ライフサイエンスコーパス: tooth germ

1 nt role in determining the size and shape of tooth germ.

2 an increase in programmed cell death in the tooth germ.

3 bles the lamina stage of the mammalian molar tooth germ.

4 ogenic mesenchymal cells close to developing tooth germs.

5 ack of fgf8 and pax9 expression in zebrafish tooth germs.

6 ce exhibit early developmental arrest of all tooth germs.

7 in the epithelial cells of early developing tooth germs.

8 ng pathway appears not to be active in these tooth germs.

9 ts and modulation of Wnt signaling by Nog in tooth germs.

10 prior to grafting, BMP4 rescues Msx1 mutant tooth germs all the way to definitive stages of enamel a

11 x genes is similar between molar and incisor tooth germs, although 3 low-abundance transcripts were f

12 ng molecules are expressed in the developing tooth germ and interact each other to mediate the induct

13 egulating Shh expression in mouse developing tooth germ and limb bud.

14 ular incisor arrested as a single, bud-stage tooth germ and Meckel's cartilage was absent.

15 of exogenous Shh protein directly into early tooth germs and adjacent to tooth germs, resulted in abn

16 ttern surrounding the developing mouse molar tooth germs and mice lacking Osr2 developed supernumerar

17 esenchymal Fgfs in wild-type and Msx1 mutant tooth germs and tested the ability of FGFs to induce Fgf

18 tential Msx1 downstream genes in Msx1 mutant tooth germs and we have performed functional experiments

19 In this study, we used the embryonic mouse tooth germ as a tool to search for the downstream target

20 /11 (LM-511/521) is the major laminin in the tooth germ basement membrane.

21 iferation, and apoptotic activity within the tooth germ between the wild-type and Lef1 null mutant mi

22 , and second in the development of cap-stage tooth germs by increasing epithelial cell survival.

23 of ectopic MFrzb1 protein on the developing tooth germs by transplanting explants treated with Mfrzb

24 show that addition of BMP4 to Msx1 deficient tooth germs bypasses the requirement for Msx1 and rescue

25 4, by differential hybridization using mouse tooth germ cDNA microarrays.

26 olar tooth germs while their maxillary molar tooth germs completed morphogenesis.

27 Tooth germ culture showed that the developing tooth inva

28 The enamel knot, a signaling center for tooth germ development, is defective, and there is a sig

29 As the tooth germ develops and proceeds to the cap stage, the e

30 d alveolar bone leads to an expansion of the tooth germ, driven by increased proliferation, indicatin

31 During their early development, tooth germs exhibit many morphological and molecular sim

32 of this increased cell death, the bud stage tooth germ fails to advance to the cap stage in the abse

33 ests that Wnt signaling is required early in tooth germ formation and that interference with signalin

34 s with epithelium during the early stages of tooth germ formation and undergo complex changes which,

35 ing epithelial/mesenchymal cell signaling in tooth germ formation.

36 Mutant tooth germs formed multiple dental epithelial buds into

37 of ectomesenchymal cells that surrounds the tooth germ in early stages of tooth development.

38 pithelium but repressed Shh in the wild-type tooth germ in vivo.

39 The degree of mineralization of permanent tooth germs in dental age assessment has been an area of

40 activin betaA mutant embryos is lost in all tooth germs, including the maxillary molars.

41 h development, suggestive of a role in early tooth germ initiation and subsequent epithelial-mesenchy

42 during normal development, the growth of the tooth germ is constrained by the surrounding tissues.

43 atrix protein derived from embryonic porcine tooth germs is used clinically, but the mechanisms by wh

44 at activin betaA is expressed in presumptive tooth-germ mesenchyme and is thus a candidate for a sign

45 e mesenchyme in incisor and mandibular molar tooth germs must be carried-out in maxillary molar mesen

46 When isolated from the developing tooth germ, odontoblasts quickly lose their potential to

47 ct the expression in mouse molar and incisor tooth germs of 14 of the 19 known members of the Sox fam

48 ha5-null mouse primary dental epithelium and tooth germ organ cultures.

49 that when added to explanted Msx1-deficient tooth germs prior to grafting, BMP4 rescues Msx1 mutant

50 nt mice, both mandibular and maxillary molar tooth germs progressed to the early bell stage, with res

51 he enamel knot signalling centre in downless tooth germs provide functional data directly linking the

52 mesenchymal interactions, and the developing tooth germ provides a powerful model for elucidating the

53 experimental manipulation, the murine molar tooth germ provides a powerful system for studying the r

54 ectly into early tooth germs and adjacent to tooth germs, resulted in abnormal epithelial invaginatio

55 tegrin alpha6 antibody and wortmannin reduce tooth germ size and shape.

56 a mandibular remnant that displayed abnormal tooth germs, substandard angiogenesis, and enhanced apop

57 ation and subsequent arrest of supernumerary tooth germs that correlated with downregulation of Msx1

58 study we used early mouse molar and incisor tooth germs that possess distinct tooth-forming capabili

59 essed at embryonic day 14.5 (E14.5) in early tooth germs, then down-regulated from E15.5-E17.5 and re

60 onditional knockout and YAP transgenic mouse tooth germs using transcriptome sequencing (RNA-Seq) and

61 By adding a soluble form of Edar to tooth germs, we were able to mimic the tabby enamel knot

62 Whereas all tooth germs were arrested at the bud stage in Msx1(-/-)

63 To further test this hypothesis, Msx1 mutant tooth germs were first cultured with either BMP4 or with

64 in the dental epithelium of the Msx1 mutant tooth germ where Bmp4 expression is significantly reduce

65 The developing mouse tooth germ, which is an experimentally accessible model

66 developmental arrest of the mandibular molar tooth germs while their maxillary molar tooth germs comp

67 Lama5-null mice develop a small tooth germ with defective cusp formation and have reduce

68 in the dental epithelium resulted in a small tooth germ with reduced epithelial cell proliferation.