ライフサイエンスコーパス: tolerate

1 Venetoclax was generally well tolerated.

2 Both consolidation therapies were well tolerated.

3 Treatment was generally well tolerated.

4 in which a variety of functional groups were tolerated.

5 Repeated infusions of TCZ were well tolerated.

6 FMT with antibiotic pretreatment was well tolerated.

7 he stem and loop portions were likewise well tolerated.

8 elerated GE, and was generally safe and well tolerated.

9 avirin, for 8 weeks was efficacious and well tolerated.

10 Treatment with basimglurant was overall well-tolerated.

11 Furthermore, PF-04958242 was well tolerated.

12 th bipolar I disorder and was generally well-tolerated.

13 Conclusion rAd-IFNalpha/Syn3 was well tolerated.

14 etone, nitrile, nitro, and triazene are well tolerated.

15 polysaccharide complex possibly being better tolerated.

16 Both study drugs were well tolerated.

17 LAIV H5N2 vaccine was well tolerated.

18 raction, whereas variations in the lock were tolerated.

19 hereditary angio-oedema attacks and was well tolerated.

20 The 2- and 3-DAA combinations were well tolerated.

21 of conventional (99m)Tc-NaTcO4 and was well tolerated.

22 with rituximab depleted B cells and was well tolerated.

23 Both treatments were well tolerated.

24 ks after therapy, and DAA regimens were well tolerated.

25 per day) was permitted if the drug was well tolerated.

26 s also a common complication and is not well tolerated.

27 le infusion of elamipretide is safe and well tolerated.

28 Both vaccines were safe and well tolerated.

29 MSC infusions were well tolerated.

30 cular-targeted photodynamic therapy was well tolerated.

31 Ledipasvir-sofosbuvir was well tolerated.

32 be present, and fragile structures are also tolerated.

33 Lifitegrast appeared well tolerated.

34 maintains cellular oxidative stress that it tolerates.

35 The mice could tolerate 20mg/kg PTX formulated in nano-formulations, wh

36 entilation all six ventilated-paced subjects tolerated 8 minutes of intense phrenic stimulation, wher

37 Although Env can tolerate a high degree of mutation in five variable regi

38 he mild conditions involved in this reaction tolerate a plethora of functional groups, the process ca

39 Rev's ability to tolerate a SNES was both position and multimerization de

40 of patients treated with >/=6 months of SCIT tolerated a concentration of P. pratense over 50 times h

41 This protocol tolerates a great variety of functional groups and thus

42 Enabled by this new ligand, the reaction tolerates a wide range of alkynes furnishing the product

43 onsistently operated at room temperature and tolerates a wide range of functional groups, showing rea

44 The present method tolerates a wide range of functional groups.

45 The reaction is scalable and tolerates a wide spectrum of functional groups deliverin

46 ther the iron chelator, deferiprone, is well tolerated, able to chelate iron from various brain regio

47 eased proportions of acid-producing and acid-tolerating (aciduric) bacterial species within dental bi

48 eta-lactamase in a redox-dependent manner to tolerate AG.

49 The reaction is fast at acidic pH and tolerates alcohols, carboxylic acids, and even secondary

50 llelic contribution to determine the maximum tolerated allele count in gnomAD, we report an evaluatio

51 advanced pancreatic cancer is generally well tolerated, although major adverse events can occur.

52 lation and Suzuki-Miyaura coupling reactions tolerate an array of electronically and sterically diver

53 A polymerase (hpol) gamma have been shown to tolerate an entire RNA strand.

54 FGF22-FGFR1c2 In addition, FGF22-FGFR1c2 can tolerate an HS chain having an N-acetylglucosamine resid

55 ductase gene, nfsI have increased ability to tolerate and detoxify TNT.

56 only the low-affinity CD3/CLL1 TDB was well tolerated and able to deplete target cells.

57 Subretinal delivery of rAAV.sFLT-1 was well tolerated and demonstrated a favourable safety profile t

58 Conclusion PF-03084014 was well tolerated and demonstrated promising clinical benefit in

59 sofosbuvir-velpatasvir-voxilaprevir was well tolerated and effective at achieving virological respons

60 INTERPRETATION: Luspatercept was well tolerated and effective for the treatment of anaemia in

61 ive decline, there is an unmet need for well-tolerated and effective therapy of BPSD.

62 atasvir plus ribavirin for 24 weeks was well tolerated and effective, particularly those with hepatit

63 iterature suggests that this therapy is well tolerated and effective.

64 drugs (AEDs), in low doses, is usually well tolerated and efficacious.

65 Both lithium and divalproex were adequately tolerated and efficacious; lithium was associated with a

66 INTERPRETATION: The ZPIV candidate was well tolerated and elicited robust neutralising antibody titr

67 e patches for influenza vaccination was well tolerated and generated robust antibody responses.

68 ION: A single dose of 400 mg DSM265 was well tolerated and had causal prophylactic activity when give

69 The parenteral P2-VP8-P[8] vaccine was well tolerated and immunogenic in infants, providing a novel

70 KNO3 is potentially well tolerated and improves exercise duration and quality of

71 Conclusion Sacituzumab govitecan was well tolerated and induced early and durable responses in hea

72 aily enasidenib treatment was generally well tolerated and induced hematologic responses in patients

73 TERPRETATION: Intracerebral rAVV2/5 was well tolerated and induced sustained enzyme production in the

74 ITs were well tolerated and initially efficacious but were ultimately

75 It is generally well tolerated and may result in a durable response.

76 CAM2038 weekly, 24 and 32 mg, was safely tolerated and produced immediate and sustained opioid bl

77 acebo groups, indicating that PPOIT was well tolerated and psychological well-being was not negativel

78 Weekly i.n. GSK2245035 20 ng was well tolerated and reduced allergic reactivity to nasal chall

79 BPS804 treatment was well tolerated and resulted in increases in bone formation bi

80 hat 32 doses of BTZ monotherapy was not well tolerated and resulted in only a modest reduction in ant

81 INTERPRETATION: PfSPZ Vaccine was well tolerated and safe.

82 Heterocycle substitutions at C24 were well-tolerated and several tetrazole-containing derivatives w

83 both dosing regimens of sirukumab were well tolerated and significantly improved signs and symptoms

84 INTERPRETATION: rVSVG-ZEBOV-GP was well tolerated and stimulated a rapid onset of binding and ne

85 Deferiprone therapy was well tolerated and was associated with a reduced dentate and

86 ting that the investigational agent was well tolerated and, in subgroup analyses, participants who de

87 Treatment was well tolerated, and 100% histologic cure was achieved in 9 of

88 l screening test should be inexpensive, well tolerated, and applicable to primary care.

89 ted interferon alfa-2a therapy is safe, well tolerated, and establishes functional control of HBV and

90 GBR-identified drugs, the commonly-used well-tolerated antihyperglycemic sitagliptin, produces a dose

91 sinin-piperaquine (DP) is an effective, well tolerated artemisinin-based combination therapy.

92 at 5 mug improved lung function and was well tolerated as add-on therapy to ICS with other maintenanc

93 of discomfort, suggesting that it is poorly tolerated as an early routine treatment of HG.

94 n maintaining viral suppression and was well tolerated at 48 weeks.

95 n maintaining viral suppression and was well tolerated at 48 weeks.

96 on of AAV2-sFLT01 seemed to be safe and well tolerated at all doses.

97 the 7-hydroxy Tic pharmacophore, are better tolerated at kappa and mu receptors and yield very high

98 The intervention was well-tolerated, because the helmet-type mask caused no pain o

99 atients who have been stable on a "maximally tolerated beta-blocker dose," but this definition and ho

100 line exercise test while receiving maximally tolerated beta-blocker therapy that was continued throug

101 hat telomerase activation is not only safely tolerated but also advantageous for clonal expansion.

102 nstrated that hydrophobic substitutions were tolerated but polar or charged substitutions resulted in

103 uring infancy is highly efficacious and well tolerated, but current assays for early detection fail t

104 docetaxel and prednisone was reasonably well tolerated, but overall survival was not significantly lo

105 MEAN at an effective dose for 6 wk was well tolerated by animals.

106 re generally low, with omalizumab being well tolerated by most patients, including children.

107 h probability of tumor cure while being well tolerated by nude mice bearing subcutaneous GPA33-positi

108 High-flow nasal cannulae seem well tolerated by patients.

109 sociated with hemolytic events and is poorly tolerated by some patients.

110 nmeal and grits were below the maximum limit tolerated by the European Commission.

111 r of the mouse intestinal microbiota that is tolerated by the host.

112 al clue as to why this bacterium is normally tolerated by the immune system.

113 dicates that the corrosion products are well tolerated by the tested cells and potentially negligible

114 cyano, chloro, and bromo functionalities are tolerated by the transition metal-free catalyst.

115 ramework for identifying new conditions that tolerate challenging functional groups.

116 The capacity to tolerate climate change often varies across ontogeny in

117 The host's mucosal immune system must tolerate commensals while fighting pathogens.

118 MVC-containing regimens were safe and well tolerated compared with TDF + FTC; this study was not po

119 -containing PrEP regimens were safe and well-tolerated compared with TDF-FTC in U.S. women.

120 Charged residues were poorly tolerated, conferring extreme temperature-sensitive and

121 and/or cytidine deaminase-deficient cells to tolerate constitutive DNA damage and replication stress.

122 garding the mechanisms of resistance used to tolerate constitutive, long-term exposure to DNA methyla

123 c approach that teaches the immune system to tolerate contact allergens by expanding populations of n

124 l second-line therapy in patients who cannot tolerate continous positive airway pressure (CPAP) machi

125 study was conducted to determine the maximum-tolerated cumulative dose (MTCD) and evaluate safety, ac

126 not the overlapping regulatory subunits, to tolerate disease-associated PP2A mutations, resulting in

127 tants, yet the mechanisms that allow them to tolerate disinfection are poorly understood.

128 re a moderate amount of PD treatment and can tolerate dopamine agonist therapy.

129 n 14-day acute toxicity in rats, the maximum tolerated dose (MTD) and the no observed adverse effect

130 imary objective was to determine the maximum tolerated dose (MTD) of isatuximab with lenalidomide and

131 nano-formulations, which doubled the maximum tolerated dose (MTD) of Taxol.

132 ients received either Nexvax2 at the maximum tolerated dose (MTD) or placebo.

133 DNA alkyltransferase activity, but a maximum tolerated dose (MTD) was not reached.

134 n-human phase 1/2 study assessed the maximum tolerated dose (MTD), pharmacokinetic and pharmacodynami

135 doxifen to determine its toxicities, maximum tolerated dose (MTD), pharmacokinetics, and clinical act

136 r receptors (FGFRs) to determine the maximum tolerated dose (MTD), the recommended phase II dose (RP2

137 aive and PI-exposed patients) at the maximum tolerated dose (MTD).

138 valpituzumab tesirine, including the maximum tolerated dose and dose-limiting toxic effects.

139 The primary endpoints were maximum tolerated dose and dose-limiting toxicity for phase 1, a

140 We aimed to establish the maximum tolerated dose and establish the recommended phase 2 dos

141 ary objectives were to establish the maximum tolerated dose and recommended phase 2 dose of veliparib

142 the FAQLQ-PF was independent of the maximal tolerated dose at baseline or following four months of t

143 x 10(10) vg, n=3 per cohort) and one maximum tolerated dose cohort (cohort 5, 2 x 10(10) vg, n=7) and

144 (IV) administration of CP-Dox at the maximum tolerated dose increases the infiltration of leukocytes

145 imary objective was to establish the maximum tolerated dose of CPI-613 (as assessed by dose-limiting

146 INTERPRETATION: A maximum tolerated dose of CPI-613 was established at 500 mg/m(2)

147 olished attrition produced by a near maximum-tolerated dose of PTX.

148 The maximum tolerated dose of rovalpituzumab tesirine was 0.4 mg/kg

149 In the phase 1 part, the maximum tolerated dose of the combination was not reached.

150 point was the identification of the maximum tolerated dose of the combination.

151 INTERPRETATION: The maximum tolerated dose of trastuzumab deruxtecan was not reached

152 including mutagenicity and maximum/repeated tolerated dose studies, as well as in vivo testing in ro

153 en shown to be more efficacious than maximum tolerated dose treatment in preclinical studies, and is

154 ber of treatment cycles given at the maximum tolerated dose was 11 (IQR 4-19).

155 Gilteritinib was well tolerated; the maximum tolerated dose was established as 300 mg/day when two of

156 No maximum tolerated dose was identified.

157 The maximum tolerated dose was not identified; the recommended phase

158 , at the 20 mg/kg dose, and thus the maximum tolerated dose was not reached.

159 icity profile up to 20 mg/kg and the maximum tolerated dose was not reached.

160 Therefore, the maximum tolerated dose was not reached; the recommended phase 2

161 em to be associated with dose and no maximum tolerated dose was reached.

162 the safety profile, to determine the maximum tolerated dose, and to establish the recommended phase 2

163 the dose-limiting toxicities (DLTs), maximum tolerated dose, pharmacokinetic profile, and response ra

164 sk for TdP than patients reloaded at a prior tolerated dose.

165 termine the safety, feasibility, and maximum tolerated dose.

166 This phase 1/2 trial evaluated the maximum tolerated doses, safety, and efficacy of pomalidomide, b

167 -CD19B is pharmacodynamically active at well-tolerated doses.

168 d 60 mug doses where found to be the highest tolerated doses.

169 blockers that may aid in achieving maximally tolerated doses.

170 es, pathways and ncRNAs that are involved in tolerating drugs or induce disease; (iv) higher order ge

171 cal taxa may be physiologically incapable of tolerating dry conditions, and that their distributions

172 of decline in renal function that should be tolerated during intensive BP lowering and its associati

173 hich is beneficial for regeneration, is well tolerated during Schwann cell development and in the adu

174 As of the species, the proposed approach can tolerate edge loss in PPI networks and even discover spa

175 tudy provides evidence that some sponges can tolerate environments that appear unsuitable to many cor

176 Therapy was well tolerated, even among the 72% of patients with cardiac A

177 40 kHz ultrasound for 0.5 seconds were well tolerated, even in mice with acute colitis.

178 ation of BV plus Nivo was an active and well-tolerated first salvage regimen, potentially providing p

179 Rilonacept was well tolerated (five adverse events versus two with placebo).

180 nus is unstructured and therefore may better tolerate fluorescent protein fusions.

181 in hydrophobicity of amino acids are better tolerated for activation by capsaicin than for activatio

182 amide-motif in the phytosphingosine chain is tolerated for CD1d binding and TCR recognition, the stud

183 dil 0.02% was found to be effective and well tolerated for the treatment of patients with ocular hype

184 Parasites with an intact glycolysis can tolerate genetic deletions of TgPEPCKmt as well as of Tg

185 erobic oxidation catalysis: (1) The reaction tolerates heterocycles that commonly poison Pd catalysts

186 enabling persistent bacterial populations to tolerate high concentrations of antimicrobials.

187 E. faecalis tolerates high concentrations of GIT antimicrobials, lik

188 der experimental conditions, naked mole-rats tolerate hours of extreme hypoxia and survive 18 minutes

189 novel molecule that reduces chorea, was well tolerated in a double-blind, placebo-controlled study.

190 form of this antibody (ozanezumab) was well tolerated in a first-in-human trial.

191 sofosbuvir currently used in adults was well tolerated in adolescents and had an appropriate pharmaco

192 Belatacept was initially well tolerated in all cases.

193 Furthermore, both compounds were very well tolerated in BALB/c mice without any detectable acute to

194 PA101 was well tolerated in both cohorts.

195 We found that our paradigm is well tolerated in children as young as 6 years, that children

196 Conclusion Abexinostat is well tolerated in combination with pazopanib, allowing prolon

197 ion at the doses of two drugs that were well tolerated in combination.

198 lenalidomide and dexamethasone is active and tolerated in heavily pretreated patients with RRMM.

199 It is expected to be well tolerated in humans and is available for clinical evalua

200 ent adult progenitor cells was safe and well tolerated in patients with acute ischaemic stroke.

201 GLE and PIB was highly efficacious and well tolerated in patients with HCV genotype 1 infection and

202 INTERPRETATION: Eltrombopag is well-tolerated in patients with lower-risk myelodysplastic sy

203 esis screen to identify where mutations were tolerated in replicating viruses.

204 Its homozygous loss is tolerated in seemingly healthy individuals, with reduced

205 he lifetime absence of ADAR1-editing is well tolerated in the absence of MDA5.

206 y, disruption of ATP6AP2 is extremely poorly tolerated in the adult, and severely affects various org

207 that loss of either component alone is well tolerated in the developing brain, in contrast to epithe

208 keratinocytes and aberrant DNA retention is tolerated in the oral epithelium.

209 njection with pars plana vitrectomy was well tolerated in this cohort.

210 NTERPRETATION: PF-00547659 was safe and well tolerated in this patient population, and better than pl

211 A diverse range of aryl iodides are tolerated in this reaction, along with select heteroaryl

212 nofovir alafenamide was efficacious and well tolerated in virologically suppressed, HIV-infected chil

213 Under conditions where it was well tolerated in vivo, this FOXO4 peptide neutralized doxoru

214 s a 2-dose schedule was immunogenic and well tolerated in young girls.

215 of biologically relevant AA side chains are tolerated including those for alanine, valine, leucine,

216 ariety of strategies to avoid, eliminate, or tolerate infection.

217 udy was to determine the plasticity of gD to tolerate insertion or deletion mutations and to construc

218 hemotherapy and to unfit patients, unable to tolerate intensive chemotherapy.

219 grapevine avoids xylem embolism rather than tolerates it.

220 erved in the Orai1 and Orai3 isoforms, Orai3 tolerates larger N-terminal truncations than Orai1 in re

221 While loss of NMD is tolerated, loss of hUPF1 induces a DNA damage response a

222 HLA eplet mismatch score were less likely to tolerate low tacrolimus levels without developing dnDSA.

223 imation responses that allow some insects to tolerate low temperatures are multifactorial and involve

224 If tolerated, medication was administered until disease pro

225 By contrast, the conserved loop sequence tolerated minimal perturbations.

226 essential while the lactone functional group tolerates modifications.

227 in combination with gemcitabine using a well-tolerated multidose schedule, the same compound caused r

228 In contrast, the Rec2 and PI domains tolerate mutation better than other regions.

229 ly enriched at protein allosteric sites than tolerated mutations, suggesting a critical role for prot

230 of Proxison demonstrated effective and well tolerated neuroprotection against cell loss in a zebrafi

231 rAd-IFNalpha/Syn3 was well tolerated; no grade four or five adverse events (AEs) oc

232 Subcutaneous methotrexate was generally well tolerated; no patients died or had serious infections, m

233 The median peanut dose tolerated on the initial desensitization day was 250 mg

234 endovascular treatment, when patients cannot tolerate or have contraindications to antiplatelet thera

235 n patients allergic to one kind of PPI could tolerate other structurally different PPI without cross-

236 Eliglustat was well tolerated over 4 years; 4 (2.5%) patients withdrew becau

237 During replication, DNA polymerases tolerate patches of ribonucleotides on the parental stra

238 This well-tolerated phenotype persisted in elderly TG with no indi

239 Treatment was generally well tolerated pretransplantation and posttransplantation, wi

240 We demonstrate that M-Probes can tolerate sequence variations of up to 7 nt at prescribed

241 rect interactions as well as dynamics, while tolerating several potentially disruptive mutations.

242 Honokiol (HKL) is a well tolerated small molecule that disrupts mitochondrial fun

243 2 sites in 21 countries, adults with HCC who tolerated sorafenib (>/=400 mg/day for >/=20 of last 28

244 ositions these drugs as add-ons to maximally tolerated statin therapy or for those with statin intole

245 nts report adverse reactions to, and may not tolerate, statin therapy.

246 plasticity occurs when mitochondria adapt to tolerate stressors.

247 on if deriving apparent clinical benefit and tolerating study drug, at the investigator's discretion.

248 If tolerated, subjects continued on 4000 mg of peanut prote

249 es of SCIg IgPro20 were efficacious and well tolerated, suggesting that SCIg can be used as a mainten

250 le only to those who can access, afford, and tolerate taking daily pills.

251 hat, in both mutants, Cpd-5 should be better tolerated than the closely related NMS-P715.

252 prosurvival mechanisms that enable cells to tolerate the cytotoxic effects of sunitinib.

253 thogens, and on the resilience of tissues to tolerate the presence of pathogens.

254 eatments for patients who fail or who do not tolerate the sequence of sorafenib and regorafenib.

255 mutant mice became persistently ketotic and tolerated the KD for up to 11 weeks.

256 All subjects tolerated the PET/MRI examination well, and no adverse r

257 Twelve patients tolerated the procedure, including three with a previous

258 All 23 participants tolerated the regimen well; there were no serious advers

259 All patients tolerated the surgery well and no intraoperative or post

260 t the antimicrobial activity of thiostrepton tolerates the alteration of Dha16 to a range of amino ac

261 o attacks) is stable, when attacks should be tolerated, the consequences of asymmetric technical attr

262 Gilteritinib was well tolerated; the maximum tolerated dose was established as

263 l disorders, but direct antagonism is poorly tolerated therapeutically.

264 ients without bone sarcoma and those able to tolerate therapy for more than 3 cycles (9 weeks) benefi

265 al groups on the quinazolinone scaffold were tolerated to provide novel quinazolinone derivatives.

266 with a wide variety of substitution patterns tolerated to provide the corresponding nitrogen-containi

267 ug, followed by 30 mug, then 60 mug if doses tolerated) to parenteral P2-VP8-P[8] subunit rotavirus o

268 y alone should be considered a safe and well tolerated treatment for malignant dysphagia in the palli

269 Conclusion ACE is a feasible, safe, and well-tolerated treatment for patients with HCC; it is highly

270 rical N-allyl-N-methylglycine esters is also tolerated under the catalytic relay conditions without c

271 OF, for the discrimination of pathogenic and tolerated variants that can also generate hypotheses on

272 Satiation, as assessed by maximum tolerated volume at 16 weeks, was lower in the liragluti

273 as cultivated plants will otherwise have to tolerate warmer temperatures and possibly face novel ene

274 While 7-substituents are not well-tolerated, we have identified novel substituents at the

275 cycline-controlled Tet-transactivator, while tolerated well during development and in immunologically

276 Further study as to how fish tolerate what is an early lethal mutation in mammals cou

277 iver of divergence in isolation, (ii) can be tolerated when balancing selection prevents random loss

278 The combination was well tolerated, which allowed for dose escalation to the high

279 Ibrutinib was well-tolerated with a toxicity profile similar to labeled ind

280 reactions, long-acting cabotegravir was well tolerated with an acceptable safety profile.

281 and tenofovir alafenamide was safe and well tolerated with better gastrointestinal tolerability than

282 r, treatment with the alphaAnalogue was well tolerated with neither signs of desensitization nor beha

283 [(18) F]Nifene (185 MBq; <0.10 mug) was well tolerated with no adverse effects.

284 RCE was well tolerated with no adverse events.Twice daily RCE intake

285 Study drugs were well tolerated with no serious adverse events.

286 enalidomide-dexamethasone was generally well tolerated with only 1 dose-limiting toxicity reported (g

287 Treatment was well tolerated, with a 6-week mortality rate of 0%.

288 umab monotherapy and this treatment was well tolerated, with a low incidence of IgM flare.

289 Riluzole was generally well tolerated, with a side effect profile consistent with it

290 Ridinilazole was well tolerated, with an adverse event profile similar to that

291 PT2385 was well tolerated, with anemia (grade 1 to 2, 35%; grade 3, 10%)

292 Both treatments were well tolerated, with average follow-up adverse event scores b

293 ABT-436 was well tolerated, with diarrhea (mild-to-moderate severity) bei

294 Deutetrabenazine was generally well tolerated, with low rates of neuropsychiatric AEs.

295 jections, which were generally safe and well tolerated, with more immediate, but transient, pain in t

296 dministration of serelaxin was safe and well tolerated, with no detrimental effect on systemic blood

297 Infusions were well tolerated, with no dose-limiting toxic effects.

298 BIIB074 was well tolerated, with similar adverse events in the double-bli

299 e remaining amino acids were in general well tolerated, with the exemption of the P6 position.

300 The therapy was generally well tolerated, without any clear signal of any unexpected ad