ライフサイエンスコーパス: topical application

1 n penetrate the neovascularized cornea after topical application.

2 uate its in vitro and in vivo delivery after topical application.

3 and squamous cell carcinoma (SCC) in situ by topical application.

4 A by subconjunctival injection together with topical application.

5 t result in low ocular bioavailability after topical application.

6 ant cells and silencing of homologous RNA on topical application.

7 , and commensal organisms also in trials for topical application.

8 ool and Puerto Rico, respectively) following topical application.

9 dermis has significantly limited its use for topical application.

10 n limits the delivery of NAs into skin after topical application.

11 leaved in plasma, which supports its use for topical applications.

12 ate immune modulators limits clinical use to topical applications.

13 As can be used as functional ingredients for topical applications.

14 he infusion of 50 mg/kg/d mecamylamine or by topical application 0.1 or 1% mecamylamine to the cornea

15 r antiangiogenic agents are also amenable to topical application after formulations are identified th

16 leotide in the epidermis or dermis following topical application although immunostaining was associat

17 ells were not found in nonskin tissues after topical application, although fragments of E. coli DNA w

18 We used a trial design formulating C-82 for topical application and conducting a placebo-controlled,

19 Here, we demonstrate that the topical application and quantification of a multiplexed

20 delivery of a cholinergic agent by means of topical application can lead to the agent's successful p

21 After topical application, DermaVir-transduced cells migrate f

22 be exercised when using capsaicin-containing topical applications in the presence of a tumor promoter

23 gap chalcogenide materials and some of their topical applications in the solar energy and biological

24 It paves the way for a wide range of topical applications including subsurface, chemically sp

25 controversy about whether its consumption or topical application is entirely safe.

26 We have shown previously that topical application of (-)-epigallocatechin-3-gallate (E

27 Topical application of 0.02% MMC to intact goat globes r

28 Treatment consisted of topical application of 0.1% tacrolimus ointment three ti

29 These data show that topical application of 0.5% PVI could promote acute skin

30 The topical application of 1,000,000 MSCs on a collagen scaf

31 minutes of regional myocardial ischemia and topical application of 10 microg/mL bradykinin in a repr

32 es received clean dry cord care (control) or topical application of 10 mL of a 4% chlorhexidine solut

33 econd premolars bilaterally, followed by the topical application of 10(9) colony forming units (CFU)

34 lation of granulocytic IMCs in the skin upon topical application of 12-O-tetradecanoylphorbol-13-acet

35 We found that topical application of 15d-PGJ2 cream for 15min directly

36 Unilateral, consecutive CSDs, induced by topical application of 2 M KCl to the cortical surface o

37 In this murine study, topical application of 2% erythromycin and 3% tetracycli

38 Topical application of 2% flunarizine significantly lowe

39 IOP was measured in rabbits after a single topical application of 2% flunarizine.

40 gher PPIX formation after 4h, as compared to topical application of 20% w/w 5-ALA in a conventional c

41 pidly terminated in vivo seizures induced by topical application of 4-aminopyridine.

42 n activity was induced in adult epidermis by topical application of 4-hydroxytamoxifen (4OHT).

43 n of nevi in Dct-Survivin and non-Tg mice by topical application of 7,12-dimethylbenz(a)anthracene di

44 Topical application of [Met(5)]-enkephalin depressed tea

45 dine 0.12%, using a plastic syringe, and the topical application of a 0.12% chlorhexidine gel.

46 Finally, targeting AR by topical application of a compound (ASC-J9) that degrades

47 ncreases in DsRed signal were observed after topical application of a contact sensitizer, oxazolone,

48 ored with OCT in rabbit cornea in vivo after topical application of a glycerin-based hypertonic agent

49 Furthermore, topical application of a JP-153-loaded microemulsion aff

50 Topical application of a juvenile-hormone mimic to the f

51 e we show that in both mouse and human skin, topical application of a mitochondrially targeted antiox

52 ively, and decreases within 23 minutes after topical application of a muscarinic antagonist.

53 resent study has been planned to investigate topical application of a novel monounsaturated fatty aci

54 C57BL/6 mice were measured, with or without topical application of A or A+P.

55 icate that the protective effect mediated by topical application of a plasmid construct containing th

56 Additionally, topical application of a pledget of cotton soaked with R

57 els in vitiligo, which can be reduced with a topical application of a pseudocatalase-K.U. Schallreute

58 Topical application of a reactive hapten, DNFB, augmente

59 Topical application of a small molecular chemical inhibi

60 30% total body surface area burn followed by topical application of a specific inhibitor of p38 mitog

61 Topical application of a specific VR1 antagonist, iodore

62 Here we demonstrate that topical application of a synthetic TGF-b antagonist acce

63 ractable model of cutaneous GVHD, induced by topical application of a Toll-like receptor agonist, to

64 s delivered to the rabbit cornea by a single topical application of AAV5 (100 muL; 6.5 x 10(12) mug/m

65 Thus, topical application of Abeta1-40 onto the somatosensory

66 We found that topical application of acetylcholine (1.0 and 10 microM)

67 sponse using a laser Doppler imager (LDI) to topical application of acetylcholine (ACh) and sodium ni

68 Our data suggest that topical application of acitretin may have a therapeutic

69 Topical application of active compounds on skin is commo

70 al keratinocytes (RXR-alphabeta(ep-/-)) or a topical application of active vitamin D3 (VD3) and/or al

71 Recent evidence indicates that topical application of adenosine A(2A) receptor agonists

72 Acute topical application of aducanumab to the brain resulted

73 Topical application of aganirsen was safe and well toler

74 Topical application of Aldara cream containing the Toll-

75 Topical application of Aldara cream, containing the Toll

76 In conclusion, a single topical application of AMD3100 promoted wound healing in

77 Our findings suggest that topical application of an A2AR antagonist prevents radia

78 Topical application of an acetone insecticide formulatio

79 ital antigen-specific immune responses after topical application of an adjuvanted antigen formulation

80 severed human dental pulps and suggest that topical application of an angiogenic factor prior to rep

81 Topical application of an esterified monounsaturated fat

82 trate that targeting interleukin 1 (IL-1) by topical application of an IL-1 antagonist is efficacious

83 Topical application of antibody may be effective against

84 The most plausible approaches involve topical application of antiretroviral agents with specif

85 In addition, topical application of asphalt fumes by painting the tai

86 Today, formulations for the topical application of ATRA rely on creams and emulsions

87 Topical application of azithromycin suppresses expressio

88 Topical application of BAK to the eye causes corneal neu

89 to determine and characterize the effect of topical application of benzalkonium chloride (BAK) on co

90 Topical application of beta-cyclodextrin (beta-CD), a ch

91 Moreover, topical application of Bis (100 microM) once daily for 9

92 teral barodenervation and cervical vagotomy, topical application of bradykinin (BK, 1-10 microg/ml, 5

93 In vivo experiments show that the topical application of c-Myc siRNAs delivered by SPACE-E

94 by p53- and Bax-dependent pathways and that topical application of caffeine can enhance UVB-induced

95 Topical application of caffeine immediately after irradi

96 s at 6 h by 214% and 467%, respectively, and topical application of caffeine immediately after irradi

97 Topical application of capsaicin (1%) on the tibial nerv

98 In conclusion, topical application of capsaicin causes a small fiber ne

99 We have found that chronic, long-term topical application of capsaicin increased skin carcinog

100 Similarly, topical application of capsaicin to skin innervated by t

101 o underwent a chemical 'axotomy' through the topical application of capsaicin, and regenerative sprou

102 Finally, we show that topical application of capsaicin, which selectively acti

103 cantly augmented in skin sensitized by acute topical application of capsaicin.

104 Topical application of carrageenan at 250 microg/mL in c

105 Prophylactic and therapeutic topical application of CD ameliorated corneal disease an

106 The findings suggest that topical application of cetylated monounsaturated fatty a

107 Topical application of CGS-21680 increased the rate of w

108 Topical application of cimetidine in a liposome carrier

109 Topical application of coal tar is one of the oldest the

110 Topical application of compound 48/80, an MC secretagogu

111 Repeated topical application of concentrated fluorides is known t

112 fferent fibers were assessed in monkey after topical application of cowhage spicules or intradermal i

113 stent with these functions, we show that the topical application of CRT has profound effects on the p

114 t-derived growth factor-BB-treated controls, topical application of CRT to porcine excisional wounds

115 Topical application of CsA has the potential to overcome

116 In addition, we show that a topical application of CSA-13 penetrates the skin and re

117 Both systemic injection and topical application of CVF reduced local C3 levels >60%,

118 cisional skin lesions, we show that a single topical application of Cx43 antisense gel brings about a

119 Topical application of CYP11B1 inhibitors to reduce cuta

120 reperfusion (I/R) evoked amino acid release, topical application of D-lactate (20 mM), which is not u

121 Congruently, chronic topical application of D3 inhibits ionizing radiation-in

122 roperties and morphology of the cornea after topical application of dehydrating agents.

123 Topical application of delphinidin (1 mg/0.1 ml DMSO/mou

124 Topical application of dibenzo[a,l]pyrene (DB[a,l]P) to

125 cts received one-time MN treatment and daily topical application of diclofenac sodium.

126 more susceptible to contact dermatitis after topical application of dinitrofluorobenzene, and show en

127 ed circulating levels of IFN-gamma following topical application of DMBA, whereas IL-17 was elevated

128 wever, induction of skin inflammation by one topical application of DNFB following MBL2 inoculation i

129 Topical application of docosahexaenoic acid (DHA), a rep

130 Topical application of DOTAP-SES on mice skin resulted i

131 Topical application of EGCG (1 mg/cm(2) skin) prevented

132 ceptor transfection strategy to determine if topical application of EGF-like ligands would enhance re

133 substantially within 69 or 46 minutes after topical application of either a muscarinic or nicotinic

134 Filtration surgery with concurrent topical application of either AgNPs or MMC was performed

135 Topical application of either goat IgG specific for rabb

136 Topical application of either of 2 mechanistically disti

137 ted to chemical carcinogenesis procedures by topical application of either the complete carcinogen 1-

138 to appraise and synthesise the evidence for topical application of emollients in the prevention of i

139 Our aim was to ascertain whether topical application of emollients to enhance skin barrie

140 Notably, topical application of epidermal lipids from wild-type o

141 We have previously reported that the topical application of erythropoietin (EPO) to cutaneous

142 Topical application of F-5 peptide promoted acute and di

143 This study examines whether topical application of fingolimod, an established SK/sph

144 human cytomegalovirus in cultured cells, and topical application of FIT-039 ointment suppressed skin

145 Topical application of FL2 siRNA nanoparticles to either

146 Topical application of flagellin induced profound protec

147 urofilament light form) were counteracted by topical application of flunarizine.

148 In this protocol, we outline methods for the topical application of fluorescently quenched activity-b

149 laminar electrophysiology, we verified that topical application of GABA for 20min does not affect la

150 Topical application of GDNF through the rat isolated dor

151 and final scar size by about 50% compared to topical application of gentamicin alone.

152 Taken together, our results indicate that topical application of GFRalpha/RET receptor signaling m

153 The topical application of GM3S SNAs (50 nM) to splinted 6-m

154 Topical application of GTP resulted in significant decre

155 gradient of an LC-attracting chemokine) and topical application of hapten (to trigger LC emigration

156 These results suggest that the topical application of Hh-agonist could be effective in

157 the chemokine receptor CCR5, we report that topical application of high doses of PSC-RANTES, an amin

158 Topical application of HJ6.3 for only 14 d also decrease

159 Topical application of honokiol (0.5 and 1.0 mg/cm(2) sk

160 More intriguingly, topical application of hsp90alpha accelerated wound heal

161 Topical application of Hsp90alpha-Delta mutant protein p

162 Importantly, topical application of human MC chymase restores burn in

163 ents of skin thickness demonstrated that the topical application of hypobaric stress thinned the tiss

164 In the current studies, the topical application of imiquimod at the site of subcutan

165 Topical application of imiquimod in vivo led to epiderma

166 vation of Toll-like receptor 7/8 by means of topical application of imiquimod is the most commonly us

167 JCI, Drobits and colleagues demonstrate that topical application of imiquimod suppresses cutaneous me

168 We have shown that topical application of immunostimulating (IS) patches co

169 In vivo, topical application of INCB018424 resulted in suppressio

170 kg i.v.) on central sensitization induced by topical application of inflammatory soup (IS) on the dur

171 Topical application of InsP(6) to early-stage somatic em

172 ells and Bacillus anthracis spores following topical application of intact particles of live or gamma

173 ratio imaging fluorescence microscopy after topical application of ion/pH-sensing, dual-wavelength f

174 n with Kr-h1 and E93 was also studied by the topical application of JH analog, methoprene, to N5.

175 diabetic rats, which was inhibited (>80%) by topical application of L-NMMA (10 microM).

176 Topical application of L-NMMA only partially inhibited d

177 We hypothesized that topical application of liposomes with glycolipids that c

178 afferent transmission in the vagus nerve by topical application of local anaesthetic.

179 We found that topical application of Lupeol (1-2 mg/mouse) 30 min prio

180 We first determined the effect of topical application of Lupeol to CD-1 mouse against 12-O

181 promotion, we next determined the effect of topical application of Lupeol to mouse skin against thes

182 o recruit PMN or systemic PMN depletion plus topical application of MAb F429 resulted in less patholo

183 a model of PMA-elicited peritonitis, whereas topical application of MCV1 markedly reduced neointima f

184 Topical application of MK571 significantly decreased IOP

185 Topical application of mustard oil (allyl isothiocyanate

186 oline and nitroglycerin before and following topical application of N(G)-monomethyl-L-arginine (L-NMM

187 The combined topical application of ND-336 (a small molecule) and the

188 amount of SP and KP retained in dermis after topical application of NLC-R11 was significantly higher

189 d that the CBF and ROS increases elicited by topical application of NMDA to the mouse neocortex were

190 Furthermore, topical application of non-steroidal anti-inflammatory d

191 Topical application of nucleic acids offers many potenti

192 Topical application of OG but not 5-(tetradecyloxy)-2-fu

193 d during contact hypersensitivity induced by topical application of oxazolone.

194 One topical application of P15-1 to full-thickness excisiona

195 Topical application of pathogen-specific double-stranded

196 asome activity in wounds of db/db mice using topical application of pharmacological inhibitors improv

197 Topical application of phorbol myristate acetate (PMA) e

198 In mice, topical application of phosphatidylserine-containing oin

199 Likewise, there has been work on the topical application of phytochemicals to the skin.

200 the protective effect induced following the topical application of plasmid DNA containing the murine

201 Here, we show that topical application of polymeric microbeads functionaliz

202 o, micro-coating channels (MCCs) followed by topical application of powder drug-coated array patches

203 nel (MC) arrays in the epidermis followed by topical application of powder drug/vaccine-coated array

204 three boys, gynecomastia coincided with the topical application of products that contained lavender

205 tes of stable baseline recording followed by topical application of proparacaine (0.5%, 10 microL) wi

206 Systemic delivery, intraocular injection or topical application of putative TRPV4 antagonist prodrug

207 Additionally, topical application of PX-12 significantly enhanced neut

208 We found that topical application of RA significantly improves wound h

209 Topical application of RDP58 to the epidermis following

210 Topical application of recombinant mMCP-5 or human neutr

211 Topical application of resveratrol resulted in significa

212 Most of these changes were ameliorated by topical application of Rho kinase inhibitor.

213 Consistent with these potent actions, topical application of RvE1 in rabbit periodontitis conf

214 In this study, we show that topical application of SC-560 (a COX-1 selective inhibit

215 Topical application of selective HA fragments (large ver

216 Topical application of silibinin before or immediately a

217 Topical application of siRNAs through the skin is a pote

218 The topical application of skin with resveratrol (both pre-

219 Topical application of Smad7 protein conjugated with a c

220 report that therapeutic Wnt inhibition with topical application of small-molecule Wnt inhibitors can

221 Topical application of SP50 significantly increased the

222 Repeated topical application of SRW allergen induces a form of mu

223 r induced by compound 48/80 was mitigated by topical application of STZ.

224 Topical application of sulforaphane-rich extracts of 3-d

225 Topical application of survivin antisense oligonucleotid

226 Furthermore, topical application of TAT-GIV-CT peptides enhanced the

227 Topical application of thapsigargin, which inhibits the

228 n of wound closure we compared the effect of topical application of the adenosine receptor agonist CG

229 Topical application of the bioflavonoid 4',5,7-trihydrox

230 Topical application of the contact-sensitizing hapten, t

231 However, pigmentation could be rescued by topical application of the cyclic AMP agonist forskolin,

232 These behavioral changes were abolished with topical application of the dopamine antagonist fluphenaz

233 ost successful results were achieved through topical application of the drug formulation START (0.9%

234 distribution in different skin layers after topical application of the drug.

235 A single topical application of the EP2 agonist, butaprost, dose-

236 etected during the rehydration process after topical application of the HA.

237 significantly upregulated IL-17f, and IL-22; topical application of the IL-23 aptamer decreased both

238 he31Ile) was expressed in the epidermis upon topical application of the inducer RU486 (Aurora-AGS).

239 stemic intraperitoneal injection, as well as topical application of the MAb onto the infected eye, st

240 Topical application of the MRP4 inhibitor MK571 was test

241 These effects could be blocked by topical application of the muscarinic antagonist atropin

242 tor expression in murine epidermis after the topical application of the neuropeptide releasing agent

243 cutaneous inflammatory infiltrate following topical application of the NO donor-acidified nitrite (N

244 Topical application of the NRF2 activator sulforaphane t

245 Topical application of the patch onto laser-microperfora

246 CAPRISA 004 trial recently demonstrated that topical application of the tenofovir could partially pre

247 esponses, we administered DLI alone or after topical application of the TLR7 ligand imiquimod, which

248 oriasiform skin inflammation is triggered by topical application of the TLR7/8 agonist imiquimod.

249 perplasia of interfollicular epidermis after topical application of the tumor promotor 12-O-tetradeca

250 Topical application of three direct blockers of Na+/H+ e

251 In ear skin of p53 wild-type mice, topical application of thymidine dinucleotide induced a

252 odulates the expression of TLR and CRAMP and topical application of TLR agonists in EDE mice resulted

253 al responses in the cervicovaginal mucosa by topical application of TLR agonists prior to viral expos

254 Topical application of TME to a superficial wound on the

255 A single topical application of TPA (5 nmol) to the skin, as earl

256 Topical application of TPA by painting the skin on the b

257 Topical application of troglitazone significantly reduce

258 Topical application of vascular endothelial growth facto

259 s to neural activity (functional hyperemia), topical application of vasodilators, and decreases in bl

260 Finally, topical application of vitamin C before exposure signifi

261 ressed in transgenic mice, or when driven by topical application of vitamin D3 or low-calcemic analog

262 ophic factor (GDNF) in skin keratinocytes or topical application of XIB4035, a reported nonpeptidyl a

263 Topical applications of 100 mg of Dermabase, Dermovan, E

264 Topical applications of a specially designed Custom Blen

265 chemical receptors gave similar responses to topical applications of acid.

266 in barrier homeostasis could be improved by topical applications of an acidic buffer, indicating tha

267 Acute topical applications of ARN077 attenuated key signs of D

268 Topical applications of caffeine immediately after UVB i

269 eed for further studies to determine whether topical applications of caffeine or EGCG can inhibit sun

270 Topical applications of caffeine or EGCG had a small inh

271 Immunohistochemical analysis showed that topical applications of caffeine or EGCG increased apopt

272 Topical applications of caffeine to these mice decreased

273 third week: 5 mg/day), and was followed with topical applications of clobetasol (0.05%) twice daily f

274 Topical applications of EGCG decreased the number of non

275 Finally, topical applications of farnesol increased mRNA and prot

276 To test our hypothesis that topical applications of imiquimod may protect the skin i

277 s in mouse models, we tested the efficacy of topical applications of imiquimod to treat patients affl

278 preconditioned sites followed by additional topical applications of imiquimod.

279 udies are needed to determine the effects of topical applications of moisturizing creams on sunlight-

280 Thirdly, topical applications of PAR-2 agonist peptide, SLIGRL, d

281 Previously, we demonstrated that topical applications of peroxisome proliferator-activate

282 and show enhanced inflammatory lesions after topical applications of phorbol ester.

283 e observed robust anti-pruritic effects with topical applications of selective inhibitors for TRPV4 a

284 s of dermatitis either induced by repetitive topical applications of the detergent SDS or by high-dos

285 Maintenance of a low pH by topical applications of the polyhydroxyl acid, lactobion

286 Micro-application (topical application) of dsRNA to 5(th) instar of nymphs

287 In conclusion, topical application offers a direct and efficient delive

288 Topical application on the dural surface of the auditory

289 ability in situ; (iii) local intervention by topical application or intraocular injection; and (iv) r

290 epression could be induced in normal mice by topical application or micro-injection of alpha4* nAChR

291 ed EIU after 24 and 48 h or EIU treated with topical applications or with a single s.c. injection of

292 Three days after topical application, the MSCs homed to the injured paren

293 eloping a more physiologic mix of lipids for topical application to skin.

294 utaneous penetration of macromolecules after topical application to the skin.

295 current state of the art in this field with topical applications to inorganic, especially microporou

296 nylephrine and time of measurement following topical application using random-effects models with inv

297 The anti-inflammatory activity of 5-8 after topical application was investigated in two mouse models

298 after systemic application as well as after topical application, which is therapeutically more relev

299 Topical application with the 15-epi-16-phenoxy-para-fluo

300 were 60 times greater than those achieved by topical application without microneedles.