ライフサイエンスコーパス: tolerated

1 Treatment was generally well tolerated.

2 Venetoclax was generally well tolerated.

3 Repeated infusions of TCZ were well tolerated.

4 in which a variety of functional groups were tolerated.

5 FMT with antibiotic pretreatment was well tolerated.

6 elerated GE, and was generally safe and well tolerated.

7 avirin, for 8 weeks was efficacious and well tolerated.

8 Furthermore, PF-04958242 was well tolerated.

9 Treatment with basimglurant was overall well-tolerated.

10 th bipolar I disorder and was generally well-tolerated.

11 etone, nitrile, nitro, and triazene are well tolerated.

12 he stem and loop portions were likewise well tolerated.

13 Conclusion rAd-IFNalpha/Syn3 was well tolerated.

14 polysaccharide complex possibly being better tolerated.

15 Both study drugs were well tolerated.

16 LAIV H5N2 vaccine was well tolerated.

17 hereditary angio-oedema attacks and was well tolerated.

18 The 2- and 3-DAA combinations were well tolerated.

19 of conventional (99m)Tc-NaTcO4 and was well tolerated.

20 raction, whereas variations in the lock were tolerated.

21 with rituximab depleted B cells and was well tolerated.

22 n through 96 weeks and was well accepted and tolerated.

23 Opicapone was safe and well tolerated.

24 hioamides with variations in electronics are tolerated.

25 The vaccine and regimens were well tolerated.

26 ition of tumor growth at doses that are well-tolerated.

27 every 2 weeks, was found to be safe and well tolerated.

28 functional variation in Nav1.1 is less well tolerated.

29 enting stone recurrence and are often poorly tolerated.

30 he steel cycle will exceed that which can be tolerated.

31 Repeated IV administrations of TCZ are well tolerated.

32 Both treatments were well tolerated.

33 hy younger patients, ibrutinib has been well tolerated.

34 rate than did placebo and was generally well tolerated.

35 ks after therapy, and DAA regimens were well tolerated.

36 per day) was permitted if the drug was well tolerated.

37 s also a common complication and is not well tolerated.

38 le infusion of elamipretide is safe and well tolerated.

39 Both vaccines were safe and well tolerated.

40 MSC infusions were well tolerated.

41 cular-targeted photodynamic therapy was well tolerated.

42 Ledipasvir-sofosbuvir was well tolerated.

43 be present, and fragile structures are also tolerated.

44 Lifitegrast appeared well tolerated.

45 Both consolidation therapies were well tolerated.

46 entilation all six ventilated-paced subjects tolerated 8 minutes of intense phrenic stimulation, wher

47 of patients treated with >/=6 months of SCIT tolerated a concentration of P. pratense over 50 times h

48 ther the iron chelator, deferiprone, is well tolerated, able to chelate iron from various brain regio

49 Ebselen treatment was well tolerated across all doses and no significant difference

50 t the majority of murine PDAC cells analyzed tolerated acute and sustained Kras silencing by adapting

51 llelic contribution to determine the maximum tolerated allele count in gnomAD, we report an evaluatio

52 advanced pancreatic cancer is generally well tolerated, although major adverse events can occur.

53 only the low-affinity CD3/CLL1 TDB was well tolerated and able to deplete target cells.

54 Subretinal delivery of rAAV.sFLT-1 was well tolerated and demonstrated a favourable safety profile t

55 Conclusion PF-03084014 was well tolerated and demonstrated promising clinical benefit in

56 Nivolumab is well tolerated and effective as a monotherapy for patients wi

57 sofosbuvir-velpatasvir-voxilaprevir was well tolerated and effective at achieving virological respons

58 INTERPRETATION: Luspatercept was well tolerated and effective for the treatment of anaemia in

59 ive decline, there is an unmet need for well-tolerated and effective therapy of BPSD.

60 atasvir plus ribavirin for 24 weeks was well tolerated and effective, particularly those with hepatit

61 iterature suggests that this therapy is well tolerated and effective.

62 drugs (AEDs), in low doses, is usually well tolerated and efficacious.

63 Both lithium and divalproex were adequately tolerated and efficacious; lithium was associated with a

64 coli bioconjugate vaccine candidate was well tolerated and elicited functional antibody responses aga

65 INTERPRETATION: The ZPIV candidate was well tolerated and elicited robust neutralising antibody titr

66 e patches for influenza vaccination was well tolerated and generated robust antibody responses.

67 10-1074 was well tolerated and had a half-life of 24.0 d in participants

68 ION: A single dose of 400 mg DSM265 was well tolerated and had causal prophylactic activity when give

69 INTERPRETATION: VRC5283 was well tolerated and has advanced to phase 2 efficacy testing.

70 Nasosorption was well tolerated and identified all RSV+ samples.

71 The parenteral P2-VP8-P[8] vaccine was well tolerated and immunogenic in infants, providing a novel

72 KNO3 is potentially well tolerated and improves exercise duration and quality of

73 CD38-targeting antibodies are generally well tolerated and induce partial response or better in appro

74 Conclusion Sacituzumab govitecan was well tolerated and induced early and durable responses in hea

75 aily enasidenib treatment was generally well tolerated and induced hematologic responses in patients

76 TERPRETATION: Intracerebral rAVV2/5 was well tolerated and induced sustained enzyme production in the

77 ITs were well tolerated and initially efficacious but were ultimately

78 ent-refractory anorexia nervosa, DBS is well tolerated and is associated with significant and sustain

79 It is generally well tolerated and may result in a durable response.

80 RPRETATION: Pembrolizumab appears to be well tolerated and might confer anti-tumour activity in patie

81 CAM2038 weekly, 24 and 32 mg, was safely tolerated and produced immediate and sustained opioid bl

82 acebo groups, indicating that PPOIT was well tolerated and psychological well-being was not negativel

83 Weekly i.n. GSK2245035 20 ng was well tolerated and reduced allergic reactivity to nasal chall

84 PQ combined with either CQ or AL was well tolerated and reduced recurrence of vivax malaria by 5-f

85 nomeric allergoid sublingual tablets is well tolerated and reduces the CPT reaction in house dust mit

86 BPS804 treatment was well tolerated and resulted in increases in bone formation bi

87 TATION: Weekly infusions of rFIXFc were well tolerated and resulted in low bleeding rates in children

88 hat 32 doses of BTZ monotherapy was not well tolerated and resulted in only a modest reduction in ant

89 gated anti-miR-122 oligonucleotide, was well tolerated and resulted in substantial viral load reducti

90 ion with a single dose of NDI-010976 is well tolerated and results in a profound dose-dependent inhib

91 INTERPRETATION: PfSPZ Vaccine was well tolerated and safe.

92 Heterocycle substitutions at C24 were well-tolerated and several tetrazole-containing derivatives w

93 both dosing regimens of sirukumab were well tolerated and significantly improved signs and symptoms

94 INTERPRETATION: rVSVG-ZEBOV-GP was well tolerated and stimulated a rapid onset of binding and ne

95 Deferiprone therapy was well tolerated and was associated with a reduced dentate and

96 ting that the investigational agent was well tolerated and, in subgroup analyses, participants who de

97 Treatment was well tolerated, and 100% histologic cure was achieved in 9 of

98 l screening test should be inexpensive, well tolerated, and applicable to primary care.

99 ted interferon alfa-2a therapy is safe, well tolerated, and establishes functional control of HBV and

100 CBD was well tolerated, and rates of adverse events were similar betw

101 GBR-identified drugs, the commonly-used well-tolerated antihyperglycemic sitagliptin, produces a dose

102 sinin-piperaquine (DP) is an effective, well tolerated artemisinin-based combination therapy.

103 at 5 mug improved lung function and was well tolerated as add-on therapy to ICS with other maintenanc

104 of discomfort, suggesting that it is poorly tolerated as an early routine treatment of HG.

105 ociated with weight gain, and is not as well tolerated as expected; sustained modification of diet an

106 n maintaining viral suppression and was well tolerated at 48 weeks.

107 n maintaining viral suppression and was well tolerated at 48 weeks.

108 on of AAV2-sFLT01 seemed to be safe and well tolerated at all doses.

109 the 7-hydroxy Tic pharmacophore, are better tolerated at kappa and mu receptors and yield very high

110 The intervention was well-tolerated, because the helmet-type mask caused no pain o

111 atients who have been stable on a "maximally tolerated beta-blocker dose," but this definition and ho

112 line exercise test while receiving maximally tolerated beta-blocker therapy that was continued throug

113 hat telomerase activation is not only safely tolerated but also advantageous for clonal expansion.

114 nstrated that hydrophobic substitutions were tolerated but polar or charged substitutions resulted in

115 uring infancy is highly efficacious and well tolerated, but current assays for early detection fail t

116 docetaxel and prednisone was reasonably well tolerated, but overall survival was not significantly lo

117 Administration of (177)Lu-3BP-227 was well tolerated by all patients.

118 MEAN at an effective dose for 6 wk was well tolerated by animals.

119 effector cells and were immunologically well tolerated by lung tissues.

120 re generally low, with omalizumab being well tolerated by most patients, including children.

121 h probability of tumor cure while being well tolerated by nude mice bearing subcutaneous GPA33-positi

122 High-flow nasal cannulae seem well tolerated by patients.

123 sociated with hemolytic events and is poorly tolerated by some patients.

124 bstitutions in xylan are not only sterically tolerated by the cellulose surfaces but that they increa

125 nmeal and grits were below the maximum limit tolerated by the European Commission.

126 r of the mouse intestinal microbiota that is tolerated by the host.

127 al clue as to why this bacterium is normally tolerated by the immune system.

128 dicates that the corrosion products are well tolerated by the tested cells and potentially negligible

129 cyano, chloro, and bromo functionalities are tolerated by the transition metal-free catalyst.

130 MVC-containing regimens were safe and well tolerated compared with TDF + FTC; this study was not po

131 -containing PrEP regimens were safe and well-tolerated compared with TDF-FTC in U.S. women.

132 Charged residues were poorly tolerated, conferring extreme temperature-sensitive and

133 study was conducted to determine the maximum-tolerated cumulative dose (MTCD) and evaluate safety, ac

134 and CD19 CAR-T cells at or below the maximum tolerated dose (</= 2 x 10(6) CAR-T cells/kg).

135 n 14-day acute toxicity in rats, the maximum tolerated dose (MTD) and the no observed adverse effect

136 imary objective was to determine the maximum tolerated dose (MTD) of isatuximab with lenalidomide and

137 nano-formulations, which doubled the maximum tolerated dose (MTD) of Taxol.

138 ients received either Nexvax2 at the maximum tolerated dose (MTD) or placebo.

139 DNA alkyltransferase activity, but a maximum tolerated dose (MTD) was not reached.

140 n-human phase 1/2 study assessed the maximum tolerated dose (MTD), pharmacokinetic and pharmacodynami

141 doxifen to determine its toxicities, maximum tolerated dose (MTD), pharmacokinetics, and clinical act

142 This phase 1 study evaluated maximum tolerated dose (MTD), pharmacokinetics, pharmacodynamics

143 r receptors (FGFRs) to determine the maximum tolerated dose (MTD), the recommended phase II dose (RP2

144 aive and PI-exposed patients) at the maximum tolerated dose (MTD).

145 valpituzumab tesirine, including the maximum tolerated dose and dose-limiting toxic effects.

146 The primary endpoints were maximum tolerated dose and dose-limiting toxicity for phase 1, a

147 We aimed to establish the maximum tolerated dose and establish the recommended phase 2 dos

148 02 patients (29.4%) reloaded at a previously tolerated dose and in 11 of 30 patients (36.7%) admitted

149 ary objectives were to establish the maximum tolerated dose and recommended phase 2 dose of veliparib

150 the FAQLQ-PF was independent of the maximal tolerated dose at baseline or following four months of t

151 x 10(10) vg, n=3 per cohort) and one maximum tolerated dose cohort (cohort 5, 2 x 10(10) vg, n=7) and

152 (IV) administration of CP-Dox at the maximum tolerated dose increases the infiltration of leukocytes

153 imary objective was to establish the maximum tolerated dose of CPI-613 (as assessed by dose-limiting

154 INTERPRETATION: A maximum tolerated dose of CPI-613 was established at 500 mg/m(2)

155 olished attrition produced by a near maximum-tolerated dose of PTX.

156 The maximum tolerated dose of rovalpituzumab tesirine was 0.4 mg/kg

157 In the phase 1 part, the maximum tolerated dose of the combination was not reached.

158 point was the identification of the maximum tolerated dose of the combination.

159 INTERPRETATION: The maximum tolerated dose of trastuzumab deruxtecan was not reached

160 including mutagenicity and maximum/repeated tolerated dose studies, as well as in vivo testing in ro

161 en shown to be more efficacious than maximum tolerated dose treatment in preclinical studies, and is

162 ber of treatment cycles given at the maximum tolerated dose was 11 (IQR 4-19).

163 Gilteritinib was well tolerated; the maximum tolerated dose was established as 300 mg/day when two of

164 No maximum tolerated dose was identified.

165 The maximum tolerated dose was not identified; the recommended phase

166 , at the 20 mg/kg dose, and thus the maximum tolerated dose was not reached.

167 icity profile up to 20 mg/kg and the maximum tolerated dose was not reached.

168 Therefore, the maximum tolerated dose was not reached; the recommended phase 2

169 em to be associated with dose and no maximum tolerated dose was reached.

170 the safety profile, to determine the maximum tolerated dose, and to establish the recommended phase 2

171 the dose-limiting toxicities (DLTs), maximum tolerated dose, pharmacokinetic profile, and response ra

172 sk for TdP than patients reloaded at a prior tolerated dose.

173 termine the safety, feasibility, and maximum tolerated dose.

174 ailable therapy (hydroxyurea [at the maximum tolerated dose], interferon or pegylated interferon, pip

175 This phase 1/2 trial evaluated the maximum tolerated doses, safety, and efficacy of pomalidomide, b

176 -CD19B is pharmacodynamically active at well-tolerated doses.

177 d 60 mug doses where found to be the highest tolerated doses.

178 blockers that may aid in achieving maximally tolerated doses.

179 of decline in renal function that should be tolerated during intensive BP lowering and its associati

180 hich is beneficial for regeneration, is well tolerated during Schwann cell development and in the adu

181 Therapy was well tolerated, even among the 72% of patients with cardiac A

182 40 kHz ultrasound for 0.5 seconds were well tolerated, even in mice with acute colitis.

183 Treatment was well tolerated; fewer patients receiving tiw versus qw were p

184 ation of BV plus Nivo was an active and well-tolerated first salvage regimen, potentially providing p

185 Rilonacept was well tolerated (five adverse events versus two with placebo).

186 in hydrophobicity of amino acids are better tolerated for activation by capsaicin than for activatio

187 amide-motif in the phytosphingosine chain is tolerated for CD1d binding and TCR recognition, the stud

188 growth of multiple tumors, yet is very well tolerated for prolonged periods, suggesting that cyst(e)

189 dil 0.02% was found to be effective and well tolerated for the treatment of patients with ocular hype

190 novel molecule that reduces chorea, was well tolerated in a double-blind, placebo-controlled study.

191 form of this antibody (ozanezumab) was well tolerated in a first-in-human trial.

192 Treatment with BOS was well tolerated in adolescent and young adult patients with Eo

193 sofosbuvir currently used in adults was well tolerated in adolescents and had an appropriate pharmaco

194 Belatacept was initially well tolerated in all cases.

195 Furthermore, both compounds were very well tolerated in BALB/c mice without any detectable acute to

196 PA101 was well tolerated in both cohorts.

197 We found that our paradigm is well tolerated in children as young as 6 years, that children

198 Conclusion Abexinostat is well tolerated in combination with pazopanib, allowing prolon

199 ion at the doses of two drugs that were well tolerated in combination.

200 lenalidomide and dexamethasone is active and tolerated in heavily pretreated patients with RRMM.

201 It is expected to be well tolerated in humans and is available for clinical evalua

202 treatment for HCV that is effective and well tolerated in most individuals infected with HCV, as well

203 ent adult progenitor cells was safe and well tolerated in patients with acute ischaemic stroke.

204 agents (DAAs) are highly effective and well tolerated in patients with chronic hepatitis C virus inf

205 GLE and PIB was highly efficacious and well tolerated in patients with HCV genotype 1 infection and

206 INTERPRETATION: Eltrombopag is well-tolerated in patients with lower-risk myelodysplastic sy

207 onclusion ATO consolidation cycles were well tolerated in pediatric patients with APL and allowed sig

208 6n-2 was found to be well-tolerated in phase 1 clinical studies and represents a p

209 esis screen to identify where mutations were tolerated in replicating viruses.

210 Its homozygous loss is tolerated in seemingly healthy individuals, with reduced

211 olization is feasible and appears to be well tolerated in severely obese patients.

212 he lifetime absence of ADAR1-editing is well tolerated in the absence of MDA5.

213 y, disruption of ATP6AP2 is extremely poorly tolerated in the adult, and severely affects various org

214 that loss of either component alone is well tolerated in the developing brain, in contrast to epithe

215 keratinocytes and aberrant DNA retention is tolerated in the oral epithelium.

216 njection with pars plana vitrectomy was well tolerated in this cohort.

217 NTERPRETATION: PF-00547659 was safe and well tolerated in this patient population, and better than pl

218 A diverse range of aryl iodides are tolerated in this reaction, along with select heteroaryl

219 tive functional groups, and heterocycles are tolerated in this reaction, which significantly expands

220 Lumacaftor/ivacaftor was well tolerated in this young population; no new safety concer

221 nofovir alafenamide was efficacious and well tolerated in virologically suppressed, HIV-infected chil

222 Under conditions where it was well tolerated in vivo, this FOXO4 peptide neutralized doxoru

223 s a 2-dose schedule was immunogenic and well tolerated in young girls.

224 of biologically relevant AA side chains are tolerated including those for alanine, valine, leucine,

225 tent LDL-C reductions and was generally well tolerated independent of background statin type/dose.

226 While loss of NMD is tolerated, loss of hUPF1 induces a DNA damage response a

227 If tolerated, medication was administered until disease pro

228 By contrast, the conserved loop sequence tolerated minimal perturbations.

229 in combination with gemcitabine using a well-tolerated multidose schedule, the same compound caused r

230 ly enriched at protein allosteric sites than tolerated mutations, suggesting a critical role for prot

231 of Proxison demonstrated effective and well tolerated neuroprotection against cell loss in a zebrafi

232 The vaccine was well tolerated: no vaccine-related serious adverse events occ

233 rAd-IFNalpha/Syn3 was well tolerated; no grade four or five adverse events (AEs) oc

234 Subcutaneous methotrexate was generally well tolerated; no patients died or had serious infections, m

235 The median peanut dose tolerated on the initial desensitization day was 250 mg

236 Eliglustat was well tolerated over 4 years; 4 (2.5%) patients withdrew becau

237 This well-tolerated phenotype persisted in elderly TG with no indi

238 Treatment was generally well tolerated pretransplantation and posttransplantation, wi

239 SCIT was well tolerated; six mild local reactions occurred, and there

240 Honokiol (HKL) is a well tolerated small molecule that disrupts mitochondrial fun

241 2 sites in 21 countries, adults with HCC who tolerated sorafenib (>/=400 mg/day for >/=20 of last 28

242 ositions these drugs as add-ons to maximally tolerated statin therapy or for those with statin intole

243 If tolerated, subjects continued on 4000 mg of peanut prote

244 es of SCIg IgPro20 were efficacious and well tolerated, suggesting that SCIg can be used as a mainten

245 hat, in both mutants, Cpd-5 should be better tolerated than the closely related NMS-P715.

246 mutant mice became persistently ketotic and tolerated the KD for up to 11 weeks.

247 All subjects tolerated the PET/MRI examination well, and no adverse r

248 Patients tolerated the procedure well without significant acute a

249 Twelve patients tolerated the procedure, including three with a previous

250 All 23 participants tolerated the regimen well; there were no serious advers

251 All patients tolerated the surgeries and vector injections.

252 All patients tolerated the surgery well and no intraoperative or post

253 o attacks) is stable, when attacks should be tolerated, the consequences of asymmetric technical attr

254 Gilteritinib was well tolerated; the maximum tolerated dose was established as

255 l disorders, but direct antagonism is poorly tolerated therapeutically.

256 Overall, this well-tolerated therapy achieves tumor specificity by redirect

257 al groups on the quinazolinone scaffold were tolerated to provide novel quinazolinone derivatives.

258 with a wide variety of substitution patterns tolerated to provide the corresponding nitrogen-containi

259 ug, followed by 30 mug, then 60 mug if doses tolerated) to parenteral P2-VP8-P[8] subunit rotavirus o

260 Omalizumab is an effective and well-tolerated treatment for chronic spontaneous urticaria (C

261 y alone should be considered a safe and well tolerated treatment for malignant dysphagia in the palli

262 Conclusion ACE is a feasible, safe, and well-tolerated treatment for patients with HCC; it is highly

263 rical N-allyl-N-methylglycine esters is also tolerated under the catalytic relay conditions without c

264 A wide range of functional groups could be tolerated under the reaction conditions to produce C(sp(

265 A wide range of terminal alkynes is tolerated under the reaction conditions, including beta-

266 OF, for the discrimination of pathogenic and tolerated variants that can also generate hypotheses on

267 Satiation, as assessed by maximum tolerated volume at 16 weeks, was lower in the liragluti

268 6, satiation (volume to fullness and maximum tolerated volume), satiety, and fasting and postprandial

269 While 7-substituents are not well-tolerated, we have identified novel substituents at the

270 xtures of different vaccine strains could be tolerated, we tested cocktails of DISC vaccines in combi

271 cycline-controlled Tet-transactivator, while tolerated well during development and in immunologically

272 iver of divergence in isolation, (ii) can be tolerated when balancing selection prevents random loss

273 The combination was well tolerated, which allowed for dose escalation to the high

274 - RTV) and subtype C, and was generally well tolerated, which supported continued development of GSK3

275 Ibrutinib was well-tolerated with a toxicity profile similar to labeled ind

276 reactions, long-acting cabotegravir was well tolerated with an acceptable safety profile.

277 and tenofovir alafenamide was safe and well tolerated with better gastrointestinal tolerability than

278 r, treatment with the alphaAnalogue was well tolerated with neither signs of desensitization nor beha

279 [(18) F]Nifene (185 MBq; <0.10 mug) was well tolerated with no adverse effects.

280 RCE was well tolerated with no adverse events.Twice daily RCE intake

281 Study drugs were well tolerated with no serious adverse events.

282 enalidomide-dexamethasone was generally well tolerated with only 1 dose-limiting toxicity reported (g

283 f pralatrexate and romidepsin was safe, well tolerated, with 3 DLTs across all schedules (grade 3 ora

284 Treatment was well tolerated, with a 6-week mortality rate of 0%.

285 umab monotherapy and this treatment was well tolerated, with a low incidence of IgM flare.

286 Riluzole was generally well tolerated, with a side effect profile consistent with it

287 Ridinilazole was well tolerated, with an adverse event profile similar to that

288 PT2385 was well tolerated, with anemia (grade 1 to 2, 35%; grade 3, 10%)

289 Both treatments were well tolerated, with average follow-up adverse event scores b

290 ABT-436 was well tolerated, with diarrhea (mild-to-moderate severity) bei

291 rVSVDeltaG-ZEBOV-GP was generally well-tolerated, with increased rates of injection-site and sy

292 Deutetrabenazine was generally well tolerated, with low rates of neuropsychiatric AEs.

293 jections, which were generally safe and well tolerated, with more immediate, but transient, pain in t

294 dministration of serelaxin was safe and well tolerated, with no detrimental effect on systemic blood

295 Infusions were well tolerated, with no dose-limiting toxic effects.

296 BIIB074 was well tolerated, with similar adverse events in the double-bli

297 e remaining amino acids were in general well tolerated, with the exemption of the P6 position.

298 est that rt-PA appears to be reasonably well tolerated without prohibitive risks for adverse events a

299 Infusions were well tolerated without serious or severe adverse events.

300 The therapy was generally well tolerated, without any clear signal of any unexpected ad