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1 re the frequency of complete resolution with topical 5-FU treatment and the rate of OSSN recurrence.
2 time-intensity taste analysis revealed that topical addition of both l- and d-MSpG enhanced the perc
3 inal neuroprotective effects of systemic and topical administration (eye drops) of GLP-1R agonists in
4 has also been used as an analgesic, and its topical administration is approved for the treatment of
6 ion using an inducible promoter activated by topical administration of doxycycline achieved the same
9 ired MSC recruitment that is reversed by the topical administration of recombinant GPNMB protein to t
10 ntly suppressed skin inflammation induced by topical administration of the TLR7 agonist imiquimod.
13 lving genetically modified mice treated with topical agents and human dermatological conditions, such
14 compounds have the potential to be effective topical agents for treating respiratory inflammatory dis
15 an unmet dermatological need for innovative topical agents that achieve better longterm outcomes wit
16 sm used in rinse-off formulations to deliver topical agents to the skin and hair; this process produc
17 ssions or emergency procedures have become a topical and controversial issue for the UK National Heal
19 pilot trial assessed safety and efficacy of topical and intradermal gentamicin in 5 RDEB patients wi
21 hich improved with corticosteroid treatment (topical and intralesional) alone or in combination with
23 the reported therapeutic modalities, such as topical and systemic corticosteroids, systemic immunomod
24 corticosteroids, systemic immunomodulators, topical and systemic retinoids, and laser, HHD can still
28 limited mobility, sutureless incisions, and topical anesthesia also have become key components of st
32 r, our results show that IVM is endowed with topical anti-inflammatory properties that could have imp
33 calculating the proportion filling 1 or more topical antibiotic prescription within 14 days of initia
34 te conjunctivitis, 198 462 (58%) filled >/=1 topical antibiotic prescriptions; 38 774 filled prescrip
36 acute conjunctivitis fill prescriptions for topical antibiotics and factors associated with antibiot
37 effect of topical povidone-iodine 1.25% and topical antibiotics commonly available in the developing
38 vidone-iodine 1.25% ophthalmic solution with topical antibiotics for treatment of bacterial keratitis
39 t povidone-iodine and rates with and without topical antibiotics from Diabetic Retinopathy Clinical R
46 We used a trial design formulating C-82 for topical application and conducting a placebo-controlled,
50 e we show that in both mouse and human skin, topical application of a mitochondrially targeted antiox
51 al keratinocytes (RXR-alphabeta(ep-/-)) or a topical application of active vitamin D3 (VD3) and/or al
53 ital antigen-specific immune responses after topical application of an adjuvanted antigen formulation
58 more susceptible to contact dermatitis after topical application of dinitrofluorobenzene, and show en
64 vation of Toll-like receptor 7/8 by means of topical application of imiquimod is the most commonly us
65 n with Kr-h1 and E93 was also studied by the topical application of JH analog, methoprene, to N5.
69 o, micro-coating channels (MCCs) followed by topical application of powder drug-coated array patches
71 significantly upregulated IL-17f, and IL-22; topical application of the IL-23 aptamer decreased both
72 s to neural activity (functional hyperemia), topical application of vasodilators, and decreases in bl
75 The anti-inflammatory activity of 5-8 after topical application was investigated in two mouse models
83 the published literature on the efficacy of topical atropine for the prevention of myopic progressio
87 the injection procedure was more common with topical bimatoprost than Bimatoprost SR (17.3% vs 6.7% o
88 hs of implant, respectively, vs 8.4 mm Hg in topical bimatoprost-treated pooled fellow eyes (data cen
92 ermine the risk of systemic toxic effects of topical brimonidine, 0.33%, gel when used for hemostasis
93 98671 homozygotes were less likely to report topical calcineurin inhibitor use (OR, 0.16; 95% CI, 0.0
94 tant topical corticosteroids with or without topical calcineurin inhibitors where inadvisable for top
95 ches (with either topical corticosteroids or topical calcineurin inhibitors) in mild AD cases or the
96 d's AD required the use of topical steroids, topical calcineurin inhibitors, or other medications wit
97 and among all patients that had discontinued topical calcineurin inhibitors, those with the rs1898671
99 e 1 trial, single-dose O6-benzylguanine with topical carmustine for patients with early stage (stage
100 mphoma, MF type, to evaluate treatment using topical carmustine plus 2 subsequent daily doses of intr
103 g without genetic engineering, and fuels the topical controversy of reviving long extinct species.
105 oral corticosteroids to less than 10 mg/d or topical corticosteroid drops to less than 2 drops daily,
109 INTERPRETATION: Dupilumab added to standard topical corticosteroid treatment for 1 year improved ato
111 i-Programmed cells Death-1 was stopped and a topical corticosteroid treatment was administrated.
113 ds in the last 3 months (aHR, 2.23); current topical corticosteroid use [>/=8x/day vs. none] (aHR, 2.
114 , sex, prior oral corticosteroid dose, prior topical corticosteroid use, and concomitant immunosuppre
116 6, more patients who received dupilumab plus topical corticosteroids achieved the coprimary endpoints
117 udy (HEDS) I showed a significant benefit of topical corticosteroids and oral acyclovir for stromal k
118 g atopic dermatitis (AD) was still primarily topical corticosteroids and, for more severe disease, sy
120 the risk benefit associated with the use of topical corticosteroids for the management of inflammato
121 topical corticosteroids versus placebo with topical corticosteroids in adults with moderate-to-sever
122 s by using proactive approaches (with either topical corticosteroids or topical calcineurin inhibitor
123 % [125 patients] who received dupilumab plus topical corticosteroids qw and 39% [41 patients] who rec
124 ds, especially when the cumulative dosage of topical corticosteroids throughout the pregnancy is very
126 and safety of dupilumab with medium-potency topical corticosteroids versus placebo with topical cort
127 41 patients] who received dupilumab q2w plus topical corticosteroids vs 12% [39 patients] who receive
128 atopic dermatitis and inadequate response to topical corticosteroids were enrolled at 161 hospitals,
130 nts with recurrent nasal polyposis receiving topical corticosteroids who required surgery, mepolizuma
131 All three groups were given concomitant topical corticosteroids with or without topical calcineu
132 were randomly assigned to dupilumab qw plus topical corticosteroids, 106 to dupilumab q2w plus topic
133 83%) patients who received dupilumab qw plus topical corticosteroids, 97 (88%) patients who received
134 (31.7%), respectively, made comparisons with topical corticosteroids, and 25 (64.1%) and 15 (36.6%),
135 l corticosteroids, 106 to dupilumab q2w plus topical corticosteroids, and 315 to placebo plus topical
136 wever, maternal use of potent to very potent topical corticosteroids, especially when the cumulative
137 ion, even using higher doses of systemic and topical corticosteroids, is of importance in preventing
139 mmon in patients treated with dupilumab plus topical corticosteroids-treated patients than in patient
146 12% [39 patients] who received placebo plus topical corticosteroids; p<0.0001) and EASI-75 (64% [204
149 ation of action commensurate with inhaled or topical delivery resulted in potent pan-JAK inhibitor 2
150 This comprehensive review summarizes the topical developments in the field of luminescent MOF and
151 stratum corneum and therefore enhancement of topical drug delivery, for two decades the technique has
152 offer, as a result, potential sites in which topical drug formulations might be sequestered post-pora
153 nt to lower intraocular pressure is based on topical drugs, laser therapy, and surgical intervention
155 , a crucial constituent of the ECM, into the topical EPO-containing gel, can potentiate the accelerat
156 were compared before and five minutes after topical exposure to vasoconstrictors (50 mM KCl and 20 n
158 hs from 281 participants randomized to apply topical fluorouracil or placebo were evaluated at baseli
161 ment in photoaging with a standard course of topical fluorouracil, 5%, cream, a finding that may be a
166 erally controlled compassionate use study of topical gentamicin in which five NPPK patients with c.79
167 how in vitro and in vivo that treatment with topical glucocorticoids leads to rapid restoration of gl
171 ndoscopic imaging of human bladder cancer by topical (i.e. intravesical) administration of QD-conjuga
174 reported modest clinical 3-year benefit for topical imiquimod compared with surgery for superficial
175 the IL-23-induced ear swelling model and the topical imiquimod model, and significantly reduced the n
178 lence was seen for the DeltaBbpacC strain in topical insect bioassays using larvae from the greater w
180 polymer and polypeptide layers, which is of topical interest for interface studies, such as membrane
181 ing the proof of concept of the potential of topical intestinal TGR5 agonists as therapeutic agents i
182 a comprehensive review regarding the various topical, intracavitary, and intravenous hemostatic techn
187 improvement in VO2 peak , adaptation to the topical LCHF diet negated performance benefits in elite
188 y Local Eye symptoms than those treated with topical medications (eg, at 12 months, 153 of 269 [56.9%
191 ns can be applied to increase the potency of topical microbicides and vaccine-elicited antibodies.
192 e was low- to moderate-quality evidence that topical minoxidil (2% and 5%) was associated with improv
193 otic monotherapy, combination treatment with topical modalities, and limiting the duration of oral an
194 94 signaling pathways were activated in the topical MSCs transplanted onto the cortex of brain injur
197 Treatment Trial (MUTT) I showed a benefit of topical natamycin over topical voriconazole for fungal u
201 it from the addition of oral voriconazole to topical natamycin, and physicians should consider prescr
205 ted vasopressors: intraosseous phentolamine, topical nitroglycerin ointment, and intraarterial verapa
208 To describe the effect of routine use of topical nonsteroidal anti-inflammatory drugs (NSAIDs) on
209 ents who had a perioperative prescription of topical NSAIDs filled in addition to topical steroids we
213 yte-derived GC synthesis protected skin from topical phorbol 12-myristate 13-acetate-induced inflamma
215 t is recommended for adequate penetration of topical photosensitizing agents and subsequent protoporp
216 significant difference between the effect of topical povidone-iodine 1.25% and topical antibiotics co
217 this, we sought to determine the effects of topical reformulations of the angiotensin type 1 recepto
221 loaded with cytotoxic drugs applied via the topical route, can be a promising strategy for improving
224 oral suspension (BOS), a novel muco-adherent topical steroid formulation, to reduce symptoms and esop
225 substitution of the most affordable generic topical steroid from the corresponding potency class may
226 uld result from substitution of the cheapest topical steroid from the corresponding potency class.
231 wer adverse-effect profile than conventional topical steroid treatments or other medical or surgical
232 idal anti-inflammatory drug (NSAID) added to topical steroid use after uncomplicated phacoemulsificat
233 nt savings from substitution of the cheapest topical steroid within the corresponding potency class w
235 rneal findings, resolution was achieved with topical steroids and lubrication, whereas some patients
244 se in Medicare and out-of-pocket spending on topical steroids that is driven by higher costs for gene
245 tion of topical NSAIDs filled in addition to topical steroids were compared to those taking topical s
246 shed new light on the mechanism of action of topical steroids, and demonstrates the critical role of
247 Medicare and patient out-of-pocket costs for topical steroids, and to model potential savings that co
248 of whether a child's AD required the use of topical steroids, topical calcineurin inhibitors, or oth
252 immune disease and/or malignancy, as well as topical, systemic, and surgical treatments received.
254 und implications for lymphedema treatment as topical tacrolimus is FDA-approved for other chronic ski
256 ese finding can be used to inform the design topical therapeutics to mitigate allergic responses in s
257 that flavones may have clinical potential as topical therapeutics, particularly in T2R38 AVI/AVI indi
260 ave important clinical implications, because topical therapies that target IFN-gamma signaling in ker
261 mprovement in PASI score of 33%, with use of topical therapy (60%), biological therapy (66%, mostly a
264 re plaque psoriasis who had not responded to topical therapy were randomly assigned with an interacti
267 he human nail remains a difficult challenge; topical therapy, in particular, is limited by very poor
268 nts were excluded who were receiving chronic topical therapy, such as glaucoma medications, or had a
269 nvolvement leads to the inappropriate use of topical therapy, the standard of care for causes of cica
270 cular surface pyogenic granulomas respond to topical timolol treatment, which has a lower adverse-eff
271 ldren's Hospital from 2014 to 2016 with only topical timolol, 0.5%, twice daily for a minimum of 21 d
273 in murine chest wall mammary cancers with a topical toll-like receptor (TLR)-7 agonist, imiquimod.
275 we propose that repurposing statin drugs for topical treatment of DFUs may offer another option for m
277 in mice and is therefore an interesting new topical treatment opportunity in asthmatic patients.
278 increased in K14CreERT;DLX3(fl/fl) skin, and topical treatment with an inhibitor of STAT3 activation
279 apinarof (GSK2894512) is a naturally derived topical treatment with demonstrated efficacy for patient
284 172 individuals with bacterial keratitis to topical treatment with povidone-iodine or antibiotics (n
287 rolled IOP (34.5 +/- 11 mmHg), under maximum topical treatment, in a period of 2 to 6 months followin
291 investigated the efficacy of calcipotriol, a topical TSLP inducer, in combination with 5-fluorouracil
292 rgets for cutaneous inflammation and suggest topical usage of inhibitory ligands as an approach to tr
297 I showed a benefit of topical natamycin over topical voriconazole for fungal ulcers, particularly amo
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