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1 selumetinib and trametinib (albeit with poor tolerability).
2 nal symptoms as well as treatment safety and tolerability.
3 The primary endpoint was safety and tolerability.
4 ageable safety profile, including acceptable tolerability.
5 d an outcome system integrating efficacy and tolerability.
6 ctives were evaluation of tumor response and tolerability.
7 ) and there were no differences in safety or tolerability.
8 of the risk for allograft rejection and poor tolerability.
9 The primary objectives were safety and tolerability.
10 eriatric patients, with excellent safety and tolerability.
11 eeks of treatment were cured, with excellent tolerability.
12 cts on disease-related symptoms, safety, and tolerability.
13 The primary endpoint was safety and tolerability.
14 profiles for optimal antitumor activity and tolerability.
15 with the reversal of anhedonia and improved tolerability.
16 in tests because negative responses indicate tolerability.
17 ) values were 33.21% for efficacy and 0% for tolerability.
18 The primary outcomes were safety and tolerability.
19 se for future studies and to evaluate safety/tolerability.
20 e primary objective was to assess safety and tolerability.
21 cancer therapeutics with improved safety and tolerability.
22 ported and because negative results indicate tolerability.
23 r-boosted darunavir once daily, with similar tolerability.
24 ients on the basis of dyskinesia control and tolerability.
25 e primary objective was to assess safety and tolerability.
26 se and network meta-analyses of efficacy and tolerability.
27 rdive dyskinesia, with favourable safety and tolerability.
28 mantle cell lymphoma (MCL), with manageable tolerability.
29 dence, an optimal dosing regimen, and better tolerability.
30 and has an established record of safety and tolerability.
31 ontrol strategies with improved efficacy and tolerability.
32 of the risk for allograft rejection and poor tolerability.
33 and also suggest good to moderate treatment tolerability.
34 inst usual treatment options and longer term tolerability.
35 ferentiated by very high efficacy but poorer tolerability.
36 ere comparable in terms of high efficacy and tolerability.
38 robust anti-tumour activity with acceptable tolerability across a broad range of neuroendocrine tumo
39 en-ended end-of-study feedback at 6 mo), and tolerability (acute mental health services referral).
40 rt of limited size, brexanolone demonstrated tolerability among SRSE patients of heterogeneous etiolo
41 otype 4 infection have low efficacy and poor tolerability, an unmet need exists for effective all-ora
44 cannabidiol were included in the safety and tolerability analysis, and 137 (64%) patients were inclu
45 d not induce systemic effects, implying good tolerability and a favorable safety profile for RNAdjuva
50 nt phase 1b trial was to evaluate the safety/tolerability and CP-blocking potential of 4 weekly doses
54 y study for prioritizing compounds with good tolerability and efficacy that ultimately led to the sel
55 esults can be crossed with information about tolerability and functioning to yield an outcome system
59 ce a week was chosen based on better patient tolerability and no demonstrable improvement in radiolog
60 ant tuberculosis; and (3) evaluating safety, tolerability and pharmacokinetics of tuberculosis drugs
65 lated to a maximum dose of 200 mg/d based on tolerability and response) or matching placebo (n = 99).
66 roperties and efficacy, and a very desirable tolerability and safety profile, 14f (BMS-986142) was ad
69 , adverse effects of statins may limit their tolerability and therefore the ability to attain effecti
71 arable pharmacokinetics, improved safety and tolerability, and a more favorable toxicity profile when
72 nstration project that evaluated the safety, tolerability, and acceptability of TDF/FTC and patterns
74 D and our recent experience with the safety, tolerability, and cerebrospinal fluid penetration of the
75 expected to improve their efficacy, safety, tolerability, and duration of effect in future studies.
77 oral DAA regimens show high rates of safety, tolerability, and efficacy for treatment of HCV genotype
79 an open-label trial to evaluate the safety, tolerability, and efficacy of ledipasvir and sofosbuvir
80 ouraged investigators to explore the safety, tolerability, and efficacy of mesenchymal stromal cell-b
85 clinical treatment remains unclear: safety, tolerability, and pharmacokinetic data for many tubercul
92 nstrate the feasibility, selective toxicity, tolerability, and potential efficacy of pharmacological
93 This phase 1/2 study assessed the safety, tolerability, and preliminary efficacy of the oral prote
97 d on a comparison of the antiviral activity, tolerability, and safety of the two intramuscular dosing
98 s mitochondrial energy; however, its safety, tolerability, and therapeutic effect on cardiac structur
100 sing clinical and laboratory parameters, and tolerability as rated by the Gastrointestinal Symptom Ra
103 ting plasma Lp(a) concentration, safety, and tolerability at day 30 in the single-ascending-dose phas
106 ycodone-naloxone are found to exhibit better tolerability characteristics in comparison with other op
112 m of action, clinical trial data, safety and tolerability concerns, and monitoring requirements.
113 amatically improved preclinical efficacy and tolerability data were generated for the pamoic acid lea
114 efficacy (change in depressive symptoms) and tolerability (discontinuations due to adverse events).
116 ical antipsychotic drugs (APDs), with better tolerability due to more selective dopamine (DA) recepto
119 Cohort expansion was based on safety and tolerability, FLT3 inhibition in correlative assays, and
123 l drugs have a high cure rate and favourable tolerability for patients with hepatitis C virus (HCV).
124 d maintain survival outcomes while improving tolerability for patients with HPV-positive oropharyngea
127 vidence-based therapies are often limited by tolerability, hypotension, electrolyte disturbances, and
128 Secondary end points included toxicity, tolerability, imaging response using volumetric magnetic
129 ation, scripted interaction), and safety and tolerability in a multicenter, randomized, double-blind,
130 birch pollen allergen, showed good clinical tolerability in a previous phase I/IIa clinical trial.
131 promising clinical efficacy with acceptable tolerability in chemotherapy-naive PDAC patients with pe
132 promising clinical efficacy with acceptable tolerability in chemotherapy-naive PDAC patients with pe
133 zumab has antitumour activity and acceptable tolerability in cisplatin-ineligible patients with uroth
135 phase I clinical trials to assess safety and tolerability in healthy human subjects prior to the init
136 doses without titration, and has shown good tolerability in healthy individuals in phase 1 studies.
137 has demonstrated high efficacy, safety, and tolerability in hepatitis C virus (HCV)-infected patient
140 has been shown to significantly enhance drug tolerability in patients as compared to the conventional
143 has durable clinical activity and favourable tolerability in patients with relapsed or refractory chr
147 tor that demonstrated favorable efficacy and tolerability in the treatment of tardive dyskinesia in p
151 aches have limitations, including pain, poor tolerability, lack of adherence, and inadequate delivery
152 L) amyloidosis were to determine the safety, tolerability, maximum tolerated dose (MTD), recommended
156 parallel design, we tested the efficacy and tolerability of 4-wk intranasal OXT treatment (24 Intern
159 is study was to evaluate the response to and tolerability of a single dose of (177)Lu-PSMA-617 in a l
160 ve of the study was to assess the safety and tolerability of a single intravitreous injection of AAV2
162 The PANORAMA study assessed the safety and tolerability of acetylcysteine combined with pirfenidone
163 determine the recommended dose, safety, and tolerability of ADI-PEG 20, cisplatin, and pemetrexed in
165 present proof-of-concept of the efficacy and tolerability of antiangiogenesis therapy in advanced cer
169 in SRSE patients to evaluate the safety and tolerability of brexanolone (USAN; formerly SAGE-547 Inj
171 ry objective was to establish the safety and tolerability of cannabidiol and the primary efficacy end
172 authors evaluated the efficacy, safety, and tolerability of cariprazine, an atypical antipsychotic c
173 We aimed to assess the efficacy, safety, and tolerability of ceftazidime-avibactam compared with best
174 ary endpoints of the studies were safety and tolerability of combining idelalisib with lenalidomide a
175 rly (PRIDE) study evaluated the efficacy and tolerability of continuation ECT plus medication compare
177 to evaluate the efficacy, safety, and local tolerability of diclofenac HPbetaCD administered as a lo
178 rall indicate efficacy, safety, and relative tolerability of diclofenac HPbetaCD used locally as a su
179 echanism of action as well as the safety and tolerability of drugs in pediatric patients, including c
180 andomised, phase 2 study showed activity and tolerability of eribulin in advanced or metastatic soft-
181 ne therapy trial to determine the safety and tolerability of escalated doses of an adeno-associated v
182 e of this study was to assess the safety and tolerability of evolocumab in a pooled safety analysis f
183 We aimed to assess the efficacy, safety, and tolerability of fixed doses of deutetrabenazine-a novel
184 e I clinical trial evaluating the safety and tolerability of human parthenogenetic stem cell derived
186 sought to evaluate the efficacy, safety, and tolerability of intradermally administered grass allerge
190 esults demonstrate the safety, efficacy, and tolerability of low-dose naltrexone, in conjunction with
192 port both the long-term clinical benefit and tolerability of maintenance olaparib in patients with BR
193 s for improved disease control and increased tolerability of medications, and also presents new safet
194 e authors assessed the efficacy, safety, and tolerability of MIN-101, a compound with affinities for
195 104 was designed to evaluate the safety and tolerability of multiple doses of VRC01 administered eit
197 y is to investigate the pharmacokinetics and tolerability of NSC23925b, a novel and potent P-glycopro
200 nd older, the clinical efficacy, safety, and tolerability of omalizumab have been demonstrated in sev
202 is study evaluates the efficacy, safety, and tolerability of regimens containing sofosbuvir (SOF) in
203 y objective is to investigate the safety and tolerability of repeat doses of GSK2330672, and explore
205 ndings suggest an improved effectiveness and tolerability of rituximab compared with fingolimod in st
206 Future studies should optimize efficacy and tolerability of salvage therapy by stratifying patients
209 TGF-beta1/3, demonstrating the efficacy and tolerability of selective TGF-beta ligand blockade for i
211 ort on the virological response, safety, and tolerability of SOF and SMV with or without RBV in compe
212 he effect of SSRI dosing on the efficacy and tolerability of SSRIs for major depressive disorder.
213 o assess the feasibility, acceptability, and tolerability of storytelling among bereaved surrogates i
214 ty with cephalosporins and aztreonam and the tolerability of such alternative beta-lactams, all subje
215 We investigated the efficacy, safety, and tolerability of switching to a single-tablet regimen con
216 med to investigate the efficacy, safety, and tolerability of switching to this regimen compared with
220 at the end of treatment were the safety and tolerability of the treatment regimen, analysed in the i
223 once daily), and to evaluate the safety and tolerability of these combination regimens in individual
224 basis of the PFS, overall response rate, and tolerability of these two antivascular therapies, furthe
231 In GATSBY, we examined the efficacy and tolerability of trastuzumab emtansine in patients previo
232 We aimed to assess the efficacy, safety, and tolerability of two unique antisense oligonucleotides de
233 availability, cost effectiveness and better tolerability of ultrasonography make it a modality of fi
234 further evaluated the efficacy, safety, and tolerability of valbenazine as a treatment for tardive d
238 el phase III trial, we evaluated the safety, tolerability, pharmacodynamics, and efficacy of lumacaft
239 RP2D) was determined on the basis of safety, tolerability, pharmacokinetics (PK), and by mRNA express
240 in healthy human subjects evaluated safety, tolerability, pharmacokinetics and sleep-promoting effec
242 m of this study was to assess the safety and tolerability, pharmacokinetics, and antiviral effect of
243 dose clinical study assessed the safety and tolerability, pharmacokinetics, and clinical efficacy of
245 s first-in-human study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of
246 tion study was conducted to evaluate safety, tolerability, pharmacokinetics, and pharmacodynamics of
247 This study aimed to characterize the safety, tolerability, pharmacokinetics, and pharmacodynamics of
248 We aimed to compare the efficacy, safety, tolerability, pharmacokinetics, and pharmacodynamics of
249 s of nusinersen showed acceptable safety and tolerability, pharmacology consistent with its intended
251 inumab regimens had an acceptable safety and tolerability profile but did not significantly reduce as
252 s long-term clinical benefit and a favorable tolerability profile compared with docetaxel in previous
253 tuzumab vedotin has an acceptable safety and tolerability profile in patients with NHL but not in tho
254 primates not only document the efficacy and tolerability profile of bifunctional MOP/NOP receptor ag
256 pirfenidone does not substantially alter the tolerability profile of pirfenidone, and is unlikely to
258 lus tremelimumab 1 mg/kg showed a manageable tolerability profile, with antitumour activity irrespect
264 tent preclincal efficacy as well as improved tolerability relative to current agents that target the
265 losis Trials Consortium study evaluating the tolerability, safety, and antimicrobial activity of rifa
266 ated the pharmacokinetics, pharmacodynamics, tolerability, safety, and efficacy of OM in patients wit
267 s no significant difference in the composite tolerability scores between the 2 groups (P = 0.06).
268 s for switching therapy include convenience, tolerability, simplification, anticipation of potential
269 r potency, defined chemical nature, and good tolerability, SNAs are attractive new modalities for dev
272 raging durable response rates, survival, and tolerability, supporting its therapeutic use in untreate
273 raging durable response rates, survival, and tolerability, supporting its therapeutic use in untreate
275 well tolerated with better gastrointestinal tolerability than dolutegravir, abacavir, and lamivudine
277 Secondary objectives included safety and tolerability, time to progression, progression-free surv
278 series of PPI-related DHR, followed up their tolerability to alternative anti-ulcer agents, and inves
279 potential risk of cross-hypersensitivity or tolerability to other PPI after their hypersensitivity e
282 ty in the corresponding phenotypes and least tolerability to variation: ABAT, KIAA2022, COL4A1, CACNA
284 ment in progression-free survival and better tolerability versus temsirolimus in patients with relaps
290 were no new or long-term safety concerns and tolerability was similar across groups (neoadjuvant and
291 To establish their relative efficacy and tolerability, we searched MEDLINE, PubMed, Embase, and C
296 imed to assess whether efficacy, safety, and tolerability were non-inferior in patients switched to a
297 tic as monotherapy but demonstrate favorable tolerability, which has prompted interest in combination
299 ertension (OHT), bimatoprost 0.01 % improved tolerability while retaining the intraocular pressure (I
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