ライフサイエンスコーパス: topically

1 espective corticosteroids previously applied topically.

2 or model animals when administered orally or topically.

3 rug resistance and was nontoxic when applied topically.

4 ering in mice and was effective when applied topically.

5 rine, or a relevant vehicle was administered topically.

6 nce of sodium nitrite (30 nmol) administered topically 1 min before reperfusion.

7 almic solution 0.1% or a placebo was applied topically, 1 drop per 45 minutes for 3 hours before anim

8 Flagellin applied topically 24 h prior to C. albicans inoculation signific

9 -dependently inhibited PCA when administered topically 24 hours before antigen challenge but provoked

10 , or DEX (0.1%) were repeatedly administered topically 3 hours before paracentesis and continued for

11 Either eye drop treatment of 1% apoEdp topically 4 times a day for 14 consecutive days or intra

12 5-Fluorouracil 1% administered topically 4 times daily for 1 week followed by a drug ho

13 ravenously 5 min before ischemia and 50 nmol topically 6 min before reperfusion).

14 lying a soft-drug concept in the design of a topically acting PDE4 inhibitor for treatment of dermato

15 morphological and histological evidence that topically active cimetidine is a potent inhibitor of P.

16 Potent, topically active corticosteroids with minimum systemic a

17 Resiquimod (R-848), a topically active immune response modifier, induced produ

18 When topically added to rabbit eyes, lacritin promotes basal

19 The authors examined whether topically administered biliverdin can counteract the eff

20 tion through the outer BRB may be needed for topically administered drugs to exert effects in the ret

21 up 3 was treated with buffer (10 ul; n = 12) topically administered four times a day for up to 7 days

22 animalis subsp. lactis (B. lactis) HN019 was topically administered in the subgingival region of MFMs

23 his study looked at the relationship between topically administered insulin (1 mIU insulin/ml and 100

24 ta from patients dosed with either orally or topically administered ketoprofen were generated using b

25 The results of this study suggest that topically administered ketorolac 0.45% may allow meaning

26 Topically administered lewisite induced potent acute inf

27 ible subjects were randomized 1:1 to receive topically administered lifitegrast (5.0%) or placebo (ve

28 Topically administered mecamylamine could provide an app

29 Topically administered non-steroidal anti-inflammatory d

30 We imaged topically administered peptide using a fluorescence conf

31 -benzotria zin-7-yl)phenyl benzoate ( 12), a topically administered prodrug delivered as an eye drop

32 icient skin exhibits enhanced sensitivity to topically administered retinol.

33 en together, these findings demonstrate that topically administered sodium nitrite protects the rat k

34 ional activity of taste cells in response to topically administered tastants in live mice.

35 closporine (0.05%), or artificial tears were topically administered to eyes of normal New Zealand Whi

36 lumilast, tofacitinib, and ruxolitinib, were topically administered to the mouse ears, which were sub

37 study indicate that mercaptoalkylguanidines, topically administered, may significantly reduce experim

38 If topically administered, tamoxifen allows recombination i

39 nhibitors are limited to zanamivir, which is topically administered.

40 l or TLR9 siRNA before infection and treated topically afterward.

41 and 20 rabbits were inoculated in both eyes topically and intrastromally to study the formation of s

42 an adjustable vascular loop around the right topically anesthetized eye of Sprague-Dawley rats.

43 Topically applied "moisturizers" work by acting as humec

44 We topically applied 20 nucleotide phosphorothioate interce

45 % lidocaine with 0.5% bupivacaine or saline, topically applied after skin harvest, to determine what

46 Capsaicin and menthol, two other topically applied agents widely used for similar purpose

47 nstituents of prosthetic device coatings, as topically applied agents, and within dental materials ar

48 Topically applied all-trans retinoic acid can repair pho

49 It was hypothesized that topically applied allogeneic MSCs would improve wound he

50 vailable and emerging evidence of the use of topically applied analgesics with particular reference t

51 adsorbed to the waxy leaf cuticle both when topically applied and when produced by cells on plants.

52 Topically applied Ang II (10(-10) M to 10(-4) M) caused

53 mutual medication that improves coverage of topically applied anti-parasite medicines.

54 The results strongly suggest that topically applied anti-sense oligonucleotides can be del

55 sal SHIV (an HIV/SIV chimaera) challenge and topically applied antibodies can protect macaques agains

56 Both systemically injected and topically applied antibodies to the conserved cell surfa

57 e the potential to serve as a novel class of topically applied antimicrobials for the treatment of cu

58 1-Tetradecanol complex (1-TDC) was topically applied at 1- and 10-mg/ml concentrations in f

59 an advantage over the previous detection of topically applied BA using microdialysis coupled to HPLC

60 Topically applied bevacizumab has limited capacity to pe

61 The topically applied bimatoprost insert may provide an alte

62 ervational trial the prophylactic effects of topically applied Ca-SP were compared with those of syst

63 Topically applied camphor elicits a sensation of cool, b

64 These effects of topically applied capsaicin and bradykinin were not due

65 Effects of topically applied cardiac glycosides on intraocular pres

66 he haptens FITC and oxazolone confirmed that topically applied cFLIP antisense could reduce inflammat

67 s challenge, the diffusion, in real time, of topically applied chemicals into the human nail has been

68 ntal periodontitis in rabbits in response to topically applied cimetidine.

69 Finally, topically applied clofibrate also increased apoptosis.

70 These studies suggest that while most of topically applied clonidine reaches the retina by a syst

71 trial as a first in class, VEGFr2 targeting, topically applied compound for the treatment of AMD.

72 e development of efficient microbicides, the topically applied compounds that protect uninfected indi

73 These data show that topically applied CpG-ODN induces intraocular inflammati

74 Recent studies show that topically applied CRT has diverse and profound biologica

75 SPACE-peptide (SP50) delivered about 30% of topically applied CsA into the porcine skin in vitro and

76 ytokines) were all inhibited specifically by topically applied decoy ODNs.

77 ex-NW has comparable therapeutic efficacy to topically applied Dex eye drops in experimental mouse dr

78 tion with comparable efficacy to twice a day topically applied dexamethasone eye drop treatment.

79 r results indicate that functional fat-1 and topically applied DHA potentiate cellular defense agains

80 veloped a T-cell-mediated immune response to topically applied DMBA.

81 roscopy was used to assess the permeation of topically applied drugs and formulation excipients into

82 skin and mapping of penetration pathways of topically applied drugs in mice and humans.

83 tic analogs of natural neurotoxic alkaloids, topically applied ex vivo to human skin.

84 Topically applied fibronectin was found to significantly

85 E-mediated passive cutaneous anaphylaxis) we topically applied fingolimod prophylactically, as well a

86 Topically applied flunarizine reduces IOP and attenuates

87 y large increase in the rate of clearance of topically applied fluorescein from the cornea and anteri

88 We hypothesized that topically applied fluoride would readily penetrate such

89 nflammatory reaction to microbicide products topically applied for the prevention of sexually transmi

90 Topically applied formulations (e.g., emollients and moi

91 In this study, we topically applied gamma-aminobutyric acid (GABA) in the

92 Topically applied glucocorticosteroids (GS) have been sh

93 A suspension of topically applied gold-coated silica microparticles exhi

94 In this study, we examined the ability of a topically applied Hh-agonist to modulate follicular cycl

95 tissue biopsies obtained from patients after topically applied immunodulatory treatment resulted in i

96 cacy and mechanism of action of imiquimod, a topically applied inducer of cytokines.

97 These results led to the conclusion that topically applied insulin accumulates in the retina and

98 the involvement of the superficial layers we topically applied lidocaine.

99 This was based on the observation that topically applied LT induces migration of activated anti

100 Topically applied medications are frequently used in oph

101 Topically applied mesenchymal stromal cells (MSCs) provi

102 Compounds (4a-4q') were screened as topically applied mosquito repellents by measuring the d

103 We topically applied naked plasmid DNA containing the lucif

104 In diabetic mice, knockout or topically applied nanoconstruct-mediated knockdown of GM

105 Topically applied nanomaterials have been shown to enter

106 Resveratrol was topically applied on the skin of SKH-1 hairless mice at

107 ororuacil (5-FU) coated with eucalyptus oil, topically applied onto the skin.

108 Interestingly, nine topically applied OP or MC insecticides or analogs also

109 Topically applied PAO induces cutaneous erythema, edema

110 These studies demonstrate that topically applied peroxisome proliferator activated rece

111 A topically applied phosphorothioate antisense oligonucleo

112 Furthermore, topically applied PPARalpha activators also increased ap

113 We recently showed that topically applied PPARalpha activators promote epidermal

114 n, the aim of this study was to determine if topically applied PPARalpha ligands regulate keratinocyt

115 The ability of topically applied pTT to induce protective physiologic r

116 sessed the ability of nanogram quantities of topically applied purified toxic shock syndrome toxin-1

117 yclosporin A, which fails to penetrate skin, topically applied R7-CsA was efficiently transported int

118 These results demonstrate that topically applied RDP58 is an effective anti-inflammator

119 These results suggest that topically applied RMR-linked FLG monomers are able to pe

120 We used the method to detect topically applied salicylic acid.

121 e findings suggest that a simple strategy of topically applied Shh gene therapy may have significant

122 These results demonstrate that the topically applied single-chain antibody fragment ESBA105

123 While locally injected or topically applied siRNA has progressed into numerous cli

124 estimates of the epidermal concentrations of topically applied solutes.

125 tion of epidermal cholesterol synthesis with topically applied statins only modestly affects epiderma

126 or infectious agents and potential toxins in topically applied substances.

127 Topically applied THC can effectively attenuate contact

128 We evaluated the impact of topically applied THC on DNFB-mediated allergic contact

129 nd establish a potentially safe and painless topically applied therapeutic option for treating vision

130 Bevacizumab 1% was topically applied three times a day to the corneas of mi

131 s using Porphyromonas gingivalis (10(9) CFU) topically applied three times a week for a 6-week period

132 Therefore, topically applied THs deserve further exploration as can

133 easibility and excellent safety profile of a topically applied TLR7 agonist used as a vaccine adjuvan

134 lloid 1 agonist capsaicin and placebo creams topically applied to contralateral areas on the skin of

135 ons of toluidine blue or methylene blue were topically applied to fresh thick skin excisions for seve

136 g Bbcyp52x1 displayed reduced virulence when topically applied to Galleria mellonella, but no reducti

137 Kinetic analysis of oligonucleotide topically applied to hair-clipped BALB/c mouse skin show

138 Antibodies to PVL or control sera were topically applied to infected corneas 0, 24, and 32 hour

139 mino)-17-demethoxygeldanamycin (17AAG), when topically applied to mouse skin, inhibits UVR-induced de

140 ate through the stratum corneum barrier when topically applied to mouse skin.

141 Vehicle was topically applied to one eye, and 2 microg PGF(2alpha)-i

142 ive mitogen that promotes basal tearing when topically applied to rabbit eyes.

143 The 1 alpha-OHase-GFP plasmid was topically applied to shaved C57/BL6 mice.

144 f 0.5% clonidine appeared to be greater when topically applied to the eye that received ischaemia tha

145 ts were highly attenuated for virulence when topically applied to the skin following exponential grow

146 Omeprazole topically applied to the skin of UV-irradiated human sub

147 In this study, GFP-MSCs were topically applied to the surface of cerebral cortex with

148 enetrate the gram-negative cell wall and was topically applied to the wound and was followed by red-l

149 fic p38 MAPK inhibitor or vehicle, which was topically applied to wounds.

150 3% MEG, 0.3% GED, or placebo (vehicle) gels, topically applied twice daily to premolar teeth.

151 kingly, reduced basal epidermal melanin when topically applied twice daily, 5 d per wk, for 3 wk to s

152 -O-tetradecanoylphorbol-13-acetate (TPA) are topically applied, prominent epidermal thickening occurs

153 XPL can be topically applied, rapidly curing at the skin interface

154 0% O(2) during normocapnia and concomitantly topically applying artificial CSF that had been bubbled

155 the acid SC-buffer system was accelerated by topically applying the LXR activator, 22(R)-hydroxychole

156 bility and activity of ONYX-015 administered topically as a mouthwash to patients with clinically app

157 against tetanus toxin challenge when applied topically at doses as low as 1 microg.

158 We conclude that C34, if used topically at susceptible mucosal sites, and if continual

159 drugs such as cyclosporin A are ineffective topically because of their poor penetration into skin.

160 lity to successfully deliver siRNA molecules topically brings these novel RNAi-based therapeutics one

161 d in a similar way to clonidine when applied topically but because of the number of experiments carri

162 ly before or after ischaemia or when applied topically by a specific regime.

163 When delivered topically, CFTRact-K089 doubled basal tear volume for 4

164 When topically challenged via dermal ear skin, hALX transgeni

165 BALB/c mice were topically challenged with SRW pollen after they were sen

166 Arnebin-1 was applied topically daily on wounds of hydrocortisone-treated or u

167 udies, indicate that it might be feasible to topically deliver a therapeutically useful amount of som

168 Topically delivered 12 may be efficacious in human dry e

169 This topically delivered compound exhibited excellent ocular

170 es may be promising agents for personalized, topically delivered gene therapy of cutaneous tumors, sk

171 n IL-7-encoding plasmid (pCMV-Tag1-IL-7) was topically delivered to sites flanking the stressed skin

172 Topically-delivered lentiviral vectors encoding interleu

173 PAP-1 was equally effective when applied topically, demonstrating that it effectively penetrates

174 contact/rub with other volunteers previously topically dosed.

175 Rabbit eyes were treated topically every 30 minutes from 4 to 9 or 10 to 15 hours

176 voriconazole (1%) or natamycin (5%), applied topically every hour while awake until reepithelializati

177 ibited plasma leakage in hamster cheek pouch topically exposed to tissue culture trypomastigotes (TCT

178 The present study reveals that when applied topically, fingolimod attenuates both immediate and late

179 nonselective NOS inhibitor NMA was suffused topically followed by physiologic buffer.

180 eceived 3 doses of acidified nitrite applied topically for 12 weeks with an additional 12 weeks of fo

181 Ingenol mebutate gel applied topically for 2 to 3 days is effective for field treatme

182 control versus DL-TBOA (100 microM; applied topically for 35 min prior to ischemia) animals.

183 e immunized intraperitoneally and challenged topically for 7 consecutive days with short ragweed poll

184 kin integrity and function both when applied topically for anti-inflammatory treatments and during co

185 temic toxic effects when brimonidine is used topically for hemostasis is unknown.

186 e show that gold conjugates can be delivered topically for imaging throughout the whole epithelium.

187 short ragweed (SRW) allergen and challenged topically for seven consecutive days with SRW allergen.

188 e immunized subcutaneously, intranasally, or topically had serum antibody titers of 10,240, 187, and

189 Rabbits that were subcutaneously or topically immunized for endophthalmitis experiments had

190 Topically immunized mice have also demonstrated resistan

191 Rabbits were inoculated topically in both eyes with the CDV-resistant variants R

192 6 rabbits each (Ad1 and Ad6) were inoculated topically in both eyes, with 1.5 X 10(6) pfu/eye of the

193 morpholino antisense applied systemically or topically in conjunction with antigen, sensitizes T cell

194 tulated by estradiol treatment both in vivo (topically in male mice) and in vitro (corneal epithelial

195 New Zealand White rabbits were treated topically in one eye with the adenosine A(1) agonist CHA

196 ity (a measure of angiogenesis) when applied topically in rat dorsal skin flap window chambers.

197 Both morphine and lidocaine were active topically in the tail formalin assay, although their tim

198 These were applied topically in vivo in five doses over a 3-hour period exc

199 0 approximately 250 nM, which when delivered topically increased tear fluid secretion in mice and sho

200 mice and control mice after GAS was applied topically, indicating that MC activity is most important

201 eport to demonstrate a promising approach to topically induce PGD(2) for improving pruritus.

202 However, agents that can topically induce PGD(2) for itch relief are not well est

203 n the nodes increased 2-3-fold when skin was topically inflamed by the TLR7 agonist imiquimod.

204 ied corneas of BALB/c and C57BL/6J mice were topically inoculated and observed daily for keratitis se

205 In vivo, 40 rabbits were topically inoculated in both eyes with Ad5 after corneal

206 Corneas of BALB/c mice were scarified and topically inoculated with 10(5) or 10(6) colony-forming

207 Corneas of BALB/c mice were scarified and topically inoculated with 10(6) colony-forming units of

208 Burn wounds were topically inoculated with a lethal dose of Pseudomonas a

209 f young and aged A/J mice were scarified and topically inoculated with a log phase S. aureus parent s

210 Scarified corneas of BALB/c mice were topically inoculated with Candida albicans and compared

211 Scarified corneas of adult BALB/c mice were topically inoculated with Candida albicans strain SC5314

212 lophosphamide-treated adult BALB/c mice were topically inoculated with Fusarium solani after corneal

213 or cyclophosphamide-treated BALB/c mice were topically inoculated with one of three human isolates of

214 ed virulence of the DeltaMakatG1 mutant when topically inoculated, but no impairment when the insect

215 tibacterial clays, when hydrated and applied topically, kill human pathogens including antibiotic res

216 The probes can also be used to topically label human carotid plaques demonstrating simi

217 The probes could also be used to topically label human carotid plaques demonstrating simi

218 Additionally, human carotid plaques were topically labeled with the probe and analyzed by both so

219 Topically loaded Mn(2+) did not diffuse into the vitreou

220 MEMRI with topically loaded MnCl(2) was also conducted in eyes with

221 curcumin application (either systemically or topically) may be an effective radiation modifying modal

222 onazole, itraconazole, and posaconazole) and topically (miconazole and clotrimazole) and by a tetrazo

223 treated adult NIH Swiss and BALB/c mice were topically mock inoculated or inoculated with 10-fold inc

224 ncentrations of TA (0-16 ng/mL) were applied topically on embryonic day (E) 7 to the chorioallantoic

225 When applied topically on rabbit eyes, these derivatives potently red

226 sive cynomolgus monkeys (n = 8) were treated topically once daily with four 5-muL drops of 0.5% R-DOI

227 elective and specific NHE inhibitor, applied topically onto rat cerebral cortex prior to and during a

228 nhibitor of the reverse mode of NCX, applied topically onto rat cerebral cortex prior to and during i

229 opropyl)-amiloride (EIPA; 25 microM) applied topically onto the rat cerebral cortex prior to and duri

230 oncept, we showed that calcitriol, delivered topically or intraperitoneally, increased tumoral accumu

231 xis studies evaluated tenofovir administered topically or orally (with or without emtricitabine).

232 uronic F-127 (F-127) was administered either topically or systemically and in conjuction with deminer

233 Administration of pazopanib topically or systemically suppressed retinal vascular le

234 In an initial challenge, BCD applied topically prior to SIV(mac251) prevented intravaginal tr

235 dicate that caffeine, administered orally or topically, promotes apoptosis of UVB-irradiated keratino

236 Such an inhibitor could be applied topically provided it was sufficiently permeable via the

237 robing (defined as asking > or =1 additional topically related question), providing open-ended opport

238 et simple-to-implement non-viral approach to topically reprogram tissues through a nanochannelled dev

239 these polymeric nanomicelles and by applying topically resulted in significant reduction in inflammat

240 lling ant lion Myrmeleon carolinus, although topically sensitive to formic acid, is able to prey on f

241 bacterial burdens in the cornea when applied topically starting 8 hours post-infection.

242 breach the skin barrier and deliver vaccines topically, suggesting significant clinical and practical

243 zyme in a liposomal delivery vehicle applied topically (T4N5 liposome lotion) to lower the rate of ne

244 When applied topically, the most alpha2-selective derivatives effecti

245 If applied topically, there are additional issues with rinsing off

246 Mice were treated topically three times per day beginning on the day of tu

247 Mice eyes were treated with PGE(2) (100 ng topically, three times a day) for up to 7 days.

248 Imiquimod cream, 5%, was applied topically to a designated target lesion once per day for

249 ukin-1 receptor antagonist (IL-1ra) was used topically to determine whether suppression of IL-1 could

250 y also carry cargos into retina when applied topically to eyes, and cross blood brain barrier when ad

251 genital HSV-2 applied resiquimod or vehicle topically to herpes lesions 2 times weekly for 3 weeks a

252 Pilocarpine and atropine were applied topically to manipulate resting refraction, accommodativ

253 /v) solution of 17AAG (500 nmol) was applied topically to mouse skin in conjunction with each UVR exp

254 e expression of PPAR-alpha mRNA when applied topically to mouse skin.

255 lied to cultured human skin keratinocytes or topically to mouse skin.

256 n shown to increase bone growth when applied topically to murine bone; however, it causes considerabl

257 both when sodium dodecyl sulfate is applied topically to normal human skin as well as when it is add

258 BKCa protocol: (1) EMLA cream (EMLA, applied topically to skin surface), (2) tetraethylammonium (TEA)

259 abbits were inoculated in both eyes with Ad5 topically to study adenovirus replication, and 20 rabbit

260 mouse) was administered intraperitoneally or topically to the conjunctiva 3 days before final allerge

261 gue-Dawley rats by applying Fluoro-Gold (FG) topically to the dorsal root entry zone.

262 group LPS+HU, HU-308 (500 ng/mL) was applied topically to the GT daily.

263 Various concentrations of TTX were applied topically to the L5 DRG by using chronically implanted p

264 n-complexed plasmid DNA vaccines are applied topically to the murine pulmonary mucosa as an immune pr

265 emic vaccination, when conjugate was applied topically to the nasal mucosae whereas gp140 alone was p

266 whether lacritin is prosecretory when added topically to the ocular surface of normal living rabbits

267 and the analgesic efficacy of icilin applied topically to the paws or intrathecally was tested in rat

268 to determine: (i) whether oxysterols applied topically to the skin of mice induce differentiation in

269 such as curcumin are effective when applied topically to the skin or administered orally to affect t

270 laryngeal mucosa, or by citric acid applied topically to the trachea or larynx.

271 ts might be more effective if they were used topically to treat inflammatory dermatoses.

272 formation and number of tumors when applied topically to UVB-pretreated high-risk mice.

273 reptomyces hyaluronidase (StrepH), delivered topically, to degrade epidermal HA and blunt the accumul

274 secondary outcome assessed wound closure of topically treated erosions.

275 unds (0.8 cm) were created on the dorsum and topically treated over 7 days with either vehicle (phosp

276 response, mice were infected with HSV-1 and topically treated with dexamethasone (DEX) or control ey

277 SKH-1 hairless mice were topically treated with GTP (5 mg/0.2 ml acetone/mouse) a

278 s of EP2 and EP4, UVB-exposed CD-1 mice were topically treated with indomethacin to block endogenous

279 ice depleted of complement component C3 were topically treated with MAb F429 starting 8 hours post-in

280 ght measurements, right eyes of rabbits were topically treated with vehicle, BOL-303242-X (1.0% or 0.

281 rEP) is a promising strategy, which utilizes topically (vaginally or rectally), orally or other syste

282 Some rats were treated topically with 1 mM Compound 49b.

283 dermis and upper hair follicles when treated topically with 12-O-tetradecanoylphorbol-13-acetate (TPA

284 Cynomolgus monkeys were treated topically with 150 microg ECHO in one (n = 4 eyes) or bo

285 Hairless mice were treated topically with activators of PPARalpha (WY14643), PPARde

286 nosuppression amongst mice that were treated topically with available anti-cancer drugs (imiquimod an

287 g the next several months, were then treated topically with caffeine (6.2 micromol) or (-)-epigalloca

288 neous carcinogenesis, mice were treated once topically with DMBA followed by twice weekly with PMA fo

289 Eyes were treated either topically with drops of lysostaphin (0.3%) or with a sin

290 Mice were then treated topically with either AZM or vehicle.

291 H, irrigated copiously with PBS, and treated topically with either Tbeta4 or PBS twice daily.

292 cted subconjunctivally prior to or coapplied topically with gatifloxacin 16 hours after infection.

293 ed with house dust mite allergen and treated topically with HOCl hydrogel both preventively and thera

294 One eye of each cat was treated topically with prostaglandin F2alpha, fluprostenol (FP r

295 Eyes were treated topically with spermidine before and after lens applicat

296 D-2(-/-) mice and in C57BL/6 mice pretreated topically with the MD-2 antagonist eritoran tetrasodium.

297 Rabbits were pretreated topically with the moderately selective adenosine A1 ant

298 tion and keratinocyte apoptosis when treated topically with TPA.

299 FP+ neurofluorescent mouse eyes were treated topically with vehicle or BAK (0.01% or 0.1%).

300 mice chronically exposed to UVB and treated topically with vitamin E alone showed a trend towards in