ライフサイエンスコーパス: tissue-specific

1 tissues but that distal regulation is highly tissue specific.

2 o chemotherapy depend on time-of-day and are tissue specific.

3 eover, H3K9me3-marked lincRNA genes are more tissue-specific.

4 genetic or epigenetic differences is highly tissue-specific.

5 ghts into the complex control of alternative tissue-specific 3' UTR formation and its consequences fo

6 APA patterns, we generate developmental and tissue-specific 3'-seq libraries from Drosophila yakuba

7 meostasis regulation, we generated mice with tissue-specific ablation of Bmp6 in different liver cell

8 eria toxin receptor (DTR) is widely used for tissue-specific ablation of cells.

9 ature calyx of Held (P16-20), we report that tissue-specific ablation of dynamin-1 (cKO), an endocyti

10 le that BRAINSPAReDT can be used for Cre/DTR tissue-specific ablation outside the brain using CNS dri

11 elopmental stages of leaf and fruit suggests tissue-specific accumulation of the major triterpenoids

12 eceptor transcriptome and contributes to the tissue-specific actions of glucocorticoids.

13 Since some DAMPs confer tissue-specific activation of the inflammasomes, we test

14 c processes that coalesce around variants in tissue-specific active chromatin regions.

15 essed in different tissues and have distinct tissue-specific activities and functions.

16 Such tissue-specific adaptability may be a more common mechan

17 functions to adapt to metabolic cues and to tissue-specific age-related traits.

18 through their expression and presentation of tissue-specific Ags to developing thymocytes, resulting

19 osinophilic esophagitis (EoE) is an emerging tissue-specific allergic disease with an unclear pathoge

20 eosinophilic esophagitis (EoE), an emerging tissue-specific allergic disease, involves dysregulated

21 ndicate towards a crucial role played by the tissue-specific alternative splicing and relative abunda

22 1 (TBC1D1) in skeletal muscle, suggesting a tissue-specific AMPK-dependent increase in TBC1D1-driven

23 We have discovered local tissue-specific amplifiers of type 2-mediated macrophage

24 ent with previous reports in the brain, with tissue-specific analyses suggesting that classes II and

25 The regulation exerted by the CPuORF was tissue specific and did not act in the absence of light.

26 NMD is regulated in a tissue-specific and developmentally controlled manner, r

27 ing genomic loci in the human genome exhibit tissue-specific and disease-specific expression suggests

28 multi-exonic non-coding transcripts that are tissue-specific and enriched for GWAS SNPs as well as ep

29 together with broad H3K4me3 domains, shape a tissue-specific and evolutionarily conserved atlas of mi

30 Using tissue-specific and germline mutants, we examined the re

31 qRT-PCR analysis revealed tissue-specific and hormone-responsive expression patter

32 We report tissue-specific and sex-biased expression in genes commo

33 ed prostate, breast and skin tumors detected tissue-specific and shared data sets of known and candid

34 arget expression of a given gene and provide tissue-specific and stage-specific regulation of gene ex

35 Dsx's target repertoires are highly sex- and tissue-specific and that Dsx can exercise its regulatory

36 in IR- or TH-associated gene signatures were tissue-specific and varied over time, and the relative i

37 .e. incorporation, flux, and oxidation, in a tissue-specific and whole-body fashion) in health, disea

38 This defect was tissue-specific, and epicutaneous application of antigen

39 on profiles in response to TH treatment were tissue-specific, and the diversity of regulated genes al

40 unique cellular interactions that influence tissue-specific angiogenesis in mammals.

41 Adipose tissue-specific AnkB-KO mice develop obesity and progres

42 ot regulate autoimmune diseases induced with tissue-specific antigens emulsified in adjuvant oils, su

43 Our data suggests that, cell- or tissue-specific antimiR-29 delivery may have therapeutic

44 al CD8alphaalpha T cells in AGMs may lead to tissue-specific antiviral immune responses in lymphoid f

45 We document broadly analogous tissue-specific APA trends in these species, but also ob

46 the numbers of genes known to be subject to tissue-specific APA, such as 3' untranslated region (UTR

47 in vitro human models that can recapitulate tissue-specific architecture has hindered our understand

48 Tissue-specific ATP6AP2 inactivation in mouse suggested

49 s, but they may not be sufficient to prevent tissue-specific autoimmune diseases.

50 show that EBF2 interacts with and recruits a tissue-specific BAF chromatin remodeling complex to brow

51 but it improved glucose handling, displaying tissue-specific beneficial actions.

52 suggests that, within the developing kidney, tissue-specific beta-catenin activity is regulated by co

53 ered transposon variants for constitutive or tissue-specific cancer gene discovery screening.

54 id receptor antagonists as well as data from tissue-specific CB1 receptor-deficient mice suggest the

55 ls into organoids - aggregates with multiple tissue-specific cell types and three-dimensional structu

56 gnostics and therapeutics, yet prediction of tissue-specific cellular function remains a critical cha

57 In 48 tissues with known tissue-specific cellular functions, OhmNet provides more

58 at buffer TF expression, thereby maintaining tissue-specific cellular identity during development and

59 ants, which together cooperate to circumvent tissue-specific challenges.

60 and glp-1 mutants displayed unique age- and tissue-specific changes in autophagic activity, indicati

61 Consequently, tissue-specific changes in DNA methylation are part of t

62 er driver mechanisms do not explicitly model tissue-specific changes in pathway networks and the regu

63 n-associated methylation changes differ from tissue-specific changes.

64 any source of interest, preserving cell- and tissue-specific chemical modifications that are known to

65 opose that the PMM2 promoter mutation alters tissue-specific chromatin loop formation, with consequen

66 el mechanism by which EBF2 cooperates with a tissue-specific chromatin remodeling complex to activate

67 Linc-RAM as a regulatory lncRNA required for tissues-specific chromatin remodelling and gene expressi

68 rcRNAs is largely unknown, the cell type-and tissue-specific circRNA expression has implicated their

69 that profound TJ-restructuring by organ and tissue-specific claudin switching characterize obese org

70 hemical techniques, and provide evidence for tissue-specific clearance mechanisms, which could reduce

71 Drosophila cells, we detected a large set of tissue-specific coding and non-coding RNAs that are boun

72 s to a MEC fate, indicating the necessity of tissue specific components of the mECM.

73 NPCs have been shown to have tissue-specific composition, suggesting that their funct

74 that mutations perturbing SCO1 function have tissue-specific consequences for the machinery that ulti

75 that particular augmentors activate Ltk in a tissue-specific context to induce iridophore differentia

76 We quantify the tissue-specific contribution to axis elongation using 3D

77 PP amyloid formation via direct binding as a tissue-specific control mechanism.

78 adenylation (APA), which is subject to broad tissue-specific control.

79 However, how these tissue-specific cues participate in the training of immu

80 The presented method can be trained on any tissue-specific dataset of enhancers and known functiona

81 translation machinery cause early-onset and tissue-specific deficiency of one or more OXPHOS complex

82 Using mice with tissue-specific deletion of the mTORC1 regulator Raptor

83 ons of the engineered nanoparticles used for tissue-specific delivery by non-invasive delivery approa

84 nant adeno-associated virus is limited while tissue-specific delivery of gRNAs and Cas9 is desired.

85 GFbetaR1-mediated signalling may explain the tissue-specific development of these unique DCs.Developm

86 ion of hundreds of mRNAs underlying critical tissue-specific developmental processes is largely regul

87 se target genes assemble into house-keeping, tissues-specific developmental, and immune response modu

88 Tissue-specific deviations of the approximation from the

89 We show that InFlo robustly characterizes tissue-specific differences in activities of signalling

90 In contrast to neutrophils, we found tissue-specific differences in C5aR2 expression in eosin

91 he cancer's tissue of origin, which revealed tissue-specific differences in selective signals.

92 tem cells of the testis, there are important tissue-specific differences.

93 nvironment that promotes cell attachment and tissue-specific differentiation leading to full-sized or

94 SPHINX 1.8 appears to be involved in tissue-specific differentiation, including essential fun

95 genes involved in cell growth, viability and tissue-specific differentiation.

96 itously expressed RNA-binding proteins cause tissue specific disease.

97 on in the allergy field is to understand how tissue-specific disease is manifested.

98 ot vascularization, which we confirmed using tissue-specific DNA methylome data.

99 non-coding DNA regions and in particular in tissue-specific DNase I hypersensitivity sites (DHSs).

100 Using the calyx of Held synapse from tissue-specific dynamin-1 knockout (cKO) mice (P16-20),

101 wledge, this is the first demonstration of a tissue specific ECM driving differentiation of cells to

102 ing IL-15 signals also significantly impacts tissue-specific effector and memory CD8 T cell formation

103 Our new mouse line can be used to study tissue-specific effects of Armc5.

104 , but not in other human tissues, suggesting tissue-specific effects of this sSNP.

105 n excised plant material, but the underlying tissue-specific emptying/refilling dynamics remain uncle

106 ible due to regulation of GR expression by a tissue-specific enhancer.

107 type of datasets to include when predicting tissue-specific enhancers genome-wide, while providing a

108 ons facilitates the genome-wide discovery of tissue-specific enhancers in vivo.

109 n-biased gene expression may be regulated by tissue-specific enhancers or by post-transcriptional dif

110 w "anti-repressive" function for hundreds of tissue-specific enhancers.

111 ted quantitative trait associations revealed tissue-specific enrichment of regulatory annotations in

112 On the basis of tissue-specific enzyme activity and inhibition by cataly

113 DNA methylation is an important tissue-specific epigenetic event that influences transcr

114 nscription-factor binding sites (n = 3), and tissue-specific epigenetic marks (n = 10), with the last

115 ding to the establishment and maintenance of tissue-specific, epigenetic pattern is still poorly unde

116 in we tested the hypothesis that a defect in tissue-specific esophageal genes is an integral part of

117 The tissue-specific etiology of aging and stress has been el

118 us CAPN14 is a unique protease with distinct tissue-specific expression and function in patients with

119 n patterns in a variety of tissues and their tissue-specific expression characteristics, lncRNAs hold

120 Using DNase-seq data improved predictions of tissue-specific expression compared with motifs alone.

121 E_a, PSE_b and VPE) that faithfully activate tissue-specific expression in transgenic embryos.

122 Its substrate-specificity and tissue-specific expression make it a promising target fo

123 a congruent pattern of cellular damage with tissue-specific expression of APOL1.

124 is study provides a novel strategy to enable tissue-specific expression of more than one gRNAs for mu

125 he liver, we demonstrate that this activates tissue-specific expression of stem cell markers.

126 We searched in rice transcriptomes for tissue-specific expression of TEs and found them to be r

127 Current understanding of betaCA tissue-specific expression patterns and what controls th

128 putative target genes are assigned based on tissue-specific expression patterns of flanking genes.

129 The tissue-specific expression patterns of homeobox genes su

130 ion in larval and adult Drosophila Using the tissue-specific expression system (UAS)-GAL4, we express

131 ht to have unique functions because of their tissue-specific expression, different cGMP affinities, a

132 To detect rare tissue-specific expression, we employed the transcript-e

133 ced though alternative splicing that exhibit tissue-specific expression.

134 Our results revealed the tissue-specific expression/localization profile of RD3 f

135 To detect tissue-specific factors that influence neural invasion b

136 his suggests the existence of little-studied tissue-specific factors that rewire the core polarity mo

137 enes with methylated proximal promoters in a tissue-specific fashion.

138 of the digits, and is associated with other tissue-specific fibroses.

139 mework for imaging genetic studies using the tissue-specific functional interaction network.

140 Tissue-specific functional network can provide precise c

141 functions, as well as the cell cycle and the tissue-specific functions of differentiated cells.

142 Thus, Hoxa5 possesses tissue-specific functions that differentially contribute

143 l stress that disrupts multiple systemic and tissue-specific functions.

144 In addition, we explored tissue-specific gene activation using positive feedback

145 plays a crucial role in the establishment of tissue-specific gene expression and the regulation of ke

146 is is an emerging model for the evolution of tissue-specific gene expression and the role of gene dup

147 However, the mechanisms controlling how tissue-specific gene expression changes over time are le

148 ene pairs that all show a similar pattern of tissue-specific gene expression divergence following WGD

149 o model the effect of germ-line variation on tissue-specific gene expression in the presence of effec

150 ranscription factors are required to control tissue-specific gene expression programs.

151 ong-range regulatory interactions typical of tissue-specific gene expression.

152 , in regard to the extent to which cell- and tissue-specific gene regulatory networks are established

153 cells by promoting the ectopic expression of tissue-specific genes in the thymic medullary epithelium

154 as further validated by the expression of AF tissue-specific genes.

155 are downregulated with age, often including tissue-specific genes.

156 a brain-sparing DT, termed BRAINSPAReDT, for tissue-specific genetic ablation of cells outside the CN

157 Mice with brown adipose tissue-specific genetic ablation of HDAC3 become severel

158 Here, we use tissue-specific genetics to investigate how sexual size

159 e the tissue distribution, accumulation, and tissue-specific health risk of MPs in mice.

160 Tissue-specific heritability and biological process enri

161 immunity and escape, revealing co-opting of tissue-specific immune development in the tumor microenv

162 Tissue-specific immune responses play an important role

163 in non-lymphoid tertiary organs and sustain tissue-specific immune responses remain undefined.

164 wever, this might not reflect alterations in tissue-specific immunity.

165 lecule, and transcription factor expression; tissue-specific imprinting; and foreign antigen exposure

166 hich can help scientists to design stage- or tissue-specific in vivo studies and do other subsequent

167 In mice, tissue-specific inducible overexpression of CTGF by kidn

168 immune-competent mice requires adaptation to tissue-specific innate immune microenvironments.

169 k factor for cancer development, we examined tissue-specific insulin action in intestinal tumour form

170 Both systemic insulin resistance and tissue-specific insulin resistance have been described i

171 y be feasible for simultaneous assessment of tissue-specific insulin-mediated (18)F-FDG influx rates,

172 body protocol for simultaneous assessment of tissue-specific insulin-mediated fluorine 18 ((18)F) flu

173 In addition, tissue-specific kinase-substrate interaction modules alt

174 e function of Ric-8b in vivo, we generated a tissue specific knock-out mouse by crossing OMP-Cre tran

175 Here we report that tissue specific knockout of the TMEM16A gene in mouse in

176 Here we show that mice with an adipose-tissue-specific knockout of the microRNA (miRNA)-process

177 Tissue-specific LC-MS/MS analysis revealed the presence

178 acquisition in PDXs was correlated with the tissue-specific levels of aneuploidy and genetic heterog

179 ng cerebral metabolic stress at patient- and tissue-specific levels.

180 ithm, regulatory element prediction based on tissue-specific local epigenetic marks (REPTILE), which

181 ow that (1) inner ear dysfunction due to the tissue-specific loss of Tbx1 or Slc12a2, which encodes a

182 this toxic effect only when presented as the tissue-specific M1 isoform, not when presented as the ub

183 control of Sp1 targets' expression in a cell/tissue specific manner.

184 xpression was significantly upregulated in a tissue-specific manner (p=0.006), which correlated with

185 ing RNAs (lncRNAs) are expressed in a highly tissue-specific manner and function in various aspects o

186 A.J also accumulates in mice with aging in a tissue-specific manner and in human skin.

187 ORC1 activation may be finely regulated in a tissue-specific manner in response to injury, and a para

188 transporter can be inversely regulated in a tissue-specific manner to maintain organismal Cu homeost

189 tivity quantitative trait loci (dsQTLs) in a tissue-specific manner with precision superior to severa

190 o induce tumors in experimental animals in a tissue-specific manner with the aim of uncovering the ge

191 hese age-dependent changes occur in a highly tissue-specific manner, as demonstrated by comparing cir

192 2 SNP309 regulates tumor susceptibility in a tissue-specific manner.

193 evels of brain-enriched miR-7 formation in a tissue-specific manner.

194 nment in regulating barrier deregulations in tissue-specific manner.

195 evels in mediating the actions of sSNPs in a tissue-specific manner.

196 ue to its ability to modulate key genes in a tissue-specific manner.

197 controlled APC/C activity is controlled in a tissue-specific manner.

198 Tissue-specific mapping was investigated in several huma

199 ature cDC2 in mucosal-draining LNs expressed tissue-specific markers derived from the paired mucosal

200 Tbx5-dependent ncRNAs were enriched for tissue-specific marks of active enhancers genome-wide.

201 fication regulates a previously undescribed, tissue-specific mechanism of RA signaling that is requir

202 These data highlight that diverse tissue-specific mechanisms govern education of Th17 cell

203 system in the skin to investigate changes in tissue-specific mechanisms involved in the decreased res

204 to assess enrichment of ASD GWAS results for tissue-specific meQTLs.

205 The fungus is known to secrete tissue-specific metabolites and cause changes in host ge

206 led methylation haplotype load, we performed tissue-specific methylation analysis at the block level.

207 In conclusion, we identified tissue-specific microRNA expression patterns associated

208 Here, using a tissue-specific miRNA transgenic mouse model, we show th

209 evering enzymes implement a diverse range of tissue-specific molecular functions throughout developme

210 what is poorly understood are the details of tissue-specific molecular mechanisms that limit VO2 max

211 They also identify tissue-specific molecular targets for GM hemorrhage inte

212 us to make progress in the understanding of tissue-specific morphogenetic programs.

213 nderstanding of how genes are modulated in a tissue-specific network contribute to tumorigenesis and

214 affect more transcription factor hubs in the tissue-specific network.

215 ffers a potential mechanism for the observed tissue specific neurodegeneration and the role of enviro

216 eviously unappreciated score that quantifies tissue-specific nuclease accessibility significantly imp

217 nteraction of Parkin and SLP-2, and further, tissue-specific or global overexpression of SLP-2 transg

218 , but whether their functions are redundant, tissue-specific or integrated in the cGAS-cGAMP pathway

219 We found that adipose tissue-specific overexpression of Id1 causes age-associa

220 sing 3D volumetric techniques, then quantify tissue-specific parameters such as cell density and prol

221 Despite the tissue-specific pathology that occurs in this disease, o

222 We developed a tissue-specific pathway interaction enrichment analysis

223 these different biological contexts requires tissue-specific perturbation.

224 However, it is not clear how a subset cause tissue-specific phenotypes.

225 n, but not Plin1 phosphorylation, in adipose tissue-specific Pik3r1-null (AKO) mice.

226 sues, as well as communities associated with tissue-specific processes that coalesce around variants

227 expressing estrogen receptors (ERs), suggest tissue-specific proclivities for metastatic tumor format

228 Mechanisms that regulate tissue-specific progenitors for maintenance and differen

229 concept of "tissue tolerance" to discuss the tissue-specific programs that contribute to target tissu

230 ated by expressing mammalian oncogenes under tissue-specific promoters, here we describe a method tha

231 in selected tissues and single cells without tissue-specific promoters.

232 xpressing fluorescent proteins under several tissue-specific promoters.

233 oordinating angiogenesis with acquisition of tissue-specific properties in endothelial cells is essen

234 this approach enables routine and efficient tissue-specific protein ablation.

235 lso generates more accurate hypotheses about tissue-specific protein actions.

236 , a process that requires neurabin (a neural tissue-specific protein).

237 l expression across normal tissues confirmed tissue-specific RD3 mRNA levels.

238 eloped a library of 76 healthy and 20 cancer tissue-specific reconstructions.

239 on in the gene IKBKAP/ELP1 that results in a tissue-specific reduction of the IKAP/ELP1 protein, a su

240 Thus, Mdm2 SNP309G exhibits tissue-specific regulation and differentially impacts ca

241 wed that many editing sites display distinct tissue-specific regulation by the ADAR enzymes in vivo.

242 mal cells, as shown here for hepatocytes, in tissue-specific regulation of CD1d-restricted immunity a

243 (3C) techniques are crucial to understanding tissue-specific regulation of gene expression, but curre

244 ed sites between these three tissues suggest tissue-specific regulation of m(5)C.

245 oughout the human lifespan, examined whether tissue-specific regulation of NRG3 occurs in humans, and

246 polyadenylation site (PAS) in temporal- and tissue-specific regulation of UNC-44/ankyrin isoforms.

247 ction and in vivo reporter assays can reveal tissue-specific regulatory information conserved across

248 stent with natural selection influencing the tissue-specific regulatory landscape.

249 Most variants are likely to have tissue-specific regulatory roles through joint contribut

250 acterized commonalities in variant burden on tissue-specific regulatory sites by calculating the enri

251 tools to precisely dissect the isoform- and tissue-specific requirements of foraging's functions and

252 logical pathways and processes to facilitate tissue-specific requirements, consistent with their rest

253 or cell-autonomous silencing in animals with tissue-specific rescue of rde-4.

254 n nearly unaltered, aging is associated with tissue-specific rewiring, which can be prevented by calo

255 sequences of functional genomic regions and tissue-specific RNA expression in eight tissue types for

256 t extend into the gene body, as evidenced by tissue-specific RNA-seq and other DNA-encoded splice sig

257 ntegrative annotation pipeline, we assembled tissue-specific RNA-Seq libraries from 113 datasets and

258 Using tissue-specific RNAi-mediated knockdown, we showed that

259 Collectively, our results demonstrate a tissue-specific role for AC in regulating neutrophilic i

260 Thus, we found a temporal and tissue-specific role for Bim in limiting thymic agonist

261 rehensive investigative regimen, a novel and tissue-specific role of claudin-3, a tight junction inte

262 Furthermore, subtypes of IFN play distinct tissue-specific roles in innate control of persistent MN

263 bZIP60, as they exert partially independent tissue-specific roles in recovery from ER stress, but re

264 approaches to enable routine analysis of the tissue-specific roles of C. elegans proteins.

265 an metamorphosis as a mechanism for altering tissue-specific Se burdens.

266 cate the need to better understand cell- and tissue-specific signaling mechanisms and their disease-r

267 However, how the oral microbiome and tissue-specific signals balance immunity and regulation

268 are tuned to quickly respond to and amplify tissue-specific signals.

269 sis is applied to obtain single cell-type or tissue specific signatures from a mixed signal and most

270 lar control of dsRNA movement could modulate tissue-specific silencing by feeding RNAi in other inver

271 y mass spectrometry revealed substantial and tissue-specific sphingolipid disturbances in several tis

272 The tight correlation between the number of tissue-specific stem cell divisions and cancer risk of t

273 ns are present, the presented data suggest a tissue-specific stoichiometry and/or post-translational

274 We find that tissue-specific strain-biased gene expression may be reg

275 involved in homeostasis to those involved in tissue-specific stresses, such as DNA damage or ineffici

276 These results provide new insights into tissue-specific subfunctionalization of duplicated exons

277 tionarily conserved, less abundant, and more tissue-specific, suggesting that their pre- and post-tra

278 Because tissue-specific targeting of SERCA2b by Tg analogues is

279 ells that can progress to differentiate into tissue-specific, terminal cell types.

280 GWAS catalog, and are also more likely to be tissue specific than eQTLs identified by linear regressi

281 d recruit different co-regulators to produce tissue-specific therapeutic effects.

282 strand-specific RT-PCR and also demonstrated tissue-specific transcription and stress-induced TE-linc

283 scaffolds that promote the local assembly of tissue-specific transcription complexes and show how nuc

284 Furthermore, tissue-specific transcription factors (tsTFs) are signif

285 etic deregulation in cancer not only targets tissue-specific transcription factors, but also modulate

286 hysiology and disease in part by controlling tissue-specific transcription of host genes.

287 We identified signatures of tissue-specific transcriptional responses indicative of

288 ic and functional heterogeneity derives from tissue-specific transcriptional signatures shaped by the

289 Here we generated tissue-specific transcriptome and DNA methylome data fro

290 eoxymannose 3,5-epimerase-4-reductase (FX or tissue specific transplantation antigen P35B [TSTA3]).

291 d to secondary transformation leading to the tissue-specific triterpenoid biosynthesis.

292 Since vitamin A is food-derived, tissue-specific uptake and storage mechanism are needed.

293 These data suggest that the tissue-specific variability in DSM-IF network compositio

294 may resemble an anaerobic environment, with tissue-specific variations in redox stress and oxygen co

295 Dramatic tumor- and tissue-specific variations in selective pressures sugges

296 ate, jagged-2 is differentially expressed in tissue-specific vascular beds, but its expression is ind

297 tic differences between them may confer host tissue-specific virulence.

298 we developed an approach using split GFP for tissue-specific visualization of ribosomes in Caenorhabd

299 Our data demonstrate the utility of tissue-specific visualization of ribosomes in vivo, and

300 also find that escape from X-inactivation is tissue-specific, with leg muscle showing an unexpectedly