ライフサイエンスコーパス: tolerance induction

1 organ, the liver also has a central role in tolerance induction.

2 epithelial cells, a key process for central tolerance induction.

3 innate and adaptive immune systems in Ag-SP tolerance induction.

4 ased DCs suggests their nonredundant role in tolerance induction.

5 c anatomical sites may preferentially favour tolerance induction.

6 ay important roles in antiviral immunity and tolerance induction.

7 II, the primed cells remained susceptible to tolerance induction.

8 f immunomodulating agents in transplantation tolerance induction.

9 ch contributes to intestinal homeostasis and tolerance induction.

10 auses of graft failure or remove barriers to tolerance induction.

11 mpact of immunosenescence on chimerism-based tolerance induction.

12 o assess whether PA can be prevented by oral tolerance induction.

13 ome and so was crucial for effective central tolerance induction.

14 rsity do not constitute a uniform barrier to tolerance induction.

15 lf-antigens in the medulla in the context of tolerance induction.

16 ) thymocytes, a process important for T cell tolerance induction.

17 iscuous gene expression required for central tolerance induction.

18 the effect of corticosteroids on respiratory tolerance induction.

19 matory quality of IgG molecules formed on TD tolerance induction.

20 nvestigate whether donor brain death affects tolerance induction.

21 dioxygenase (IDO), an enzyme associated with tolerance induction.

22 matory sialylated IgGs that are formed on TD tolerance induction.

23 thogenic T(H)2 cells is an essential step in tolerance induction.

24 etween an effector inflammatory response and tolerance induction.

25 y molecule PD-L1 that is essential for Ag-SP tolerance induction.

26 essary step in some but not all protocols of tolerance induction.

27 CTLA4/B7.1/B7.2 and for PD-1 for CD8 T-cell tolerance induction.

28 n-treated mice disrupts alloantigen-specific tolerance induction.

29 cell death provides an important signal for tolerance induction.

30 e profound effects on the insulin autoimmune tolerance induction.

31 findings and has important implications for tolerance induction.

32 a productive response and avoid death and/or tolerance induction.

33 intravenous injection as a model for immune tolerance induction.

34 ave been implicated in T cell activation and tolerance induction.

35 ion with major implications for immunity and tolerance induction.

36 n hematopoietic cells was necessary for oral tolerance induction.

37 able barrier to long-term graft survival and tolerance induction.

38 ed HSC mobilization and completely abrogated tolerance induction.

39 perprolactinemia on the mechanisms of B cell tolerance induction.

40 tate the likelihood of success or failure of tolerance induction.

41 may exhibit differential susceptibilities to tolerance induction.

42 totic body ingestion by CD8(+) DCs initiates tolerance induction.

43 controls the fate of developing B cells and tolerance induction.

44 ons are critical for long-term chimerism and tolerance induction.

45 ing the crucial role of B cells in perinatal tolerance induction.

46 delivery platform specifically for low-dose tolerance induction.

47 ivation, promoting rejection, and inhibiting tolerance induction.

48 microenvironments for T-cell development and tolerance induction.

49 control B cell responses following allograft tolerance induction.

50 e portion of self determinants presented for tolerance induction.

51 te the underlying mechanisms responsible for tolerance induction.

52 transfer of ICAM cells was unable to support tolerance induction.

53 ameters of the dosing regime that influences tolerance induction.

54 n transplanted hepatocytes for expansion and tolerance induction.

55 eration in ICAM-1 expression is required for tolerance induction.

56 a critical role in delaying and/or reversing tolerance induction.

57 -specific B cells before and after bee venom tolerance induction.

58 In vivo, HDAC11KO T cells were refractory to tolerance induction.

59 s for the use of antigen-specific therapy in tolerance induction.

60 ne marrow cell (BMC) engraftment and promote tolerance induction.

61 an contribute to graft rejection and also to tolerance induction.

62 erimental approach to immune suppression and tolerance induction.

63 a non-inflammatory context is beneficial for tolerance induction.

64 within the lymph node (LN) are integral for tolerance induction.

65 apoptotic cell antigens and failure of long-tolerance induction.

66 eractions provides a new research target for tolerance induction.

67 g B cell development, selection, and central tolerance induction.

68 inst mitochondrial content, and amenable for tolerance induction.

69 suggests that they are possible targets for tolerance induction.

70 riming capacity, which supports its role for tolerance induction.

71 on DC subsets can be exploited for improved tolerance induction.

72 tins) and are probably of prime relevance to tolerance induction.

73 repertoire, weakens the platform for central tolerance induction.

74 e host thymus implying an impairment in self-tolerance induction.

75 g a critical role of Tef cell elimination in tolerance induction.

76 ll engraftment and then evaluated transplant tolerance induction.

77 as not all alloantigens are revealed during tolerance induction.

78 e to deliver Ags to DCs for presentation and tolerance induction.

79 have been shown to be a critical barrier to tolerance induction.

80 ity could be a potential strategy for walnut tolerance induction.

81 apeutic manipulation of MDSCs for transplant tolerance induction.

82 ecific CD4(+) T cells transferred at time of tolerance induction (7 days before transplantation) beca

83 epletion of CD4+CD25+ cells did not abrogate tolerance induction, adoptive transfer of CD4+ cells fro

84 tween iNKT cells and Tregs in the context of tolerance induction after allogeneic HCT and set the sta

85 Thus, tolerance induction after IUHCTx depends on both direct

86 ings extend the notion that requirements for tolerance induction after lung transplantation differ fr

87 iated acceptance of most tissues and organs, tolerance induction after lung transplantation is critic

88 However, the precise cellular mechanisms of tolerance induction against particle-bound antigens, the

89 We therefore hypothesized that tolerance induction also requires these pluripotent prec

90 ts, novel treatment options may include oral tolerance induction, although most authors do not curren

91 diting, is the major irreversible pathway of tolerance induction among peripheral B cells.

92 itional deletion of Pten, resulted in failed tolerance induction and abundant autoantibody production

93 Tolerance induction and alloreactivity can be applied to

94 en implicated as being important for mucosal tolerance induction and because reovirus attachment prot

95 hymus medulla formation for alphabeta T cell tolerance induction and demonstrated a Rank-mediated rec

96 , implicating TCR revision as a mechanism of tolerance induction and demonstrating that TCR-dependent

97 gh self-antigen doses required for effective tolerance induction and elicits anergic, interleukin (IL

98 mice and found they were resistant to immune tolerance induction and exhibited greater susceptibility

99 rvations have implications for understanding tolerance induction and how B cell depletion may prevent

100 ermore, reducing alpha4 laminin circumvented tolerance induction and induced cardiac allograft inflam

101 chronic liver injury and fibrosis abrogated tolerance induction and led to an immunogenic reprogramm

102 and strengthen the cadre of Tregs to promote tolerance induction and long-term allograft survival.

103 been generally considered an organ prone to tolerance induction and maintenance.

104 nowledge, this is the first demonstration of tolerance induction and persistence of chimerism in a la

105 s in innate immune activation may help drive tolerance induction and reduce the rate of rejection.

106 for maintaining control of peripheral B cell tolerance induction and repressing autoimmunity.

107 ade of B7-H1/CD80 interaction prevented oral tolerance induction and restored T-cell responsiveness t

108 Anti-ER-TR7 prevented tolerance induction and resulted in allograft inflammati

109 perties and hepatic gene transfer results in tolerance induction and suppression of autoimmune diseas

110 ) versus donor-specific transfusion (DST) in tolerance induction and sustenance in living donor renal

111 roinflammatory cytokines interfere with oral tolerance induction and that blocking the IL-6 pathway i

112 ends great appeal as a strategy for targeted tolerance induction and treatment of autoimmune diseases

113 TCR-CD3 degradation, regulates naive T cell tolerance induction and Treg cell function.

114 lt in enhanced alloreactivity, resistance to tolerance induction, and destabilization of the establis

115 Treg population, were essential for in vivo tolerance induction, and expressed a biased, restricted

116 Aire:Brd4 association was critical for tolerance induction, and its disruption could account fo

117 lergen-specific T cell epitopes required for tolerance induction, and upon immunization of animals in

118 Immune-modulation such as tolerance induction appears to be an upcoming concept to

119 The mechanism of immune tolerance induction appears to be IL-10 dependent, as me

120 ific IgA antibody responses and lack of oral tolerance induction are all associated with aging.

121 g-loaded dendritic cells (DCs) delays T cell tolerance induction as well as refunctionalizes already

122 ular, we discuss phenotypic diversity during tolerance induction as well as signals that drive effect

123 ut minimally affected events associated with tolerance induction at the immature stage.

124 that aGVHD weakens the platform for central tolerance induction because individual TRAs are purged f

125 protein Ag delivery system facilitates oral tolerance induction because of a reduction in Ag-specifi

126 T regulatory cells that are dispensable for tolerance induction but required for long-term tolerance

127 f protein antigens is a preferred method for tolerance induction, but degradation during gastrointest

128 itional developmental stage that facilitates tolerance induction, but inflammation converts antigen-e

129 nted repressive nucleosome repositioning and tolerance induction, but the "open" promoter required en

130 enhance anti-transplant responses and impair tolerance induction, but the effect of Qa-1 deficiency o

131 ed regulation of gene expression and central tolerance induction, but this influence is unlikely to r

132 LA(-/-) OT-II cells were less susceptible to tolerance induction by a high-dose OVA peptide administe

133 We previously demonstrated that tolerance induction by anti-CD45RB antibody requires rec

134 re, reduced nuclear p50 levels and permitted tolerance induction by APCs.

135 ocking sites of oxidation in HMGB1 prevented tolerance induction by apoptotic cells.

136 oxygen species (ROS), which were critical to tolerance induction by apoptotic cells.

137 , enhanced luciferase activity and abrogated tolerance induction by CD154 mAb.

138 owed by rapid tumor regrowth, reminiscent of tolerance induction by CD3 mAb-mediated T-cell depletion

139 This study illustrates tolerance induction by contact-based immune cell interac

140 Tolerance induction by dendritic cells (DCs) is, in part

141 serum prolactin levels interfere with B cell tolerance induction by impairing BCR-mediated clonal del

142 Tolerance induction by mixed chimerism without toxic con

143 Recent evidence on tolerance induction by regulatory T-cells and on B-cell

144 o not develop allergic contact dermatitis is tolerance induction by repeated exposure to low doses of

145 In contrast, tolerance induction by TD antigens without costimulation

146 iscusses the cellular and molecular basis of tolerance induction by the eye and notes the parallels t

147 These results suggest that tolerance induction can occur in the presence of IFN-gam

148 of IFN-gamma-mediated inflammation, and that tolerance induction can prevent the tissue injury caused

149 n of CD4(+)CD25(+)FOXP3(+) Treg cells during tolerance induction completely abolishes the development

150 ing pathways that are being investigated for tolerance induction, detailing preclinical studies and t

151 In contrast, plasma cells induced on tolerance induction did not downregulate alpha2,6-sialyl

152 Immunological requirements for rejection and tolerance induction differ between various organs.

153 ptophan degradation pathway is important for tolerance induction during systemic allergen immunothera

154 ne conditions for stable mixed chimerism and tolerance induction following combined hematopoietic cel

155 e in the control of T-cell alloresponses and tolerance induction following hepatocyte transplantation

156 re amenable to therapeutic manipulations for tolerance induction for cardiac transplantation.

157 rial therapy may be a promising strategy for tolerance induction for clinical xenogeneic islet transp

158 Moreover, the known need in tolerance induction for TGF-beta signaling to T cells ca

159 ffectiveness and additional requirements for tolerance induction for xenogeneic islet transplantation

160 progress to be made in moving strategies for tolerance induction from the bench to the bedside and di

161 Mucosal tolerance induction generally requires multiple or large

162 A large number of approaches to tolerance induction have been described in the experimen

163 ver, the cellular interactions that underlie tolerance induction have not been identified.

164 intrathymically and was essential for robust tolerance induction in a mouse model of spontaneous ence

165 une parameters that capture novel markers of tolerance induction in allergic patients.

166 icted TCR responsible for Ag recognition and tolerance induction in CD8(+) T cells can, in the absenc

167 ry of T cell antigens could be harnessed for tolerance induction in clinical settings.

168 e system that allows interrogation of T-cell tolerance induction in endogenous naive and memory CD8 T

169 To test this system for tolerance induction in experimental allergic encephalomy

170 mmunotherapy may be a promising approach for tolerance induction in experimental arthritis and perhap

171 In order to elucidate cellular mechanisms of tolerance induction in healthy and injured liver, we dev

172 gs and is a promising reagent for studies of tolerance induction in hematopoietic cell transplantatio

173 might therefore be a less optimal agent for tolerance induction in human organ transplantation.

174 rolled trials exploring the efficacy of oral tolerance induction in infancy for the prevention of FA.

175 e ability of intestinal grafts to facilitate tolerance induction in major histocompatibility complex

176 ndings highlight the critical role of LCs in tolerance induction in mice to the prototype innocuous h

177 -cell precursor frequency, both obstacles to tolerance induction in other models of antigen-specific

178 herapy and could be an attractive target for tolerance induction in patients with food allergy.

179 as shown preliminary success for intentional tolerance induction in pilot clinical trials.

180 as shown preliminary success for intentional tolerance induction in pilot clinical trials.

181 Our data show that NK cells are required for tolerance induction in recipients given donor splenocyte

182 68-M1 gene was associated with resistance to tolerance induction in studies using gammaHV68-M1 mutant

183 The mechanisms that determine the tolerance induction in subjects with LZT are still elusi

184 Tolerance induction in T cells takes place in most tumor

185 ly administered autoantigen-secreting LL for tolerance induction in T1D.

186 of xenogeneic thymus tissue allows xenograft tolerance induction in the highly disparate pig-to-mouse

187 Particle-associated tolerance induction in the liver protected mice from kid

188 ghlight the need for tailored approaches for tolerance induction in the lung.

189 and airway inflammation by allergen-specific tolerance induction in the offspring.

190 that Aire plays an important role in T cell tolerance induction in the thymus, mainly by promoting e

191 idity CD8(+) T cells are more susceptible to tolerance induction in the tumor microenvironment.

192 ompetent hepatocytes, which was required for tolerance induction in these mice.

193 atory T cells might be a useful strategy for tolerance induction in this context.

194 DCs and invariant NKT cells are required for tolerance induction in this system that was translated i

195 ) regulatory T cells play a critical role in tolerance induction in transplantation.

196 Mixed chimerism is an effective approach for tolerance induction in transplantation.

197 DC subset may result in a higher efficacy of tolerance induction in vivo and may support the developm

198 ll activation, its role in peripheral T cell tolerance induction in vivo has not been addressed.

199 Foxp3 demethylation was associated with tolerance induction, indicating that Treg cells play an

200 chanisms of CD4 cell tolerance in a model of tolerance induction involving establishment of mixed hem

201 Early tolerance induction is an attractive approach for primar

202 ar whether the efficiency of engraftment and tolerance induction is influenced by targeting antigen t

203 lectively, these findings indicate that full tolerance induction is largely dependent on substantial

204 The role of maternal immune responses in tolerance induction is poorly understood.

205 HSC engraftment and tolerance induction is readily achieved after myeloablat

206 However, resistance to tolerance induction is seen with certain T-cell depletin

207 idity in patients before they undergo immune tolerance induction (ITI) and in those with persistent h

208 to attempt to eliminate inhibitors is immune tolerance induction (ITI) via a protocol requiring inten

209 ogenic therapies, other than standard immune tolerance induction (ITI), is an unmet goal.

210 significant) were shorter with the HD immune tolerance induction (ITI).

211 tive randomized, multicenter study of immune tolerance induction(ITI) in patients with hemophilia A r

212 Tolerance induction led to deletion of TS-specific CD8(+

213 lating therapies (including antigen-specific tolerance induction) need to be further delineated.

214 trate that NFAT1 is neither required for CD4 tolerance induction nor for their regulatory function on

215 s of normal tissue result in the deletion or tolerance induction of WT1-specific T cells.

216 mediated inflammation, maintenance of immune tolerance, induction of the two suppressive cytokines in

217 These data suggest that tolerance induction operates in B cells at a postactivat

218 Treg) cells, as their depletion early during tolerance induction or late after established tolerance

219 st cell activation was initiated during oral tolerance induction or OVA immunization.

220 us a key data on the role of this feeding in tolerance induction or sensitization in children.

221 s conserved DC subset a promising target for tolerance induction or vaccination.

222 However, IFN-gamma can also participate in tolerance-induction pathways, indicating it is not solel

223 series of experiments that implicate LCs in tolerance induction, positioning these cells as key regu

224 o siglecs, CD22 and Siglec-G, contributed to tolerance induction, preventing plasma cell differentiat

225 autoreactive B-lymphocytes bypassing normal tolerance induction processes to be the subset of antige

226 erwent LDRT between 2007 and 2011: 606 under tolerance induction protocol (TIP) and 310 with our usua

227 ach in demographically well-balanced groups, tolerance induction protocol (TIP) was used with SCT in

228 Tolerance induction protocol consisted of SCT/DST under

229 y led to the first clinical application of a tolerance induction protocol for kidney transplantation.

230 the remaining obstacles to introduction of a tolerance induction protocol to clinical practice in han

231 lls and T cells from HLA-matched donors in a tolerance induction protocol.

232 By using a mixed chimerism-based tolerance-induction protocol, we found that mice undergo

233 n, "What do we need to have in place to make tolerance induction protocols a 'standard of care' for o

234 type 1 diabetes and are used to investigate tolerance induction protocols for islet transplantation

235 e a useful tool in the development of future tolerance induction protocols in non-sensitized patients

236 cute rejections and are an essential part of tolerance induction protocols in various animal models;

237 sed to accomplish this goal, both as part of tolerance induction protocols or to reduce the requireme

238 process, test new antirejection treatments, tolerance induction protocols or to understand basic imm

239 s been demonstrated in mixed chimerism-based tolerance induction protocols; however, the development

240 nfections at the time of transplantation and tolerance induction provide a pro-inflammatory milieu th

241 rgy show promise for oral immunotherapy, but tolerance induction remains elusive, and additional ther

242 The involvement of B cells in allergen tolerance induction remains largely unexplored.

243 tients with such enzyme deficiencies, immune tolerance induction should be advocated in the patients

244 tions, there is an immediate need to develop tolerance induction strategies and to elucidate the mech

245 To date, there are no known tolerance induction strategies that prevent transplant a

246 Such a mechanism supports a pulse tolerance induction strategy with anti-LFA-1 rather than

247 Here, we developed a delayed tolerance induction strategy with mixed chimerism throug

248 Kinetic tolerance induction studies revealed a critical period f

249 umors result in either complete ignorance or tolerance induction, suggesting inadequate DC function.

250 y DC10 are requisite, but not sufficient for tolerance induction, suggesting that DC10 and Th2 effect

251 Building on previous strategies for tolerance induction that exploited natural mechanisms fo

252 we focused on identifying regimens of immune tolerance induction that may be readily available for cl

253 pment of more robust and safer protocols for tolerance induction that will be guided by innovative im

254 > 1:80) in patients after successful immune tolerance induction therapy (n = 23), and 100% (n = 20,

255 on, host CD8(+) DCs play a requisite role in tolerance induction through interactions with NKT cells.

256 range of nonmalignant indications, including tolerance induction through mixed chimerism.

257 Moreover, these Tregs were capable of serial tolerance induction through modulation of macrophages th

258 tablish a role for MDSCs in antigen-specific tolerance induction through preferential antigen uptake

259 The data are consistent with tolerance induction to a cell component of porcine islet

260 We analyzed the mechanisms of perinatal tolerance induction to allergens, with particular focus

261 chimeric form of FasL protein (SA-FasL) for tolerance induction to cardiac allografts.

262 that clearance of apoptotic cells results in tolerance induction to cleared Ags by dendritic cells (D

263 for this Th17 suppression is consistent with tolerance induction to col(V).

264 roach using liver-targeted gene delivery for tolerance induction to donor antigen.

265 ein tested the effect of B-cell depletion on tolerance induction to factor VIII (FVIII) in a mouse mo

266 te cellular and molecular mechanisms of oral tolerance induction to food and aeroallergens in human t

267 markedly resistant to local and systemic UV tolerance induction to hapten sensitization and contact

268 control the ability of TLR agonists to block tolerance induction to hematopoietic and skin allografts

269 of the alloantibody response and transplant tolerance induction to mismatched islet allografts.

270 K cells have regulatory function and promote tolerance induction to murine cardiac allografts.

271 er studies that explore the efficacy of oral tolerance induction to other common food allergens and t

272 mine and ranitidine were administered during tolerance induction to OVA.

273 Clinical tolerance induction to permit minimization or cessation

274 argets for depletion, immunosuppression, and tolerance induction to promote long-term graft survival.

275 ine a period of heightened susceptibility to tolerance induction to tissue-restricted antigens (TRAs)

276 may have important clinical implications in tolerance induction to transplanted tissues.

277 tokines, and local inflammation demonstrated tolerance induction toward the secondary antigen in the

278 Tolerance induction toward the semiallogeneic fetus is c

279 CD25 T cells; half of the recipients undergo tolerance induction treatment.

280 medicine, offering approaches for developing tolerance-induction treatments relevant to cell therapie

281 In the latter case, we found that tolerance induction triggered recessive mechanisms leadi

282 In theory, delaying conditioning for tolerance induction until after organ transplantation co

283 tic understanding, and clinical potential of tolerance induction using apoptotic Ag-coupled apoptotic

284 Tolerance induction was also successful in preimmune mic

285 The resistance to tolerance induction was dependent on the synergistic eff

286 Oral tolerance induction was enhanced in mice lacking express

287 Tolerance induction was facilitated when anti-CD4 mAbs w

288 round mice treated with OVA, suggesting that tolerance induction was impaired by spaceflight.

289 Tolerance induction was specific for the tolerogenic vac

290 The requirement for NK cells in tolerance induction was tested by administering anti-NK1

291 Using a classical system of tolerance induction, we examined the immunological conse

292 te the mechanisms underlying this barrier to tolerance induction, we used complementary murine models

293 Mechanisms of tolerance induction were analyzed in a murine model of L

294 2,3 dioxygenase (IDO)-tryptophan pathway in tolerance induction were assessed, and the frequency and

295 M2-like subsets predominate tolerance induction whereas M1 MPhis predominate in infl

296 bility of DCs to delay tumor-mediated T cell tolerance induction, whereas interfering with 4-1BBL, CD

297 d alloimmune response and are susceptible to tolerance induction, which is associated with a clonal d

298 role of the TCR/calcineurin/NFAT pathway for tolerance induction with anti-CD154.

299 ted patients, and patients undergoing immune tolerance induction with large doses of factor VIII to e

300 f autoimmune conditions can be reinforced by tolerance induction with peptide epitopes, but the mecha