ライフサイエンスコーパス: tolerance

1 is truncated by loss of efficacy (analgesic tolerance).

2 sensitivity, insulin secretion, and glucose tolerance.

3 gh efficiency and excellent functional group tolerance.

4 ect peripheral tolerance rather than central tolerance.

5 f NRF2, the master regulator of redox stress tolerance.

6 lay a pivotal role in maintaining peripheral tolerance.

7 s high selectivity and good functional-group tolerance.

8 ng previously established airway immunologic tolerance.

9 ssful conditions like hypoxia and abets drug tolerance.

10 ns, previously involved in error-free damage tolerance.

11 levels of transpiration and display drought tolerance.

12 dentify 17 genetic loci associated with cold tolerance.

13 into the function of SlCBL10 in salt stress tolerance.

14 tion enjoys broad scope and functional group tolerance.

15 these mechanisms can lead to a breakdown of tolerance.

16 clinical outcomes for lactose digestion and tolerance.

17 IFG, but not in subjects with normal glucose tolerance.

18 oved insulin sensitivity, and better glucose tolerance.

19 s were ineffective in inducing food allergen tolerance.

20 to safeguarding Treg-mediated immunological tolerance.

21 n and resolution of chronic inflammation and tolerance.

22 aling to enforce both central and peripheral tolerance.

23 development and in coordinating plant stress tolerance.

24 eogenesis without affecting systemic glucose tolerance.

25 for S. pombe Oxs1 and Pap1 to enhance stress tolerance.

26 termined levels of host-plant resistance and tolerance.

27 of EpMBF1 was found to participate in stress tolerance.

28 gen presentation along with those for T cell tolerance.

29 nes showed the highest degree of insertional tolerance.

30 ngineering crop plants with improved drought tolerance.

31 ain produced by paclitaxel without producing tolerance.

32 programs balance immune protection and self-tolerance.

33 g the molecular mechanism underlying drought tolerance.

34 tic hydrogen production and diminished light tolerance.

35 g processes, with excellent functional-group tolerance.

36 tion in the periaqueductal gray (PAG) drives tolerance.

37 host natural killer T (NKT) cells to induce tolerance.

38 that inhibit T cell activation and maintain tolerance.

39 l targets that are more likely to evade self-tolerance.

40 immunity abrogated the potential for durable tolerance.

41 ticipate in enforcement of peripheral B cell tolerance.

42 plants was associated with increased drought tolerance.

43 pathway which augments tumor-induced immune tolerance.

44 hanism coordinating plant growth and drought tolerance.

45 rease hypoxemia without compromising patient tolerance.

46 ony-level disease avoidance, resistance, and tolerance.

47 roteins (TDPs) are essential for desiccation tolerance.

48 oexistence among species with the same shade tolerance.

49 itive at-risk children with impaired glucose tolerance.

50 n important role in transplant rejection and tolerance.

51 clic scaffolds with diverse functional group tolerance.

52 pression to assess for robust donor-specific tolerance.

53 ying genomic regions associated with drought tolerance.

54 recipients subsequently develop Ag-specific tolerance.

55 exogenous citrate significantly enhanced Ga tolerance.

56 llergen immunotherapy exactly aims to induce tolerance.

57 ty of disordered proteins involved in stress tolerance.

58 e pollutant as well as to breed crops for O3 tolerance.

59 exhibited better thermal stability and water tolerance ability compared to the 3DOM Co3O4-supported A

60 coronary heart disease and impaired glucose tolerance, acarbose did not reduce the risk of major adv

61 aft survival and that they can induce immune tolerance, accelerate recovery from AKI, and promote fun

62 eris vittata arsenite efflux (PvACR3), on As tolerance, accumulation, translocation and speciation in

63 Forge' and 'Princeton,' also indicated that tolerance against DED might be mediated by different mec

64 h a few plant MSR genes are known to provide tolerance against oxidative stress, their role in plant-

65 d in the absence of concerns for toxicity or tolerance; alternatively, monotherapy with gemcitabine o

66 realistic daily heat pulses enhanced thermal tolerance among infected individuals, but the magnitude

67 nvestigate the mechanism of arsenate (As(V)) tolerance and accumulation in rice.

68 d stress, and plays role in Cd and As stress tolerance and accumulation.

69 Airway tolerance and allergen-induced airway inflammation model

70 on experiments, and identification of stress tolerance and antibiotic resistance genes in bacteria.

71 ed bacteria having more genes linked to acid tolerance and chemotaxis, while bacteria on limestone we

72 mates, knockout mice showed impaired glucose tolerance and circulating leptin, GLP-1, and insulin lev

73 which confer glutamine (Gln)-dependent acid tolerance and contribute to the glutamate (Glu)-dependen

74 idating the molecular adaptions that produce tolerance and determining its behavioral impact have pro

75 t sphingomyelin hydrolysis, improved glucose tolerance and dyslipidemia.

76 tinuously required for maintenance of immune tolerance and for a major part of their characteristic g

77 n interventions that can break immunological tolerance and halt cancer progression, whereas on the co

78 ong; the determinants of the balance between tolerance and immunogenicity in AAV vector-mediated gene

79 ults indicated that SeCspA conferred drought tolerance and improved physiological traits in wheat pla

80 mmatory impact of a high fat diet on glucose tolerance and insulin resistance.

81 , Lin28aKI(VMH) mice showed improved glucose tolerance and insulin sensitivity compared with controls

82 irst evidence for initially improved glucose tolerance and insulin sensitivity in response to 2 weeks

83 Exos obtained from lean mice improve glucose tolerance and insulin sensitivity when administered to o

84 an essential role in maintaining peripheral tolerance and is among the most promising immunotherapeu

85 mation allows unprecedented functional group tolerance and it is well-suited for the amination of ele

86 munotherapeutics that can circumvent central tolerance and limit graft-versus-host disease.

87 eripheral MOR antagonists to limit analgesic tolerance and OIH.

88 ncation in mE4M-B6 mice facilitated morphine tolerance and reduced morphine dependence without affect

89 f FDC secretion of IFN-alpha restored B cell tolerance and reduced the amount of GCs and pathogenic a

90 etabolic workload can modulate immunological tolerance and review the molecular mechanisms and the st

91 7-associated truncation diminished morphine tolerance and reward without altering physical dependenc

92 even 1 night of shift work decreases glucose tolerance and that circadian disruption is linked to glu

93 Opioid tolerance and the potential for addiction is a significa

94 contribute to the maintenance of peripheral tolerance and whether their function is coordinated with

95 is allows for coexistence of different shade tolerances and the second axis for coexistence among spe

96 (95% CI: -12.90, -7.10 g/L; impaired glucose tolerance) and -6 g/L (95% CI: -8.47, -3.53 g/L; normogl

97 impaired fasting glucose or impaired glucose tolerance) and were randomly assigned into exercise (AEx

98 traits are important for determining drought tolerance, and are largely independent of wood density-a

99 wth, nutrient use efficiency, abiotic stress tolerance, and disease resistance-into agricultural prod

100 This study supports the safety, tolerance, and efficacy of fluoxetine for hypochondriasi

101 action conditions with high functional group tolerance, and gives the products in moderate to good yi

102 ycemia and vascularization, improved glucose tolerance, and increased insulin content.

103 m-economical, exhibit broad functional group tolerance, and occur readily at room temperature under v

104 iated with higher body fat, impaired glucose tolerance, and reduced insulin secretion in first- (F1)

105 e treatment in LAR, increasing immunological tolerance, and reducing the clinical symptoms and the us

106 antly enhanced water use efficiency, drought tolerance, and soil water conservation properties.

107 TDPs are required for tardigrade desiccation tolerance, and these genes are sufficient to increase de

108 monoclonal anti-TIM-4 Ab promoted allograft tolerance, and this was dependent on B cell expression o

109 pelin effects, such as angiogenesis, glucose tolerance, and vasodilatation.

110 pathways that regulate immune activation or tolerance are less clear.

111 vely, recorded their impacts on variation in tolerance are virtually unexplored.

112 y to promote insulin sensitivity and glucose tolerance; as a class, these lipids are referred to as '

113 s it lost this effect on glucose and insulin tolerance at 16 weeks HFD in obese mice.

114 on showed a transient improvement in glucose tolerance at 5 weeks of HFD whereas it lost this effect

115 The NS1 gene exhibited distinct mutational tolerances at different stages of the screen.

116 aset, exploring relationships between peanut tolerance, baseline peanut/egg sensitization, eczema sev

117 s, it is proposed that SlCBL10 mediates salt tolerance by regulating Na(+) and Ca(2+) fluxes in the v

118 asis at inductive and effector sites of oral tolerance by suppressing peripheral regulatory T cell (p

119 LP1R agonists, resulting in improved glucose tolerance, cAMP production, and insulin secretion as wel

120 indicated that these lines possessed stress tolerance characteristics, including lower malondialdehy

121 the regulatory hierarchy governing alkaline tolerance circumvents calcineurin signalling.

122 articipants (63.8%) developed normal glucose tolerance compared with 8 placebo-treated participants (

123 duced female offspring with impaired glucose tolerance compared with offspring of chow-fed dams throu

124 stop codon read-through and rescues oxidant tolerance consistent with this model.

125 inery and a main regulator of the DNA damage tolerance (DDT) pathway.

126 nor DNA damage may be overcome by DNA damage tolerance (DDT) pathways that bypass such obstacles, pos

127 n decreased beta cell mass, impaired glucose tolerance, defective insulin secretion, and increased ap

128 istance of the respiratory system to develop tolerance, desensitization of neurons in the Kolliker-Fu

129 ed at 5 degrees C for 28 h, and yet, glucose tolerance did not change, owing to a doubling of insulin

130 While glucose tolerance did not differ between genotypes at baseline i

131 allergy who were not able to acquire immune tolerance during childhood.

132 DNA damage tolerance during eukaryotic replication is orchestrated

133 Immune tolerance during human pregnancy is maintained by a rang

134 hich could ultimately perturb maternal-fetal tolerance during pregnancy.

135 nctional mediators of tardigrade desiccation tolerance, expanding our knowledge of the roles and dive

136 ing on their response to therapy and patient tolerance for subsequent surgery.

137 t pathogens, where non-linear resistance and tolerance functions can interact such that small changes

138 Identification of major salt tolerance genes and marker assisted selection (MAS) can

139 sociated with lactase expression and lactose tolerance, had higher dietary vitamin D intake and highe

140 therapies that disrupt PD-L1-mediated tumour tolerance has highlighted the need to understand the mol

141 Quantitative trait loci (QTL) for O3 tolerance have been identified in model and crop species

142 the start or stop of therapy impaired immune tolerance, highlighting the dependence of the therapy-in

143 orized into quartiles) with impaired glucose tolerance (IGT) and gestational diabetes mellitus (GDM),

144 to 40% of individuals with impaired glucose tolerance (IGT) or frank diabetes based on the rarely ut

145 group of subjects with NGT, impaired glucose tolerance (IGT), and T2DM.

146 e observed in subjects with impaired glucose tolerance (IGT).

147 cetic acid successfully enhanced the drought tolerance in Arabidopsis, rapeseed, maize, rice and whea

148 that repeatedly had associations with frost tolerance in at least two different environments with tw

149 BCL9L dysfunction contributes to aneuploidy tolerance in both TP53-WT and mutant cells by reducing b

150 rovement of water use efficiency and drought tolerance in crops.

151 ntly lower blood glucose and improve glucose tolerance in diet-induced obese mice.

152 r group, but did transiently improve glucose tolerance in high fat-fed mice.

153 health and disease but its role in endotoxin tolerance in human DCs is still controversial.

154 The lack of cellular tolerance in KF neurons correlates with the relative lac

155 n may facilitate the selection for increased tolerance in low-diverse communities.

156 more, miR-718 regulates the induction of LPS tolerance in macrophages.

157 evelopment, but not maintenance, of morphine tolerance in male rats.

158 greatly impairs insulin release and glucose tolerance in mice fed with a calorie-rich diet.

159 ghting the dependence of the therapy-induced tolerance in mice with new-onset diabetes on the presenc

160 at circadian disruption is linked to glucose tolerance in mice.

161 L-10 might play a key role in acquisition of tolerance in patients with CM-FPIES.

162 xyquinoline N-oxide (HQNO) induces multidrug tolerance in S. aureus through respiratory inhibition an

163 n trials, might allow for improved treatment tolerance in this patient population.

164 ore an excellent choice for studying drought tolerance in trees.

165 r deleterious effects on loss of B cell self-tolerance in vivo, we depleted neutrophils at different

166 te how IL-33 affects established immunologic tolerance in vivo.

167 activation, increase cell death, and induce tolerance in vivo.

168 Cross-tolerance, in which plants pre-treated with chitin (a fu

169 ncrease the extensibility, softening, mixing tolerance index (MTI) and stickiness, whereas decrease t

170 n impairs the development of nonconventional tolerance-inducing cell fates.

171 Although most tolerance-inducing regimens rely on regulatory T cells,

172 iated acceptance of most tissues and organs, tolerance induction after lung transplantation is critic

173 ends great appeal as a strategy for targeted tolerance induction and treatment of autoimmune diseases

174 Immunological requirements for rejection and tolerance induction differ between various organs.

175 rolled trials exploring the efficacy of oral tolerance induction in infancy for the prevention of FA.

176 on, host CD8(+) DCs play a requisite role in tolerance induction through interactions with NKT cells.

177 er studies that explore the efficacy of oral tolerance induction to other common food allergens and t

178 In the latter case, we found that tolerance induction triggered recessive mechanisms leadi

179 Oral tolerance induction was enhanced in mice lacking express

180 Foxp3 demethylation was associated with tolerance induction, indicating that Treg cells play an

181 ne marrow cell (BMC) engraftment and promote tolerance induction.

182 Mechanisms of tolerance initiated in the thymus are indispensable for

183 This type of tolerance is Ag specific, and tolerant mice retain immun

184 However, tolerance is brief, and allergen hypersensitivity can re

185 ation between the rs4343 variant and glucose tolerance is modulated by dietary fat intake.

186 couple anti-tumor activity from loss of self-tolerance is necessary to increase the therapeutic effic

187 This high antibiotic tolerance is related to bacterial persisters, a sub-popu

188 ication of protein by drugs may disrupt self-tolerance, leading to lymphocyte activation.

189 mune response to FVIII, because of a lack of tolerance, leading to the formation of inhibitory antibo

190 liver triglycerides, with decreased glucose tolerance, liver NAD(+) levels and citrate synthase acti

191 ction of these cells may represent a disease tolerance mechanism that contributes to the development

192 that likely serves as a universal plant cold tolerance mechanism.

193 likely than immunodominant clones to escape tolerance mechanisms and may contribute to protective an

194 Efforts to exploit aneuploidy tolerance mechanisms and the BCL9L/caspase-2/BID axis ma

195 evolutionary role in enhancing plant stress tolerance mechanisms including NTSR warrants further inv

196 Tolerance mechanisms that act endogenous to the T cell a

197 r therapeutically to induce antigen-specific tolerance might overcome these obstacles.

198 transplant recipients enrolled in the Immune Tolerance Network immunosuppression withdrawal (ITN030ST

199 We assessed tolerance, neurocognitive progression, brain growth, NAG

200 studied for use in the prevention of nitrate tolerance, none are currently recommended owing to a pau

201 open scanner design may potentially improve tolerance of cardiac MRI and therefore allow to examine

202 BCL9L deficiency promoted tolerance of chromosome missegregation events, propagati

203 ) as a means to enhance environmental stress tolerance of corals and the success of coral reef restor

204 Cultural relativism fosters tolerance of diverse beliefs and behaviors by forbidding

205 s a general mechanism underlying the thermal tolerance of embryos.

206 0.05; low-quality evidence); no reduction in tolerance of enteral feeds (risk ratio, 0.94 [95% CI, 0.

207 arrested, metabolic rate is suppressed, and tolerance of environmental stress is bolstered.

208 nsequently, ClpG largely contributes to heat tolerance of P. aeruginosa primarily in stationary phase

209 ne, dampened protein synthesis and increased tolerance of proteostatic stress.

210 bile duct antigens efficiently break immune tolerance of recipient mice, capturing several key featu

211 The tolerance of the enzyme for these altered orientations i

212 The tolerance of the gRNA and donor DNA to chemical modifica

213 In humans, tolerance of the loss of one or both functional copies o

214 e affects host defences (e.g. resistance and tolerance) of the amphibian chytrid fungus Batrachochytr

215 cifically in nociceptors eliminated morphine tolerance, OIH and pronociceptive synaptic long-term pot

216 ice displayed normal body weight and glucose tolerance on a regular chow (RC) diet.

217 esented no significant difference in glucose tolerance or insulin secretion compared with mice expres

218 of immune responses, including inflammation, tolerance, or even fibrosis.

219 e data demonstrate that breaching peripheral tolerance permits a cross-reactive HIV-1 autoantibody re

220 ed excellent efficiency and functional group tolerance, producing polysulfonates with a variety of si

221 traploid wheat varieties with varying stress tolerance profiles, and built differential expression li

222 e, the most common seem to affect peripheral tolerance rather than central tolerance.

223 ow acclimatization capacity or physiological tolerance related to history of exposure to corrosive co

224 ficantly (P < 0.001) associated with drought tolerance related traits in barley.

225 ee species because of critical environmental tolerances related to growth, mortality, reproduction, d

226 relevance of this diversity to maintain self-tolerance remains unknown.

227 Only 1 method of preventing nitrate tolerance remains widely accepted: the use of a dosing s

228 Maintaining immune tolerance requires the production of Foxp3-expressing re

229 e volume changes and increased BW or glucose tolerance response.

230 -2(low)Foxp3(-) T cell population, where the tolerance state is IL-10 dependent.

231 fic transgenic CD4 T cells revealed a "split tolerance" status in mAAQ(+) mice: T cells recognizing i

232 esponse nor did it affect whole-body insulin tolerance, suggesting that TBC1D1 is not required for in

233 fied, frequently sampled intravenous glucose tolerance test (FSIGT), we estimated hepatic versus extr

234 .4 +/- 0.8 were subjected to an oral-glucose-tolerance test (OGTT) on 4 separate days with the use of

235 es based on the rarely utilized oral glucose tolerance test (OGTT).

236 The glucose tolerance test showed major improvement of the glucose c

237 se insulin release on an intravenous glucose tolerance test that was higher than the threshold.

238 tivity to insulin action measured by insulin tolerance test.

239 lenge change in glucagon during oral glucose tolerance tests (OGTTs), hypothesizing that higher postc

240 Oral glucose tolerance tests were administered at the same time and l

241 how that PBTTT exhibits significantly higher tolerance than P3HT.

242 lted in Arabidopsis lines with enhanced salt tolerance than wild type plants, as indicated by reduced

243 on plays an important role in abiotic stress tolerance that likely serves as a universal plant cold t

244 cording to radiological response and patient tolerance thereafter.

245 ce 2-hour glucose is an indicator of glucose tolerance, this study indicated CRP gene is associated w

246 ages and fibroblasts contribute to treatment tolerance through a cytokine-signaling network that invo

247 to inflammatory stimuli and promotes immune tolerance through effector T-cell anergy and enhanced Tr

248 ght interception, photosynthetic efficiency, tolerance to abiotic stressors, resistance to fungal pat

249 sistance genes to play a significant role in tolerance to antimicrobials.

250 at; rather, they apply their impressive heat tolerance to avoid competitors and predators.

251 lubilize aggregated proteins and confer heat tolerance to cells.

252 model is important for understanding loss of tolerance to cholangiocytes and is relevant to the patho

253 cocaine self-administration in rats, we link tolerance to cocaine effects at the dopamine transporter

254 as an immune checkpoint molecule to enforce tolerance to cognate antigens.

255 racted the interest of breeders for its high tolerance to drought and as potential genetic source in

256 le of the SUMO protease, OsOTS1 in mediating tolerance to drought in rice.

257 Tolerance to Dutch elm disease (DED) has been linked to

258 ces CD8(+) dT effector responses to maintain tolerance to fetal antigens.

259 mbers of the microbiota in the regulation of tolerance to food has exciting potential for new interve

260 of regulatory T (Treg) cells in the loss of tolerance to gluten remains poorly understood.

261 4 ligands might be useful to potentiate oral tolerance to haptens and alleviate ACD in human subjects

262 Induction of oral tolerance to haptens is an efficient way to prevent alle

263 city or potential for evolutionary change in tolerance to high temperature.

264 ] responsiveness incorporated with increased tolerance to high temperatures during flowering and grai

265 ant in antiviral immunity and in maintaining tolerance to inert antigens.

266 ted lung Treg cells and impaired immunologic tolerance to inhaled antigens.

267 ion data highlight regional variation in the tolerance to missense variation within the protein-codin

268 otein association and blocks acute analgesic tolerance to morphine and kappa opioid receptor inactiva

269 NIUA patients may develop tolerance to NSAIDs over time, a process that seems to b

270 orphology, a more rigid membrane, and higher tolerance to nZVI.

271 Feeding high doses of peanut to pups induced tolerance to peanut protein.

272 gulatory T cells, we found that induction of tolerance to proteins in aluminum hydroxide can be achie

273 use tissues, and increased in vitro cellular tolerance to spontaneous genome doubling.

274 However, the limited tolerance to steric hindrance of these couplings restric

275 rus plants expressing BlMGL showed increased tolerance to T. semipenetrans infestation and to determi

276 Animals did not develop tolerance to the anti-hyperalgesic activity of NM0127 an

277 neurons correlates with the relative lack of tolerance to the respiratory depressant effect of opioid

278 nutrient deficiencies, and may contribute to tolerance to these stresses.

279 itory receptors expressed by T cells mediate tolerance to tumor antigens, with coexpression of these

280 Populus hopeiensis exhibits exceptional tolerance to water-deficit environments and is therefore

281 henotype in offspring by enhancing metabolic tolerance to xenobiotics.

282 and trainable memory capability with strong tolerances to input faults and variations, which shows t

283 response against a pathogen and yet maintain tolerance toward commensal bacteria and innocuous dietar

284 e Nonabokra and Pokkali show a high level of tolerance towards salinity stress compared to IR64 varie

285 The achievement of immunological tolerance using helminth-derived products is also an exc

286 ere chosen for further analysis of Cd and Zn tolerance variation, which is evident at different plant

287 Tolerance was associated with significantly higher numbe

288 Systemic glucose tolerance was improved in obese GR-deficient mice, which

289 Oral tolerance was induced by DNFB gavage in germ-free and mi

290 sponse genes and the role of GBF3 in drought tolerance was studied in Arabidopsis thaliana.

291 ciated molecular pattern) have improved salt tolerance, was observed in Arabidopsis, but is not well

292 eliminating processes in response to drought tolerance were mechanisms exclusive to cv. RB867515, hel

293 coronary heart disease and impaired glucose tolerance were randomly assigned (1:1), in blocks by sit

294 genes are sufficient to increase desiccation tolerance when expressed in heterologous systems.

295 phenotype with a slight decrease in glucose tolerance, whereas patients with the ZnT8 R325W polymorp

296 nocarcinoma (PDA) is characterized by immune tolerance, which enables disease to progress unabated by

297 1 provides a mechanism of replication stress tolerance, which sustains survival of BRCA2-deficient ce

298 dulthood, while an increase in immunological tolerance with aging suppresses disease onset after late

299 blunt the development of morphine analgesic tolerance, without affecting normal P2X7 receptor functi

300 gen is central to adaptive immunity and self-tolerance, yet how this is determined by different antig