ライフサイエンスコーパス: tonsillar

1 tes included bladder (95; 16%), laryngeal or tonsillar (92; 15%), cutaneous (84; 14%), and pulmonary

2 y of tonsillar T follicular helper cells and tonsillar Ag-specific Ab-secreting cells.

3 type 2 cytokines IL-5 and IL-13, from human tonsillar and blood ILC2s in response to stimulation wit

4 ed IL-22, IL-17F, and GM-CSF production from tonsillar and gut ILC3s.

5 ial and breast epithelia, and throughout the tonsillar and vaginal epithelia.

6 ical, vaginal, vulvar, penile, anal, tongue, tonsillar, and oropharyngeal).

7 planned neck dissection for carcinoma of the tonsillar area and to compare these data with the result

8 Tonsillar B and T cells expressed CD154 at a similar den

9 e; similar observations were made in primary tonsillar B cell cultures.

10 activation, strongly perturbed CD40-induced tonsillar B cell proliferation while potentiating the B

11 ty of the IgD(+)Strictly-IgM(-)CD38(+) human tonsillar B cell subpopulation have now allowed detectio

12 uli, including ligation of CD40, dense human tonsillar B cells (>98% cells in G(0)) have increased cl

13 egularly detected in purified naive (IgD(+)) tonsillar B cells (13 of 16 tonsils tested) but was neve

14 hanced significantly on peripheral blood and tonsillar B cells after activation by cross-linking surf

15 de Burkitt's B-cell lymphoma lines, isolated tonsillar B cells and at low levels in peripheral blood

16 in or B cell antigen receptor (BCR) on human tonsillar B cells and B cell lines promoted tyrosine pho

17 coprecipitates with Ig in lysates from human tonsillar B cells and B cell lines.

18 Gene expression profiling of human tonsillar B cells and mouse B cell lymphomas showed that

19 sed by a relatively large percentage of IgD+ tonsillar B cells and this percentage is proportional to

20 Here we show that activated blood and tonsillar B cells can be productively infected with HHV-

21 or KSHV reservoir, and virus activation from tonsillar B cells can result in salivary shedding and vi

22 CFSE staining of purified human tonsillar B cells demonstrated that naive IgD(+) and CD2

23 -derived dendritic cells (DCs) differed from tonsillar B cells in the set of cell fate genes they exp

24 gly costimulate proliferation of dense human tonsillar B cells ligated via their B-cell antigen recep

25 ene copies and the proportion of IgD-bearing tonsillar B cells that react with G6.

26 Here we show with purified tonsillar B cells that SDF-1alpha also attracts naive an

27 gement in multiple B cell lines and in human tonsillar B cells to define the role of p38 MAPK in prol

28 pare BCR signaling responses in mature human tonsillar B cells undergoing germinal center (GC) reacti

29 ated peripheral blood B cells and in vivo on tonsillar B cells with an activated phenotype.

30 Pretreating CD40-stimulated tonsillar B cells with anti-CD95 abolished B cell antige

31 Interestingly, pretreatment of tonsillar B cells with cytochalasin B dramatically reduc

32 ted by IRF8, we transfected purified primary tonsillar B cells with enhanced green fluorescent protei

33 Splenic and tonsillar B cells, CD34(+) stem cells, resting T cells,

34 Here, we subdivided human tonsillar B cells, including IgD(-)CD38(+) GC B cells, i

35 observed in certain B cell lines but not in tonsillar B cells, indicating a more general role for HE

36 4 beta7 integrins on B cell lines and normal tonsillar B cells, induces tyrosine phosphorylation of m

37 ssed on the surface of transfected cells and tonsillar B cells.

38 No such restriction was observed in tonsillar B cells.

39 velopment- and function-based transitions in tonsillar B cells.

40 8 density on freshly isolated unfractionated tonsillar B lymphocytes and on the activated 1,25(OH)2D3

41 hocyte infection with KSHV in which infected tonsillar B lymphocytes were expanded by providing mitog

42 is up-regulated upon activation of quiescent tonsillar B lymphocytes, although mRNA for the protein m

43 h a germinal center phenotype (RAMOS) or the tonsillar B-cell centroblast fraction with CD40 rapidly

44 Analysis of human tonsillar B-cell subpopulations revealed that FOXP1 show

45 cal progression were typical of other cases, tonsillar biopsy and subsequent examination of multiple

46 ve detectable prion deposition in diagnostic tonsillar biopsy or markers of prion infection in blood.

47 tissues from a necropsy series and assessed tonsillar biopsy samples as a diagnostic investigation f

48 HPV-positive tonsillar cancer in particular is emerging as a specific

49 eloped human papillomavirus (HPV)-associated tonsillar cancer within 12 months of each other.

50 In patients with tonsillar cancer, the mean difference in SUV(max) betwee

51 t compare radiotherapy (RT) with surgery for tonsillar cancer.

52 16, which is present in most HPV-associated tonsillar cancers, was the most prevalent high-risk oral

53 Recent data suggest that the incidence of tonsillar carcinoma in the United States is increasing,

54 in 2 couples with concurrent development of tonsillar carcinoma who did not have other risk factors,

55 d HIV-infected men are at increased risk for tonsillar carcinoma.

56 ect diagnosed with moderately differentiated tonsillar carcinoma.

57 experiments, we found that VZV infects human tonsillar CD4(+) T cells in culture, with 15 to 25% bein

58 CR3 was expressed in vivo on newly activated tonsillar CD4(+) T cells.

59 ymography in two Burkitt cell lines and in a tonsillar cell suspension, while gelatinase A and inters

60 nal centers (GCs), we isolated GC cells from tonsillar cell suspensions and exposed them to EBV in vi

61 ubsets sorted from a unique collection of IM tonsillar cell suspensions.

62 ers its cellular phenotype, we exposed human tonsillar cells to KSHV and characterized infected cells

63 However, clusters of infected tonsillar cells were detected where the epithelial surfa

64 Additionally, coculture of tonsillar cells with infected hepatoma cells lead to an

65 ay be found in the centroblastic fraction of tonsillar cells.

66 both established HIV infection in individual tonsillar cells.

67 parallel those reported in ex vivo isolated tonsillar centroblasts, centrocytes, and memory B cells.

68 Here we found that ECs lining tonsillar crypts formed pockets populated by B cells exp

69 erium avium subsp. paratuberculosis into the tonsillar crypts of neonatal calves resulted in peripher

70 e show membranous expression of PD-L1 in the tonsillar crypts, the site of initial HPV infection.

71 In ex vivo tonsillar cultures, we observed that EBER1-loaded exosom

72 Tonsillar cytokine expression is closely related to exis

73 One of three survivor strains isolated from tonsillar discard material from patients expressed high

74 vely) and a greater likelihood of cerebellar tonsillar ectopia (30.7%; P < .002 and P < .001, respect

75 e presence of GpIb alpha mRNA and protein in tonsillar endothelium.

76 th obstructive sleep apnea (OSA) followed by tonsillar enlargement (OR = 2.0; 95% CI, 1.0-3.8), enlar

77 e absence of tender anterior cervical nodes, tonsillar enlargement, or exudate (negative likelihood r

78 levels of miR-200 family members in oral and tonsillar epithelia and in saliva.

79 Using immortalized human tonsillar epithelial (HTE) cells, increased radiation se

80 SJ755 blocked Fn binding by human tonsillar epithelial and A549 cells, suggesting that int

81 rnalization of streptococci by primary human tonsillar epithelial cells and immortalized human epithe

82 that membrane vesicles secreted by oral and tonsillar epithelial cells may serve as a tissue-specifi

83 V can infect both T and B cells from primary tonsillar explant cultures.

84 e likelihood of strep throat are presence of tonsillar exudate, pharyngeal exudate, or exposure to st

85 the four Centor criteria: history of fever, tonsillar exudates, no cough, and tender anterior cervic

86 TdT(+) cells found within the tonsillar fibrous scaffold expressed CD34 and/or CD1a, i

87 s the prevalence of relevant immune cells in tonsillar follicles and support the use of tonsils as ly

88 T lymphocyte clusters in synovium and within tonsillar follicles.

89 er RT for early-stage cancers was higher for tonsillar fossa/posterior pillar cancers than for those

90 d the ability of cytokines to maintain human tonsillar GC B cells (IgD-/CD39-/CD38+/CD77+) in the "CD

91 ated PC differentiation using purified human tonsillar GC B cells and a GC B cell-like cell line.

92 siologic mechanism, we screened single human tonsillar GC B cells for mutations occurring in the BCL-

93 miniscent of the feature of CD40L-stimulated tonsillar GC B cells.

94 ysis, we found that PD-1-expressing cTfh and tonsillar GCTfh cells were clonally related.

95 ition, staining for IRF8 was most intense in tonsillar germinal center (GC) dark-zone centroblasts.

96 escribed in vitro culture system using human tonsillar germinal center B cells was used to study the

97 Tonsillar herniation, foramen magnum stenosis, and sever

98 L40 completely blocked lymphocyte binding to tonsillar HEVs, whereas MECA-79 inhibited only 60%.

99 tags from a cDNA library prepared from human tonsillar high endothelial cells, we have identified a c

100 In human tonsillar histocultures, NL4-3 replicated to higher leve

101 ential induction of cell cycle regulators in tonsillar human B cell subpopulations that were activate

102 equent in acute infectious mononucleosis and tonsillar hyperplasia and identical to those observed in

103 with infectious mononucleosis and 12/16 with tonsillar hyperplasia).

104 nucleosis and 16 Swiss children with chronic tonsillar hyperplasia.

105 ildren without recurrent throat infection or tonsillar hypertrophy (304 enrolled; 266 followed up) we

106 ers are myriad, from subtle findings such as tonsillar hypertrophy to fulminant manifestations such a

107 involves the latent infection of a subset of tonsillar IgMl-expressing B cells, which then proliferat

108 Tonsillar ILC3s and regulatory B cells were visualized w

109 Transcriptomes of sorted tonsillar ILC3s were assessed by using microarray analys

110 ligand (CD40L) expression on circulating and tonsillar ILC3s.

111 The relationships between tonsillar immune responses, and viral infection and alle

112 s to evaluate the effectiveness of nasal vs. tonsillar immunization with S. mutans antigens in induci

113 y of human tonsil sections demonstrates that tonsillar interdigitating DC are also DO(+).

114 Tonsillar intraepithelial lymphocytes were also enriched

115 Tonsillar lymphocytes and SKW3 T lymphoma cells tethered

116 r, PSGL-1 levels were substantially lower on tonsillar lymphocytes than on circulating lymphocytes, s

117 ginating from nondissected tonsil tissue and tonsillar lymphocytes were found to have sequences predo

118 ldren's nondissected tonsil tissue, isolated tonsillar lymphocytes, and isolated stromal cells that d

119 n tandem repeats but were isolated only from tonsillar lymphocytes.

120 (XLA) lacking Btk expression, as well as in tonsillar lymphoid cells.

121 ation led to apoptosis that was localized to tonsillar lymphoid follicles.

122 e lymphocytic effusion and an EBV-associated tonsillar lymphoproliferative disorder suggested that th

123 Tonsillar MBC responses correlated with systemic MBC and

124 In contrast, only tonsillar memory B cells (MB) and PCs, from both tonsil

125 nter centroblasts and centrocytes as well as tonsillar memory B cells express a more restricted patte

126 pattern we have found in latently infected, tonsillar, memory B cells is used because it allows for

127 Tonsillar naive B cells express the EBNA2-dependent lymp

128 eratinocyte cell clones derived from primary tonsillar or foreskin epithelia immortalized with HPV-16

129 ng cells in human lymphoid tissue, we used a tonsillar organ culture model.

130 Tfh cells or exogenous IL-21 reduce tonsillar PC apoptosis and increases PC recovery but doe

131 nduced a marked increase of Ig production by tonsillar PC, and this effect was impaired when endogeno

132 id and transient phosphorylation of STAT3 in tonsillar PC.

133 ers than for those arising from the anterior tonsillar pillar.

134 The in vitro coculture of purified tonsillar plasma cells and T cells revealed a T-cell sur

135 Tonsillar plasma cells were maintained within the grafts

136 cal variant CJD is uniformly associated with tonsillar prion infection, we screened 2000 anonymous su

137 Whereas the tonsillar process was a potentially malignant EBV-positi

138 for certain anatomical sites, especially the tonsillar region, with viral DNA identified in approxima

139 ifferentiated tumors arising from Waldeyer's tonsillar ring.

140 approximately 60% of SCCs of the Waldeyer's tonsillar ring.

141 oup immunized by the nasal compared with the tonsillar route, indicating that nasal immunization was

142 intravenous (i.v.), intratracheal (int), or tonsillar routes.

143 d from peripheral blood of healthy donors or tonsillar samples.

144 curate imaging biomarker for differentiating tonsillar SCC from physiologic (18)F-FDG uptake.

145 ears + or - 10.45 [standard deviation]) with tonsillar SCC were included.

146 themselves, is critical for tumorigenesis of tonsillar SCC.

147 ially HPV-16, is detected in the majority of tonsillar SCCs and is almost exclusively associated with

148 Well keratinized tonsillar SCCs lack HPV DNA and are associated with over

149 the detection of its ligand, E-cadherin, on tonsillar squamous cells.

150 eractions of lymphocytes with cultured human tonsillar stromal cells and their extracellular matrix u

151 ethered and rolled on monolayers of cultured tonsillar stromal cells and their matrix.

152 ereas the majority of clones from the DNA of tonsillar stromal cells had sequences characteristic of

153 opoietic precursor cells, B lymphocytes, and tonsillar stromal cells.

154 iver, primary human B lymphocytes, and human tonsillar stromal cells.

155 We identified 5 tonsillar T cell developmental intermediates: (a) CD34(+

156 ted in abundance on the surfaces of infected tonsillar T cells.

157 Tonsillar T follicular helper (Tfh) lymphocytes are know

158 rrelation was found between the frequency of tonsillar T follicular helper cells and tonsillar Ag-spe

159 ssion of IFN-alpha was increased in lymphoid tonsillar tissue (LT) of patients with progressive (HIV(

160 ation of spirochetes inside the RWV-cultured tonsillar tissue demonstrated that the number of B. burg

161 d testing in autopsies: consented testing of tonsillar tissue is potentially attributable to interrup

162 dentified within the mucosal surfaces of the tonsillar tissue of HIV-1-infected persons.

163 d penile tissues and enhanced replication in tonsillar tissue relative to acute Envs.

164 Analysis of human tonsillar tissue revealed that plasma cells and their pr

165 We found that ex vivo-cultured tonsillar tissue supports productive infection by the Ne

166 ed against HIV-1 (in vitro and ex vivo human tonsillar tissue system) and human herpes viruses.

167 National prospective collection of tonsillar tissue to be tested anonymously for abnormal l

168 We inoculated blocks of human tonsillar tissue with B. burgdorferi spirochetes, cultur

169 In human tonsillar tissue, this vaccine strain infects naive (CD4

170 Asymptomatic individuals without tonsillar tissue, which is believed to be an important s

171 = 39) Hi resided intracellularly in the core tonsillar tissue.

172 IL-7R alpha status in blood did not hold in tonsillar tissue.

173 In a parallel study, adenoid and tonsillar tissues from children with obstructive sleep a

174 lation (CD20(hi)/CD27(lo)/CD21(lo)) in human tonsillar tissues was recently defined by the expression

175 preparation (E-GTF) administered by nasal or tonsillar topical spray.

176 tified all four components of the complex in tonsillar vessels.

177 Tonsillar virus detection showed a strong negative assoc

178 without OSA do not have increased adenoid or tonsillar volume; reduced upper airway size is caused by

179 ually involves one or more of the following: tonsillar zones, larynx, soft palate, uvula, and nasal c