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1 edge by using multiple sequencing approaches to generate 110 ZIKV genomes from clinical and mosquito
2 14-step, one-pot synthesis that can be used to generate (13)C- and (15)N-labeled dihydrofolates (H2F
4 These new findings provide a convenient way to generate 3,4-disubtituted chroman-2-ones and beta,bet
5 nvelope phase-stable signal and idler pulses to generate 33 muJ, 0.88-cycle, multi-gigawatt pulses ce
6 ocused ion beam-scanning electron microscopy to generate 3D reconstructions of intracellular organell
7 e molecular arrays packed into offset layers to generate a "brick-wall" motif with strong 2D interlay
9 [4Fe-4S] cluster and is reductively cleaved to generate a 5'-deoxyadenosyl radical, which initiates
12 phosphorylates KNL1 on conserved MELT motifs to generate a binding site for the Bub3-Bub1 complex [4-
13 ilding block, thereby offering the potential to generate a broad range of fluorinated small-molecule
15 CrPV-1A modulates several cellular processes to generate a cellular environment that promotes viral t
16 n factor can act through multiple mechanisms to generate a common behavioral output, and that Lef1 re
18 with adenine residues on the opposing strand to generate a complex lesion consisting of an interstran
19 we integrate multiple transcript collections to generate a comprehensive atlas of 27,919 human lncRNA
20 sures robustness of the microbiota's ability to generate a consistent immunomodulatory impact, servin
21 ng computational and experimental approaches to generate a deeper understanding of the biofilm format
26 ted) and treated effluent (n = 233) was used to generate a fecal library to perform community-based M
27 head-direction network is generally assumed to generate a fixed representation of perceived directio
34 t of rapamycin (mTOR) signaling is necessary to generate a mechanically induced increase in skeletal
36 ein modelling and (13)C-direct detection NMR to generate a model for soluble monomeric medin comprisi
39 ice) were outbred to a C3H/C57bl6 background to generate a mouse model for Alagille syndrome (Jag1(Nd
41 enhancing motifs into a short polyQ sequence to generate a mutant, here called "betaHP," that exhibit
42 the GSDMD-related protein DFNA5 after Asp270 to generate a necrotic DFNA5-N fragment that targets the
43 pproach utilizing the yeast one-hybrid assay to generate a network of protein-DNA interactions that p
45 contact prediction methods PSICOV and DNcon to generate a new score as feature for quality assessmen
47 regional fish biomass data from The Bahamas to generate a novel platform-scale production model that
48 SPR-Cas systems exploit the phage life cycle to generate a pattern of spacer acquisition that ensures
49 binds to Pd(II) followed by styrene binding to generate a Pd-alkylperoxide that liberates acetopheno
50 a key mediator of the UPR, cleaves Xbp1 mRNA to generate a potent transcription factor adaptive towar
51 ditioning reprograms macrophages and tubules to generate a protective environment, in which tissue he
53 ition reaction via a 1D coordination polymer to generate a pyridyl-functionalized cyclobutane stereos
54 e, as well as encapsulation of multiple dyes to generate a ratiometric signal with varying spectra.
56 incipal Component Analysis (PCA) and Isomap, to generate a reduced representation of the data while p
57 dimensional cell wall analysis was performed to generate a reference profile for leaf and stem biomas
58 uencing, and BioNano optical genome mapping, to generate a reference-quality genome sequence for Ae.
59 g, representing an 'evolutionary adaptation' to generate a reliable neural estimate of the variable w
60 ss different harvests, organs and genotypes, to generate a representative reference profile for misca
61 of S. cerevisiae whole cell lysate was used to generate a retention dataset of approximately 30000 p
62 r the study of human development and a means to generate a scalable source of cells for therapeutic a
63 indicates that Affimer-MAb CLIA can be used to generate a sensitive immunodiagnostic kit, which offe
64 loy diverse CRISPR/Cas9 genome editing tools to generate a series of targeted lesions within the endo
65 a knock-out/knock-in strategy in Drosophila to generate a strain with hTau inserted into the endogen
66 Copper-mediated coupling between alkynes to generate a structurally rigid, linear 1,3-diyne linka
69 by addition of ERGIC-53-containing membranes to generate a transport intermediate for the export of b
70 ter is particularly cold and dense, it sinks to generate a tropic-ward flow on the ocean floor of the
71 tebrate adaptive immunity, has the potential to generate a vast diversity of antigen receptor sequenc
72 d gamma-secretase cleavage of the mutant C99 to generate Abeta, leading to recessively inherited AD.
73 small number of peripherally placed sources to generate acoustic vortex fields and stably levitate a
74 urnover frequency of 440 s(-1), and continue to generate additional initiators throughout the auto-ox
77 em cells (HSCs) have been functionally shown to generate all mature cell types for the lifetime of th
78 h are rapidly intercepted by amine reactants to generate amides/peptides and o-mercaptobenzamides.
81 e 50% of the structure, making it difficult to generate an accurate homology model of the protein.
86 nization [Minimal Chromatin Model (MiChroM)] to generate an ensemble of 3D chromosome conformations a
87 hat involves intermolecular hydride transfer to generate an imine intermediate that is subsequently c
88 pharmacokinetic (PK) characteristics are key to generate an in vivo response, specifically whether sy
89 pontaneous activity and odor responses so as to generate an increased signal-to-noise ratio at the ou
91 f interest was placed on the suggestive area to generate an SUVmax; a similar region of interest was
92 lyzed IE samples by tandem mass spectrometry to generate an unbiased, shotgun-proteomics view of prot
93 nt stem cells (hPSCs) and hold the potential to generate an unlimited supply of beta cells for diabet
94 orter pluripotent stem cells (PSCs) in vitro to generate and isolate human primordial lung progenitor
95 ous PTC-inducing non-sense mutations is able to generate and present epitopes downstream of the termi
96 ectromagnetic devices and active transistors to generate and process gigahertz (GHz) signals, provide
98 With MASC, a theoretical footing now exists to generate and test computationally explicit prediction
99 tertiary organolithium species are difficult to generate, and the alpha-S-substituted analogues are c
100 ion can be translated to a human cell source to generate anisotropic human neocartilage with enhanced
103 We did a systematic review and meta-analysis to generate average estimates of kOCV efficacy and direc
105 uzuki coupling of acetals with boronic acids to generate benzylic ethers, a reaction that failed with
106 Our evaluation shows that Seqping was able to generate better gene predictions compared to three HM
107 rting the use of network analysis techniques to generate biologically meaningful partitions of brain
108 stimulation/expansion offers the possibility to generate BK-specific T cell lines for adoptive immuno
109 p and characterize a clinical-scale protocol to generate BK-specific T cell lines from viremic KTR.
110 his increased ability of oligomeric Delta123 to generate bNAbs correlates with occlusion of the non-n
111 rofiles suggest that commonly used protocols to generate bone marrow-derived cultured dendritic cells
113 ional framework provides the necessary tools to generate brain maps that integrate data from connecti
114 ion, and predominantly at major Glu(11) site to generate C89, resulting in truncated Abeta production
115 e 1 (BACE1) cleaves APP at minor Asp(1) site to generate C99 for amyloid beta protein (Abeta) product
116 E: Recent advances have improved our ability to generate cardiomyocytes from human induced pluripoten
117 otease cleaves the host protein procaspase 8 to generate Casp8p41, which can bind and activate Bak to
119 iption factor input, feedback and redundancy to generate cell type-specific levels of dve expression
121 etric cell division is the primary mechanism to generate cellular diversity, and it relies on the cor
124 n contact phase activation, cleaves chem163S to generate chem158K, which can be further processed to
127 model of huddling interactions is also shown to generate criticality when subjected to the same evolu
128 ovide a convenient means for individual labs to generate customized CRISPR libraries of variable size
131 types of defects and controllable strategies to generate defects in electrocatalysts are presented, a
132 this challenge, we used end-to-end annealing to generate defects that are directly observable using s
135 e 'developmentally programmed' in the thymus to generate discrete gammadelta T cell effector subsets
139 nd automated reasoning, with neural networks to generate embeddings of nodes that encode for related
140 A photodegradable material-based approach to generate endothelialized 3D vascular networks within
142 muscles, suggesting that dyW-/- muscles fail to generate enough muscle cells to sustain fetal myofibe
143 mutated distinguishing active-site residues to generate enzymes that had a common Zn(2+) bimetallo c
144 d data by prefecture and applied GBD methods to generate estimates of burden, and attributable burden
149 ion exchange and normal phase chromatography to generate fractions of saturated hydrocarbons, aromati
151 ability of phylogenomic datasets, strategies to generate genome-scale data from organisms involved in
153 DB2PQR and Adaptive Poisson-Boltzmann Solver to generate grid-based electrostatic potential files for
157 ped a lentiviral vector and cloning strategy to generate high-complexity pooled dual-knockout librari
158 with orthogonal poling directions, is shown to generate high-quality hyperentangled photon pairs via
160 and synthetic systems exploit self-assembly to generate highly intricate closed supramolecular archi
161 -deficient L. reuteri mutant that was unable to generate histamine did not suppress carcinogenesis, i
163 esent a method using molecular self-assembly to generate hydrogel-based 3D architectures that resembl
164 e H2O2-dependent oxidation of chloride anion to generate hypochlorous acid, a potent antimicrobial ag
165 ing and exploring high dimensional data sets to generate hypotheses and discovering novel insights.
166 The information thus gained can be used to generate hypothesis which can be experimentally valid
167 strain-matched H chain isotype are critical to generate ideal surrogate Abs for testing immuno-oncol
168 cells, the capacity of tonsil B-cell subsets to generate IgE(+) PCs and the class switching pathways
169 gen receptor-positive model T126, was chosen to generate in vivo mouse models containing orthotopic b
170 hy volunteers (n = 91) and used their tissue to generate induced pluripotent stem cells (iPSCs) and h
174 In addition, we used Zinc finger nucleases to generate isogenic SHANK3 knockout human embryonic ste
175 , can be sufficiently enhanced with feedback to generate large interactions between single photons.
176 pproach using basic developmental principles to generate large numbers of bonafide hair cells in vitr
177 ed cell therapies since they can be expanded to generate large numbers of cells and differentiated in
178 e antimalarial screening data, was optimized to generate lead compounds that possess potent antimalar
182 platforms suffer from low potency, inability to generate long-term immune memory and decreased activi
183 ng engineered biomaterials has the potential to generate manufacturing processes that produce standar
184 ines collected from healthy individuals, and to generate mathematical models that predict cellular se
185 ntrast to "self-powered" (bio)sensors aiming to generate maximum energy output, we propose the system
186 significant differences in GQL-15 scores and to generate mean and mean differences between cases and
187 llylic iodides couple with alpha-diazoesters to generate metal-coordinated iodonium ylides, which und
188 he Lepr gene were crossed with AgRP-Cre mice to generate mice with AgRP neuron-specific rescue of Lep
189 re we use stimulated Raman adiabatic passage to generate microwave photon Fock states in a supercondu
190 we describe a simple and reproducible method to generate mMSCs by utilizing hypoxia and basic fibrobl
192 ster translation of a given mRNA is unlikely to generate more of the encoded protein, particularly at
193 iazoalkane formation and [3+2] cycloaddition to generate more than 30 azoles in a telescoped fashion.
194 Alpl-null mice die before weaning, we aimed to generate mouse models of late-onset HPP with extended
197 ata demonstrate that CRISPR-Cas9 can be used to generate multiple subtypes of soft tissue sarcomas in
198 ase (UNG) and mismatch repair (MMR) pathways to generate mutations at G-C and A-T base pairs, respect
199 volutionary model with a metabolic trade-off to generate networks of mutational paths in microbial co
202 4 function in yeast cells leads to a failure to generate new propagons, the molecular entities necess
203 to decipher disease causing MMP networks and to generate new treatment options through targeted polyp
204 athogens have developed versatile strategies to generate niches inside the eukaryotic cells that allo
206 All compounds preserve their capability to generate NO under visible light and possess overall s
207 ed to integrate inputs from multiple sources to generate normal neuronal functions.SIGNIFICANCE STATE
209 , we report that (S)P(MeAN) can be activated to generate O(MeAN) and perform the oxidation of externa
210 [(H-PNP)RuN](+) (H-PNP = HN(CH2CH2P(t)Bu2)2) to generate octahedral ammine complexes that are kappa(2
211 a linear-response TDDFT calculation is used to generate orbitals perturbed by the excitonic state, a
212 Reversibility in bond formation is essential to generate ordered networks, as it allows the error-che
213 fied excitatory interneurons were sufficient to generate oscillatory bursts with properties similar t
216 -one as "masked" heterocyclic hydroxylamines to generate Paal-Knorr intermediates of the Trofimov pyr
220 ed by sensory input into functional circuits to generate persistent neural activity, which interacts
221 bones and ultimately gross limb morphology, to generate phenotypic variation during prenatal develop
222 Cs into NBL by enforced expression of N-Myc, to generate phenotypically and molecularly accurate tumo
223 al properties and in particular, the ability to generate plateau potentials, similar to that of STN n
224 ine) and inserts multiple ethylene (E) units to generate polyethylene that contains -CH2 F chain ends
227 come this, entanglement swapping may be used to generate remote quantum correlations between particle
228 se data show the versatility of NB-LRR genes to generate resistance to unrelated pathogens with compl
229 blast-derived induced pluripotent stem cells to generate retinal pigment epithelium (RPE) from an ind
230 many subunit vaccines under development fail to generate robust LLPC responses, and therefore a varie
232 nzymatically catalysed reactions is employed to generate secondary metabolites by iteratively appendi
233 regions could combine with local adaptation to generate sharper declines well away from trailing edg
234 ents with IBD, soluble fiber is the best way to generate short-chain fatty acids such as butyrate, wh
235 Two-dimensional (2D) separations are able to generate significantly higher peak capacities than th
236 e demonstrate the use of genetic programming to generate simple models of dielectric breakdown based
237 a stochastic to a deterministic process, and to generate single-crystal joints with their c-axis orie
239 laced on stereochemical analysis and methods to generate sp(3) -hybridized carbenoids in stereodefine
240 ssion of plateau potentials in motor neurons to generate spasms, and inhibitory interneurons to curta
241 ychaete worm jaw, we report a novel approach to generate stiffness gradients in polymeric materials v
242 lgorithm was used to find the optimum matrix to generate straight trajectories of the end-effector in
243 cells (TSCs) in a three-dimensional scaffold to generate structures whose morphogenesis is markedly s
244 s are efficiently trapped with electrophiles to generate substituted isocyanides incorporating contig
245 These methods thus require months of culture to generate sufficient cell numbers for feasibility stud
246 demonstrated that these transducers are able to generate sufficient pressure to induce cavitation of
248 integrate qualitative pathogenic information to generate tailored protective adaptive immune response
249 using sequencing (SiMSen-seq) was developed to generate targeted barcoded libraries with minimal DNA
250 initiate at subtelomeric CTCF-binding sites to generate telomere repeat-encoding RNA (TERRA), but th
252 in stimulates endothelial NO synthase (eNOS) to generate the antiatherosclerotic signaling radical NO
254 Ti-catalyzed asymmetric Diels-Alder reaction to generate the cis-decalin skeleton, and a late-stage l
255 twork-free, meaning that it does not require to generate the complete reaction network implied by rul
259 ating agents via C(sp(3) )-H bond activation to generate the desired amidated products is reported.
261 uent, or amino acid residues was carried out to generate the desired products in 47-88% yield and 90:
262 synthesis includes a newly developed method to generate the dihydrobenzodioxolone core by palladium-
264 ls, and endothelial cells (in a 2:1:1 ratio) to generate the hCMP, which began generating calcium tra
266 vances in nanomaterials are becoming pivotal to generate the high-resolution, high-contrast images ne
268 scriptome of male and female Syrian hamsters to generate the necessary resources to continue our rese
270 ction products reveals that AmISY reduces C7 to generate the opposite stereoconfiguration in comparis
271 12-lipoxygenase (12-LOX), which is required to generate the PMN chemoattractant hepoxilin A3 (HXA3)
273 rotein and require substantially less vector to generate the same immune responses as RD-Ad vectors.
274 ace receptors that couple to phospholipase C to generate the second messenger inositol trisphosphate
275 regardless of integration processes required to generate the shape percept.SIGNIFICANCE STATEMENT Vis
279 CNE1 associates with the alpha-subunit KCNQ1 to generate the slowly activating, voltage-dependent pot
280 smaller in a control group using a key press to generate the sounds instead of learning to play the m
281 ational change or intermolecular association to generate the structures that are surface active.
282 ral dimensions of J-RGC dendritic patterning to generate the substrate for specific patterns of synap
284 considerable attention; however, strategies to generate them in artificial systems that would allow
286 pathway commonly employed by living systems to generate these large classes of structurally related
287 her with single-particle electron microscopy to generate three-dimensional models of MCM complexes.
289 provides a highly efficient and simple means to generate transgenic cotton plants, but also helps add
290 th aryl groups of the diaryliodonium reagent to generate triarylamines starting from simple anilines,
291 on of Env trimers as well as other platforms to generate trimers that now span multiple subtypes.
292 ing cancer cells, which are otherwise unable to generate tumors after independently seeding the skele
294 roduce two triplet excitons that can be used to generate two electron-hole pairs, leading to a predic
295 es in each of the disorders, which were used to generate two unique, highly specific and sensitive DN
296 antages of this approach include the ability to generate two well-controlled monodisperse microdrople
297 , we present a novel and convenient approach to generate ultra-low molecular weight pectin with high
298 tence of cryptic gene and pathway functions, to generate variation and adapt to selective pressures.
300 feasibility of using primary patient samples to generate zebrafish patient-derived xenografts (zPDX)
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