ライフサイエンスコーパス: tolerable

1 es increasingly attractive (or at least more tolerable).

2 living with the disease more reasonable and tolerable.

3 ion consolidation was 1.3 mg/m(2) and proved tolerable.

4 mine whether STN-DBS in early PD is safe and tolerable.

5 lotteries undesirable, adolescents find them tolerable.

6 ive non-Hodgkin lymphoma, is efficacious and tolerable.

7 n 85% survival at 2 years and was clinically tolerable.

8 Vorinostat was safe and tolerable.

9 e third of patients by day 29 was considered tolerable.

10 t doses that are systemically active and yet tolerable.

11 The regimens were similarly tolerable.

12 sting that treatment to the modified CTV was tolerable.

13 duction chemotherapy regimen is feasible and tolerable.

14 Other acute and chronic side effects were tolerable.

15 e survival compared with dacarbazine and was tolerable.

16 d both regimens to be safe, deliverable, and tolerable.

17 The maximum dose of topotecan plus M6620 is tolerable.

18 than accuracy, as long as the error level is tolerable.

19 tudy population is feasible, acceptable, and tolerable.

20 shorter overall survival (OS), and was less tolerable.

21 ctive agents determine which crystal size is tolerable.

22 cal internalisation of bleomycin is safe and tolerable.

23 9 in combination with FOLFIRINOX is safe and tolerable.

24 decreased (18)F-FDG uptake and is active and tolerable.

25 Adjuvant 13cRA and IFN-alpha was moderately tolerable; 29% of patients in the treatment arm required

26 Differences in maximum tolerable absorbed dose to normal liver between (90)Y ra

27 -DADFT, 1] revealed the polyether to be more tolerable, achieving higher concentrations in the liver

28 y has been developed to estimate the maximum tolerable activity (MTA) of (131)I that can be safely ad

29 hout dosimetric determination of the maximum tolerable activity (MTA).

30 and good long-term survival, as well as the tolerable acute and cumulative toxic effects, associated

31 Oral sirolimus is tolerable, adequate blood levels are achievable, and the

32 with highly potent antitumor activity and a tolerable adverse effect profile in a cohort of patients

33 gimen of nab-paclitaxel plus gemcitabine has tolerable adverse effects with substantial antitumor act

34 le, and the combination is associated with a tolerable adverse-effect profile.

35 ntinues in search of more effective and more tolerable agents.

36 stigated as potentially more efficacious and tolerable alternatives for this multiply-relapsing disea

37 mab, olaparib, or cediranib combinations are tolerable and active in recurrent women's cancers.

38 The AALL01P2 regimen is a tolerable and active reinduction platform, suitable for

39 otecan, a selective TOP1 inhibitor, would be tolerable and active, particularly in tumors with high r

40 d durvalumab plus intermittent cediranib are tolerable and active.

41 ombination of neratinib and temsirolimus was tolerable and demonstrated antitumor activity in multipl

42 ple infusions of tremelimumab were generally tolerable and demonstrated single-agent antitumor activi

43 lzomib-lenalidomide-dexamethasone therapy is tolerable and demonstrates high rates of MRD negativity

44 ulinum toxin type A shows promise as a safe, tolerable and effective drug for migraine prevention, wi

45 utaneous injection every 28 days seems to be tolerable and effective, thus supporting the further dev

46 Even in an era of more tolerable and efficacious ART, decision making in regard

47 ncept for PS2-sparing inhibition as a novel, tolerable and efficacious gamma-secretase targeting stra

48 he balance between offering intensive versus tolerable and function-preserving therapy has been throw

49 BV is tolerable and has activity in SR-aGVHD and merits furthe

50 mDCF with bevacizumab appears tolerable and has notable patient outcomes in patients w

51 Denileukin diftitox is tolerable and has promising activity in steroid-refracto

52 e in continuous administration, but they are tolerable and highly effective in intermittent dosing.

53 was found to be completely inactive at both tolerable and highly toxic dose levels.

54 Conclusion BGJ398 at the MTD/RP2D had a tolerable and manageable safety profile and showed antit

55 ly improves progression-free survival with a tolerable and manageable safety profile in Asian patient

56 profile for cobimetinib and vemurafenib was tolerable and manageable, and no new safety signals were

57 Stomatitis was generally tolerable and managed by dose reduction or drug holidays

58 n alfa-2a treatment for 48 weeks is safe and tolerable and offers some efficacy in the post-OLT setti

59 osphamide analog, were performed to define a tolerable and potentially active target concentration fo

60 Antibody treatment is considered tolerable and potentially effective in the therapy of ne

61 revir 240 mg QD with PegIFN/RBV was safe and tolerable and produced substantial SVR rates in prior nu

62 Carfilzomib 56 mg/m(2) +/- dexamethasone was tolerable and provided durable responses.

63 dy suggest that low-frequency stimulation is tolerable and reduces epileptiform discharges and seizur

64 ombination of TriMixDC-MEL and ipilimumab is tolerable and results in an encouraging rate of highly d

65 s small trial, IV-D after aSAH was feasible, tolerable and safe.

66 mbination with clofarabine and cytarabine is tolerable and shows activity in relapsed/refractory pedi

67 d first set the gradient time to the longest tolerable and then set the temperature to the highest ac

68 50 mg/m(2) level, which was determined to be tolerable, and an MTD was not identified.

69 le, with a de-escalated level of 3 mg if not tolerable, and aspirin 81 mg once per day thromboprophyl

70 onist eltrombopag has been shown to be safe, tolerable, and effective for adults with chronic immune

71 Inosine was generally safe, tolerable, and effective in raising serum and cerebrospi

72 This medication regimen was tolerable, and is therefore feasible for further studies

73 TDL are a feasible, tolerable, and novel donor cell therapy alternative for

74 n stage IIIB NSCLC is feasible and generally tolerable, and results compare favorably with the predec

75 9 administered with PI 5-FU and XRT is safe, tolerable, and seems effective against primary EC.

76 oxicities made the 4,370-mg dose (n = 6) not tolerable, and the next lower dose cohort (3,120 mg) was

77 It is most practical, tolerable, and tumoricidal in its most potent form treat

78 The regimen is tolerable, and use of rituximab was not associated with

79 patients and highlights the need for better-tolerable anti-CMV drugs.

80 Low-dose naltrexone was rated equally tolerable as placebo, and no serious side effects were r

81 TPZ/CIS chemoradiotherapy was tolerable at a modified starting dose.

82 Rash and diarrhea, generally mild and tolerable at doses <or= 600 mg/d, were DLTs at 800 mg/d

83 se findings suggest that IPH2101 is safe and tolerable at doses that achieve full inhibitory KIR satu

84 bination with fludarabine and cytarabine, is tolerable at doses up to 55 mg/m(2) in pediatric patient

85 Bortezomib plus Int-DAC proved tolerable at the highest dose tested.

86 The combination of O6BG and TMZ was tolerable at TMZ doses less than half of the conventiona

87 ues may reflect a mechanism used to strike a tolerable balance between the requirement for efficient

88 -segment hypoplasia <40% could be considered tolerable because both resulted in only a 12% decrease i

89 l cysteine-rich regions of prokineticins are tolerable because chimeric prokineticins with swapped cy

90 ith indolent B-cell non-Hodgkin lymphoma was tolerable but did not lead to increased objective respon

91 et 1.3 mg/m(2) on days 5, 8, 12, and 15) was tolerable, but bortezomib-related neuropathy developed a

92 This regimen is tolerable, but is of unclear benefit.

93 istration of TPCS2a was found to be safe and tolerable by all patients.

94 We conclude that tipifarnib is tolerable, can induce disease stabilization, and can inh

95 ctively induce immune activation at safe and tolerable clinical doses.

96 y; cohort 6, not even 200 mg every third day tolerable; cohort 7, not defined; cohort 8, 200 mg each

97 approximately 3% of the provisional maximum tolerable daily intake (PMTDI) recommended for fumonisin

98 s (TDI-iAs) exceeds the previous provisional tolerable daily intake (PTDI) value of 2.1 mug day(-1) k

99 that, in case of children, would exceed the tolerable daily intake (TDI) of 0.1mg/kg bw/day.

100 around 5 orders of magnitude lower than the tolerable daily intake (TDI) reported by the European Fo

101 the children exceeded 1 for the HI based on tolerable daily intake (TDI) values (considered as poten

102 ded the U.S. Environmental Protection Agency Tolerable Daily Intake (TDI) values and the EFSA Referen

103 out based on probable daily intake (PDI) and tolerable daily intake (TDI).

104 st erucic acid content already surpassed the tolerable daily intake established by Food Standards Aus

105 eds the previous WHO recommended provisional tolerable daily intake value (2.1 mug day(-1) kg(-1) BW)

106 Law limits set fumonisins tolerable daily intake with respect to several maize bas

107 the age/gender groups of the population, the Tolerable Daily Intakes (TDIs) recommended by the EFSA w

108 were found to be lower than the provisional tolerable daily intakes proposed by Joint FAO/WHO Expert

109 1.13 mug/kg, which is above the Provisional Tolerable Daily Maximum Intake (PTDMI) of 1 mug/kg b.w.

110 In the animal study, a tolerable distance (<1 cm) between target and needle tip

111 ipate, and C) RAMP can identify biologically tolerable diversity of a metabolic network in an optimiz

112 igated the comparative effectiveness of more tolerable dosages of lithium as part of optimized person

113 This study determined the maximum tolerable dose (MTD) and toxicity of ch14.18 given in co

114 Primary end points were maximally tolerable dose (MTD) of LEN and progression-free surviva

115 has made it difficult to predict the maximal tolerable dose as a function of microsphere activity and

116 most damage processes, vastly increasing the tolerable dose before the specimen is destroyed.

117 count late-onset toxicities to ensure that a tolerable dose is identified for future efficacy and com

118 x 3 design was used to determine the highest tolerable dose of (90)Y-DOTATOC, with administered activ

119 fferent between the 3 conditions.The highest tolerable dose of mustard we were able to use did not el

120 ze the pharmacokinetics (PK) and determine a tolerable dose of oral sorafenib in patients with hepati

121 tration and allowed the use of a lower, more tolerable dose of tariquidar.

122 f seizures, the maximal allowable or highest tolerable dose was reached, or a criterion indicating tr

123 precision of dosimetry, validate the maximum tolerable dose, and evaluate the effectiveness of the tr

124 in mice was observed for ADNR at the maximum tolerable dose, as compared to more than 70% body weight

125 TICE is an effective and tolerable dose-intense treatment for patients with previ

126 peptide loss 2 years after diagnosis using a tolerable dose.

127 ighest dose seems to be close to the maximum tolerable dose.

128 alpha2b has also been evaluated at maximally tolerable doses compared with the observation group in t

129 fficult to reach this threshold with patient-tolerable doses of current DNMT inhibitors (DNMTIs).

130 ed through drinking water at physiologically tolerable doses, ameliorated clinical symptoms and disea

131 file might be improved by use at lower, more tolerable doses, in combination with a second agent acti

132 ue concentrations of rapamycin at clinically tolerable doses.

133 e substantial therapeutic benefit using well-tolerable dosing regimens.

134 remarkably low doses, far below the maximum tolerable drug doses.

135 older studies, (a) suggest a class of safe, tolerable drugs for stroke and neurodegeneration; (b) pr

136 0.05, which has been proposed as the maximum tolerable effect to keep the ecosystem intact.

137 umab plus reduced-dose ipilimumab might be a tolerable, efficacious treatment option for patients wit

138 X chromosome formation, then the X is not a tolerable environment for genes with very high maximal n

139 ial barriers to wider adoption of this safe, tolerable, evidence-based, and cost-effective prediabete

140 ready moderate amounts of CHOL increased the tolerable FE content in membranes by an order of magnitu

141 This novel approach to cancer prevention is tolerable, feasible, and has demonstrable activity.

142 in, and pemetrexed could be an effective and tolerable first-line treatment option for patients with

143 Substitution of P1 with dGlu was tolerable for binding, but not catalysis, whereas substi

144 The reaction conditions are tolerable for dialkyl-, aryl(hetaryl) alkyl-, and cycloa

145 nt with chlorambucil alone, while also being tolerable for patients who have few treatment options.

146 ission rates and standard duty cycles may be tolerable for some applications.

147 k emollient creams, rendering their eruption tolerable for the duration of treatment.

148 ich interventions are the most effective and tolerable for treating usual-type vulvar intraepithelial

149 creased toxicity in vivo and no benefit of a tolerable GEMCAP combination was identified in the allog

150 dose was escalated until patients developed tolerable grade 2 rash or until the maximum allowed dose

151 in commensals is that they evoke a small but tolerable host immune response in order to have the host

152 s, we investigated whether a physiologically tolerable hypercapnic stimulus ( approximately 25 mm Hg

153 be valuable to the effective design of more tolerable immunosuppression regimens.

154 clude that ezetimibe is both efficacious and tolerable in cardiac transplant recipients taking cyclos

155 venous administration of PEG-asparaginase is tolerable in children with ALL, and potentially therapeu

156 Lenalidomide was tolerable in children with CNS tumors at doses of 116 mg

157 In mouse models, such doses are not tolerable in continuous administration, but they are tol

158 Sapacitabine seems active and tolerable in elderly patients with AML.

159 error-prone than Pols II or V, which may be tolerable in its synthesis of short RNAs that serve as p

160 l complementary target sites with mismatches tolerable in miRNA-target recognition.

161 t hypercaloric enteral nutrition is safe and tolerable in patients with amyotrophic lateral sclerosis

162 hese data suggest bosutinib is effective and tolerable in patients with chronic phase imatinib-resist

163 rtezomib-dexamethasone appears effective and tolerable in patients with relapsed or relapsed and refr

164 Given fewer agents are both active and tolerable in patients with squamous cell carcinoma compa

165 ch14.18 in combination with IL-2 was tolerable in the early post-HDC/SCR period.

166 ndesartan appears to be effective and highly tolerable in the prevention of migraine, but needs to be

167 onstrate that complete ablation of K9 is not tolerable in vivo and that K9 is required for terminal d

168 560 represents an exception as it is largely tolerable in vivo despite displaying only a small select

169 the absence of C2GnT and C4GnT activities is tolerable in vivo, core 2 O glycosylation exerts a signi

170 ation therapy to approximately 80 Gy appears tolerable in well-selected patients with unresectable lu

171 over PS2 subclass of gamma-secretases and is tolerable in wild-type mice but causes dose-dependent No

172 th 12 mg/m(2)/d mitoxantrone for 3 days is a tolerable induction regimen and achieves plasma concentr

173 th 3 days of irinotecan at 40 mg/m(2)/d is a tolerable induction regimen for patients with acute leuk

174 entions are not required, that is, are there tolerable infectious risks of transfusion?

175 The most efficacious and tolerable initial empirical treatment has not been defin

176 However, higher percentages of tolerable intake levels are observed when calculating ri

177 A sufficient but tolerable intensity of 3 mA was more effective than lowe

178 uptake is low, but new highly effective and tolerable interferon-free direct-acting antiviral (DAA)

179 ely inhibits HDAC6 while retaining a low and tolerable level of class I HDAC inhibition.

180 concentrations well below the maximum human tolerable level.

181 hence are subject to regulations of maximum tolerable levels in food.

182 nimize the contribution of photoswitching to tolerable levels in future FRAP experiments.

183 nsiderations that have an impact on defining tolerable levels of difference.

184 The maximum tolerable limits by European Regulation No.

185 1mmol.L(-1), which is in accordance with the tolerable limits for coffee.

186 us supplements and doses under the set upper tolerable limits.

187 bevacizumab 5 mg/kg every 2 weeks may not be tolerable long term, and alternate sorafenib dosing sche

188 If correlations can be ignored with tolerable losses of information, the readout of neural s

189 ic inflammatory response can be destructive, tolerable low doses of LPS render the brain transiently

190 tation and are intended to manage dying in a tolerable manner based on what the decision maker believ

191 domains of error rates: negligible (yeast), tolerable (metazoan), and high (some plants), with the h

192 Wireless pH-metry is a safe and tolerable method when investigating children for GERD.

193 The 200 mg/m2/dose was also tolerable on the continuous dosing schedule.

194 he AP-WP regimen is an equally effective and tolerable option for the adjuvant treatment of patients

195 e-daily dose regimens that the patient found tolerable, or placebo.

196 molecular rationale for the use of 2ME2 as a tolerable oral immunomodulatory agent for the treatment

197 Effective and tolerable palliative treatments are needed for patients

198 On a scale of 0 (intolerable) to 10 (very tolerable) patients rated DPDT as 9.5 and AWLPDT as 9 (P

199 IONIS-APO(a)-LRx is a novel, tolerable, potent therapy to reduce Lp(a) concentrations

200 ata, the F + 0 protocol appears to be a more tolerable procedure.

201 onuclide-labeled anti-PD-L1 antibody yielded tolerable projected marrow doses, further supporting its

202 he critical normal organ receiving a maximum tolerable radiation dose.

203 hat antitumor effects would be expected with tolerable radiation exposure to the normal tissues.

204 tes investigated were found to be within the tolerable range, the preliminary probabilistic estimatio

205 ining its signaling within a physiologically tolerable range.

206 d episodes or slowing of SVT to a clinically tolerable rate.

207 we develop a mathematical model to estimate tolerable rates of homing-resistant allele generation to

208 o achieve meaningful population suppression, tolerable rates of resistance allele generation are orde

209 tion with weekly paclitaxel is an active and tolerable regimen as first-line therapy for women with M

210 nt cisplatin and radiotherapy, is a safe and tolerable regimen for patients with localized esophageal

211 perior to standard AC (DFS and OS) and was a tolerable regimen in both older and younger patients.

212 pite activity, BV plus bendamustine is not a tolerable regimen in these patients.

213 s cheap copper catalyst down to industrially tolerable residues, and some biomedical and cosmetic app

214 GEMOX-B showed antitumour activity with tolerable safety in patients with advanced BTCs.

215 st-line nivolumab monotherapy demonstrated a tolerable safety profile and durable responses in first-

216 , first-line nivolumab plus ipilimumab had a tolerable safety profile and showed encouraging clinical

217 , first-line nivolumab plus ipilimumab had a tolerable safety profile and showed encouraging clinical

218 These results together with its generally tolerable safety profile and the added advantage of oral

219 tuximab talirine demonstrates activity and a tolerable safety profile as a single agent in patients w

220 gnificantly reduced seizure frequency with a tolerable safety profile compared with placebo in patien

221 759 at a dose of 200 mg twice daily showed a tolerable safety profile in patients with NSCLC and CNS

222 T-VEC with ipilimumab had a tolerable safety profile, and the combination appeared t

223 ty and 75 mg temsirolimus showed a generally tolerable safety profile.

224 ata offer the least biased results at a well-tolerable scan duration and should thus be pursued whene

225 induced differentiation of cancer cells with tolerable side effects.

226 ivity at doses and schedules associated with tolerable side effects.

227 surfaceome for overexpressed molecules with tolerable systemic expression.

228 vastatin and pravastatin seem safer and more tolerable than other statins.

229 e treatments, may prove more efficacious and tolerable than the available arsenal of treatments.

230 l effects on the disease, more effective and tolerable therapies are needed.

231 atient selection and the development of more tolerable therapies as higher priorities than carrying e

232 ve the way for more targeted, effective, and tolerable therapies for children with systemic vasculiti

233 the manipulated lipid saturation affects the tolerable thermal window, and altered Delta9-desaturase

234 The artificial ruggedness decreases to tolerable thresholds for cutoffs larger than the critica

235 hat the elevation of proteasomal activity is tolerable to cells and may be beneficial to prevent the

236 tional constraints limit the available sites tolerable to escape mutations.

237 3 disrupts this circuit and makes cells more tolerable to stresses, as its gain-of-function mechanism

238 60 mg/m2 in cycle 1 (which was escalated, if tolerable, to 330 mg/m(2) in cycle 2), or arm 2 (n = 186

239 The tolerable toxicity profile and long half-life of this ir

240 eduction in dose density (cohort 3) led to a tolerable toxicity profile and was chosen as the phase I

241 Ranpirnase demonstrated activity and a tolerable toxicity profile in patients with unresectable

242 ssible to demonstrate that 17-AAG exhibits a tolerable toxicity profile with therapeutic plasma conce

243 with impressive durations of response and a tolerable toxicity profile.

244 in durable engraftment of donor stem cells, tolerable toxicity, and acceptable rates of relapse risk

245 i) (90)Y-DOTA-biotin cured 100% of mice with tolerable toxicity, whereas conventional RIT with (90)Y-

246 tin has an encouraging efficacy profile with tolerable toxicity.

247 drug doses and schedules investigated, with tolerable toxicity.

248 ition of LDHA with FX11 is an achievable and tolerable treatment for LDHA-dependent tumors.

249 llowed by weekly paclitaxel is an active and tolerable treatment for patients with carcinoma of unkno

250 trastuzumab emtansine as an efficacious and tolerable treatment in this patient population.

251 that, in this non-curative setting, maximum tolerable treatment must necessarily be used first-line.

252 es to expand, allowing for more flexible and tolerable treatment plans.

253 In an era of highly efficacious and highly tolerable treatment, such an approach will benefit not j

254 herapy can be postponed until more effective/tolerable treatments become available.

255 While there is a need of more effective and tolerable treatments for ovarian cancer patients, we aim

256 e natural history and determining effective, tolerable treatments.

257 adykinin inhibitors may offer safer and more tolerable treatments.

258 7% (89.6%, 91.8%) consumed more than the IOM Tolerable Upper Intake Level (2300 mg).

259 use of high dosages of FASs that exceed the Tolerable Upper Intake Level (UL) (>/=1000 mug/d) on chi

260 of these sources to usual intakes above the tolerable upper intake level (UL) (1000 microg/d) and to

261 The prevalence of adults who exceeded the tolerable upper intake level (UL) for calcium, zinc, iro

262 ntly to usual intakes above the age-specific tolerable upper intake level (UL) for folic acid and to

263 Currently, the tolerable upper intake level (UL) for leucine is unknown

264 3%) of dietary supplement users exceeded the Tolerable Upper Intake Level (UL) for total folic acid (

265 trition Board (FNB) to derive a revised safe Tolerable Upper Intake Level (UL) for vitamin D.

266 of women (85%) had sodium intakes above the Tolerable Upper Intake Level (UL).

267 1 in 2 had sodium intakes that exceeded the Tolerable Upper Intake Level (UL); >/=16% and 41% of the

268 Intakes greater than the Tolerable Upper Intake Level greatly increased the odds

269 al preformed retinol intake exceeded the DRI tolerable upper intake level in 78% of the subjects with

270 whey protein production and up to 70% of the tolerable upper intake level was found, thus revealing t

271 for those aged > or =50 y, and 5% exceed the Tolerable Upper Intake Level.

272 h no individual exceeding the United Kingdom Tolerable Upper Intake Level; the 2.5th percentile of th

273 Conclusion: Calcium intake within tolerable upper intake levels (2000 to 2500 mg/d) is not

274 The usual sodium intake above the Tolerable Upper Intake Levels (ULs), potassium intakes a

275 As safety guidance, tolerable upper intake levels have been established by t

276 ents of safety are badly needed for updating Tolerable Upper Intake Levels.

277 th Recommended Dietary Allowances (RDAs) and Tolerable Upper Intake Levels.

278 h calcium intake-that is, beyond recommended tolerable upper intake levels.

279 ment (EAR), RDA, Adequate Intake (AI), and a tolerable Upper Level (UL) -and not a single reference v

280 ood and supplements that does not exceed the tolerable upper level of intake (defined by the National

281 The current tolerable upper level of zinc recommended by the Institu

282 hese results support the need to establish a tolerable upper limit for DHA intake particularly in the

283 DNA vaccine field and provide a novel, more tolerable vaccine with broad immunogenicity to avian inf

284 to any critical normal organ to its maximum tolerable value.

285 own farmland, may exceed the toxicologically tolerable values allowed, and therefore long-term consum

286 rmed 45-min DR (-15% slope) at their maximal tolerable velocity.

287 220 mL [183-257 mL]; P = 0.006) and maximum tolerable volume in 9 of 13 (PRE: mean 350 mL [323-377]

288 Thus considering the Provisional Tolerable Weekly Intake (PTWI) of Hg, Pb and Cd the leve

289 n this work would not exceed the provisional tolerable weekly intake (PTWI).

290 compared calculated values with provisional tolerable weekly intake (PTWI).

291 of vemurafenib and cobimetinib was safe and tolerable when administered at the respective maximum to

292 tau isoform to maintain MT dynamics within a tolerable window of activity.

293 agweed AIT of 12 Amb a 1-U was effective and tolerable with a safety profile that permitted daily sel

294 Alisertib 60 mg/m(2) per dose for 7 days is tolerable with a standard irinotecan and temozolomide ba

295 ty in metastatic renal cell carcinoma and is tolerable with chronic daily therapy.

296 AMG 386 combined with weekly paclitaxel was tolerable, with a manageable and distinct toxicity profi

297 he combination of erlotinib and dasatinib is tolerable, with adverse effects consistent with the two

298 schedules at 120 mg once a day but none was tolerable, with DLTs of thrombocytopenia, gastrointestin

299 hase 2 dose of 2 mg trametinib once a day is tolerable, with manageable side-effects.

300 Both regimens were tolerable, with modest toxicity increase with sorafenib.