ライフサイエンスコーパス: titration

1 on fraction receiving aggressive vasodilator titration.

2 ral titration matches that of the functional titration.

3 lorimetry, water vapor adsorption, and Boehm titration.

4 The values were confirmed by volumetric titration.

5 ariable, highlighting the importance of dose titration.

6 ated with poor tolerability and the need for titration.

7 measurements were confirmed by argentometric titration.

8 help to direct safer and more effective PEEP titration.

9 several anions were investigated by (1)H NMR titrations.

10 nd enthalpies (BDEN-H) via redox and acidity titrations.

11 a diffuse layer modeling of the GO acid/base titrations.

12 o sites directly from the NMR spectra of the titrations.

13 d inhibitor were assessed using NMR-detected titrations.

14 ociations emerge from PCA comparisons of the titrations.

15 unctional groups based on probe gas-particle titration; 2.

16 for its anion binding properties by (1)H NMR titrations, 2D NOESY experiments and computational studi

17 gy with a lung recruitment maneuver and PEEP titration according to the best respiratory-system compl

18 ine if lung recruitment associated with PEEP titration according to the best respiratory-system compl

19 we implement in a new software tool, TITAN (TITration ANalysis).

20 -week treatment periods, each with a 16-week titration and a 16-week maintenance period.

21 These advances could inform accurate drug titration and brain state monitoring during anaesthesia.

22 y variable-temperature NMR spectroscopy, NMR titration and diffusion experiments, IR spectroscopy, co

23 ng equilibria have been quantified using NMR titration and dilution experiments for seven systems fea

24 en the oligomers were investigated using NMR titration and dilution experiments in toluene.

25 Galvanostatic intermittent titration and electrochemical quartz crystal microbalanc

26 rface reduction, as unravelled from chemical titration and electron energy-loss spectroscopy.

27 NMR titration and Molecular Dynamics simulation identified t

28 oof of principle is demonstrated through the titration and monitoring of pH gradients in real time.

29 e utilizing positive end-expiratory pressure titration and recruitment maneuvers while measuring hemo

30 as illustrated for a biphasic, NMR-detected titration and the cardiac MRI movie.

31 NMR titration and theoretical calculation confirmed the bind

32 ics of mtSSB binding to ssDNA by equilibrium titrations and stopped-flow kinetic measurements.

33 ng ab initio simulations with thermochemical titrations and XAFS spectroscopy to understand the unusu

34 scuss the actual methods behind preparation, titration, and dosing strategies utilized.

35 in-ligand interactions by mass spectrometry, titration, and H/D exchange) to the regional level by in

36 be administered at therapeutic doses without titration, and has shown good tolerability in healthy in

37 d in solution by NMR spectroscopy and UV-vis titration, and in the solid state by X-ray crystallograp

38 was assayed by 2,6-dichlorophenolindophenol titration, and pathways were monitored by (14)C-radiolab

39 herapy with moderate-intensity statins, down-titration, and using a different statin may promote pers

40 ive sulfhydryl site-blocking, potentiometric titrations, and surface complexation modeling.

41 utomation compared with common but laborious titration approaches, and greatly improves screening eff

42 ped a single-molecule colocalization binding titration assay (smCoBRA) that can quantitatively charac

43 This study intends to demonstrate that acid titration at low pH is very well adapted to the monitori

44 Combined spectrophotometric-potentiometric titrations at biologically realistic GSH/Cu(I) ratios, e

45 l dose reduction of >/= 50% followed by dose titration based on tolerance.

46 terventions (including systematic medication titration by doctors, pharmacists, or patients; educatio

47 ensitivity approaches capture near-source O3 titration by fresh NO emissions, in particular subgrid p

48 new antihypertensive class, and separately, titration by the addition of a new class or increase in

49 a CD23/IgE-Fc complex and conduct isothermal titration calorimetric binding studies.

50 Isothermal titration calorimetric measurements also showed an entha

51 Here we report isothermal titration calorimetric studies of the effects of selecti

52 Isothermal titration calorimetry (ITC) analyses demonstrated that t

53 ding the Sm site of pre-snRNAs by isothermal titration calorimetry (ITC) and mutagenesis assays.

54 a were collected and analyzed via isothermal titration calorimetry (ITC) and surface plasmon resonanc

55 Previously, isothermal titration calorimetry (ITC) experiments performed in dif

56 st substrate, consistent with the isothermal titration calorimetry (ITC) experiments.

57 Isothermal titration calorimetry (ITC) is a powerful tool for acqui

58 Laser light scattering (LLS) and isothermal titration calorimetry (ITC) studies revealed that the ta

59 We have used NMR and isothermal titration calorimetry (ITC) to study the interactions of

60 Isothermal titration calorimetry (ITC) using a histone H4 peptide s

61 ic data is given with emphasis on isothermal titration calorimetry (ITC), a method still underreprese

62 Herein, batch sorption isotherms, isothermal titration calorimetry (ITC), and Cd K-edge EXAFS spectro

63 PheH using X-ray crystallography, isothermal titration calorimetry (ITC), and small-angle X-ray scatt

64 nce displacement assays (FID) and isothermal titration calorimetry (ITC), with binding preference to

65 , hGal-3C, and hGal-7 measured by isothermal titration calorimetry (ITC).

66 native or complex solution using isothermal titration calorimetry (ITC).

67 nding properties obtained through isothermal titration calorimetry (ITC).

68 luated by molecular modelling and isothermal titration calorimetry (ITC).

69 by surface plasmon resonance and isothermal titration calorimetry analyses.

70 analyze CMC values determined by isothermal titration calorimetry and confirm the conclusions with t

71 he aNT-d interaction, as shown by isothermal titration calorimetry and gel filtration of recombinant

72 Using NMR spectroscopy, isothermal titration calorimetry and molecular dynamics simulations

73 We have evaluated, through isothermal titration calorimetry and molecular-dynamics simulation,

74 Isothermal titration calorimetry and NMR indicate a 100 fold enhan

75 Here, we employ isothermal titration calorimetry and NMR spectroscopy to characteri

76 Here, using isothermal titration calorimetry and NMR spectroscopy, we report th

77 Using a combination of isothermal titration calorimetry and quantum and molecular dynamics

78 netic resonance spectroscopy, and isothermal titration calorimetry and to exhibit lethality in cells

79 n was further characterized using isothermal titration calorimetry and upconversion emission measurem

80 Isothermal titration calorimetry assays also revealed that recombin

81 lobally fit temperature-dependent isothermal titration calorimetry data for binding of 11 tryptophan

82 , and by comparing the results to isothermal titration calorimetry data.

83 sence of OligoG CF-5/20, however, isothermal titration calorimetry demonstrated a weak calcium-mediat

84 Isothermal titration calorimetry experiments revealed tight binding

85 Isothermal titration calorimetry experiments show that only LtnA1 b

86 We show through isothermal titration calorimetry experiments that dsRBD2 of TRBP bi

87 ting in isolation, as revealed by isothermal titration calorimetry experiments.

88 molecular dynamic simulations and isothermal titration calorimetry experiments.

89 troscopies, electrochemistry, and isothermal titration calorimetry experiments.

90 Isothermal titration calorimetry has been used to investigate both

91 Isothermal titration calorimetry has the potential to directly quan

92 with investigation of binding by isothermal titration calorimetry illustrated significant difference

93 Isothermal titration calorimetry indicated a stoichiometry of two o

94 Isothermal titration calorimetry measurements and mutagenesis analy

95 Further, solution (19)F NMR and isothermal titration calorimetry measurements suggest interactions

96 Isothermal titration calorimetry performed at cyanobacterial cytoso

97 Isothermal titration calorimetry results revealed that the gating b

98 Furthermore, isothermal titration calorimetry revealed that the CBM48 domain of

99 Isothermal titration calorimetry showed a direct interaction betwee

100 of the AtIPMDH2 K232M mutant and isothermal titration calorimetry supports a key role of Lys-232 in

101 Following our previous observation by titration calorimetry that the ETS member PU.1 dimerizes

102 Here, we use isothermal titration calorimetry to demonstrate that UHMK1 phosphor

103 We further used isothermal titration calorimetry to show that ligand binding in rho

104 Isothermal titration calorimetry using recombinant full-length Plas

105 Nano isothermal titration calorimetry was applied to determine thermodyn

106 Isothermal titration calorimetry was applied to study the binding o

107 y the Ca(2+) affinity measured by isothermal titration calorimetry was only significantly affected by

108 ary complexes by a combination of isothermal titration calorimetry, (1)H, NOESY, and ROESY NMR, and i

109 graphy, computer simulations, and isothermal titration calorimetry, a screening of ganglioside analog

110 ides to CXCL5 using solution NMR, isothermal titration calorimetry, and molecular dynamics simulation

111 mbination of UV-vis spectroscopy, isothermal titration calorimetry, and multidimensional NMR reveals

112 lts from fluorescence anisotropy, isothermal titration calorimetry, and NMR titrations indicated that

113 r YMU1 (1a) by molecular docking, isothermal titration calorimetry, and photoaffinity labeling.

114 istry, fluorescence polarization, isothermal titration calorimetry, and quartz crystal microbalance)

115 coli together with the results of isothermal titration calorimetry, and radio-ligand uptake and fluor

116 Here, using CD spectroscopy, isothermal titration calorimetry, and small-angle X-ray scattering,

117 ere, using X-ray crystallography, isothermal titration calorimetry, confocal fluorescence microscopy,

118 ding to the Syt7 C2 domains using isothermal titration calorimetry, did not reveal major differences

119 Solid state NMR, isothermal titration calorimetry, electrophysiology, antiviral assa

120 , NMR, surface plasmon resonance, isothermal titration calorimetry, fluorescence, and UV-visible spec

121 indicator displacement assay and isothermal titration calorimetry, it was confirmed that fructose do

122 Using isothermal titration calorimetry, mass spectrometry, and differenti

123 ned by surface plasmon resonance, isothermal titration calorimetry, microscale thermophoresis and bio

124 ction was further investigated by isothermal titration calorimetry, NMR spectroscopy, and X-ray cryst

125 s using phase solubility studies, Isothermal Titration Calorimetry, Nuclear Magnetic Resonance spectr

126 ding affinities were studied with isothermal titration calorimetry, of which seven compounds had bind

127 optosis, we examined FPV039 using isothermal titration calorimetry, small-angle X-ray scattering, and

128 , and structural properties using isothermal titration calorimetry, surface plasmon resonance, nuclea

129 Using isothermal titration calorimetry, we determined the dissociation co

130 Using isothermal titration calorimetry, we found that Munc18c, like Munc1

131 Using isothermal titration calorimetry, we show that mJHBP specifically b

132 binding was further confirmed by isothermal titration calorimetry.

133 Ap) with both Hscen2 and Crcen by isothermal titration calorimetry.

134 electro-mobility shift assay and isothermal titration calorimetry.

135 h the stable 10 nm Kd measured by isothermal titration calorimetry.

136 h biochemical/cellular assays and isothermal titration calorimetry.

137 r interactions were determined by isothermal titration calorimetry.

138 ects in antibody binding by using isothermal titration calorimetry.

139 he heat changes were monitored by isothermal titration calorimetry.

140 as observed from ellipsometry and isothermal titration calorimetry.

141 gh-resolution crystallography and isothermal titration calorimetry.

142 forms of cobalamin in vitro using isothermal titration calorimetry.

143 tical to the value measured using isothermal titration calorimetry.

144 complex of 2 mum determined with isothermal titration calorimetry.

145 um exchange mass spectrometry and isothermal titration calorimetry.

146 With the current platform, four titrations can be obtained per minute (based on approxim

147 m (1)H NMR and UV-vis spectroscopies and ITC titrations carried out in CD2Cl2/CD3OD (9/1, v/v) or dic

148 Our combined titration, circular dichroism and dynamic light scatteri

149 NMR titration combined with in vitro and in vivo protein-pro

150 amino acid position 623 (E623Q) displayed a titration curve shifted to the left relative to wild typ

151 on the analysis of residual distribution in titration data fitting.

152 (1)H NMR titration data show that preorganization of the calix[5]

153 Water contact angle titrations demonstrate interfacial pKa shifts for the li

154 Our chemical potential titrations describe the thermodynamic linkage for bindin

155 Based on structural models, NMR titrations, DNA-binding studies, site-directed mutagenes

156 Serum titration established the superiority of FcMonoIgG for m

157 The titration experiment is performed over the concentration

158 the limited information content of a single titration experiment.

159 NMR titration experiments and in vitro DNA binding assays al

160 These structural studies, together with titration experiments and molecular dynamics simulations

161 Titration experiments and variable temperature UV-Vis-NI

162 NMR titration experiments are a rich source of structural, m

163 Substrate titration experiments demonstrated the transition of the

164 euterated) protein concentration, WaterLOGSY titration experiments give access to ligand binding mode

165 s in solution have been determined by UV-vis titration experiments in CH2Cl2 at room temperature.

166 ion of isotherms from different calorimetric titration experiments into a global analysis, statistica

167 Titration experiments showed that CXCR6 and CCR5 were mo

168 Titration experiments typically take 1-2.5 h each, and g

169 The selected gases for the titration experiments were: N(CH3)3 for the identificati

170 tidines in these domains are determined from titration experiments, and proton-exchange rates are mea

171 HRMS analysis, (1)H NMR titration experiments, and TD-DFT calculations were perf

172 metry, theoretical calculation, and fluoride titration experiments, providing detailed understanding

173 a from the Randomized Evaluation of Sedation Titration for Respiratory Failure clinical trial, a pedi

174 a from the Randomized Evaluation of Sedation Titration for Respiratory Failure clinical trial.

175 ness test (Randomized Evaluation of Sedation Titration for Respiratory Failure extubation readiness t

176 Sixty-one Randomized Evaluation of Sedation Titration for Respiratory Failure patients (5%) with mod

177 anaged per Randomized Evaluation of Sedation Titration for Respiratory Failure protocol, usual care e

178 al care or Randomized Evaluation of Sedation Titration for Respiratory Failure protocol.

179 anaged per Randomized Evaluation of Sedation Titration for Respiratory Failure protocol.

180 The Randomized Evaluation of Sedation Titration for Respiratory Failure study tested the effec

181 sedation (Randomized Evaluation of Sedation Titration for Respiratory Failure).

182 ent or a healthy habit assessment, auto-CPAP titration (for CPAP indication), health-related quality-

183 , with Km decreasing from 3.0 to 0.6 mm upon titration from 0 to 0.3 m Na(+) In the presence of 5 mm

184 ection at this wavelength based on gas phase titration (GPT) measurements.

185 For the pharmacokinetic-titration group versus placebo group at 20 weeks, least

186 guided by pharmacokinetics (pharmacokinetic-titration group), or placebo for 20 weeks.

187 p and 318 (129) ng/mL in the pharmacokinetic-titration group.

188 No single method of PEEP titration has been shown to improve clinical outcomes co

189 In this work, potentiometric titrations have been employed in combination with electr

190 UV/vis absorption titrations have been used to investigate the formation o

191 lts, as confirmed by (1) H NMR spectroscopic titrations, ICP-MS, single-crystal structural analyses,

192 Virus titration, immunofluorescence and confocal laser scannin

193 ne use of lung recruitment maneuver and PEEP titration in these patients.

194 High-throughput UV-vis titrations in combination with chemical double-mutant cy

195 tures the binding isotherm from NMR-detected titrations in fast, slow, and even intermediate and mixe

196 End-expiratory pressure titration increased end-expiratory lung volumes (Delta11

197 y, isothermal titration calorimetry, and NMR titrations indicated that covalent modifications to a ca

198 One method for PEEP titration is a PEEP/FiO2 table that prioritizes support

199 blation, but the thermal feedback for energy titration is absent.

200 Here, potentiometric titration is demonstrated as a method for quantifying th

201 explored by UV-Vis, LC-MS, FIR, Fluorescence titration, Job's plot method and theoretical approaches.

202 hich react with iodine, causing Karl Fischer titration (KFT) to give inaccurate, typically higher, re

203 the kinetic parameters of Karl Fischer water titration (KFT).

204 U was carried out by isothermal calorimetric titration, liquid-liquid extraction, (31)P NMR and IR sp

205 The conclusions drawn from potentiometric titrations, low-temperature mass spectrometry, temperatu

206 The midpoint of the structural titration matches that of the functional titration.

207 As a method, anoxic dithionite titrations may further allow additional insight into the

208 A pH titration method enhanced this polypeptide's solubility

209 n is an internally referenced Raman-based pH titration method that enables reliable quantification of

210 atter studies required a highly accurate NMR titration method that we developed to measure the additi

211 Using this Raman titration method, we determined for the first time the f

212 f 2.5 x 10(5) m(-1) obtained from isothermal titration microcalorimetry.

213 Dose titration mitigated symptomatic bradycardic events.

214 6 [95% confidence interval, 1.10-1.23]), and titration [odds ratio, 1.13 [95% confidence interval, 1.

215 The absorbance titration of 1 with CN(-) revealed a new band at 540 nm

216 chloride current (ICl ) that is described by titration of a protonatable site with pK = 7.3.

217 We show that titration of an interfering strain into a signaling netw

218 Timely initiation and subsequent titration of antihypertensive medications to achieve ind

219 Titration of aspartate, a competitive inhibitor of Ans,

220 The titration of bromide into a [Ru(deeb)(bpz)2](2+) (Ru(2+)

221 e were randomized to 1) blood pressure care: titration of chest compression depth to a systolic blood

222 ve regulation of H-NS, or of GadY, likely by titration of CsrA.

223 tability can at least partly be explained by titration of DnaB by TrfA1.

224 Individual titration of dose and frequency of daily injections with

225 For this, we proposed the model of titration of double protein (TDP) and its relevant lever

226 Titration of indole with sodium hydroxide or ammonium hy

227 permit sensitive, large-scale screening and titration of infectious virus in experimental and clinic

228 cannot be measured because the experimental titration of inputs and simultaneous readout of outputs

229 The titration of iodide into acetonitrile solutions of BiI3

230 h are believed to be linked to the staggered titration of key acidic residues.

231 Thus, our results reveal that careful titration of laser irradiation conditions allows inducti

232 f the calculated blood volume and subsequent titration of mean arterial blood pressure approximately

233 moval of 30% of the blood volume, subsequent titration of mean arterial pressure at 35 mm Hg), anesth

234 Titration of MR antagonist therapy to raise renin might

235 R, ddPCR-Tail) with standard methods for the titration of NGS libraries.

236 of functional neovasculature requires close titration of NO-Tie2 signalling and localized VEGF induc

237 ve was to determine whether SBP reduction or titration of oral neurohormonal antagonists during acute

238 thesized that lung recruitment maneuvers and titration of positive end-expiratory pressure were both

239 with published guidelines, with emphasis on titration of proven neurohormonal therapies for HF.

240 bration could therefore also be used for the titration of respiratory rate on the PetCO2 for a wider

241 Left unchecked, this causes titration of RNA polymerase and a global downshift in ho

242 , and fluorescence analyses, that reversible titration of the excess positive charges of the reflecti

243 The method is demonstrated by in vivo titration of the photorelease of an anticancer prodrug.

244 However, co-expression as well as regulated titration of the putative Wag31 target demonstrated that

245 Over a 78-week study, using dose titration of the rAAV vectors, we showed that G6pt-/- mi

246 evealed a possible method for potentiometric titration of the redox indicator.

247 tilation in terms of PCO2 can be achieved by titration of the respiratory rate and/or tidal volume.

248 stent with the results of the potentiometric titration of the triprotic acid (1H3)(2+).

249 alysis revealed chemical perturbations after titration of USP7-NTD with vIRF1 (44)SPGEGPSGTG(53) pept

250 duced ejection fraction underwent aggressive titration of vasoactive HF therapies with assessment of

251 enation reinforces the need for personalized titration of ventilation settings.

252 pled MRI-based E-field models with amplitude titrations of motor threshold (MT) and seizure threshold

253 and positive end-expiratory pressure (PEEP) titration on clinical outcomes in patients with acute re

254 demic adverse event, followed by statin down-titration or discontinuation, or switching between >/=3

255 ies, but its quantification with Karl Fisher titration or thermal gravimetric analysis is problematic

256 -week treatment periods, each with a 16-week titration period and a 16-week maintenance period.

257 rity at 12 weeks of treatment (including the titration period), which were determined using the 10-it

258 After an initial titration period, the dose was adjusted to attain the pr

259 with haloperidol in the initial haloperidol titration phase.

260 Nuclear magnetic resonance (NMR) titrations, potentiometric sandwich membrane experiments

261 pon the binding of BPTES or CB-839, yielding titration profiles that make it possible to measure the

262 aspects of performance: accuracy, precision, titration response, number of complete features, limit o

263 Rocuronium titration resulted in significant declines of Vt (mean +

264 Comparisons with existing titration results from experiments yield excellent agree

265 ispersion experiments and NMR chemical shift titrations reveal diminished enzyme flexibility and a re

266 Biophysical titrations reveal that the 5'-AUAGC-3' bulge undergoes a

267 An accelerated titration schedule was applied until moderate or dose-li

268 A series of photophysical titrations show this Eu(III) chelate behaves as an "on-o

269 internal reference peak as a function of the titration solution's pH.

270 ted at each positive end-expiratory pressure-titration step, and whole-lung CT taken every second ste

271 decremental positive end-expiratory pressure titration (steps of 2 cm H2O starting from >/= 26 cm H2O

272 Some PEEP titration strategies attempt to weigh beneficial effects

273 Titration studies using recombinant LEP and siRNA knockd

274 sorption spectroscopy and Zn(II) competition titrations support the formation of a Zn(II)-His6 motif.

275 correlation analysis, and the (1)H NMR/DOSY titration technique is applied to obtain their binding c

276 -ray diffraction, galvanostatic intermittent titration technique, and cyclic voltammetry at varied sc

277 MR/diffusion-ordered NMR spectroscopy (DOSY) titration technique.

278 roup demonstrated with UV-visible difference titrations that the Kd value is in the low nanomolar ran

279 n we describe a novel NMR methodology (LOGSY titration) that allows the determination of binding mode

280 e dissociation constants (KD) through ligand titration, the results were found to be strongly depende

281 PL titrations, thermochemical cycles, and kinetic analysis

282 n = 279; no maximum dose), with twice-weekly titration to a glucose target of 72 to 90 mg/dL.

283 d surface-selective and time-dependent redox titrations to directly measure the surface OER kinetics

284 -A2 were used, allowing MART1 or WT1 peptide titrations to easily assess the impact of Ag density.

285 nd-observe and complimentary (15)N,(1)H-HSQC titrations to monitor interactions from the protein's pe

286 However, using liposome titrations under Ca(2+) saturating conditions, we show t

287 re treated with 1.0 mg/kg luspatercept; dose titration up to 1.75 mg/kg was allowed, and patients cou

288 Fluorescence titrations using genomic DNA extracted from various cell

289 cale egg production, (iv) automated compound titration, (v) dispensing of embryos into microtiter pla

290 age factor k = 2) based on nitrogen monoxide titration values and a value of 11.22 x 10(-18) cm(2) mo

291 rage factor k = 2) based on nitrogen dioxide titration values.

292 ortion of days covered of at least 80%, down-titration was defined by switching to a low/moderate-int

293 maneuver followed by end-expiratory pressure titration was found to significantly improve lung volume

294 Yet, when the same titration was repeated in pure methanol, a solvent in wh

295 , isotopic labeling, and a surface carbonate titration, we show that the presence of residual lithium

296 l antioxidant capacity, based on coulometric titration with electrogenerated bromine (r=0.8957 at n=5

297 Spectral titrations with cholesterol, in the presence of EFV or l

298 YP121A1 was determined by UV-visible optical titrations with KD values of 2.63, 35.6, and 290 muM, re

299 Fluorescence titrations with the 27-mer duplex containing the CC mism

300 Calorimetric and fluorescence titrations yielded binding affinity in the low micromola