ライフサイエンスコーパス: tonicity

1 tatic response to changes in blood volume or tonicity.

2 subject to very high levels of extracellular tonicity.

3 analysis of p[Na +] or calculation of serum tonicity.

4 response of cell volume to changes in plasma tonicity.

5 of the kidney to elevations in extracellular tonicity.

6 a and the accompanying rise in extracellular tonicity.

7 renal medulla, is regulated by extracellular tonicity.

8 Glucose uptake via GLUT2 also raises oocyte tonicity.

9 adapt to changes of interstitial osmolality/tonicity.

10 ional activator that is regulated by ambient tonicity.

11 he neuronal responses to changes in systemic tonicity.

12 ated with hypokalemia or increased medullary tonicity.

13 that are associated with increased medullary tonicity.

14 e airway epithelium is exposed to changes in tonicity.

15 e recognition and regulation of airway fluid tonicity.

16 to the related alterations in extracellular tonicity.

17 curves, as the curves migrated towards lower tonicities.

18 IMCD3) cells adapted to increasing levels of tonicity (300, 600, and 900 mosmol/kg H(2)O) by two-dime

19 hors identify a communal transport route for tonicity-activated and polyol- activated myo-inositol re

20 on of phloretin significantly inhibited both tonicity-activated and polyol-activated myo-inositol rel

21 In cultured bovine lens epithelial cells, tonicity-activated movement of myo-inositol from cell to

22 se in medium osmolality, a mechanism for the tonicity-activated release of myo-inositol was recognize

23 Beneficial effects beyond changing serum tonicity and alternative uses, such as in polycystic kid

24 ation after EGFR transactivation occurred in tonicity and in a time-dependent manner.

25 Similar ASL tonicity and pH were found in cystic fibrosis (CFTR-null

26 ) is involved in the responses to changes in tonicity and that these may be altered in cystic fibrosi

27 with diagnoses that required specific fluid tonicity and volumes were excluded.

28 fflux sodium to decrease their intracellular tonicity, and that this is reversible by blockade of sod

29 thelial cell chloride channel is a voltage-, tonicity- and pH-regulated member of the ClC super famil

30 linical intravenous fluids (IVFs) of various tonicities are often used during treatment of vaso-occlu

31 onfirmed increased expression with increased tonicity, both acute and chronic.

32 (iv) PKAc activity increases with tonicity but cAMP does not.

33 ed when these cells were exposed to the same tonicity by addition of urea.

34 The osmosensation of luminal tonicity by ciliary TRPV4 induces bicarbonate secretion,

35 However, modulation of tonicity can induce alterations in spheroid size.

36 their interaction was adaptable to membrane tonicity changes.

37 ng the possibility that changes in medullary tonicity could play an important role in the regulation

38 t growth factors, pyrimidines and changes in tonicity could trigger ATP release into subretinal space

39 We have now tested for tonicity dependence of the TAD activity of the 983 C-ter

40 Thus, tonicity-dependent activation of the NLS is crucial in t

41 ption factor NFAT5 associated with TonE in a tonicity-dependent fashion in cultured rat renal medulla

42 important role in TonEBP/OREBP activation of tonicity-dependent gene expression; (ii) PKA activation

43 sults: (i) An inhibitor of PKA (H89) reduces tonicity-dependent increases in transactivation, ORE/Ton

44 smic proteins, the fusion proteins displayed tonicity-dependent nucleocytoplasmic trafficking like To

45 Also, amino acids 548-1531 undergo tonicity-dependent phosphorylation, and some inhibitors

46 that is regulated osmotically, apparently by tonicity-dependent phosphorylation.

47 tutively localized to the nucleus and showed tonicity-dependent posttranslational modification consis

48 onEBP/OREBP (amino acids 548-1531) contain a tonicity-dependent transactivation domain (TAD).

49 iii) amino acids 872-1271 are sufficient for tonicity-dependent transactivation of TonEBP/OREBP.

50 erminal polyglutamine stretches, demonstrate tonicity-dependent transactivation, albeit less than ami

51 ome inhibitors of protein kinases reduce the tonicity-dependent transactivation.

52 Through mutagenesis studies, the site of tonicity-dependent tyrosine phosphorylation was mapped t

53 rane in response to changes in extracellular tonicity, despite equivalent constitutive surface expres

54 Increased extracellular tonicity effected a time-dependent reduction in eNOS and

55 Ambient tonicity (effective osmolality) is the prominent signal

56 on the binding of the transcription factor, tonicity element-binding protein, or osmotic response el

57 uclear factor of activated T cells 5 (NFAT5)/tonicity enhancer binding protein (TonEBP), the only kno

58 is protein, designated NFATL1 (also known as tonicity enhancer binding protein and NFAT5) is expresse

59 iption factor associated with hypertonicity, tonicity enhancer-binding protein (TonEBP), was cloned u

60 Nuclear factor of activated T cells tonicity-enhancer-binding protein and carbohydrate-respo

61 and bypass the normal requirement of altered tonicity for activation of these transporters.

62 c peptides elicited, at most, a loss of tail tonicity from which the mice most often completely recov

63 to intense variations in extracellular fluid tonicity generated by the corticopapillary gradient.

64 sotonic conditions and increased with higher tonicity in adapted cells.

65 versibly regulated in response to changes of tonicity in primary cortical rat astrocytes and in trans

66 of significantly influencing the phenotypic tonicity in smooth muscle via ROCK2: a lack of tone in A

67 lts showing a critical role for carotid body tonicity in the aetiology of enhanced central respirator

68 We further show that modulation of medium tonicity in vitro regulates the secretion of AQP-1, thus

69 At such high concentration of NaCl, tonicity, indeed, matters, especially in water shifts ac

70 ocks NFkappaB activation, demonstrating that tonicity-induced COX2 expression depends on NFkappaB act

71 The tonicity-induced COX2 expression was suppressed by mutan

72 r examine the potential role of C/EBPbeta in tonicity-induced COX2 expression, a dominant negative C/

73 site in the COX2 promoter failed to abolish tonicity-induced COX2 reporter activity.

74 For tonicity-induced inositol efflux, BLECs were maintained

75 in myoinositol content, but only when plasma tonicity is concomitantly increased.

76 Adaptation to changes in extracellular tonicity is essential for cell survival.

77 c pathophysiologically relevant increases in tonicity lead to increases in NHE3 protein abundance and

78 r causes an increased tonicity, whereas this tonicity may be decreased by glandular secretions.

79 Here, we demonstrate that tonicity mediated cell swelling rapidly activates transc

80 We sought to determine whether changes in tonicity might regulate NOS gene expression, and if so,

81 their adaptation to rapid shifts in ambient tonicity normally occurring in the renal medulla.

82 normal subjects after inhalation of varying tonicities of saline alone, and after pretreatment with

83 itioned to detect changes in composition and tonicity of bile, we hypothesized that cilia also functi

84 We compared the effects of different tonicity of infused hypertonic saline on cerebral, lung,

85 from the gel to 880 +/- 54 mosmol kg-1; the tonicity of the absorbate from 2.5 % gels was 352 +/- 38

86 plugs inserted in the lumen, by raising the tonicity of the absorbate from the gel to 880 +/- 54 mos

87 AQP1 trafficking was mediated by the tonicity of the cell environment in a specific PKC- and

88 long-term CsA treatment reduces the salinity/tonicity of the renal medullary interstitium as a result

89 A administration is secondary to the reduced tonicity of the renal medullary interstitium.

90 e decreased salivary flow rate and increased tonicity of the saliva secreted by Aqp5(-)/- mice in res

91 of 2-PMPA, we studied the effect of vehicle tonicity on the absorption of 2-PMPA in the colon.

92 ation of such agents after such increases in tonicity only produced a hyperpolarization after a time

93 a(2+)-permeable channel that can be gated by tonicity (osmolarity) and mechanical stimuli.

94 usly, we showed that increased extracellular tonicity promotes increased type A natriuretic peptide r

95 xcitability, contractility, conductivity and tonicity provided the physiologic explanation necessary

96 sis from phosphatidylcholine is catalyzed by tonicity-regulated activity of the phospholipase B, neur

97 The high NaCl increases expression of tonicity-regulated transcription factor NFAT5 and its bi

98 toplasmic signaling through MAPK pathways in tonicity regulation of COX-2 expression in collecting du

99 external orifice of GLUT2 raises vestibular tonicity relative to the external solution.

100 pendent manner, effectively bypassing normal tonicity requirements for cotransporter regulation.

101 This suggests that the function of AQP1 in tonicity response could be coupled or correlated to its

102 Expression level of tonicity responsive enhancer binding protein, a transcri

103 Tonicity-responsive enhancer (TonE) binding protein (Ton

104 Here, we identified a tonicity-responsive enhancer (TonE) upstream of the rat

105 A tonicity-responsive enhancer (TonE) was identified at -3

106 Tonicity-responsive enhancer binding protein (TonEBP) is

107 Tonicity-responsive enhancer binding protein (TonEBP) pl

108 Tonicity-responsive enhancer binding protein (TonEBP), a

109 with SMIT1 overexpression, whereas silencing tonicity-responsive enhancer binding protein prevented t

110 ls to hypertonicity increases the binding of tonicity-responsive enhancer binding protein to the enha

111 eracting with the transcription factor named tonicity-responsive enhancer binding protein.

112 The aldose reductase gene is controlled by a tonicity-responsive enhancer, which was refractory to hy

113 Activation of tonicity-responsive enhancer-binding protein (TonEBP)/NF

114 olyte accumulation in skin, and activate the tonicity-responsive enhancer-binding protein (TONEBP, al

115 Transcription factor tonicity-responsive enhancer-binding protein (TonEBP/NFA

116 When activated by high NaCl, tonicity-responsive enhancer-binding protein/osmotic res

117 Tonicity-responsive enhancer/osmotic response element-bi

118 High NaCl activates the transcription factor tonicity-responsive enhancer/osmotic response element-bi

119 ease in activity of the transcription factor tonicity-responsive enhancer/osmotic response element-bi

120 Tonicity-responsive enhancers (TonE) play a key role in

121 We identified five tonicity-responsive enhancers that are scattered over 50

122 ylation by calcineurin; and (iii) the TonEBP tonicity-responsive proteins.

123 gs demonstrate a central role for NFAT5 as a tonicity-responsive transcription factor required for ki

124 uggest that the TonE/TonEBP pathway mediates tonicity-responsive transcriptional regulation of UT-A1,

125 An acute increase in plasma tonicity results in an adaptive increase in brain organi

126 dium transporters was altered, the medullary tonicity seemed unchanged.

127 ulated to comprise an element of the central tonicity-sensing mechanism in the mammalian hypothalamus

128 se-dependent tyrosine phosphorylation of the tonicity sensor TRPV4 at residue Tyr-253 and that this r

129 Admixtures with intermediate tonicities (sodium = 111-122 mEq/L) resulted in optimal

130 Admixtures with higher tonicities (sodium = 141 mEq/L) affected sRBC biomechani

131 m), an inhibitor of Src kinases, reduced the tonicity-stimulated COX-2 expression in a dose-dependent

132 p38) as well as Src kinases are required for tonicity-stimulated COX-2 expression in mouse collecting

133 To study the role of JNK in tonicity-stimulated COX-2 expression, IMCD-3 cell lines

134 ne varied inversely with extracellular fluid tonicity to mediate the osmotic control of AP firing by

135 We have examined the ability of medium tonicity to regulate the activity and expression of this

136 demonstrate that cancer cells modulate their tonicity to survive under compressive solid stress.

137 gations conducted over a half century ago on tonicity, transcapillary fluid exchange, and the distrib

138 changes following increases in extracellular tonicity were compared with microelectrode measurements

139 iration of cool, dry air causes an increased tonicity, whereas this tonicity may be decreased by glan

140 , we report how altering extracellular fluid tonicity with admixtures of clinical IVFs affects sRBC b

141 is unknown how altering extracellular fluid tonicity with IVFs affects sRBC biomechanics in the micr

142 Increasing medium tonicity with NaCl, sucrose, mannitol, and choline chlor