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1 re the frequency of complete resolution with topical 5-FU treatment and the rate of OSSN recurrence.
2  time-intensity taste analysis revealed that topical addition of both l- and d-MSpG enhanced the perc
3 inal neuroprotective effects of systemic and topical administration (eye drops) of GLP-1R agonists in
4  has also been used as an analgesic, and its topical administration is approved for the treatment of
5                                       Single topical administration of 25 pmol of 12 increased tear v
6 ion using an inducible promoter activated by topical administration of doxycycline achieved the same
7                In this study, the effects of topical administration of HOCl hydrogel (0.05%) on atopi
8              This study evaluates effects of topical administration of probiotic bacteria of the genu
9 ired MSC recruitment that is reversed by the topical administration of recombinant GPNMB protein to t
10 ntly suppressed skin inflammation induced by topical administration of the TLR7 agonist imiquimod.
11                                              Topical administration provides an attractive route for
12                          In groups C and EP, topical administrations were performed using a sham susp
13 lving genetically modified mice treated with topical agents and human dermatological conditions, such
14 compounds have the potential to be effective topical agents for treating respiratory inflammatory dis
15  an unmet dermatological need for innovative topical agents that achieve better longterm outcomes wit
16 sm used in rinse-off formulations to deliver topical agents to the skin and hair; this process produc
17 ssions or emergency procedures have become a topical and controversial issue for the UK National Heal
18                                         Both topical and intradermal gentamicin administration induce
19  pilot trial assessed safety and efficacy of topical and intradermal gentamicin in 5 RDEB patients wi
20                                              Topical and intradermal gentamicin suppresses nonsense m
21 hich improved with corticosteroid treatment (topical and intralesional) alone or in combination with
22                          Bottom Line: Use of topical and systemic antibiotics for acne is associated
23 the reported therapeutic modalities, such as topical and systemic corticosteroids, systemic immunomod
24  corticosteroids, systemic immunomodulators, topical and systemic retinoids, and laser, HHD can still
25                The pipeline of more targeted topical and systemic therapies is expanding based on our
26          Treatment included a combination of topical and systemic therapies, such as corticosteroids,
27                     ICRS were inserted under topical anesthesia after creating a corneal tunnel with
28  limited mobility, sutureless incisions, and topical anesthesia also have become key components of st
29 ry of PTSD were more likely to have received topical anesthesia with or without sedation.
30 sisted 9.5-mm diameter lamellar pocket under topical anesthesia.
31                           This validates the topical anti-inflammatory properties of this plant and p
32 r, our results show that IVM is endowed with topical anti-inflammatory properties that could have imp
33 calculating the proportion filling 1 or more topical antibiotic prescription within 14 days of initia
34 te conjunctivitis, 198 462 (58%) filled >/=1 topical antibiotic prescriptions; 38 774 filled prescrip
35                                              Topical antibiotic was not shown to add to the effective
36  acute conjunctivitis fill prescriptions for topical antibiotics and factors associated with antibiot
37  effect of topical povidone-iodine 1.25% and topical antibiotics commonly available in the developing
38 vidone-iodine 1.25% ophthalmic solution with topical antibiotics for treatment of bacterial keratitis
39 t povidone-iodine and rates with and without topical antibiotics from Diabetic Retinopathy Clinical R
40 in areas of the world where use of effective topical antibiotics may not be an option.
41                                              Topical antibiotics remain the best treatment for bacter
42  recent review found all commonly prescribed topical antibiotics to be equally effective.
43 e vs oral placebo; all participants received topical antifungal eyedrops.
44  Alternaria alternata, which we treated with topical antifungal medication.
45                                              Topical antimicrobial agents should not be applied to th
46  We used a trial design formulating C-82 for topical application and conducting a placebo-controlled,
47                         These data show that topical application of 0.5% PVI could promote acute skin
48                                We found that topical application of 15d-PGJ2 cream for 15min directly
49                                 Furthermore, topical application of a JP-153-loaded microemulsion aff
50 e we show that in both mouse and human skin, topical application of a mitochondrially targeted antiox
51 al keratinocytes (RXR-alphabeta(ep-/-)) or a topical application of active vitamin D3 (VD3) and/or al
52                                              Topical application of Aldara cream, containing the Toll
53 ital antigen-specific immune responses after topical application of an adjuvanted antigen formulation
54                  Today, formulations for the topical application of ATRA rely on creams and emulsions
55            In vivo experiments show that the topical application of c-Myc siRNAs delivered by SPACE-E
56                                              Topical application of compound 48/80, an MC secretagogu
57                         Congruently, chronic topical application of D3 inhibits ionizing radiation-in
58 more susceptible to contact dermatitis after topical application of dinitrofluorobenzene, and show en
59                                              Topical application of docosahexaenoic acid (DHA), a rep
60                                     Notably, topical application of epidermal lipids from wild-type o
61         We have previously reported that the topical application of erythropoietin (EPO) to cutaneous
62                                              Topical application of honokiol (0.5 and 1.0 mg/cm(2) sk
63                                              Topical application of Hsp90alpha-Delta mutant protein p
64 vation of Toll-like receptor 7/8 by means of topical application of imiquimod is the most commonly us
65 n with Kr-h1 and E93 was also studied by the topical application of JH analog, methoprene, to N5.
66                                              Topical application of OG but not 5-(tetradecyloxy)-2-fu
67                                              Topical application of pathogen-specific double-stranded
68                           Here, we show that topical application of polymeric microbeads functionaliz
69 o, micro-coating channels (MCCs) followed by topical application of powder drug-coated array patches
70                                              Topical application of thapsigargin, which inhibits the
71 significantly upregulated IL-17f, and IL-22; topical application of the IL-23 aptamer decreased both
72 s to neural activity (functional hyperemia), topical application of vasodilators, and decreases in bl
73                               In conclusion, topical application offers a direct and efficient delive
74                                              Topical application on the dural surface of the auditory
75  The anti-inflammatory activity of 5-8 after topical application was investigated in two mouse models
76                             Three days after topical application, the MSCs homed to the injured paren
77 t result in low ocular bioavailability after topical application.
78 ant cells and silencing of homologous RNA on topical application.
79 , and commensal organisms also in trials for topical application.
80                                        Acute topical applications of ARN077 attenuated key signs of D
81 and show enhanced inflammatory lesions after topical applications of phorbol ester.
82                                          The topical arm tested 0.1% gentamicin ointment or placebo a
83  the published literature on the efficacy of topical atropine for the prevention of myopic progressio
84 rally in the study eye; the fellow eye began topical bimatoprost 0.03% once daily.
85        All dose strengths were comparable to topical bimatoprost in overall IOP reduction through wee
86                                            A topical bimatoprost ocular insert was compared with twic
87 the injection procedure was more common with topical bimatoprost than Bimatoprost SR (17.3% vs 6.7% o
88 hs of implant, respectively, vs 8.4 mm Hg in topical bimatoprost-treated pooled fellow eyes (data cen
89       We, therefore, urge against the use of topical brimonidine as a hemostatic agent until its safe
90                                              Topical brimonidine, 0.33%, gel can result in systemic c
91                                              Topical brimonidine, 0.33%, gel has been reported for th
92 ermine the risk of systemic toxic effects of topical brimonidine, 0.33%, gel when used for hemostasis
93 98671 homozygotes were less likely to report topical calcineurin inhibitor use (OR, 0.16; 95% CI, 0.0
94 tant topical corticosteroids with or without topical calcineurin inhibitors where inadvisable for top
95 ches (with either topical corticosteroids or topical calcineurin inhibitors) in mild AD cases or the
96 d's AD required the use of topical steroids, topical calcineurin inhibitors, or other medications wit
97 and among all patients that had discontinued topical calcineurin inhibitors, those with the rs1898671
98                                              Topical carmustine and intravenous O6-benzylguanine.
99 e 1 trial, single-dose O6-benzylguanine with topical carmustine for patients with early stage (stage
100 mphoma, MF type, to evaluate treatment using topical carmustine plus 2 subsequent daily doses of intr
101 e, but not in Tlr4-d or MyD88(-/-) mice with topical challenge.
102 ery, radiotherapy, systemic chemotherapy, or topical chemotherapy) vs treatment-naive BCCs.
103 g without genetic engineering, and fuels the topical controversy of reviving long extinct species.
104                                              Topical corticosteroid (TCS) phobia refers to the negati
105 oral corticosteroids to less than 10 mg/d or topical corticosteroid drops to less than 2 drops daily,
106 art of AAT and subsequently at the time that topical corticosteroid therapy was initiated.
107                                  Intensified topical corticosteroid therapy was started immediately a
108 grade II dermatitis that was unresponsive to topical corticosteroid therapy.
109  INTERPRETATION: Dupilumab added to standard topical corticosteroid treatment for 1 year improved ato
110                              After 8 days of topical corticosteroid treatment visual acuity was worse
111 i-Programmed cells Death-1 was stopped and a topical corticosteroid treatment was administrated.
112  for a total of 6 doses in addition to daily topical corticosteroid treatment.
113 ds in the last 3 months (aHR, 2.23); current topical corticosteroid use [>/=8x/day vs. none] (aHR, 2.
114 , sex, prior oral corticosteroid dose, prior topical corticosteroid use, and concomitant immunosuppre
115                    Localised adjuvant potent topical corticosteroids (<30 g per week) were permitted
116 6, more patients who received dupilumab plus topical corticosteroids achieved the coprimary endpoints
117 udy (HEDS) I showed a significant benefit of topical corticosteroids and oral acyclovir for stromal k
118 g atopic dermatitis (AD) was still primarily topical corticosteroids and, for more severe disease, sy
119                                              Topical corticosteroids could be tapered, stopped, or re
120  the risk benefit associated with the use of topical corticosteroids for the management of inflammato
121  topical corticosteroids versus placebo with topical corticosteroids in adults with moderate-to-sever
122 s by using proactive approaches (with either topical corticosteroids or topical calcineurin inhibitor
123 % [125 patients] who received dupilumab plus topical corticosteroids qw and 39% [41 patients] who rec
124 ds, especially when the cumulative dosage of topical corticosteroids throughout the pregnancy is very
125 hoose whether to stop or continue once-daily topical corticosteroids to maximize compliance.
126  and safety of dupilumab with medium-potency topical corticosteroids versus placebo with topical cort
127 41 patients] who received dupilumab q2w plus topical corticosteroids vs 12% [39 patients] who receive
128 atopic dermatitis and inadequate response to topical corticosteroids were enrolled at 161 hospitals,
129                 Treatments with systemic and topical corticosteroids were not significant risk factor
130 nts with recurrent nasal polyposis receiving topical corticosteroids who required surgery, mepolizuma
131      All three groups were given concomitant topical corticosteroids with or without topical calcineu
132  were randomly assigned to dupilumab qw plus topical corticosteroids, 106 to dupilumab q2w plus topic
133 83%) patients who received dupilumab qw plus topical corticosteroids, 97 (88%) patients who received
134 (31.7%), respectively, made comparisons with topical corticosteroids, and 25 (64.1%) and 15 (36.6%),
135 l corticosteroids, 106 to dupilumab q2w plus topical corticosteroids, and 315 to placebo plus topical
136 wever, maternal use of potent to very potent topical corticosteroids, especially when the cumulative
137 ion, even using higher doses of systemic and topical corticosteroids, is of importance in preventing
138              Current clinical treatments use topical corticosteroids, which broadly and transiently s
139 mmon in patients treated with dupilumab plus topical corticosteroids-treated patients than in patient
140           At baseline, 56 eyes (75%) were on topical corticosteroids.
141 cal corticosteroids, and 315 to placebo plus topical corticosteroids.
142 calcineurin inhibitors where inadvisable for topical corticosteroids.
143 in this series had an inadequate response to topical corticosteroids.
144 s than in patients treated with placebo plus topical corticosteroids.
145 e response associated with keratitis include topical corticosteroids.
146  12% [39 patients] who received placebo plus topical corticosteroids; p<0.0001) and EASI-75 (64% [204
147                     This review will provide topical coverage of target validation and drug discovery
148           Herein we present a new concept in topical delivery of retinoids by covalently bonding the
149 ation of action commensurate with inhaled or topical delivery resulted in potent pan-JAK inhibitor 2
150     This comprehensive review summarizes the topical developments in the field of luminescent MOF and
151 stratum corneum and therefore enhancement of topical drug delivery, for two decades the technique has
152 offer, as a result, potential sites in which topical drug formulations might be sequestered post-pora
153 nt to lower intraocular pressure is based on topical drugs, laser therapy, and surgical intervention
154                                We found that topical EPO treatment of the burns accelerated their hea
155 , a crucial constituent of the ECM, into the topical EPO-containing gel, can potentiate the accelerat
156  were compared before and five minutes after topical exposure to vasoconstrictors (50 mM KCl and 20 n
157                        The costs of applying topical fluoride were also estimated assuming the work w
158 hs from 281 participants randomized to apply topical fluorouracil or placebo were evaluated at baseli
159                 To investigate the effect of topical fluorouracil, 5%, cream on photoaging using vali
160        Participants were randomized to apply topical fluorouracil, 5%, cream or a vehicle control cre
161 ment in photoaging with a standard course of topical fluorouracil, 5%, cream, a finding that may be a
162 mopreventive effects of a standard course of topical fluorouracil.
163 pproach to study the differential effects of topical formulations using a limited sample size.
164                                              Topical gentamicin corrected dermal-epidermal separation
165 esults indicate the therapeutic potential of topical gentamicin for NPPK.
166 erally controlled compassionate use study of topical gentamicin in which five NPPK patients with c.79
167 how in vitro and in vivo that treatment with topical glucocorticoids leads to rapid restoration of gl
168                                              Topical glucocorticosteroids are considered an efficient
169                          Safe and acceptable topical HIV prevention methods that target the rectum ar
170                    It has been reported that topical hypochlorous acid (HOCl) formulations lead to re
171 ndoscopic imaging of human bladder cancer by topical (i.e. intravesical) administration of QD-conjuga
172                                              Topical IDR-1002 treatment successfully dampened PMA-ind
173 d closure in vivo, which could be rescued by topical IL-27 treatment.
174  reported modest clinical 3-year benefit for topical imiquimod compared with surgery for superficial
175 the IL-23-induced ear swelling model and the topical imiquimod model, and significantly reduced the n
176 ed benefit for lesions that respond early to topical imiquimod.
177                                              Topical immunization of conditional knockout mice with E
178 lence was seen for the DeltaBbpacC strain in topical insect bioassays using larvae from the greater w
179                                          New topical insecticide formulations have proven to be effec
180  polymer and polypeptide layers, which is of topical interest for interface studies, such as membrane
181 ing the proof of concept of the potential of topical intestinal TGR5 agonists as therapeutic agents i
182 a comprehensive review regarding the various topical, intracavitary, and intravenous hemostatic techn
183                                              Topical intraocular pressure lowering therapy had to be
184                                       Rescue topical IOP-lowering medication or a single repeat treat
185       Within this framework, here we address topical issues at the intersection of DLBCL biology and
186                        Our results show that topical IVM improved allergic skin inflammation by reduc
187  improvement in VO2 peak , adaptation to the topical LCHF diet negated performance benefits in elite
188 y Local Eye symptoms than those treated with topical medications (eg, at 12 months, 153 of 269 [56.9%
189                             We conclude that topical mevastatin accelerates wound closure by promotin
190                                     Of note, topical mevastatin stimulated epithelialization and angi
191 ns can be applied to increase the potency of topical microbicides and vaccine-elicited antibodies.
192 e was low- to moderate-quality evidence that topical minoxidil (2% and 5%) was associated with improv
193 otic monotherapy, combination treatment with topical modalities, and limiting the duration of oral an
194  94 signaling pathways were activated in the topical MSCs transplanted onto the cortex of brain injur
195                                              Topical MSCs triggered earlier astrocytosis and reactive
196                                              Topical nasal corticosteroids are the treatment of choic
197 Treatment Trial (MUTT) I showed a benefit of topical natamycin over topical voriconazole for fungal u
198  with no new treatments since the 1960s when topical natamycin was introduced.
199  Treatment Trial (MUTT) II became available, topical natamycin, 5%, was added for all patients.
200 After 39 participants (16.3%) were enrolled, topical natamycin, 5%, was also added.
201 it from the addition of oral voriconazole to topical natamycin, and physicians should consider prescr
202            Patients were randomized (1:1) to topical nepafenac 0.3% or vehicle once-daily starting th
203                                              Topical nepafenac 0.3% reduces PCME in patients with pre
204                                              Topical nepafenac 0.3% significantly reduces the inciden
205 ted vasopressors: intraosseous phentolamine, topical nitroglycerin ointment, and intraarterial verapa
206                Define the effectiveness of a topical non-steroidal anti-inflammatory drug (NSAID) add
207          Here we sought to determine whether topical nonsense-suppression (readthrough) therapy using
208     To describe the effect of routine use of topical nonsteroidal anti-inflammatory drugs (NSAIDs) on
209 ents who had a perioperative prescription of topical NSAIDs filled in addition to topical steroids we
210                                              Topical NSAIDs were associated with a modest reduction o
211                Herein, we determined whether topical or intradermal gentamicin administration induces
212 ears of effort and investment, there are few topical or systemic medications for skin wounds.
213 yte-derived GC synthesis protected skin from topical phorbol 12-myristate 13-acetate-induced inflamma
214                               Crisaborole, a topical phosphodiesterase 4 (PDE4) inhibitor, became ava
215 t is recommended for adequate penetration of topical photosensitizing agents and subsequent protoporp
216 significant difference between the effect of topical povidone-iodine 1.25% and topical antibiotics co
217  this, we sought to determine the effects of topical reformulations of the angiotensin type 1 recepto
218                                      In this Topical Review we discuss the experimental data which su
219                                      In this topical review we focus on the role of the Notch signall
220                          References for this topical review were identified by searches of PubMed and
221  loaded with cytotoxic drugs applied via the topical route, can be a promising strategy for improving
222                                              Topical solenopsin derivatives normalized cutaneous hype
223 nvironmentally sustainable and easy to adopt topical spray.
224 oral suspension (BOS), a novel muco-adherent topical steroid formulation, to reduce symptoms and esop
225  substitution of the most affordable generic topical steroid from the corresponding potency class may
226 uld result from substitution of the cheapest topical steroid from the corresponding potency class.
227                             Anecdotal use of topical steroid oral prophylaxis has been reported in pa
228                                         With topical steroid therapy 5 times per day during the first
229 e may be treated effectively with aggressive topical steroid therapy and lubrication.
230                                  With hourly topical steroid therapy none of the patients developed C
231 wer adverse-effect profile than conventional topical steroid treatments or other medical or surgical
232 idal anti-inflammatory drug (NSAID) added to topical steroid use after uncomplicated phacoemulsificat
233 nt savings from substitution of the cheapest topical steroid within the corresponding potency class w
234 ntraocular inflammation that resolved with a topical steroid.
235 rneal findings, resolution was achieved with topical steroids and lubrication, whereas some patients
236                                     Although topical steroids are among the most commonly prescribed
237              Medicare Part D expenditures on topical steroids between 2011 and 2015 were $2.3 billion
238             To compare standard and frequent topical steroids for postsurgical macular edema (ME).
239 erved in 6 eyes (7.5%) and was reversed with topical steroids in all cases.
240                                              Topical steroids might reduce stomatitis incidence and s
241 pical steroids were compared to those taking topical steroids only.
242         Patients' out-of-pocket spending for topical steroids over the same period was $333.7 million
243                                         Most topical steroids prescribed were generic drugs.
244 se in Medicare and out-of-pocket spending on topical steroids that is driven by higher costs for gene
245 tion of topical NSAIDs filled in addition to topical steroids were compared to those taking topical s
246 shed new light on the mechanism of action of topical steroids, and demonstrates the critical role of
247 Medicare and patient out-of-pocket costs for topical steroids, and to model potential savings that co
248  of whether a child's AD required the use of topical steroids, topical calcineurin inhibitors, or oth
249  D participants who filled prescriptions for topical steroids.
250 therapies and were generally manageable with topical steroids.
251 recedes PPK onset, which can be prevented by topical sulforaphane-mediated activation of NRF2.
252 immune disease and/or malignancy, as well as topical, systemic, and surgical treatments received.
253 ntraocular pressure (IOP) >22 mm Hg, despite topical/systemic medications.
254 und implications for lymphedema treatment as topical tacrolimus is FDA-approved for other chronic ski
255                                              Topical therapeutic intervention with SAHM1 or a control
256 ese finding can be used to inform the design topical therapeutics to mitigate allergic responses in s
257 that flavones may have clinical potential as topical therapeutics, particularly in T2R38 AVI/AVI indi
258                 To facilitate development of topical therapeutics, we need an efficient model for ass
259  of intrapatient target lesions treated with topical therapeutics.
260 ave important clinical implications, because topical therapies that target IFN-gamma signaling in ker
261 mprovement in PASI score of 33%, with use of topical therapy (60%), biological therapy (66%, mostly a
262                   Among these products, AgNP topical therapy is proposed for treating patients with u
263                                              Topical therapy was used in 82.7%, and 34.2% received lo
264 re plaque psoriasis who had not responded to topical therapy were randomly assigned with an interacti
265        Here using mouse models, we show that topical therapy with tacrolimus, an anti-T-cell immunosu
266 ipants received any antibiotics (systemic or topical therapy) within 1 month before the study.
267 he human nail remains a difficult challenge; topical therapy, in particular, is limited by very poor
268 nts were excluded who were receiving chronic topical therapy, such as glaucoma medications, or had a
269 nvolvement leads to the inappropriate use of topical therapy, the standard of care for causes of cica
270 cular surface pyogenic granulomas respond to topical timolol treatment, which has a lower adverse-eff
271 ldren's Hospital from 2014 to 2016 with only topical timolol, 0.5%, twice daily for a minimum of 21 d
272 wild-type mice a Western diet or by applying topical TLR7/8 (Toll-like receptor) agonists.
273  in murine chest wall mammary cancers with a topical toll-like receptor (TLR)-7 agonist, imiquimod.
274                                              Topical treatment of AhR-sufficient mice with tapinarof
275 we propose that repurposing statin drugs for topical treatment of DFUs may offer another option for m
276                                              Topical treatment of mice with TIP39 accelerated wound r
277  in mice and is therefore an interesting new topical treatment opportunity in asthmatic patients.
278 increased in K14CreERT;DLX3(fl/fl) skin, and topical treatment with an inhibitor of STAT3 activation
279 apinarof (GSK2894512) is a naturally derived topical treatment with demonstrated efficacy for patient
280                                 Importantly, topical treatment with fibronectin restored the epiderma
281  mice upon induction of skin inflammation by topical treatment with imiquimod cream (Aldara).
282                                              Topical treatment with NaNO2 (10 muM) enhanced corneal e
283                   These results suggest that topical treatment with PEDF+DHA promotes corneal nerve r
284  172 individuals with bacterial keratitis to topical treatment with povidone-iodine or antibiotics (n
285                                              Topical treatment with SR1001 reduces epidermal and derm
286                                              Topical treatment with vemurafenib in two wound-healing
287 rolled IOP (34.5 +/- 11 mmHg), under maximum topical treatment, in a period of 2 to 6 months followin
288                       Recommended first-line topical treatments include neuroregenerative and anti-in
289 lammatory disease, to assess the efficacy of topical treatments.
290  after 16 weeks of successful treatment with topical triamcinolone.
291 investigated the efficacy of calcipotriol, a topical TSLP inducer, in combination with 5-fluorouracil
292 rgets for cutaneous inflammation and suggest topical usage of inhibitory ligands as an approach to tr
293                                              Topical use of B. lactis HN019 promotes a protective eff
294 ed by hepatic microsomes, which supports its topical use.
295                                  We explored topical vaginal application as an approach to initiate l
296                                              Topical vaginal estrogen treatment increased (p < 0.001)
297 I showed a benefit of topical natamycin over topical voriconazole for fungal ulcers, particularly amo
298 zole or a placebo (all participants received topical voriconazole, 1%).
299                        All patients received topical voriconazole, 1%, and after the results of the M
300                                     In vivo, topical WR12 and D-IK8 significantly reduced both the ba

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