (TGase), a protein that has been

168 to the enzyme (transamidase) active site of tissue transglutaminase (TGase), eliminated RA protectio

169 lar aggregates that may be formed in part by tissue transglutaminase (Tgase).

170 Tissue transglutaminase (TGase-2), which binds GTP and c

171 RA induces expression of tissue-transglutaminase (TGase) and promotes migration a

172 We demonstrate amplification of tissue transglutaminase (TGC), keratinocyte transglutami

173 lipase Cdelta1 (PLCdelta1) is an effector in tissue transglutaminase (TGII)-mediated alpha1B-adrenore

174 Tissue transglutaminase (TGM2) belongs to a family of ca

175 In vitro tissue transglutaminase (Tgm2) cross-linking was monitor

176 By gene expression screening, tissue transglutaminase (TGM2) was identified as one of

177 ifferent extents on stiffer substrates; TAZ, tissue transglutaminase (TGM2), and soluble frizzled-rel

178 sensitive fluorometric well plate assay for tissue transglutaminase that is suitable for multiple ki

179 The peptide reacted with tissue transglutaminase, the major autoantigen in Celiac

180 RTX toxin cross-links actin independently of tissue transglutaminase, thus eliminating an indirect mo

181 e as predicted after GC-1g, and the mean IgA-tissue transglutaminase titers declined, contrary to the

182 Addition of exogenous tissue transglutaminase to cultured cells mimicking exte

183 silon-(gamma-glutamyl) lysine cross-link and tissue transglutaminase took place predominantly in the

184 Expression of tissue transglutaminase (transglutaminase II, tTG) was s

185 Tissue transglutaminase (transglutaminase type II) is an

186 undergoing short-term antigen challenge and tissue transglutaminase-treated, overlapping synthetic p

187 e dissimilar with known CD-specific antigens tissue transglutaminase (tTG) and deamidated gliadin, an

188 )((app))) of FXIIIa and the guinea pig liver tissue transglutaminase (tTG) and reactivities of Gln su

189 l transglutaminase (TGe) and closely related tissue transglutaminase (tTG) are considered to be autoa

190 Human factor XIII (FXIII) and tissue transglutaminase (tTG) are homologous proteins.

191 Immunoglobulin A (IgA) antibodies to tissue transglutaminase (tTG) are the serologic test of

192 Tissue transglutaminase (tTG) assay was available, but o

193 d to proteolytic degradation of cell surface tissue transglutaminase (tTG) at the leading edge of mot

194 core protein dimer was determined to be the tissue transglutaminase (tTG) because, first, tTG could

195 Tissue transglutaminase (tTG) catalyzes a Ca(2+)-depende

196 Tissue transglutaminase (tTG) catalyzes a Ca2+-dependent

197 Tissue transglutaminase (tTG) exhibits a magnesium-depen

198 (TIMP) expression, stellate cell apoptosis, tissue transglutaminase (tTg) expression, and matrix cro

199 Tissue transglutaminase (tTG) functions as a GTPase and

200 se (CD) often relies on the presence of anti-tissue transglutaminase (tTG) IgA autoantibodies.

201 The possible involvement of tissue transglutaminase (tTG) in apoptosis during photor

202 r studies have suggested a possible role for tissue transglutaminase (tTG) in this process.

203 for this defect, we analyzed the activity of tissue transglutaminase (tTG) in TSP-2-null dermal fibro

204 Crosslinking of Abeta peptides by tissue transglutaminase (tTg) indicates that Gln15 of on

205 Our previous work showed that cell surface tissue transglutaminase (tTG) induces clustering of inte

206 Tissue transglutaminase (tTG) is a calcium-dependent enz

207 Tissue transglutaminase (tTG) is a multifunctional enzym

208 Tissue transglutaminase (tTG) is a multifunctional prote

209 Tissue transglutaminase (tTG) is a sulfhydryl rich prote

210 Tissue transglutaminase (tTG) is a unique member of the

211 Tissue transglutaminase (tTG) is an acyltransferase/GTP-

212 The recognition scaffold is the following: tissue transglutaminase (tTG) is immobilized as a captur

213 Here, we show that tissue transglutaminase (tTG) is one such protein.

214 Tissue transglutaminase (tTG) is present in the human ne

215 , duodenal biopsy, and serologic analysis of tissue transglutaminase (tTg) levels; endomysial antibod

216 Experimental renal scarring indicates that tissue transglutaminase (tTg) may be associated with the

217 Tissue transglutaminase (tTG) serves as a potent and ubi

218 hological crosslinking of alpha-synuclein by tissue transglutaminase (tTG) using immunohistochemistry

219 ometry, glycated haemoglobin (HbA1c) and IgA tissue transglutaminase (tTg) were collected prior to, a

220 ndomysial antibodies (EMA) and antibodies to tissue transglutaminase (tTG) were developed to screen f

221 ne expression for transglutaminase (TGase 2; tissue transglutaminase (tTG)) in hippocampus and isocor

222 n cell lines stably overexpressing wild type tissue transglutaminase (tTG), a mutant inactive tTG, or

223 irected to different antigens, in particular tissue transglutaminase (tTG), gliadin (Glia), and endom

224 The protein-crosslinking enzyme, tissue transglutaminase (tTg), has recently been implica

225 ty to bind the protein cross-linking enzyme, tissue transglutaminase (tTG), in cancer cell migration.

226 Tissue transglutaminase (tTG), involved in PTM of gluten

227 e repeats are glutaminyl-donor substrates of tissue transglutaminase (tTG), it has been hypothesized

228 sforming growth factor-beta1 (TGF-beta1) and tissue transglutaminase (tTG), two proteins with documen

229 rface adhesion/signaling receptors including tissue transglutaminase (tTG).

230 l activity of the retinoid-response gene rat tissue transglutaminase (tTG).

231 celiac disease have serum antibodies against tissue transglutaminase (tTG).

232 transfer of the protein cross-linking enzyme tissue transglutaminase (tTG).

233 The IgA endomysium (EMA-IgA) and tissue transglutaminase (TTG-IgA) tests were both highly

234 Ca2+-dependent protein cross-linking enzyme tissue transglutaminase (tTGase) is involved in THG-indu

235 Previously, tissue transglutaminase (tTGase) was found to contribute

236 they are recognized and deamidated by human tissue transglutaminase (tTGase) with high selectivity.

237 Recently, tissue transglutaminase (tTGase)-catalyzed deamidation o

238 The positive predictive value of tissue transglutaminase type 2 (tTG) antibodies performe

239 nt increase in liver retinoid concentration, tissue transglutaminase type II (TGaseII) activity, tran

240 These studies revealed that tissue transglutaminase was activated in the nucleus, a

241 2 to more than 12000 participants) found IgA tissue transglutaminase was associated with high accurac

242 es, the nuclear localization and activity of tissue transglutaminase was examined.

243 tin, hepatocyte growth factor activator, and tissue transglutaminase was quantitated.

244 These oligomers and those prepared with tissue transglutaminase were used to establish a mechani

245 cellular matrix is stabilized by the enzyme, tissue transglutaminase, which we demonstrated to be ove

246 ification of the fibronectin-binding site on tissue transglutaminase will help to dissect the role of

247 QQDCTLSLQLTT106 inhibited the interaction of tissue transglutaminase with fibronectin and decreased t

248 Substitution of individual domains of tissue transglutaminase with those from homologous facto