ライフサイエンスコーパス: titratable

1 ity to be safe, effective, reproducible, and titratable.

2 ammonium excretion, citrate absorption, and titratable acid excretion to the same levels in Tg/Tg:ET

3 , as well as hypercitraturia, with increased titratable acid excretion.

4 mmonium excretion or tubular acid secretion (titratable acid plus bicarbonate reabsorption).

5 and inversely correlated to acidic taste and titratable acidity (p<0.10).

6 ermine soluble solids (SS), dry matter (DM), titratable acidity (TA) and pulp firmness (PF).

7 n terms of total soluble solids (TSS), pH or titratable acidity (TA) at harvest.

8 ectroscopy (FT-MIR) for the determination of titratable acidity (TA) in cow's milk.

9 ated flow pH-method for the determination of titratable acidity (TA) in edible oil without titration

10 oncentration, total soluble solids (TSS) and titratable acidity (TA) were evaluated after 0, 25 and 5

11 pH and titratable acidity (TA) were highest in treated fruit, w

12 olorimetry, mechanical texture analysis, pH, titratable acidity (TA), and soluble solid (SS), soluble

13 tion was paid to total soluble solids (TSS), titratable acidity (TA), colour, free amino acids (FAA),

14 racterized for soluble solids content (SSC), titratable acidity (TA), glucose, fructose, sucrose, mal

15 icochemical characterisation analysis (total titratable acidity (TA), total soluble solids (TSS), TSS

16 ted to conventional methodologies: pH, total titratable acidity (TA), total soluble solids, microbial

17 formance of soluble solids content (SSC) and titratable acidity (TA).

18 Soluble solid contents, titratable acidity and ascorbic acid contents were highe

19 hanges for degrees Brix, pH, water activity, titratable acidity and colour parameters in sonicated sa

20 gar concentration, 0.98 and 3.88 g L(-1) for titratable acidity and for pH 0.94 and 0.12.

21 s, pH and colour development increased while titratable acidity and fruit firmness decreased 14.7% an

22 grees C, resulting in higher flesh firmness, titratable acidity and lesser physiological disorders, a

23 phenolic concentration, sugar concentration, titratable acidity and pH by modified partial least squa

24 while flavour assessments were associated to titratable acidity and sugar-to-acid ratio.

25 correspond to 15.15 and 15.71 degrees Brix; titratable acidity changed between 2.6 and 2.8g/L, citri

26 ine, GLRaV-3 infection prior to 2008 reduced titratable acidity compared with the uninfected control.

27 he highest contents of total soluble solids, titratable acidity content and ascorbic acid, 'Capri' ha

28 However, since Juliette exhibited a lower titratable acidity content than Albion, it consequently

29 rbic acid were reduced; retarded the loss of titratable acidity during 96h after treatment.

30 of water activity, total soluble solids, and titratable acidity exhibited non-significant increase up

31 n concentration were significantly lower and titratable acidity higher in berries collected from vine

32 ness and pitting resistance and decreases in titratable acidity loss and decay of both cultivars.

33 The titratable acidity of apple must was significantly highe

34 , presented a pH range from 3.89 to 4.17 and titratable acidity range from 0.798 to 0.826%, with good

35 s ranged from 4.0 to 6.0 by day 7, while the titratable acidity ranged from 2.5 to 5.0g/mL (P<0.05).

36 velopment, whereas the solid soluble content/titratable acidity ratio (SSC/TA) increases significantl

37 , while CH-CS-EOM-coated fruits showed lower titratable acidity than CH-CS-coated fruits at the end o

38 In direct lemon juice, titratable acidity was 52.4 g/L, being the citric acid t

39 he influences of product (soluble solids and titratable acidity) and process (temperature and heating

40 emical properties (i.e. pH, degrees Brix and titratable acidity), volatile and non-volatile component

41 Total soluble solids, titratable acidity, and color of grapes coated with algi

42 firmness, retarded losses in ascorbic acid, titratable acidity, and skin color, and reduced splittin

43 degrees Brix, pH, water activity, viscosity, titratable acidity, cloud assessment and turbidity), ant

44 he yogurts were assessed for morphology, pH, titratable acidity, color, rheology and sensory analysis

45 fermentation patterns were observed for pH, titratable acidity, density, sugar consumption, and etha

46 moisture content, protein, fat, ash, pH and titratable acidity, mineral content (sodium, potassium,

47 rther, few changes in soluble solid content, titratable acidity, pH of the pulp as well as in sugar c

48 ferences were found among treatments for pH, titratable acidity, soluble solids, total anthocyanin an

49 analyzed for their levels of soluble solids, titratable acidity, sugars, organic acids, vitamin C and

50 d higher dry matter, soluble solids content, titratable acidity, taste index, beta-carotene, ascorbic

51 The BIB packaging materials affected the titratable acidity, total and free SO2 and colour of win

52 haracteristics (L( *), a( *), b( *), C( *)), titratable acidity, total phenolic, monomeric anthocyani

53 water was the highest, whereas water volume, titratable acidity, total soluble solids and total pheno

54 Physicochemical characterization (pH, titratable acidity, total soluble solids), bioactive com

55 rs of all samples stored under pressure (pH, titratable acidity, total soluble solids, browning degre

56 al composition (i.e. the content of ethanol, titratable acidity, total sulfur dioxide, total phenolic

57 alyzed for pH, antioxidant properties, total titratable acidity, vitamin C, lycopene and total phenol

58 Parameters monitored included: titratable acidity, volatile acidity, pH, total SO2, fre

59 ntly higher content of phosphorus and higher titratable acidity.

60 t, water activity, vitamin C content, pH and titratable acidity.

61 group Cavendish ( degrees Brix;0.2, pH;4.73, titratable acidity; 0.56g/100g malic acid, total solids;

62 02' were characterised by light colour, high titratable acids and low flavonoid concentrations.

63 itative traits such as total soluble solids, titratable acids and total sugars.

64 fat, amounts of macronutrients, minerals and titratable acids decreased during the ripening process.

65 Her2-expressing tumor cells, and afford dose-titratable activation of CAR-T cells ex vivo and complet

66 gested that RacE1 and RacE2 both possess two titratable active site residues important for catalysis.

67 lasminogen activator urokinase and developed titratable active sites.

68 mean pH 7.9 vs 10.9), lower alkalinity (mean titratable alkalinity 0.4 vs 1.4 mol H(+) kg(-1)), lower

69 y explain up to a quarter of the increase in titratable alkalinity within 1000 meters of the ocean su

70 tained through analysis of deletion mutants, titratable alleles of ribonucleotide reductase genes, an

71 tic, benzocaine, does not, suggesting that a titratable amine is required for high-affinity inhibitio

72 selectivity mechanisms postulate that (1) a titratable amino acid residue in the permeation pathway

73 s is the interactions between the charged or titratable amino acid residues (e.g., Glu, Lys, and His)

74 the four histidines protonated and if other titratable amino acid residues in lieu of the histidines

75 one must assign correct ionization states to titratable amino acid residues in protein channels.

76 est this hypothesis, the pK(a) values of the titratable amino acid residues in rhodopsin have been ca

77 wo redox-active tyrosines with N-containing, titratable amino acid side chains in their environments.

78 le to the sites of protonation, allowing all titratable amino acid side chains to be probed sequence

79 Substitutions of aspartate or other titratable amino acids for glutamate 522 conferred an in

80 ds within the two extracellular loops to non-titratable amino acids had no effect on pH sensitivity.

81 A cluster of titratable amino acids with upshifted pK(a) values, incl

82 Mutations of other titratable amino acids within the two extracellular loop

83 ces with hydrogens, predicting pK values for titratable amino acids, assigning predefined partial cha

84 roximal to charged moieties, including ions, titratable amino acids, sulfates, phosphates, and nucleo

85 We introduce an additional titratable amino group to the side chain of 4-O analogue

86 itoring and equipment, safer and more easily titratable anaesthetic agents, and possibly the practice

87 that DNA-PK's ability to repress HR is both titratable and entirely dependent on its enzymatic activ

88 by external ligands in a rapid, reversible, titratable and independent manner.

89 eacetylase inhibitors (HDACi) may allow more titratable and longer-term dosing.

90 pH, titratable and total acidity, sodium, creatinine, and ca

91 e protein, some SH groups become more easily titratable, and at pH 9.0 the PMP peak appeared around 3

92 The method described is safe, effective, titratable, and easily monitored.

93 ducible degradation system to achieve rapid, titratable, and reversible control of Polo-like kinase 4

94 as both the lysine and phosphate groups are titratable, and so calculations are given for several ch

95 t successful incorporation of the isosteric, titratable Arg analog, canavanine, into a neurotransmitt

96 Unlike all other amino acids, histidine is titratable at pH 6-7 carrying a positive charge below pH

97 both bound to the same subunit (cis), then a titratable burst of ATP hydrolysis is observed correspon

98 Substitution to arginine creates a channel titratable by external pH, suggesting that the side grou

99 te polyadenylation because they fail to bind titratable cap-binding factors.

100 not dependent on deprotonation of any of the titratable cationic groups in the peptide in the pH 4-10

101 A titratable Cdk2 inhibitor compensates for the absence of

102 Recent development of titratable coions has paved the way for realizing all-at

103 s approach to achieve rapid, reversible, and titratable control of protein localization for eight dif

104 nts inhibits Drosha processing, resulting in titratable control over gene silencing.

105 mechanism(s) other than the recruitment of a titratable corepressor.

106 ymatic activity and the presence of two DTNB-titratable cysteine residues.

107 vitro using egg extracts, demonstrating that titratable cytoplasmic factors determine nuclear size to

108 e lack of safe, efficient, reproducible, and titratable delivery methods.

109 Midazolam is the most titratable drug in our population, avoiding excessive ov

110 Using immortalized human myoblasts with a titratable DUX4 transgene, we identify by mass spectrome

111 he authors generate a novel mouse model with titratable expression of DUX4, and show that it recapitu

112 neering of synthetic utilization pathways as titratable expression systems and for metabolic engineer

113 To determine whether a titratable factor might be involved in the initial trans

114 var gene family, suggesting that a limiting titratable factor plays a role in var gene activation.

115 e families, suggesting that the var-specific titratable factor previously described is shared by all

116 rs proceed through a common step involving a titratable factor.

117 Mutational analysis identified a titratable glutamate residue (Glu-536) in the linker bet

118 due in the M1-H5 linker was mutated to a non-titratable glutamine, i.e. H116Q in GIRK1 and H120Q in G

119 on of [3H]-3 alpha-Diol showed that the same titratable group (pK = 7.50 +/- 0.30) was eliminated in

120 ant were superimposable, suggesting a common titratable group (pKb = 6.3) for both reactions.

121 These profiles revealed that the titratable group assigned to the general acid (pK = 6.50

122 via deprotonation at C-5' proceeds with one titratable group displaying an apparent pK(a) value of a

123 Since only the Y55F mutant eliminated the titratable group in both the reduction and oxidation dir

124 D97N mutant, possibly the same as the second titratable group modulating the absorption spectrum.

125 of the cofactor redox potentials, and of the titratable group pK(a) values, in hydroxylamine oxidored

126 In wild-type 3 alpha-HSD, the titratable group responsible for 3-ketosteroid reduction

127 d intermediates is expected and implicates a titratable group with a pKa of approximately 6.6.

128 K84R, and K84M showed the presence of a new titratable group with a pKb = 8.3-9.9.

129 at C-5' follows a pH-rate profile having one titratable group with an apparent pK(a) value of approxi

130 at is dependent only upon deprotonation of a titratable group within the ribosomal active site.

131 ral titrations of BPR indicate that a second titratable group, in addition to the retinylidene Schiff

132 total of 100 ns, that the pKa values of the titratable groups are in good agreement with experimenta

133 iency at pH 9.0, and apparent pKa values for titratable groups at approximately 8.7 and 9.3 are revea

134 g to the calculated ionization states of its titratable groups at the user-specified pH; the output i

135 First the pK(a) values of all the acidic titratable groups in HdeA are obtained and reveal a larg

136 The pK values of the titratable groups in ribonuclease Sa (RNase Sa) (pI=3.5)

137 dronium ions, but instead must interact with titratable groups that line the pore of the channel.

138 -PpoI reveals a macroscopic pK(a) of 8.4 for titratable groups that modulate product release.

139 way by altering the spatial juxtaposition of titratable groups to regulate their activity in a spatio

140 nd MTA exhibits a pH-rate profile having two titratable groups with apparent pK(a) values of 1.2 +/-

141 , k(c), fits best to a model for two or more titratable groups with pK(a) of ca 5.6, suggesting a rol

142 , also exhibiting a pH-rate profile with two titratable groups with pK(a) values of approximately 0.8

143 The pH dependence indicates two titratable groups with pKa values of 6.52 +/- 0.26 and 6

144 acid composition and the organization of the titratable groups with the 3D structure.

145 the protein by adding, removing or changing titratable groups.

146 it occurs independently of the generation of titratable GTP-bound RhoA.

147 and EIII act together to stabilize a single titratable H+ ion and behave nearly symmetrically in inf

148 TREK2 channel is regulated independently via titratable His.

149 Importantly, BM2 contains a second titratable histidine, His-27, in the tetrameric transmem

150 rium differences to the presence of a second titratable histidine, His27, which may increase the prot

151 The standard enthalpy of ionization of six titratable histidines in horse metaquomyoglobin was dete

152 Also, only three sites are titratable in the wild-type protein because one site can

153 that all three systems function and exhibit titratable induction, together covering a dynamic range

154 These models suggest that a titratable inhibitor may play an important part in bista

155 noviral-Cre or lentiviral-Cre vectors allows titratable initiation of pancreatic neoplasias that prog

156 that CH bond cleavage is not masked by other titratable kinetic steps belonging to the reductive half

157 rge was measured as a function of pH for two titratable lipids that were fluorescently labeled.

158 l-depleted donor bone marrow, which promotes titratable macrochimerism and a reshaping of the T cell

159 ase, and phenotype of sCAR-T cells in a dose-titratable manner in a Nalm-6 xenograft rodent model of

160 the late promoter in a sequence-specific and titratable manner, resulting in a delay in late gene exp

161 domain, these synthetic peptides function as titratable, modular, and potent transcriptional activato

162 a unique reaction mechanism that exhibits a titratable moiety at a near-neutral pK(a).

163 stidine button' engineered in TnI produces a titratable molecular switch that 'senses' changes in the

164 reating antagonist-agonist pairs of EOM with titratable, naturally occurring myogenic signaling and g

165 NBD-lysophosphatidylethanolamine, having one titratable negative charge, was increased in the presenc

166 Rapid titratable offset of action has been more difficult to a

167 promise, the development of specific, easily titratable, parenteral agents has made intensive care un

168 A titratable perturbation is observed at the 1H resonance

169 environment, and the availability of readily titratable pharmacologic agents together stimulated the

170 This titratable pharmacologic regulation could allow physicia

171 ncy of the enzyme and loss of one of the two titratable pK(a) values that govern the activity of the

172 t this hypothesis, we changed Glu-177 into a titratable, positively charged lysine (E177K).

173 lose kinase promoter is a tightly regulated, titratable promoter which will be useful for target vali

174 pH 6.5 and 8.5, indicating that there is no titratable protonatable group that influences significan

175 g of Pi and tungstate, a P(i) analog lacking titratable protons over the pH range of 5-11, and from t

176 Interestingly, there was no titratable residue in these motifs.

177 ately predicting the pK(a) value of a buried titratable residue, Asp-66, in the interior of the V66E

178 teraction energy and (iii) pKa of a selected titratable residue.

179 high pH, provided that the effects of nearby titratable residues are considered in the data analysis.

180 ndicative of a potential near -170 mV if the titratable residues are constituted of aspartates and gl

181 mology model to calculate the pKa of several titratable residues around the glutamate binding site to

182 Mutation of the titratable residues around the metal-binding site ruled

183 lease involves ionization changes in several titratable residues associated with CD and EF loop appos

184 is especially true in complexation involving titratable residues at the complex interface.

185 Although the surrounding solvent of several titratable residues changed from water to lipid in this

186 work, we computed the protonation states of titratable residues for this system and obtained values

187 The microscopic pKa values of titratable residues in BACE-1 including its aspartyl dya

188 Site-specific mutations of all titratable residues in the N terminus, however, did not

189 The only two titratable residues in the pore, His168 and His318, are

190 pting the standard protonation state for all titratable residues leaves a large net charge on the sys

191 the protonation states at neutral bulk pH of titratable residues lining the lumen of the native Esche

192 ca exchange to determine the pK(a) values of titratable residues of a glycoside hydrolase (GH) family

193 The pK(a) values of the titratable residues show that E22 and D23 side chains fo

194 he virtual pK(a) (i.e., the composite of all titratable residues that contribute to the LCC) is 5.8.

195 cial area, dielectric environment of the key titratable residues, and geometry of the residue disposi

196 ed by a cluster of evolutionarily conserved, titratable residues, at the cytoplasmic ends of TMs II,

197 ase and alphaLP have the same number of acid-titratable residues, kinetic studies revealed that the h

198 veals conformational changes in Fc and three titratable salt bridges that confer pH-dependent binding

199 aline pH values; this can be attributed to a titratable shift (pKa = 7.8) in the slope of the urea de

200 calculate the pKa shifts for the ligands and titratable side chains of D-alanine:D-alanine ligase of

201 Additionally, six other highly conserved and titratable side chains were also mutated.

202 the effects of pH, the protonation states of titratable side chains were sampled by running constant-

203 invariant residues in the protein that have titratable side chains.

204 The only titratable side-chain that appears to be suitably positi

205 he inactivation ball domain as a critical H+ titratable site mediating the pH effects on N-type inact

206 2) in the ball domain constitutes another H+ titratable site that mediates the pH effects in the more

207 by considering the protonation states of all titratable sites as well as the energy contributed at th

208 e binding data with respect to the number of titratable sites as well as the impact of each mutation

209 When individual titratable sites in a molecule interact with each other,

210 e photocycle is addressed by including as pH-titratable sites not only Glu204 and Glu194, residues ne

211 ile mutation of sites 1, 3, or 4 leave three titratable sites that are mostly filled with 3 Ca(2+) eq

212 n of site 2 leaves the protein with only two titratable sites, while mutation of sites 1, 3, or 4 lea

213 ned 11 5,5-dithiobis(2-nitrobenzoate) (DTNB)-titratable sulfhydryl (SH) groups.

214 otential of safer, more specific, focal, and titratable treatment, with far-reaching clinical applica

215 Introducing titratable water in molecular dynamics offers a means to

216 We also identified a titratable window within which in vitro cleavage rates a

217 late-FITC and FR-positive cells and was dose titratable with folate-FITC switch.

218 dependence that is reversible and externally titratable, yet highly targetable and less invasive than