ライフサイエンスコーパス: tolerize

1 L-12 restored the ability of low-dose LPS to tolerize.

2 nstrate that this repertoire is peripherally tolerized.

3 responsive to the sialylated antigen become tolerized.

4 ce traffic to the prostate where they become tolerized.

5 ot ignorant and naive CD4(+) T cells are not tolerized.

6 ay express antigens to which the host is not tolerized.

7 K1 or the E3 ubiquitin ligase Itch cannot be tolerized.

8 ed very weak effector function and were soon tolerized.

9 ail to develop cytolytic function and become tolerized.

10 could control tumor growth without becoming tolerized.

11 self-peptides to which the host has not been tolerized.

12 epitopes, against which wild-type mice were tolerized.

13 tigen-specific T cells were induced after a "tolerizing-administration" of antigen and that GRAIL exp

14 which IFN-gamma-producing CD8(+) T cells are tolerized after type 1 immune responses to chronic virus

15 on with vaccination restores the function of tolerized Ag-specific CD8 T cells in models of self and

16 was unexpectedly influenced by the source of tolerizing Ag and help was selectively required to facil

17 e CD8 cell effector differentiation when the tolerizing Ag derived from self.

18 When Th1 effector CD4 cells encounter tolerizing Ag in vivo, their capacity to express the eff

19 , when parenchymal self-Ag was the source of tolerizing Ag, enforced dual costimulation selectively b

20 Similarly, LEW rats neonatally tolerized against either Rhsp65 or Bhsp65 were significa

21 Mice tolerized against either TSKB20 or TSKB74, or both epito

22 loreactive T cells were not detected in mice tolerized against specific alloantigens.

23 Furthermore, BALB/c mice tolerized against the TSKD14 peptide effectively control

24 adjuvant, when administered together with a tolerizing agent such as nondepleting anti-CD4, can faci

25 the PD-1/PD-L1 pathway is needed to rapidly tolerize alloreactive CD8 cells in a model that requires

26 Thus, the requirements for tolerizing alloreactive and autoreactive NOD CD4 cells a

27 y of human and mouse TADCs, respectively, to tolerize and induce suppressive activity by T cells.

28 ressed as a self-antigen become functionally tolerized and express high levels of surface PD-1 by the

29 However, the major difference when comparing tolerized and primed T cells was that the latter formed

30 Although both tolerized and rejecting alloreactive CD8 cells up-regula

31 cells, offspring B cells were not centrally tolerized and retained their ability to respond to the i

32 to determine whether an immunocompetent rat, tolerized and transplanted with a human hepatoma cell li

33 HCV-inoculated immunocompetent rats tolerized and transplanted with Huh 7 cells support HCV

34 in both human and mouse prostate cancer that tolerizes and induces suppressive activity in tumor-spec

35 monocytes and in vitro-differentiated naive, tolerized, and trained macrophages.

36 or obstacle to antitumor immunity because it tolerizes/anergizes tumor-reactive T cells by binding to

37 The DC of the tolerized animal, especially plasmacytoid DC, produced i

38 11b(+) DCs, which are abundant in the CNS of tolerized animals, play a crucial role in i.v. tolerance

39 n of OVA with low-dose LPS was suppressed in tolerized animals.

40 Aiming to tolerize anti-rabbit responses, we coadministered a brie

41 paternal Ag during insemination activated or tolerized anti-paternal CD8+ T cells.

42 mouse allergic model, injection of high-dose tolerizing antigen failed to block the development of ai

43 ession is upregulated in T cells by self and tolerizing antigens in the thymus and periphery, governe

44 reg cell development in response to self and tolerizing antigens.

45 In vitro CD8(+)CD28(-)CD56(+) T cells tolerize APCs, prevent the priming of naive CD4(+) T cel

46 velopmental blockade implies the presence of tolerizing autoantigens that are mimicked by the membran

47 reveal the mechanisms on how mixed chimerism tolerizes autoreactive B cells in T1D.

48 but it is still unclear how mixed chimerism tolerizes autoreactive B cells.

49 nvestigate the ability of mixed chimerism to tolerize B cells producing antibodies of this important

50 high levels of self-reactivity that must be tolerized before entry into the mature B cell pool.

51 of a promoter site of MARCO was increased in tolerized BMDM.

52 ssion of MARCO, and impaired phagocytosis in tolerized BMDM.

53 ed allogeneic or xenogeneic chimerism indeed tolerizes both preexisting anti-Gal-producing B cells an

54 nfluences their decision to become primed or tolerized, but this has not been examined directly in vi

55 in this model, the autoreactive B cells are tolerized by anergy.

56 sponse, resulting from their inability to be tolerized by B. burgdorferi.

57 Mice were immunized or tolerized by DST or DST plus anti-CD40L mAb.

58 , TLR4 endocytosis is induced in macrophages tolerized by exposure to either LPS or UT12 and is indep

59 opulation that is naturally autoreactive and tolerized by functional anergy (BND cells).

60 frequently arise in the bone marrow but are tolerized by mechanisms including receptor editing, func

61 ts survived much longer and were more easily tolerized by non-immunosuppressed recipients.

62 These can be tolerized by nonmyeloablative induction of mixed chimeri

63 tored T-cell responsiveness to Ag previously tolerized by oral administration.

64 an thymocytes in human thymus grafts are not tolerized by the presence of an additional porcine thymu

65 Immune-tolerized canines achieved increased tissue enzyme level

66 the steady-state phenotype of DCs and their tolerizing capacity in vivo.

67 MHC-II molecules, suggesting they might also tolerize CD4 T cells.

68 for CD4 and CD8 is an effective strategy to tolerize CD4(+) and CD8(+) T cells in a tissue-specific

69 whether immature DCs in general are able to tolerize CD4(+) T cells or if this is a prerogative of s

70 ve mechanism where LN-resident stromal cells tolerize CD4(+) T cells through the presentation of self

71 imulation is partially restored when self-Ag-tolerized CD4 cells are retransferred into mice infected

72 gene gains transcriptional competence, these tolerized CD4 cells fail to express substantial amounts

73 Dby-SP-tolerized CD4(+) T cells fail to proliferate, secrete IF

74 hether Ag-SP tolerance could also be used to tolerize CD8+ T cells.

75 It is unclear whether tolerized CD8 T cells coexpress PD-1 and LAG-3 or whethe

76 injection of Ag-loaded DCs also reactivated tolerized CD8 T cells in the tumor tissue.

77 ntial for licensing CD8alpha+ DC and helping tolerized CD8 T cells.

78 nuation of chemokine expression in endotoxin-tolerized cells as shown in interferon regulatory factor

79 LPS-tolerized cells were observed to regain responsiveness i

80 ve regulators of TLR4 signaling, increase in tolerized cells.

81 and CD40 during infection, consistent with a tolerizing condition.

82 functional consequences to CD8 T cells under tolerizing conditions and manipulation of both Ag and cy

83 e populations of CD8 T cells activated under tolerizing conditions based on LAG-3 and PD-1 staining,

84 In contrast, p27delta cells proliferated in tolerizing conditions because of Cdk kinase activation a

85 enotypes on CD8 T cells under activating and tolerizing conditions.

86 OVA-specific IgE, as compared to uninfected tolerized control mice.

87 The lungs of surviving mice contained tolerized CXCR3-deficient Teff, as well as a large incre

88 n this article, we examined the self-antigen-tolerized DC phenotype, function, and mechanisms respons

89 r, the pathways essential for conferring the tolerizing DC phenotype and optimal methods for their in

90 te is not terminally differentiated and that tolerized DCs can recover their ability to induce immuni

91 However, tolerized DCs demonstrated a novel inducible expression

92 Moreover, tolerized DCs from sulfatide-treated animals can adoptiv

93 Tolerized DCs share some characteristics with immature D

94 We conclude that ex vivo A(2)AR-induced tolerized DCs suppress NKT cell activation in vivo and p

95 Tolerized DCs were not refractory to maturation after st

96 uced due to H. pylori gGT enzymatic activity tolerizes DCs by inhibiting cAMP signaling and dampening

97 evelopment of selective S1P3 antagonists for tolerizing DCs for cell-based therapy or for systemic ad

98 ells interacting with recipient class II MHC tolerize directly alloreactive CD8 cells.

99 Myelin microarrays demonstrate that tolerizing DNA vaccination plus GpG-ODN further decrease

100 Moreover, the addition of GpG-ODN to tolerizing DNA vaccination therapy effectively reduced o

101 BHT-3009 is a tolerizing DNA vaccine for MS, encoding full-length huma

102 desired CpG-induced inflammatory effect of a tolerizing DNA vaccine in a Th1-mediated autoimmune dise

103 (EAE), combining a myelin cocktail plus IL-4-tolerizing DNA vaccine with a suppressive GpG oligodeoxy

104 argeting pathogenic T cells with Ag-specific tolerizing DNA vaccines encoding autoantigens is a power

105 that will boost the efficacy of Ag-specific tolerizing DNA vaccines used for treating Th1-mediated a

106 Tolerized donor-reactive T-cell receptor transgenic CD8

107 so with no demonstrable specificity for the tolerizing donor antigens.

108 al application of this novel class of T-cell-tolerizing drugs for patients with optic neuritis.

109 TLRs and inflammatory cytokines, may become tolerized during sustained exposure to bacterial structu

110 Immature dendritic cells (imDCs) can have a tolerizing effect under normal conditions or after trans

111 ing systemic responses are refractory to the tolerizing effects of mucosal Ag encounter.

112 critically and nonredundantly to H. pylori's tolerizing effects on murine DCs in vitro and in vivo.

113 erally expressed endogenous superantigen are tolerized either by deletion or TCR revision.

114 of antibody and miRNA-150 was established by tolerizing either panimmunoglobulin-deficient JH(-/-) or

115 sponse can be initiated by a DC vaccine, the tolerizing environment created by the tumor still exerts

116 ells at high levels after stimulation within tolerizing environments.

117 PKs; conversely, IL-13(-/-) macrophages were tolerized equivalently to WT MPhis by LPS pretreatment.

118 ells (DCs) is generally a noninflammatory or tolerizing event to prevent the development of autoreact

119 dentified IL-10 as the secreted inflammasome-tolerizing factor that acts in an autocrine manner to co

120 se model in which CD8 T cells are neonatally tolerized following interaction with a parenchymal self-

121 TNF tolerized genes encoding inflammatory molecules to preve

122 deposit active histone marks at promoters of tolerized genes.

123 ontrast, cytokine induction was preserved in tolerized GILZ KO animals.

124 ng identifies clear features in T cells from tolerized grafts that are distinct from those involved i

125 uch as hBD2 and LL-37 was augmented, even in tolerized HCECs.

126 RNEU(420-429) in nontolerized FVB/N but not tolerized HER-2/neu (neu-N) mice.

127 ed that tumor-free survival in up to 100% of tolerized HER-2/neu transgenic mice can be achieved by a

128 cted groups of mice were immunized (s.c.) or tolerized (i.v.) with the SVL9 peptide before transplant

129 Like WT mice, 100% of LPS-tolerized IL-4Ralpha-deficient mice survived LPS + d-gal

130 ivity and had an increased ability to resist tolerizing immune microenvironments.

131 a model, we found that CD8(+) T cells became tolerized in <24 h in an established tumor environment.

132 Research into how self-reactive T cells are tolerized in lymph nodes has focused largely on dendriti

133 or many years, how are self-specific T cells tolerized in the periphery?

134 ptively transferred into TRP-SIY mice became tolerized in the prostate draining lymph nodes.

135 nants of a native self protein are generally tolerized in the thymus, whereas those potentially direc

136 e host and that effector T cells are rapidly tolerized in the tumors.

137 Additionally, macrophages were partially tolerized in their ability to respond to TLR agonists.

138 Fetal rats were tolerized in utero with 10(5) Huh 7 cells.

139 In contrast, CD4 cells are tolerized independently of this pathway following BMT wi

140 ander regulation raises the possibility that tolerized individuals might also have a reduced capacity

141 mal cell expression of B7-H1 is required for tolerizing infiltrating T cells and preventing the persi

142 icularly challenging for NK cells, for which tolerizing inhibitory receptors for self-MHC class I is

143 must be present to protect from diabetes and tolerize islet-specific CD8(+) T cells, SCID mice were r

144 rom insulitis and diabetes, and to partially tolerize islet-specific CD8(+) T cells.

145 or activated islet antigen-specific T cells, tolerized islet antigen-specific T cells moved freely an

146 oreactive B cells escape elimination and are tolerized later in their lives via anergy.

147 portant in restoration of immune function of tolerized leukocytes under inflammatory events.

148 vity in response to a second LPS exposure in tolerized macrophages is accompanied by failure to depos

149 ical to MARCO expression and phagocytosis in tolerized macrophages, but did not affect the inflammato

150 ous CD4(+) T-cell proliferation by endotoxin-tolerized macrophages.

151 n salmonella-infected and lipopolysaccharide-tolerized macrophages.

152 y primed to overcome tumor Ag presented in a tolerizing manner and protected from the suppressive mec

153 ls because, in their absence, these uniquely tolerized MBP-specific T cells can again induce autoimmu

154 naturally autoreactive and controlled by the tolerizing mechanism of functional anergy.

155 A model for a new tolerizing mechanism that could account for the C delta-

156 ndritic cell (DC) vaccine could overcome the tolerizing mechanisms of tumor-bearing transgenic adenoc

157 Tolerizing mechanisms within the host and tumor microenv

158 Moreover, CD4(+)CD25(+) Tregs from tolerized mice adoptively transferred dominant tolerance

159 uction, adoptive transfer of CD4+ cells from tolerized mice at 6 weeks after treatment protected reci

160 sary for resistance to infection, we epitope-tolerized mice by high-dose i.v. injections of TSKB20 or

161 Tolerized mice demonstrated significantly reduced diseas

162 CD103(+) DCs from tolerized mice efficiently induced Foxp3 in cocultured n

163 e T-dependent antigen bacteriophage Phix174, tolerized mice exhibited normal primary and secondary an

164 epletion, the recovered B cells in long-term tolerized mice exhibited xenodonor-specific hyporesponsi

165 with that in tolerized mice, only those from tolerized mice expressed FOXP3.

166 ive nanovesicles that were isolated from the tolerized mice for testing in active and adoptive cell-t

167 Of interest, tolerized mice had more pronounced Th17-type inflammatio

168 ach directly suppressed by CD8+ T cells from tolerized mice in a contact-independent manner.

169 tive transfer of regulatory populations, and tolerized mice in which bystander regulation has been de

170 the inhibitory function of CD8+ T cells from tolerized mice is sustained for up to 8 wk and at all ti

171 t-sensitized and challenged mice, whereas in tolerized mice levels were significantly reduced.

172 1/PDL1 interactions in the CD8+ T cells from tolerized mice reduced their expression of Foxp3 and the

173 c lymph nodes, and Peyer's patches of orally tolerized mice showed increased transforming growth fact

174 T cells from MPO409-428- but not OVA323-339-tolerized mice to animals with established anti-MPO auto

175 iveness of autoantigen-reactive T cells from tolerized mice was associated with a dramatic loss of 3G

176 The DC population derived from tolerized mice was predominantly CD11c(+), B220(+), Gr-1

177 Additionally, CD8+ Ti cells from pCons-tolerized mice were longer-lived suppressors that up-reg

178 Additionally, CD8+ T cells from tolerized mice were weakly cytotoxic against syngeneic B

179 eated plasmid gene transfer is applicable in tolerized mice without eliciting immune responses.

180 tory T cells (Tregs) enriched in the skin of tolerized mice, and depletion of Tregs or adoptive exper

181 dual effects on CD8+ suppressor T cells from tolerized mice, increasing the intracellular expression

182 t at a lower frequency compared with that in tolerized mice, only those from tolerized mice expressed

183 e, proliferation of T cells was inhibited in tolerized mice, whereas systemic applications of cortico

184 mph nodes of both OVA323-339- and MPO409-428-tolerized mice.

185 2 and Th17 response to OVA in both naive and tolerized mice.

186 of non-T cells derived from the spleen of Ag-tolerized mice.

187 , neutrophils treated with P. gingivalis LPS-tolerized monocyte supernatant showed a high migration i

188 ter and promoting IL6 locus accessibility in tolerized monocytes.

189 ctor binding to the IL6 and TNF promoters in tolerized monocytes.

190 not alter proximal TLR4 signaling defects in tolerized monocytes.

191 In this study, we confirm that tolerized mouse bone marrow-derived macrophages (BMDM) s

192 Tolerized MPS I dogs treated with the higher dose receiv

193 Islet xenograft survival is longer in tolerized NOD.CD4a(-/-) and (NOD x C57BL/6)F1 mice than

194 in vivo generated lytic effector cells from tolerized, noncytolytic cells.

195 We found that chronic Nod2 stimulation cross-tolerizes not only to TLRs but also to the interleukin (

196 Whether B cells are tolerized or can be recruited into humoural immune respo

197 Lymph node and spleen cells from tolerized or control donors were harvested and cultured

198 POT T cells were not tolerized or deleted during thymic development and proli

199 response, CD4(+)T lymphocytes either remain tolerized or undergo clonal expansion.

200 eraction of DCs with naive CD4(+) T cells in tolerizing or priming conditions.

201 ineering variants that retain the ability to tolerize pathogenic CD4+ T cells, but do so in the absen

202 in PLNs, where they subsequently recruit and tolerize pathogenic T cells.

203 LR4) serves as one of the microbiota-induced tolerizing pathways.

204 evelopment is rare in multiply exposed, well-tolerized patients.

205 ance induction, whereas adoptive transfer of tolerized pDCs induced Treg cell development and prolong

206 Tolerizing pDCs acquired alloantigen in the allograft an

207 Exposure to a tolerizing peptide Ag regimen instead induced aggressive

208 at the time of allogeneic BM transplantation tolerizes peripheral alloreactive T cells and permits es

209 bone marrow transplantation as the means of tolerizing peripheral CD4 T cells to alloantigens.

210 relapse was associated with acquisition of a tolerized phenotype in tumor-specific CD4(+) T cells, ch

211 tion of monocytes to macrophages with immuno-tolerizing phenotypes (HLA-DRlow, CD86low, PD-L1high, IL

212 s at the Pdcd1 locus therefore determine the tolerizing potential of TCR-ligation.

213 CD40L in combination with xenogeneic BMT can tolerize preexisting peripheral and intrathymic CD4 cell

214 We have examined anti-influenza responses in tolerized primary heart recipients, secondary recipients

215 A-specific TCR-transgenic mice that the same tolerizing protocol (CD4 blockade) and the same target A

216 ecific effector cells with cells from col(V)-tolerized rats suppressed severe vasculitis and bronchio

217 okine, and antibody responses were tested in tolerized rats.

218 ne response to mycobacterial Hsp65 in B cell-tolerized rats.

219 were deficient in the ability of these cross-tolerized receptors to phosphorylate effector signaling

220 NKG2D blockade in tolerized recipients did not cause acute rejection but i

221 ction showed that intragraft Foxp3 levels in tolerized recipients were approximately 100-fold higher

222 trongly downregulated after treatment with a tolerizing regimen.

223 accination could activate a potentially less tolerized repertoire against similar Ags that may be ove

224 To investigate vaccine performance in a tolerized repertoire, male mice were vaccinated with the

225 tromal cells (LNSCs), have been described to tolerize self-reactive CD8(+) T cells in LNs.

226 ntigens (TSAs), which are presented and help tolerize self-reactive thymocytes.

227 The central tolerance phenotype implies that tolerizing self-Ag is expressed in bone marrow.

228 llowing replacement of the initial source of tolerizing self-Ag with a viral form of the same Ag.

229 ation and IL-2 production in response to the tolerizing self-antigen.

230 ge hypothesis") or by dominance of negative (tolerizing) signaling over proinflammatory signaling ("b

231 re remains incomplete knowledge about how DC-tolerizing signals evolve during tumorigenesis.

232 r findings reveal novel insights into how DC-tolerizing signals evolve in cancer to promote immune es

233 m to render responder T cells susceptible to tolerizing signals.

234 cells of a given clone can be activated and tolerized simultaneously in different microenvironments

235 o design more effective strategies to better tolerize small bowel grafts, prevent rejection and, ulti

236 with a TLR3 agonist, demonstrating that this tolerized state is not terminally differentiated and tha

237 gly, microRNA expression analysis during the tolerized state of THP-1 cells showed only miR-146a over

238 tivated APCs to differentiate into a unique, tolerized state with the ability to produce IL-10 and TG

239 esponsible for inducing or maintaining their tolerized state.

240 full development of anergy in response to a tolerizing stimulus.

241 nd that, in the absence of such recruitment, tolerizing strategies such as CD154 mAb therapy are inef

242 cells do not proliferate in response to the tolerizing superantigen, implicating TCR revision as a m

243 Such tolerized surroundings, however, can be exploited by cer

244 ells (DCs) have the potential to activate or tolerize T cells in an Ag-specific manner.

245 g and cell-intrinsic anergy is sufficient to tolerize T cells.

246 cells (DCs) determines whether they prime or tolerize T cells.

247 ly dispensable in the adult, as a previously tolerized T cell pool can buffer newly generated autorea

248 isease development in both models and safely tolerized T cell responses in an Ag-specific manner in p

249 -)CD86(-/-) DCs failed to reactivate already tolerized T cells in the tumor tissue, whereas interferi

250 nduction as well as refunctionalizes already tolerized T cells in the tumor tissue.

251 T cells and restoration of responsiveness of tolerized T cells.

252 capacity to inhibit IFN-gamma production in tolerized T cells.

253 CD8(+) T cell- and FasL-mediated lysis, and tolerizes T cells by reverse signaling through T cell-ex

254 CD5-dependent mechanisms to actively adjust tolerizing T cell responses under steady-state condition

255 In addition, TADCs tolerized TCR(hi) T cells but not TCR(lo) T cells in vit

256 1 effectors, was partially down-modulated in tolerized Th1 effectors.

257 and BCR-signaling capacity, thus being less tolerized than BND cells from healthy control subjects.

258 ill bacteria, but also those that protect or tolerize the host to potentially damaging antibacterial

259 A major goal for immunotherapy is to tolerize the immune cells that coordinate tissue damage

260 odies is known and attempts are under way to tolerize the immune system with a high level of specific

261 Finally, we could tolerize the potential for a hyperacute response, by pre

262 arify how the kidney/renal lymph node system tolerizes the immune system against circulating innocuou

263 that whereas CD8 T cells sensed TAg and were tolerized, the CD4 T cells remained ignorant throughout

264 to host lymphohemological tissues as well as tolerizing them in the host.

265 but also validate therapeutic strategies for tolerizing them.

266 Strikingly, in LPS-tolerized THP-1 monocytes, only miR-146a showed a contin

267 , whether taken from naive mice or from mice tolerized through either treatment protocol, were always

268 als were deficient in their ability to cross-tolerize to subsequent treatment with TLR2 and TLR4 liga

269 Splenic B cells from animals that have been tolerized to alglucosidase alfa with methotrexate can tr

270 chain (alphaMYHC) cause myocarditis and mice tolerized to alphaMYHC are protected from virus challeng

271 Peripheral CD4(+)Vbeta5(+) T cells are tolerized to an endogenous mouse mammary tumor virus sup

272 mmadelta T cells, when transferred from mice tolerized to an inhaled conventional Ag, suppress the al

273 This risks that the immune system tolerized to antigens expressed by progenitors may still

274 ating that NK cells in the chimeras had been tolerized to beta(2)m(-/-).

275 individuals with the intron 22 inversion are tolerized to FVIII and thus do not develop inhibitors.

276 Anti-ICOS-treated mice tolerized to hFVIII generated normal primary and seconda

277 lls expressing such activating receptors are tolerized to host tissues.

278 competent mice of two different strains were tolerized to human F.IX by hepatic gene transfer mediate

279 rly, adoptive lymphocyte transfers from mice tolerized to human FIX by hepatic AAV gene transfer indi

280 A total of 24 canines with MPS I were either tolerized to iduronidase or left nontolerant.

281 e beta (CAIKKbeta) in airway epithelium were tolerized to inhaled ovalbumin.

282 sm by which highly self-reactive B cells are tolerized to membrane and soluble self-Ags.

283 Repeated infection of infant mice tolerized to ovalbumin (OVA) through their mother's milk

284 s lacking cognate ligand, gradually becoming tolerized to self by day 100.

285 In contrast, T cells that were tolerized to the superagonist were unable to respond to

286 Remarkably, macrophages tolerized to TNF-alpha, but not to LPS, retained full se

287 Early demonstrations that mice could be tolerized to transplanted tissues with short courses of

288 Therefore, in vivo expansion of tolerized transplanted cells is emerging as a novel and

289 In tolerized, transplanted, and HCV-infected rats, Huh 7 ce

290 In tolerized, transplanted, inoculated rats, but not contro

291 effector T cells and to restore function to tolerized tumor-infiltrating T cells for cancer immunoth

292 nical immunotherapeutic strategies rely on a tolerized tumor-reactive T-cell repertoire, resulting in

293 sis for broad-based therapeutic targeting of tolerizing tumor antigens.

294 ous T cell-based cancer immunotherapy is the tolerizing-tumor microenvironment that rapidly inactivat

295 lly, two injections of cCTLA4-Ig effectively tolerized two dogs against eight consecutive challenges

296 Tolerized wild-type cells had impaired Cdk2 and Cdc2 kin

297 to citrullinated proteins in CIA, mice were tolerized with a citrulline-containing peptide, followed

298 Mice were tolerized with Ag-SP before or after initiation of OVA/a

299 eous polygenic systemic lupus erythematosus, tolerized with an artificial peptide (pConsensus) based

300 ecruited to cardiac allografts in recipients tolerized with CD154 monoclonal antibody (mAb) plus dono